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Gene Review

nph  -  nephrosis

Mus musculus

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Disease relevance of nph


High impact information on nph


Chemical compound and disease context of nph


Biological context of nph


Anatomical context of nph


Associations of nph with chemical compounds

  • After treatment, urinary, serologic, and histopathologic indices of nephrosis showed reversal of CG in 8 of 12 CYC202-treated mice compared with progression of CG in 10 of 12 vehicle-treated mice, demonstrating a significant therapeutic benefit from CYC202 (P < 0.05) [21].
  • BACKGROUND: The mouse, as opposed to the rat, is relatively resistant to the experimental nephrosis induced by puromycin aminonucleoside [22].
  • Following treatment, histopathological, serological and urinary indices of nephrosis were normalized in flavopiridol-treated but not in vehicle-treated transgenics [23].
  • Interstrain differences in murine daunomycin-induced nephrosis [24].
  • However, dose-related toxic nephrosis was found in mice given 1.35-5.0% BHT in the diet [25].

Other interactions of nph

  • IP-10 may participate in the modulation of renal damage in experimental nephrosis [10].
  • A severe nephrosis in heartwater-infected Angora goats, treated after the first day of the febrile reaction, is described [26].
  • Increase in kidney weight, glomerular nephrosis, degeneration/desquamation of tubular epithelium and characteristic amyloid deposition in glomeruli were observed only in the group of mice treated with 2000 mg/kg TCE [27].

