The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Pondimin     N-ethyl-1-[3- (trifluoromethyl) phenyl]propa...

Synonyms: Ponderal, Ponderax, Fenfluramin, Pondimin (TN), SureCN39491, ...
This record was replaced with 3337.
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Dexfenfluramine

 

Psychiatry related information on Dexfenfluramine

  • The distribution of cervical lengths was established and the significance of differences in median cervical length between subgroups according to maternal age, ethnic origin, maternal ponderal index, cigarette smoking, alcohol drinking, drug abuse and previous obstetric history was calculated [6].
  • Statistically significant findings were that patients with MVP were younger and more often female; reported an earlier age of onset of PD and more frequent panic attacks; and had a higher ponderal index, lower weight, and lower levels of triiodothyronine than patients without MVP [7].
  • The correlation between reaction time and the ponderal index [8].
 

High impact information on Dexfenfluramine

  • Increases in estimated percentage body fat and ponderal index (kilograms per cubic meter) were highly associated with changes in TRSF, but showed slightly different associations with the serum lipids and lipoproteins [9].
  • Maternal mean 24 h diastolic blood pressure at 28 weeks' gestation was also inversely associated with the infant's ponderal index at birth in multivariate analysis (p = 0.06) [10].
  • Serotonergic response patterns were assessed by measuring the increase in serum prolactin concentration during 5 hours following single-dose, oral administration of 60 mg of d,l-fenfluramine hydrochloride (Pondimin) [11].
  • The levels of estradiol in women born in the highest tertile of ponderal index (an indicator of neonatal nutritional status) were 37% and 46% higher, respectively, than levels of estradiol in women born in the low and middle ponderal index tertiles [12].
  • RESULTS: As expected, cord insulin concentrations correlated with all measures of birth size (weight, length, head and arm circumferences, sum of skinfold thicknesses, ponderal index: r=0.16-0.4, p<0.01 for all) and maternal BMI (r=0.11, p=0.005), maternal glucose (r=0.25, p<0.001) and maternal insulin resistance (r=0.23, p<0.001) [13].
 

Chemical compound and disease context of Dexfenfluramine

  • Data for adult anthropometry, fasting blood glucose, and blood glucose after an oral glucose load came from the randomized prospective Reykjavík Study. RESULTS: Postchallenge glucose concentrations were inversely related to birth weight and length in men and inversely related to birth weight and ponderal index in women (P < 0.001) [14].
  • The Gly/Arg972 of insulin receptor substrate-1 (IRS-1), the Thr/Ile130 of the hepatocyte nuclear factor-4alpha (HNF-4alpha), the Pro/Ala75 of HNF-6, and the Ile/Leu27, Ala/Val93, and Ser/Asn4s7 polymorphisms of the HNF-lalpha gene were examined for association with birth weight and length and the ponderal index [15].
  • Serum DHEA-S and urinary 17-KS and creatinine were measured in 71 patients with and without signs of androgen excess who were attending the Reproductive Endocrinology/Infertility Clinic. Serum DHEA-S levels did not correlate with body weight, surface area, or ponderal index, and were not elevated in obese women without androgen excess [16].
  • Atenolol was found to be associated with lower birth weight and ponderal index values, with a trend toward a higher prevalence of preterm (<37 weeks) delivery and small-for-gestational-age babies when compared to other antihypertensive drugs as monotherapy, or to no treatment [17].
  • Resulting assays and analyses showed that levonorgestrel concentrations of each implant formulation decreased significantly with time after placement, with increasing body weight, and with ponderal index [18].
 

Biological context of Dexfenfluramine

  • RESULTS: There were no statistically significant associations between birthweight, length or ponderal index, and either blood pressure or glucose tolerance in the twins [19].
  • Glucose intolerance and insulin resistance showed inverted U-shaped relations with ponderal index, in contrast with the monotonic inverse relation seen in this cohort at earlier ages [20].
  • We have therefore used 31P magnetic resonance spectroscopy to investigate the bioenergetics of gastrocnemius and flexor digitorum superficialis muscles in 16 normoglycaemic women who had a low ( < or = 23 kg/m3) and 9 women who had a high (> 23 kg/m3) ponderal index at birth [21].
  • The 2-h, 75-g glucose load values were significantly associated in both periods with neonatal CC/TC ratio </=10th percentile and ponderal index >/=90th percentile, whereas maternal age >35 years was an independent predictor of both neonatal CC/TC ratio </=10th percentile and macrosomia [22].
  • Newborn weight was 211 g lower (P < 0.006) and ponderal index 1.2 units lower (P < 0.02) in infants born to women who lost weight in the first trimester [23].
 

