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MeSH Review

Myocardial Contraction

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Disease relevance of Myocardial Contraction


Psychiatry related information on Myocardial Contraction


High impact information on Myocardial Contraction


Chemical compound and disease context of Myocardial Contraction


Biological context of Myocardial Contraction


Anatomical context of Myocardial Contraction


Associations of Myocardial Contraction with chemical compounds

  • However, since angiotensin II (Ang II) directly increases the strength of myocardial contraction, suppression of Ang II formation by ACE inhibitors could potentially reduce the beneficial effects of Ang II on the failing heart [26].
  • BACKGROUND: Although tissue Doppler imaging (TDI) has recently emerged to quantify regional myocardial contraction, increased translational motion during a dobutamine challenge may affect the measurements [27].
  • Diltiazem does not appear to cause significant increases in coronary blood flow or bring about improvement in ejectional and isovolumic indices of myocardial contraction - evidence of its intrinsic negative inotropic effect [28].
  • Transmembrane voltage-gated Ca2+ channels play a central role in the development and control of heart contractility which is modulated by the concentration of free cytosolic calcium ions (Ca2+) [29].
  • Interleukin-1 beta modulates myocardial contraction via dexamethasone sensitive production of nitric oxide [30].

Gene context of Myocardial Contraction

  • No MLC3F protein can be detected in the adult or embryonic mouse heart, suggesting that post-transcriptional regulation prevents this fast myosin isoform contributing to myocardial contraction [31].
  • The Ca(2+)-binding S100A1 protein displays a specific and high expression level in the human myocardium and is considered to be an important regulator of heart contractility [32].
  • OBJECTIVE: The positive inotropic effect of endothelin-1 (ET-1) on normal myocardial contraction may be altered in pathological states [33].
  • Moreover, Ucn has much more potent effects on the cardiovascular system than CRF, including enhanced cardiac contractility/heart rate and enhanced resistance of cardiac cells to injury induced, for example, by ischaemia/reperfusion [34].
  • The findings support the hypothesis that thin filament heterogeneity due to the co-expression of alternatively spliced cTnT variants may desynchronize myocardial contraction and contribute to the pathogenesis and pathophysiology of cardiomyopathy and heart failure [35].

