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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Vulnerable Populations

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Disease relevance of Vulnerable Populations


Psychiatry related information on Vulnerable Populations


High impact information on Vulnerable Populations


Chemical compound and disease context of Vulnerable Populations

  • This report reviews the evidence that intrauterine exposure to growth retardation, diabetes, and vitamin A deficiency contribute disproportionately to the rising incidence of kidney disease in disadvantaged people, because they encounter these exposures more frequently than people from developed countries [16].
  • Postoperative liver functions showed no marked derangement; the mean peak GPT was 221 U and the mean peak total bilirubin 2.3 mg d/l. Local cooling minimizes the risk of ischemia/reperfusion injury in this very vulnerable population, yet gives the surgeon adequate time to perform a challenging resection in a bloodless field [17].

Biological context of Vulnerable Populations


Anatomical context of Vulnerable Populations


Associations of Vulnerable Populations with chemical compounds


Gene context of Vulnerable Populations

  • On the whole, our data suggest that those individuals who are genetically predisposed to produce high levels of IL-6 during aging, i.e. -174 locus GG homozygous men, are disadvantaged for longevity [27].
  • When pigs were challenged with an equal mixture of the hilA mutant and wild type bacteria, the hilA mutant was at a competitive disadvantaged (attenuated) in pigs inoculated orally but not in intraperitoneally inoculated pigs [28].
  • Performance scores on the CATM were higher than on the RCPM, especially in comparison to the B8-B12 items--differences reach a peak of 61% and 67% for the disadvantaged and regular groups, respectively [29].
  • Among both men and women with epilepsy, those with partial onset and early age at onset (< 10 years) were more reproductively disadvantaged than those with generalized onset and later age at onset [30].
  • However, supermarkets have opened or remained open close to middle-income neighborhoods that have transitioned from White to African American. Development of economically disadvantaged African American neighborhoods is critical to effectively prevent diet-related diseases among this population [31].