Anatomical context of Dexfenfluramine

 

Associations of Dexfenfluramine with other chemical compounds

 

Gene context of Dexfenfluramine

  • IGF-II was weakly related to ponderal index (r = 0.18; P < 0.05) and placental weight (r = 0.18; P < 0.05), and the molar ratio of IGF-II to IGF2R was also related to birth weight (r = 0.15; P < 0.05) [33].
  • Changes in IGF-I, IGFBP3, BAP, PICP and P3NP over 30 days correlated with ponderal growth (whz change) over the same period (all P < 0.01) [34].
  • CONCLUSIONS: An inverse association of adiponectin with ponderal index by univariate analysis is not independent from confounding factors [35].
  • PGM1 did not make a significant contribution to birthweight, standardised birthweight, length or ponderal index of the baby as assessed by multiple regression [36].
  • In addition, daily fat intake was a positive predictor of postnatal length increases, and changes in prealbumin, insulin, and GH were negative predictors of postnatal changes in the ponderal index (weight x length(-3)) [37].
 

Analytical, diagnostic and therapeutic context of Dexfenfluramine

  • Thinness at birth and in adult life has opposing effects such that resistance fell with increasing ponderal index at birth but rose with increasing adult body mass index [38].
  • In contrast, offspring of diabetic mothers of groups 2 and 3 showed an increased incidence of large-for-gestational-age infants, significantly greater means of ponderal index and thoracic circumferences, and significantly smaller cranial/thoracic circumference ratios with respect to the control group [39].
  • Correlation analysis of the data from these eight subjects showed that 17-KS, PBDS, and the serum DS were all correlated with body surface area, body weight, and ponderal index and that 17-KS excretion, PBDS, and serum DS were all correlated with one another [40].
  • We used data from that study and from a follow-up study conducted in 1998-1999 (when the subjects were 21-27 y of age) to determine associations of birth weight, length at 15 d of age, ponderal index, and length at 2 y of age with adult height, weight, fat-free mass (FFM), fat mass, percentage of body fat, and waist-to-hip ratio [41].
  • Upper-arm anthropometry, skinfold thickness, and Quetelet's and Ponderal indexes were poorly correlated with TBF and FFM (r2 < 0.65) [42].

