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MeSH Review

Juxtaglomerular Apparatus

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Disease relevance of Juxtaglomerular Apparatus


High impact information on Juxtaglomerular Apparatus


Chemical compound and disease context of Juxtaglomerular Apparatus


Biological context of Juxtaglomerular Apparatus


Anatomical context of Juxtaglomerular Apparatus


Associations of Juxtaglomerular Apparatus with chemical compounds

  • Adenosine has been proposed to act within the juxtaglomerular apparatus (JGA) as a mediator of the inhibition of renin secretion produced by a high NaCl concentration at the macula densa [23].
  • The independency of sodium intake and ANG-converting enzyme make the juxtaglomerular apparatus as the site responsible for the production of this ANG unlikely [24].
  • The present studies in perfused specimens of the juxtaglomerular apparatus microdissected from rabbit kidneys were performed to quantitatively evaluate the relation between macula densa NaCl concentration and renin secretion and to study the effect of furosemide and verapamil on NaCl dependency of renin release [25].
  • Results define the renal cell types involved in prostaglandin autacoid functions within spatially restricted sites such as the juxtaglomerular apparatus, mesangium, distal convolutions and collecting duct, and in compartments of the renal interstitium [26].
  • Groups of rats were killed at 6 hr after UN plus DTT, HgCl2 alone, or HgCl2 plus DTT; and determinations of plasma renin activity (PRA) and renin activities of the superficial and deep juxtaglomerular apparatus (JGA) were performed [27].

Gene context of Juxtaglomerular Apparatus


Analytical, diagnostic and therapeutic context of Juxtaglomerular Apparatus


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  3. Increased transforming growth factor-beta2 expression in the glomerular arteriole of the juxtaglomerular apparatus in a Bartter's-like syndrome. Yamamoto, T., Takahashi, T., Yonemura, K., Matsui, K., Nagase, M., Hishida, A. Hum. Pathol. (1999) [Pubmed]
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  14. Renin gene expression in vessels of the ovine renal cortex. Darby, I.A., Aldred, P., Crawford, R.J., Fernley, R.T., Niall, H.D., Penschow, J.D., Ryan, G.B., Coghlan, J.P. J. Hypertens. (1985) [Pubmed]
  15. AT1 receptor antagonist combats oxidative stress and restores nitric oxide signaling in the SHR. Welch, W.J., Wilcox, C.S. Kidney Int. (2001) [Pubmed]
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  20. Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease. Torres, V.E., Donovan, K.A., Scicli, G., Holley, K.E., Thibodeau, S.N., Carretero, O.A., Inagami, T., McAteer, J.A., Johnson, C.M. Kidney Int. (1992) [Pubmed]
  21. Immunohistochemical localization of renin in the human kidney. Faraggiana, T., Gresik, E., Tanaka, T., Inagami, T., Lupo, A. J. Histochem. Cytochem. (1982) [Pubmed]
  22. Mechanisms for macula densa cell release of renin. Persson, A.E., Ollerstam, A., Liu, R., Brown, R. Acta Physiol. Scand. (2004) [Pubmed]
  23. Effect of adenosine1-receptor blockade on renin release from rabbit isolated perfused juxtaglomerular apparatus. Weihprecht, H., Lorenz, J.N., Schnermann, J., Skøtt, O., Briggs, J.P. J. Clin. Invest. (1990) [Pubmed]
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  26. Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse). Câmpean, V., Theilig, F., Paliege, A., Breyer, M., Bachmann, S. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
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  28. Furosemide stimulates macula densa cyclooxygenase-2 expression in rats. Mann, B., Hartner, A., Jensen, B.L., Kammerl, M., Krämer, B.K., Kurtz, A. Kidney Int. (2001) [Pubmed]
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  33. Angiotensin II feedback is a regulator of renocortical renin, COX-2, and nNOS expression. Kammerl, M.C., Richthammer, W., Kurtz, A., Krämer, B.K. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  34. Autoregulation of the glomerular filtration rate and the single-nephron glomerular filtration rate despite inhibition of tubuloglomerular feedback in rats chronically volume-expanded by deoxycorticosterone acetate. Häberle, D.A., Königbauer, B., Davis, J.M., Kawata, T., Mast, C., Metz, C., Dahlheim, H. Pflugers Arch. (1990) [Pubmed]
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  36. Functional interpretation of the kidney juxtaglomerular apparatus using renin immunohistochemistry in Bartter's, pseudo-Bartter's and Conn's syndromes. Lertprasertsuke, N., Kakudo, K., Osamura, Y., Nomoto, Y., Sakai, H., Watanabe, K. Tokai J. Exp. Clin. Med. (1990) [Pubmed]
  37. The response of the juxtaglomerular apparatus to stimuli effecting renin or erythropoietin release in canine renal allografts. Varkarakis, M.J., Mirand, E.A., Murphy, G.P. Investigative urology. (1976) [Pubmed]
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