Analytical, diagnostic and therapeutic context of nph


  1. Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15. Okamoto, M., Yokoi, N., Serikawa, T., Tajima, M., Kurosawa, T. J. Vet. Med. Sci. (2001) [Pubmed]
  2. Hodgkin's disease and lipoid nephrosis. Couser, W., Badger, A., Cooperband, S., Stilmand, M., Jermanovich, N., Aurora, S., Doner, D., Schmitt, G. Lancet (1977) [Pubmed]
  3. Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. Binder, C.J., Weiher, H., Exner, M., Kerjaschki, D. Am. J. Pathol. (1999) [Pubmed]
  4. Studies of diabetic nephropathy in animals and man. Mauer, S.M., Steffes, M.W., Michael, A.F., Brown, D.M. Diabetes (1976) [Pubmed]
  5. The nephrotic syndrome associated with neoplasia: an unusual paraneoplastic syndrome. Report of a case and review of the literature. Gagliano, R.G., Costanzi, J.J., Beathard, G.A., Sarles, H.E., Bell, J.D. Am. J. Med. (1976) [Pubmed]
  6. Regulation of glomerular basement membrane collagen expression by LMX1B contributes to renal disease in nail patella syndrome. Morello, R., Zhou, G., Dreyer, S.D., Harvey, S.J., Ninomiya, Y., Thorner, P.S., Miner, J.H., Cole, W., Winterpacht, A., Zabel, B., Oberg, K.C., Lee, B. Nat. Genet. (2001) [Pubmed]
  7. Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. Wartiovaara, J., Ofverstedt, L.G., Khoshnoodi, J., Zhang, J., Mäkelä, E., Sandin, S., Ruotsalainen, V., Cheng, R.H., Jalanko, H., Skoglund, U., Tryggvason, K. J. Clin. Invest. (2004) [Pubmed]
  8. The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1. Zaiou, M., Azrolan, N., Hayek, T., Wang, H., Wu, L., Haghpassand, M., Cizman, B., Madaio, M.P., Milbrandt, J., Marsh, J.B., Breslow, J.L., Fisher, E.A. J. Clin. Invest. (1998) [Pubmed]
  9. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Zenker, M., Aigner, T., Wendler, O., Tralau, T., Müntefering, H., Fenski, R., Pitz, S., Schumacher, V., Royer-Pokora, B., Wühl, E., Cochat, P., Bouvier, R., Kraus, C., Mark, K., Madlon, H., Dötsch, J., Rascher, W., Maruniak-Chudek, I., Lennert, T., Neumann, L.M., Reis, A. Hum. Mol. Genet. (2004) [Pubmed]
  10. Interferon-inducible protein-10 is highly expressed in rats with experimental nephrosis. Gómez-Chiarri, M., Ortiz, A., González-Cuadrado, S., Serón, D., Emancipator, S.N., Hamilton, T.A., Barat, A., Plaza, J.J., González, E., Egido, J. Am. J. Pathol. (1996) [Pubmed]
  11. Glial cell line-derived neurotrophic factor and its receptor ret is a novel ligand-receptor complex critical for survival response during podocyte injury. Tsui, C.C., Shankland, S.J., Pierchala, B.A. J. Am. Soc. Nephrol. (2006) [Pubmed]
  12. Assessment of the developmental toxicity of ethylene glycol applied cutaneously to CD-1 mice. Tyl, R.W., Fisher, L.C., Kubena, M.F., Vrbanic, M.A., Losco, P.E. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1995) [Pubmed]
  13. M2000: a revolution in pharmacology. Mirshafiey, A., Cuzzocrea, S., Rehm, B.H., Matsuo, H. Med. Sci. Monit. (2005) [Pubmed]
  14. Chronic (89-week) feeding study with hydroxypropyl distarch phosphate, starch acetate, lactose and sodium alginate in mice. Til, H.P., Feron, V.J., Immel, H.R., Vogel, W.F. Food Chem. Toxicol. (1986) [Pubmed]
  15. Hemolytic anemia, thrombosis, and infarction in male and female F344 rats following gavage exposure to 2-butoxyethanol. Ghanayem, B.I., Long, P.H., Ward, S.M., Chanas, B., Nyska, M., Nyska, A. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2001) [Pubmed]
  16. Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome. Diamond, J.R., Ding, G., Frye, J., Diamond, I.P. Am. J. Pathol. (1992) [Pubmed]
  17. No evidence of carcinogenicity of D-mannitol and propyl gallate in F344 rats or B6C3F1 mice. Abdo, K.M., Huff, J.E., Haseman, J.K., Alden, C.J. Food Chem. Toxicol. (1986) [Pubmed]
  18. Development of a short-term model of decalin inhalation nephrotoxicity in the male rat. Stone, L.C., McCracken, M.S., Kanerva, R.L., Alden, C.L. Food Chem. Toxicol. (1987) [Pubmed]
  19. Perchloroethylene-induced alterations in glucose metabolism and their prevention by 2-deoxy-D-glucose and vitamin E in mice. Ebrahim, A.S., Babakrishnan, K., Sakthisekaran, D. Journal of applied toxicology : JAT. (1996) [Pubmed]
  20. Small rodents. Harkness, J.E. Vet. Clin. North Am. Small Anim. Pract. (1994) [Pubmed]
  21. Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202. Gherardi, D., D'Agati, V., Chu, T.H., Barnett, A., Gianella-Borradori, A., Gelman, I.H., Nelson, P.J. J. Am. Soc. Nephrol. (2004) [Pubmed]
  22. Hypercholesterolemia is a prerequisite for puromycin inducible damage in mouse kidney. Cheng, Z.Z., Pätäri, A., Aalto-Setälä, K., Novikov, D., Schlöndorff, D., Holthöfer, H. Kidney Int. (2003) [Pubmed]
  23. Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol. Nelson, P.J., D'Agati, V.D., Gries, J.M., Suarez, J.R., Gelman, I.H. J. Antimicrob. Chemother. (2003) [Pubmed]
  24. Interstrain differences in murine daunomycin-induced nephrosis. Kimura, M., Takahasi, H., Ohtake, T., Sato, T., Hishida, A., Nishimura, M., Honda, N. Nephron (1993) [Pubmed]
  25. Haemorrhages due to defective blood coagulation do not occur in mice and guinea-pigs fed butylated hydroxytoluene, but nephrotoxicity is found in mice. Takahashi, O. Food Chem. Toxicol. (1992) [Pubmed]
  26. Diagnosis of heartwater at post-mortem in ruminants and the confirmation of Cowdria ruminantium in mice. Prozesky, L. Onderstepoort J. Vet. Res. (1987) [Pubmed]
  27. Trichloroethylene toxicity in mice: a biochemical, hematological and pathological assessment. Goel, S.K., Rao, G.S., Pandya, K.P., Shanker, R. Indian J. Exp. Biol. (1992) [Pubmed]
  28. Severe proteinuria, sustained for 6 months, induces tubular epithelial cell injury and cell infiltration in rats but not progressive interstitial fibrosis. Kikuchi, H., Kawachi, H., Ito, Y., Matsui, K., Nosaka, H., Saito, A., Orikasa, M., Arakawa, M., Shimizu, F. Nephrol. Dial. Transplant. (2000) [Pubmed]
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