References

  1. Dimensional analysis and theory of biological similarity. Günther, B. Physiol. Rev. (1975) [Pubmed]
  2. Ponderal index: quantifying obesity. Flewellen, E.H., Bee, D.E. JAMA (1979) [Pubmed]
  3. Birth dimensions of offspring, premature birth, and the mortality of mothers. Smith, G.D., Whitley, E., Gissler, M., Hemminki, E. Lancet (2000) [Pubmed]
  4. Variation at the insulin gene VNTR (variable number tandem repeat) polymorphism and early growth: studies in a large Finnish birth cohort. Bennett, A.J., Sovio, U., Ruokonen, A., Martikainen, H., Pouta, A., Taponen, S., Hartikainen, A.L., King, V.J., Elliott, P., Järvelin, M.R., McCarthy, M.I. Diabetes (2004) [Pubmed]
  5. Pregnancy outcome in North American women. II. Effects of diet, cigarette smoking, stress, and weight gain on placentas, and on neonatal physical and behavioral characteristics. Picone, T.A., Allen, L.H., Olsen, P.N., Ferris, M.E. Am. J. Clin. Nutr. (1982) [Pubmed]
  6. Cervical length at 23 weeks of gestation: relation to demographic characteristics and previous obstetric history. Heath, V.C., Southall, T.R., Souka, A.P., Novakov, A., Nicolaides, K.H. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. (1998) [Pubmed]
  7. Correlates of mitral valve prolapse among patients with panic disorder. Matuzas, W., al-Sadir, J., Uhlenhuth, E.H., Glass, R.M., Easton, C. Psychiatry research. (1989) [Pubmed]
  8. The correlation between reaction time and the ponderal index. Jensen, A.R., Reed, T.E. Perceptual and motor skills. (1992) [Pubmed]
  9. Relationship of changes in obesity to serum lipid and lipoprotein changes in childhood and adolescence. Freedman, D.S., Burke, G.L., Harsha, D.W., Srinivasan, S.R., Cresanta, J.L., Webber, L.S., Berenson, G.S. JAMA (1985) [Pubmed]
  10. Ambulatory blood pressure in pregnancy and fetal growth. Churchill, D., Perry, I.J., Beevers, D.G. Lancet (1997) [Pubmed]
  11. Decreased serotonin function in bulimia nervosa. Jimerson, D.C., Wolfe, B.E., Metzger, E.D., Finkelstein, D.M., Cooper, T.B., Levine, J.M. Arch. Gen. Psychiatry (1997) [Pubmed]
  12. Fatness at birth predicts adult susceptibility to ovarian suppression: an empirical test of the Predictive Adaptive Response hypothesis. Jasienska, G., Thune, I., Ellison, P.T. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  13. Paternal insulin resistance and its association with umbilical cord insulin concentrations. Shields, B.M., Knight, B., Turner, M., Wilkins-Wall, B., Shakespeare, L., Powell, R.J., Hannemann, M., Clark, P.M., Yajnik, C.S., Hattersley, A.T. Diabetologia (2006) [Pubmed]
  14. Size at birth and glucose intolerance in a relatively genetically homogeneous, high-birth weight population. Birgisdottir, B.E., Gunnarsdottir, I., Thorsdottir, I., Gudnason, V., Benediktsson, R. Am. J. Clin. Nutr. (2002) [Pubmed]
  15. Variability of the insulin receptor substrate-1, hepatocyte nuclear factor-1alpha (HNF-1alpha), HNF-4alpha, and HNF-6 genes and size at birth in a population-based sample of young Danish subjects. Rasmussen, S.K., Urhammer, S.A., Hansen, T., Almind, K., Møller, A.M., Borch-Johnsen, K., Pedersen, O. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  16. Dehydroepiandrosterone sulfate as an indicator of adrenal androgen function. Lobo, R.A., Paul, W.L., Goebelsmann, U. Obstetrics and gynecology. (1981) [Pubmed]
  17. Atenolol and fetal growth in pregnancies complicated by hypertension. Lydakis, C., Lip, G.Y., Beevers, M., Beevers, D.G. Am. J. Hypertens. (1999) [Pubmed]
  18. Levonorgestrel concentrations during use of levonorgestrel rod (LNG ROD) implants. Sivin, I., Lähteenmäki, P., Ranta, S., Darney, P., Klaisle, C., Wan, L., Mishell, D.R., Lacarra, M., Viegas, O.A., Bilhareus, P., Koetsawang, S., Piya-Anant, M., Diaz, S., Pavez, M., Alvarez, F., Brache, V., LaGuardia, K., Nash, H., Stern, J. Contraception. (1997) [Pubmed]
  19. Testing the fetal origins hypothesis in twins: the Birmingham twin study. Baird, J., Osmond, C., MacGregor, A., Snieder, H., Hales, C.N., Phillips, D.I. Diabetologia (2001) [Pubmed]
  20. Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth. McKeigue, P.M., Lithell, H.O., Leon, D.A. Diabetologia (1998) [Pubmed]
  21. A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy. Taylor, D.J., Thompson, C.H., Kemp, G.J., Barnes, P.R., Sanderson, A.L., Radda, G.K., Phillips, D.I. Diabetologia (1995) [Pubmed]
