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Gene Review

EPO  -  erythropoietin

Canis lupus familiaris

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Disease relevance of EPO


High impact information on EPO


Chemical compound and disease context of EPO


Biological context of EPO

  • We conclude that both developmental and compensatory lung growth involve paracrine EPO signaling with parallel upregulation but differential processing of EPOR [1].
  • Unexpectedly, there was a significant decline in total platelet count during EPO administration despite an increased level of TO+ platelets [11].
  • Thus, the half of the normal renal tissue was considered sufficiently contributory to EPO production needed to maintain homeostasis of red blood cell production [12].
  • The ELISA was performed using both EPO obtained from HeLa cells transfected with an expression plasmid encoding canine EPO and canine plasma with known concentrations of EPO [13].
  • Modulation of erythropoietin formation by changes in blood volume in conscious dogs [14].

Anatomical context of EPO


Associations of EPO with chemical compounds

  • These results indicate that apical secretion of EPO involves a cholesterol-dependent mechanism probably not involving lipid rafts [17].
  • To investigate the involvement of lipid rafts in the apical sorting of wtEPO, we examined the effect of cholesterol depletion with methyl-beta-cyclodextrin on the secretion polarity of EPO and analyzed Triton X-100 insoluble cell extracts by sucrose density gradients centrifugation in MDCK cells [17].
  • During EPO-treatment, the percentage of thiazole orange-positive (TO+) platelets increased significantly to 17.2 +/- 1.6% (mean +/- 1 SE; n = 3) on day 5 compared to a pre-treatment level of 8.5 +/- 0.9% (p = 0.029) [18].
  • In the remaining 26 dogs having detectable plasma EPO, the plasma concentration rate of EPO related to blood urea nitrogen and serum creatinine values [19].
  • Nocodazole, a microtubule-disrupting drug, reversed the polarized secretion of the wild-type Epo from the apical to basolateral preference with little change in the total secretion [20].

Other interactions of EPO


Analytical, diagnostic and therapeutic context of EPO


  1. Upregulation of erythropoietin receptor during postnatal and postpneumonectomy lung growth. Foster, D.J., Moe, O.W., Hsia, C.C. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  2. Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs. Hirata, A., Minamino, T., Asanuma, H., Fujita, M., Wakeno, M., Myoishi, M., Tsukamoto, O., Okada, K., Koyama, H., Komamura, K., Takashima, S., Shinozaki, Y., Mori, H., Shiraga, M., Kitakaze, M., Hori, M. J. Am. Coll. Cardiol. (2006) [Pubmed]
  3. High altitude training of dogs results in elevated erythropoietin and endothelin-1 serum levels. Glaus, T.M., Grenacher, B., Koch, D., Reiner, B., Gassmann, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2004) [Pubmed]
  4. Use of human recombinant erythropoietin and prednisone for treatment of myelodysplastic syndrome with erythroid predominance in a dog. Boone, L.I., Knauer, K.W., Rapp, S.W., Stewart, J.F., Modiano, J.F. J. Am. Vet. Med. Assoc. (1998) [Pubmed]
  5. A quest for erythropoietin over nine decades. Fisher, J.W. Annu. Rev. Pharmacol. Toxicol. (1998) [Pubmed]
  6. Cyclical neutropenia and other periodic hematological disorders: a review of mechanisms and mathematical models. Haurie, C., Dale, D.C., Mackey, M.C. Blood (1998) [Pubmed]
  7. The anemia of chronic renal failure and chronic diseases: in vitro studies of erythropoiesis. Wallner, S.F., Kurnick, J.E., Ward, H.P., Vautrin, R., Alfrey, A.C. Blood (1976) [Pubmed]
  8. Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation. Jones, J.B., Lange, R.D., Yang, T.J., Vodopick, H., Jones, E.S. Blood (1975) [Pubmed]
  9. The role of prostaglandins in the production of erythropoietin (esf) by the kidney. II. effects of indomethacin on erythropoietin production following hypoxia in dogs. Mujovic, V.M., Fisher, J.W. Life Sci. (1975) [Pubmed]
  10. Prostanoid activation of erythropoiesis. Fisher, J.W., Nelson, P.K., Belegu, M., Hagiwara, M., Beckman, B. Haematologia (Budap) (1984) [Pubmed]
  11. Erythropoietin administration increases production and reactivity of platelets in dogs. Wolf, R.F., Peng, J., Friese, P., Gilmore, L.S., Burstein, S.A., Dale, G.L. Thromb. Haemost. (1997) [Pubmed]
  12. Evaluation of erythropoietin production in dogs with reduced functional renal tissue. Oishi, A., Sakamoto, H., Shimizu, R., Ohashi, F., Takeuchi, A. J. Vet. Med. Sci. (1993) [Pubmed]
  13. A protocol to guide development of a sensitive ELISA for canine erythropoietin. Giampaoli, S., Facciabene, A., Mennuni, C. Veterinary clinical pathology / American Society for Veterinary Clinical Pathology. (2003) [Pubmed]
  14. Modulation of erythropoietin formation by changes in blood volume in conscious dogs. Ehmke, H., Just, A., Eckardt, K.U., Persson, P.B., Bauer, C., Kirchheim, H.R. J. Physiol. (Lond.) (1995) [Pubmed]
  15. Pharmacokinetic and pharmacodynamic studies following oral administration of erythropoietin mucoadhesive tablets to beagle dogs. Venkatesan, N., Yoshimitsu, J., Ohashi, Y., Ito, Y., Sugioka, N., Shibata, N., Takada, K. International journal of pharmaceutics. (2006) [Pubmed]
  16. Secondary erythrocytosis associated with high plasma erythropoietin concentrations in a dog with cecal leiomyosarcoma. Sato, K., Hikasa, Y., Morita, T., Shimada, A., Ozaki, K., Kagota, K. J. Am. Vet. Med. Assoc. (2002) [Pubmed]
  17. Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells. Maruyama, M., Kishimoto, M., Ishida, K., Watanabe, Y., Nishikawa, M., Masuda, S., Sasaki, R., Takakura, Y. Arch. Biochem. Biophys. (2005) [Pubmed]
  18. Erythropoietin potentiates thrombus development in a canine arterio-venous shunt model. Wolf, R.F., Gilmore, L.S., Friese, P., Downs, T., Burstein, S.A., Dale, G.L. Thromb. Haemost. (1997) [Pubmed]
  19. Canine plasma erythropoietin levels in 124 cases of anemia. Oishi, A., Sakamoto, H., Shimizu, R. J. Vet. Med. Sci. (1995) [Pubmed]
  20. N-glycosylation of erythropoietin is critical for apical secretion by Madin-Darby canine kidney cells. Kitagawa, Y., Sano, Y., Ueda, M., Higashio, K., Narita, H., Okano, M., Matsumoto, S., Sasaki, R. Exp. Cell Res. (1994) [Pubmed]
  21. Effects of bombesin on erythropoietin production in the anaesthetized dog. Melchiorri, P., Sopranzi, N., Roseghini, M. Naunyn Schmiedebergs Arch. Pharmacol. (1976) [Pubmed]
  22. Role of parathyroid hormone in the anemia of chronic terminal renal dysfunction in dogs. Petrites-Murphy, M.B., Pierce, K.R., Lowry, S.R., Fisher, J.W. Am. J. Vet. Res. (1989) [Pubmed]
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