Analytical, diagnostic and therapeutic context of Myocardial Contraction


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  3. N,N',N"-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs. Mink, S.N., Jacobs, H., Duke, K., Bose, D., Cheng, Z.Q., Light, R.B. Crit. Care Med. (2004) [Pubmed]
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  5. Capsaicin-sensitive afferents in the rat urinary bladder activate a spinal sympathetic cardiovascular reflex. Giuliani, S., Maggi, C.A., Meli, A. Naunyn Schmiedebergs Arch. Pharmacol. (1988) [Pubmed]
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  7. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Stypmann, J., Gläser, K., Roth, W., Tobin, D.J., Petermann, I., Matthias, R., Mönnig, G., Haverkamp, W., Breithardt, G., Schmahl, W., Peters, C., Reinheckel, T. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Negative inotropic effect of basic fibroblast growth factor on adult rat cardiac myocyte. Ishibashi, Y., Urabe, Y., Tsutsui, H., Kinugawa, S., Sugimachi, M., Takahashi, M., Yamamoto, S., Tagawa, H., Sunagawa, K., Takeshita, A. Circulation (1997) [Pubmed]
  9. Coupling between myosin ATPase cycle and creatinine kinase cycle facilitates cardiac actomyosin sliding in vitro. A clue to mechanical dysfunction during myocardial ischemia. Sata, M., Sugiura, S., Yamashita, H., Momomura, S., Serizawa, T. Circulation (1996) [Pubmed]
  10. Local continuity of myocardial blood flow studied by monochromatic synchrotron radiation-excited x-ray fluorescence spectrometry. Mori, H., Chujo, M., Haruyama, S., Sakamoto, H., Shinozaki, Y., Uddin-Mohammed, M., Iida, A., Nakazawa, H. Circ. Res. (1995) [Pubmed]
  11. L-methionine augments mammalian myocardial contraction by sensitizing the myofilament to Ca2+. Kihara, Y., Inoko, M., Sasayama, S. Circ. Res. (1995) [Pubmed]
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  13. Effect of verapamil on regional myocardial contraction during graded ischemia in the dog. Romson, J.L., Buffington, C.W., Williams, D.B., Itoh, T., Thomas, R., Breazeale, D.G., Ivey, T.D. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
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  15. Relation between plasma nitrate and mean pulmonary arterial pressure in ventricular septal defect. Takaya, J., Teraguchi, M., Nogi, S., Ikemoto, Y., Kobayashi, Y. Arch. Dis. Child. (1998) [Pubmed]
  16. Cardiotoxicity of the lipophilic compound aluminum acetylacetonate in rabbits. Corain, B., Zatta, P., Bombi, G.G., Giordano, R. Biomed. Environ. Sci. (1988) [Pubmed]
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  18. Influence of phosphodiesterase inhibition on myocardial energetics in dilative cardiomyopathy. Hasenfuss, G., Holubarsch, C., Heiss, W.H., Bonzel, T., Meinertz, T., Just, H. Basic Res. Cardiol. (1987) [Pubmed]
  19. Cardiovascular depressant effects of the neomycin-streptomycin group of antibiotics. Adams, H.R. Am. J. Vet. Res. (1975) [Pubmed]
  20. Effects of bupivacaine on contraction and membrane potential in isolated canine papillary muscles. Shibuya, N., Momose, Y., Ito, Y. Pharmacology (1993) [Pubmed]
  21. Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation. Martin, S.R., Emanuel, K., Sears, C.E., Zhang, Y.H., Casadei, B. Cardiovasc. Res. (2006) [Pubmed]
  22. Vascular versus myocardial effects of calcium antagonists. Little, W.C., Cheng, C.P. Drugs (1994) [Pubmed]
  23. Differential effects of cocaine and cocaethylene on intracellular Ca2+ and myocardial contraction in cardiac myocytes. Qiu, Z., Morgan, J.P. Br. J. Pharmacol. (1993) [Pubmed]
  24. T lymphocytes from T. cruzi-infected mice alter heart contractility: participation of arachidonic acid metabolites. Gorelik, G., Borda, E., Postan, M., Gonzalez Cappa, S., Sterin-Borda, L. J. Mol. Cell. Cardiol. (1992) [Pubmed]
  25. Cardiac surgical conditions induced by beta-blockade: effect on myocardial fluid balance. Mehlhorn, U., Allen, S.J., Adams, D.L., Davis, K.L., Gogola, G.R., Warters, R.D. Ann. Thorac. Surg. (1996) [Pubmed]
  26. Angiotensin II-forming pathways in normal and failing human hearts. Urata, H., Healy, B., Stewart, R.W., Bumpus, F.M., Husain, A. Circ. Res. (1990) [Pubmed]
  27. Comparative usefulness of myocardial velocity gradient in detecting ischemic myocardium by a dobutamine challenge. Tsutsui, H., Uematsu, M., Shimizu, H., Yamagishi, M., Tanaka, N., Matsuda, H., Miyatake, K. J. Am. Coll. Cardiol. (1998) [Pubmed]
  28. The haemodynamic effects of nifedipine, verapamil and diltiazem in patients with coronary artery disease. A review. Soward, A.L., Vanhaleweyk, G.L., Serruys, P.W. Drugs (1986) [Pubmed]
  29. Ca2+ currents in compensated hypertrophy and heart failure. Richard, S., Leclercq, F., Lemaire, S., Piot, C., Nargeot, J. Cardiovasc. Res. (1998) [Pubmed]
  30. Interleukin-1 beta modulates myocardial contraction via dexamethasone sensitive production of nitric oxide. Evans, H.G., Lewis, M.J., Shah, A.M. Cardiovasc. Res. (1993) [Pubmed]
  31. Dynamic left/right regionalisation of endogenous myosin light chain 3F transcripts in the developing mouse heart. Kelly, R.G., Zammit, P.S., Mouly, V., Butler-Browne, G., Buckingham, M.E. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  32. Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Kiewitz, R., Acklin, C., Schäfer, B.W., Maco, B., Uhrík, B., Wuytack, F., Erne, P., Heizmann, C.W. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  33. Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy. Suzuki, M., Ohte, N., Wang, Z.M., Williams, D.L., Little, W.C., Cheng, C.P. Cardiovasc. Res. (1998) [Pubmed]
  34. Urocortin. Latchman, D.S. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  35. Cardiac troponin T variants produced by aberrant splicing of multiple exons in animals with high instances of dilated cardiomyopathy. Biesiadecki, B.J., Elder, B.D., Yu, Z.B., Jin, J.P. J. Biol. Chem. (2002) [Pubmed]
  36. Intrathoracic ganglionic beta-adrenergic receptors involved in efferent sympathetic regulation of the canine heart. Armour, J.A., Butler, C. The Canadian journal of cardiology. (1989) [Pubmed]
  37. Longitudinal myocardial contraction improves early during titration with metoprolol CR/XL in patients with heart failure. Andersson, B., Sveälv, B.G., Täng, M.S., Mobini, R. Heart (2002) [Pubmed]
  38. Effect of loading conditions on peak aortic flow velocity and its maximal acceleration. Hsieh, K.S., Chang, C.K., Chang, K.C., Chen, H.I. Proc. Natl. Sci. Counc. Repub. China B (1991) [Pubmed]
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