  22. The 75-gram glucose load in pregnancy: relation between glucose levels and anthropometric characteristics of infants born to women with normal glucose metabolism. Mello, G., Parretti, E., Cioni, R., Lucchetti, R., Carignani, L., Martini, E., Mecacci, F., Lagazio, C., Pratesi, M. Diabetes Care (2003) [Pubmed]
  23. Variation in newborn size according to pregnancy weight change by trimester. Brown, J.E., Murtaugh, M.A., Jacobs, D.R., Margellos, H.C. Am. J. Clin. Nutr. (2002) [Pubmed]
  24. Thyroid uptake of 123I in a normal population. Hooper, P.L., Turner, J.R., Conway, M.J., Plymate, S.R. Arch. Intern. Med. (1980) [Pubmed]
  25. Adiponectin and leptin in maternal serum, cord blood, and breast milk. Weyermann, M., Beermann, C., Brenner, H., Rothenbacher, D. Clin. Chem. (2006) [Pubmed]
  26. Evaluation of perinatal outcome using individualized growth assessment: comparison with conventional methods. Ariyuki, Y., Hata, T., Kitao, M. Pediatrics (1995) [Pubmed]
  27. Perinatal growth disturbance in the spontaneously hypertensive rat. Lewis, R.M., Batchelor, D.C., Bassett, N.S., Johnston, B.M., Napier, J., Skinner, S.J. Pediatr. Res. (1997) [Pubmed]
  28. Plasma fibrinogen and its correlates in children from a biracial community: the Bogalusa Heart Study. Bao, W., Srinivasan, S.R., Berenson, G.S. Pediatr. Res. (1993) [Pubmed]
  29. Influence of apolipoprotein E polymorphism on serum lipids and lipoprotein changes from childhood to adulthood: the Bogalusa Heart Study. Srinivasan, S.R., Ehnholm, C., Elkasabany, A., Berenson, G. Atherosclerosis (1999) [Pubmed]
  30. Effects of fenfluramine in hypertriglyceridemic obese subjects. Brun, L.D., Bielmann, P., Gagne, C., Moorjani, S., Nadeau, A., Lupien, P.J. International journal of obesity. (1988) [Pubmed]
  31. Effect of clomiphene on the ponderal, histological and biochemical changes induced by stilbestrol and testosterone in the uterus of rats. Datta, J.K., Roy, S., Das, R.P. Steroids (1975) [Pubmed]
  32. Nutritional therapy of Crohn's disease in childhood. Seidman, E.G., Roy, C.C., Weber, A.M., Morin, C.L. Dig. Dis. Sci. (1987) [Pubmed]
  33. Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Ong, K., Kratzsch, J., Kiess, W., Costello, M., Scott, C., Dunger, D. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  34. Malnutrition, zinc supplementation and catch-up growth: changes in insulin-like growth factor I, its binding proteins, bone formation and collagen turnover. Doherty, C.P., Crofton, P.M., Sarkar, M.A., Shakur, M.S., Wade, J.C., Kelnar, C.J., Elmlinger, M.W., Ranke, M.B., Cutting, W.A. Clin. Endocrinol. (Oxf) (2002) [Pubmed]
  35. Serum adiponectin concentrations in relation to maternal and perinatal characteristics in newborns. Mantzoros, C., Petridou, E., Alexe, D.M., Skalkidou, A., Dessypris, N., Papathoma, E., Salvanos, H., Shetty, G., Gavrila, A., Kedikoglou, S., Chrousos, G., Trichopoulos, D. Eur. J. Endocrinol. (2004) [Pubmed]
  36. Lack of association between maternal phosphoglucomutase-1 phenotype and fetal macrosomia in diabetic pregnancy. Johnstone, F.D., West, J.D., Steel, J., Whitehouse, D.B., Drago, G.A., Greer, I.A., Prescott, R.J. British journal of obstetrics and gynaecology. (1994) [Pubmed]
  37. Changes in serum insulin-like growth factors, not leptin, are associated with postnatal weight gain in preterm neonates. Lo, H.C., Tsao, L.Y., Hsu, W.Y., Chi, C.Y., Tsai, F.A. JPEN. Journal of parenteral and enteral nutrition. (2005) [Pubmed]
  38. Thinness at birth and insulin resistance in adult life. Phillips, D.I., Barker, D.J., Hales, C.N., Hirst, S., Osmond, C. Diabetologia (1994) [Pubmed]
  39. What degree of maternal metabolic control in women with type 1 diabetes is associated with normal body size and proportions in full-term infants? Mello, G., Parretti, E., Mecacci, F., La Torre, P., Cioni, R., Cianciulli, D., Scarselli, G. Diabetes Care (2000) [Pubmed]
  40. Metabolism of dehydroepiandrosterone sulfate (DS) in normal women and women with high DS concentrations. Haning, R.V., Carlson, I.H., Flood, C.A., Hackett, R.J., Longcope, C. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  41. Associations between prenatal and postnatal growth and adult body size and composition. Li, H., Stein, A.D., Barnhart, H.X., Ramakrishnan, U., Martorell, R. Am. J. Clin. Nutr. (2003) [Pubmed]
  42. Body fat and fat-free mass in infants: new and classic anthropometric indexes and prediction equations compared with total-body electrical conductivity. de Bruin, N.C., van Velthoven, K.A., Stijnen, T., Juttmann, R.E., Degenhart, H.J., Visser, H.K. Am. J. Clin. Nutr. (1995) [Pubmed]
 
WikiGenes - Universities