The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Ocimum

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Ocimum

 

High impact information on Ocimum

  • Ocimum sanctum leaves have previously been reported to reduce blood glucose when administered to rats and humans with diabetes [6].
  • Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats [7].
  • The main constituents of the oil of Ocimum gratissimum were gamma-terpinene (21.9 %), beta-phellandrene (21.1 %), limonene (11.4 %) and thymol (11.2 %), while the oil of Cymbopogon citratus contained geranial (32.8 %), neral (29.0 %), myrcene (16.2 %) and beta-pinene (10.5 %) [8].
  • Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin [9].
  • Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in south India as influenced by method of harvest [10].
 

Chemical compound and disease context of Ocimum

 

Biological context of Ocimum

 

Anatomical context of Ocimum

 

Associations of Ocimum with chemical compounds

  • Modulatory influence of alcoholic extract of Ocimum leaves on carcinogen-metabolizing enzyme activities and reduced glutathione levels in mouse [17].
  • Two flavonoids, orientin and vicenin, isolated from the leaves of the Indian plant Ocimum sanctum were tested for their radioprotective effect in mice [18].
  • The cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Ocimum gratissimum (EOOG) and its main constituent, eugenol (Eug) were investigated in the experimental model of deoxycorticosterone acetate (DOCA-salt)-hypertensive rats [7].
  • Methyleugenol in Ocimum basilicum L. Cv. genovese gigante [19].
  • Ocimum sanctum modulates selenite-induced cataractogenic changes and prevents rat lens opacification [20].
 

Gene context of Ocimum

  • Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn [21].
  • The extracts from the leaves of Ocimum sanctum showed better activity against the three MRSA strains [22].
  • The present study reports the modulatory influence of alcoholic extract from the leaves of Ocimum sanctum on the activities of cytochrome p-450, cytochrome b5, and aryl hydrocarbon hydroxylase enzymes in the liver and glutathione-S-transferase and reduced glutathione level in the liver, lung, and stomach of the mouse [17].
  • A third extraction procedure was used for Ocimum sanctum which after extraction with CHCL3:CH3OH (2:1), partitioned between CCL4 and CH3OH:H2O (9:1) [23].
  • Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide [24].
 

Analytical, diagnostic and therapeutic context of Ocimum

  • Similarly, glutathione S-transferase activity was also observed to be significantly elevated by 25% compared with the control group (p < 0.05) following Ocimum extract treatment [25].

References

  1. Effective treatment of experimental acute otitis media by application of volatile fluids into the ear canal. Kristinsson, K.G., Magnusdottir, A.B., Petersen, H., Hermansson, A. J. Infect. Dis. (2005) [Pubmed]
  2. Radiation protection by the ocimum flavonoids orientin and vicenin: mechanisms of action. Uma Devi, P., Ganasoundari, A., Vrinda, B., Srinivasan, K.K., Unnikrishnan, M.K. Radiat. Res. (2000) [Pubmed]
  3. Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Vrinda, B., Uma Devi, P. Mutat. Res. (2001) [Pubmed]
  4. Cardioprotective potential of ocimum sanctum in isoproterenol induced myocardial infarction in rats. Sharma, M., Kishore, K., Gupta, S.K., Joshi, S., Arya, D.S. Mol. Cell. Biochem. (2001) [Pubmed]
  5. Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury. Mohanty, I., Arya, D.S., Gupta, S.K. BMC complementary and alternative medicine [electronic resource]. (2006) [Pubmed]
  6. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic {beta}-cells. Hannan, J.M., Marenah, L., Ali, L., Rokeya, B., Flatt, P.R., Abdel-Wahab, Y.H. J. Endocrinol. (2006) [Pubmed]
  7. Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, in DOCA-salt hypertensive conscious rats. Interaminense, L.F., Leal-Cardoso, J.H., Magalhães, P.J., Duarte, G.P., Lahlou, S. Planta Med. (2005) [Pubmed]
  8. In vivo antimalarial activity of essential oils from Cymbopogon citratus and Ocimum gratissimum on mice infected with Plasmodium berghei. Tchoumbougnang, F., Zollo, P.H., Dagne, E., Mekonnen, Y. Planta Med. (2005) [Pubmed]
  9. Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. Uma Devi, P., Satyamitra, M. Int. J. Radiat. Biol. (2004) [Pubmed]
  10. Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in south India as influenced by method of harvest. Kothari, S.K., Bhattacharya, A.K., Ramesh, S. Journal of chromatography. A. (2004) [Pubmed]
  11. Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Devi, P.U., Ganasoundari, A. Indian J. Exp. Biol. (1999) [Pubmed]
  12. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. Vats, V., Yadav, S.P., Grover, J.K. Journal of ethnopharmacology. (2004) [Pubmed]
  13. Inhibition of glutathione S-transferases (GSTs) from parasitic nematodes by extracts from traditional Nigerian medicinal plants. Fakae, B.B., Campbell, A.M., Barrett, J., Scott, I.M., Teesdale-Spittle, P.H., Liebau, E., Brophy, P.M. Phytotherapy research : PTR. (2000) [Pubmed]
  14. A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse. Devi, P.U., Bisht, K.S., Vinitha, M. The British journal of radiology. (1998) [Pubmed]
  15. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. Sakina, M.R., Dandiya, P.C., Hamdard, M.E., Hameed, A. Journal of ethnopharmacology. (1990) [Pubmed]
  16. Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig. Madeira, S.V., Matos, F.J., Leal-Cardoso, J.H., Criddle, D.N. Journal of ethnopharmacology. (2002) [Pubmed]
  17. Modulatory influence of alcoholic extract of Ocimum leaves on carcinogen-metabolizing enzyme activities and reduced glutathione levels in mouse. Banerjee, S., Prashar, R., Kumar, A., Rao, A.R. Nutrition and cancer. (1996) [Pubmed]
  18. In vivo radioprotection by ocimum flavonoids: survival of mice. Uma Devi, P., Ganasoundari, A., Rao, B.S., Srinivasan, K.K. Radiat. Res. (1999) [Pubmed]
  19. Methyleugenol in Ocimum basilicum L. Cv. genovese gigante. Miele, M., Dondero, R., Ciarallo, G., Mazzei, M. J. Agric. Food Chem. (2001) [Pubmed]
  20. Ocimum sanctum modulates selenite-induced cataractogenic changes and prevents rat lens opacification. Gupta, S.K., Srivastava, S., Trivedi, D., Joshi, S., Halder, N. Curr. Eye Res. (2005) [Pubmed]
  21. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Kelm, M.A., Nair, M.G., Strasburg, G.M., DeWitt, D.L. Phytomedicine (2000) [Pubmed]
  22. Effect of certain bioactive plant extracts on clinical isolates of beta-lactamase producing methicillin resistant Staphylococcus aureus. Aqil, F., Khan, M.S., Owais, M., Ahmad, I. J. Basic Microbiol. (2005) [Pubmed]
  23. Evaluation of antioxidant effectiveness of a few herbal plants. Maulik, G., Maulik, N., Bhandari, V., Kagan, V.E., Pakrashi, S., Das, D.K. Free Radic. Res. (1997) [Pubmed]
  24. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Subramanian, M., Chintalwar, G.J., Chattopadhyay, S. Redox Rep. (2005) [Pubmed]
  25. Chemopreventive action by an extract from Ocimum sanctum on mouse skin papillomagenesis and its enhancement of skin glutathione S-transferase activity and acid soluble sulfydryl level. Prashar, R., Kumar, A., Banerjee, S., Rao, A.R. Anticancer Drugs (1994) [Pubmed]
 
WikiGenes - Universities