Analytical, diagnostic and therapeutic context of Vulnerable Populations


  1. Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young south african adults: early programming of cortisol axis. Levitt, N.S., Lambert, E.V., Woods, D., Hales, C.N., Andrew, R., Seckl, J.R. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  2. Relationship between socioeconomic status and disease severity in cystic fibrosis. Schechter, M.S., Margolis, P.A. J. Pediatr. (1998) [Pubmed]
  3. Trends and predictors of folic acid awareness and periconceptional use in pregnant women. de Jong-Van den Berg, L.T., Hernandez-Diaz, S., Werler, M.M., Louik, C., Mitchell, A.A. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  4. Citalopram--a review of pharmacological and clinical effects. Bezchlibnyk-Butler, K., Aleksic, I., Kennedy, S.H. Journal of psychiatry & neuroscience : JPN. (2000) [Pubmed]
  5. Clusters of census tracts with high proportions of men with distant-stage prostate cancer incidence in New Jersey, 1995 to 1999. Abe, T., Martin, I.B., Roche, L.M. American journal of preventive medicine. (2006) [Pubmed]
  6. Nicotine psychobiology: how chronic-dose prospective studies can illuminate some of the theoretical issues from acute-dose research. Parrott, A.C. Psychopharmacology (Berl.) (2006) [Pubmed]
  7. Addressing lesbian, gay, bisexual, and transgender issues from the inside: one federal agency's approach. Craft, E.M., Mulvey, K.P. American journal of public health. (2001) [Pubmed]
  8. Autonomy for vulnerable populations: the Supreme Court's reckless disregard for self-determination and social science. Bersoff, D.N. Villanova law review. (1992) [Pubmed]
  9. Sociodemographic and behavioral characteristics of African-American women with HIV and AIDS in Los Angeles County, 1990-1997. Wohl, A.R., Lu, S., Odem, S., Sorvillo, F., Pegues, C.F., Kerndt, P.R. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1998) [Pubmed]
  10. Dementia associated with epilepsy. Caramelli, P., Castro, L.H. International psychogeriatrics / IPA. (2005) [Pubmed]
  11. A randomized controlled trial of an HIV sexual risk-reduction intervention for young African-American women. DiClemente, R.J., Wingood, G.M. JAMA (1995) [Pubmed]
  12. Choline and human nutrition. Zeisel, S.H., Blusztajn, J.K. Annu. Rev. Nutr. (1994) [Pubmed]
  13. Colocalization of tau and alpha-synuclein epitopes in Lewy bodies. Ishizawa, T., Mattila, P., Davies, P., Wang, D., Dickson, D.W. J. Neuropathol. Exp. Neurol. (2003) [Pubmed]
  14. Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease; evidence that all three MTHFR C677T genotypes confer different levels of risk. Kluijtmans, L.A., Whitehead, A.S. Eur. Heart J. (2001) [Pubmed]
  15. "Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population" by Walton et al. Butchko, H.H. Biol. Psychiatry (1994) [Pubmed]
  16. Intrauterine determinants of diabetic kidney disease in disadvantaged populations. Nelson, R.G. Kidney Int. Suppl. (2003) [Pubmed]
  17. Hepatic resection under in situ hemihepatic hypothermic perfusion with hepatoprotective agents. Yamanaka, N., Okamoto, E., Furukawa, K., Oriyama, T., Fujimoto, J., Kanno, H., Kawamura, E., Tanaka, T., Tomoda, H., Ichikawa, N. Hepatogastroenterology (1995) [Pubmed]
  18. The growing prevalence of non-insulin-dependent diabetes in migrant Asian populations and its implications for Asia. Fujimoto, W.Y. Diabetes Res. Clin. Pract. (1992) [Pubmed]
  19. A programme to promote breast feeding in a socio-economically disadvantaged area of Cape Town, Republic of South Africa. Hoffman, M.N., Disler, P.B., Power, D.J. Public health reviews. (1984) [Pubmed]
  20. Effects of chronic alcohol consumption and withdrawal on the somatostatin-immunoreactive neurons of the rat hippocampal dentate hilus. Andrade, J.P., Fernando, P.M., Madeira, M.D., Paula-Barbosa, M.M., Cadete-Leite, A., Zimmer, J. Hippocampus. (1992) [Pubmed]
  21. Family history of coronary artery disease and cholesterol: screening children in a disadvantaged inner-city population. Wadowski, S.J., Karp, R.J., Murray-Bachmann, R., Senft, C. Pediatrics (1994) [Pubmed]
  22. Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain. Bennett, M.I. Pain (1997) [Pubmed]
  23. A study of benzhexol abuse. Crawshaw, J.A., Mullen, P.E. The British journal of psychiatry : the journal of mental science. (1984) [Pubmed]
  24. Pharmacotherapy of Raynaud's phenomenon. Belch, J.J., Ho, M. Drugs (1996) [Pubmed]
  25. Oseltamivir. Bardsley-Elliot, A., Noble, S. Drugs (1999) [Pubmed]
  26. Pharmacokinetics and therapeutic drug monitoring of gentamicin in the elderly. Triggs, E., Charles, B. Clinical pharmacokinetics. (1999) [Pubmed]
  27. A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Bonafè, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Mayegiani, F., Cardelli, M., Pieri, C., Marra, M., Antonicelli, R., Lisa, R., Rizzo, M.R., Paolisso, G., Monti, D., Franceschi, C. Eur. J. Immunol. (2001) [Pubmed]
  28. Systemic and enteric colonization of pigs by a hilA signature-tagged mutant of Salmonella choleraesuis. Lichtensteiger, C.A., Vimr, E.R. Microb. Pathog. (2003) [Pubmed]
  29. The assessment of analogical thinking modifiability among regular, special education, disadvantaged, and mentally retarded children. Tzuriel, D., Klein, P.S. Journal of abnormal child psychology. (1985) [Pubmed]
  30. Reproduction among individuals with idiopathic/cryptogenic epilepsy: risk factors for reduced fertility in marriage. Schupf, N., Ottman, R. Epilepsia (1996) [Pubmed]
  31. Neighborhood racial composition, neighborhood poverty, and the spatial accessibility of supermarkets in metropolitan Detroit. Zenk, S.N., Schulz, A.J., Israel, B.A., James, S.A., Bao, S., Wilson, M.L. American journal of public health. (2005) [Pubmed]
  32. Audiologic assessment of extremely low birth weight infants: a preliminary report. Doyle, L.W., Keir, E., Kitchen, W.H., Ford, G.W., Rickards, A.L., Kelly, E.A. Pediatrics (1992) [Pubmed]
  33. Constitutive expression of the low-affinity neurotrophin receptor and changes during axotomy-induced death of sensory neurones in the neonatal rat dorsal root ganglion. Murray, S.S., Cheema, S.S. J. Anat. (2003) [Pubmed]
  34. Drug treatment of epilepsy in elderly people: focus on valproic Acid. Stephen, L.J. Drugs & aging. (2003) [Pubmed]
  35. Meningococcal meningitis in critical care: an overview, new treatments/preventions, and a case study. Estep, M. Critical care nursing quarterly. (2005) [Pubmed]
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