Disease relevance of mesotocin

• Effect of dehydration, haemorrhage and oviposition on serum concentrations of vasotocin, mesotocin and prolactin in the chicken [1].
• 1. Renal tissue blood flow (renal perfusion) and plasma levels of arginine vasotocin (AVT) and mesotocin (MT) were measured in anesthetized chickens before and during hemorrhage [2].
• 1. The effect of an acute heat stress on plasma arginine vasotocin (AVT) and mesotocin (MT) levels were determined in non-heat-acclimated domestic fowl [3].
• Mesotocin (0.001 -- 0.1 micrograms/g) elicited modest but significant weight gains (ca. 1%/h) caused solely by increased integumental osmosis [4].

Psychiatry related information on mesotocin

• Effects of central vasotocin and mesotocin manipulations on social behavior in male and female zebra finches [5].
• Plasma mesotocin levels did not change with water deprivation [6].

High impact information on mesotocin

• Cloning and sequence analysis of cDNAs for neurohypophysial hormones vasotocin and mesotocin for the hypothalamus of toad, Bufo japonicus [7].
• AVT, arginine vasopressin, and lysine vasopressin were about 100-fold more potent than mesotocin, valitocin, and oxytocin [8].
• Gravid myometrium became increasingly sensitive to mesotocin stimulation as pregnancy progressed, and nitric oxide induced marked relaxation at all stages examined, by a guanylyl-cyclase mediated pathway [9].
• Nongravid myometrium, from the uterus ipsilateral to a Graafian follicle, was spontaneously active but unresponsive to the oxytocic peptide mesotocin and the smooth muscle relaxant nitric oxide [9].
• Mesotocin and mesotocin receptor gene transcripts with high sequence homology to eutherian oxytocin/oxytocin receptors were demonstrated, and mesotocin, neurophysin, and the receptor were all localized predominantly in the epithelial cells of the glandular acini [10].

Chemical compound and disease context of mesotocin

• Serum concentrations of arginine vasotocin (AVT), mesotocin and prolactin were determined by radioimmunoassay in Rhode Island Red chickens during and after dehydration, haemorrhage and oviposition [1].
• Water deprivation and circadian changes in plasma arginine vasotocin and mesotocin in the domestic hen (Gallus domesticus) [11].
• Hemorrhage was a relatively specific stimulus for AVP secretion, but MT secretion was highly stimulated during severe hypovolemia [12].

Biological context of mesotocin

• The primary structures of the precursors of neurohypophysial hormones vasotocin (VT) and mesotocin (MT) in the hypothalamus of the toad Bufo japonicus were determined by analyzing the nucleotide sequences of the cloned cDNAs encoding them [7].
• The oxytocin-like peptide of most Australian marsupials is mesotocin, which stimulates uterine contractions and is important for normal birth in the tammar wallaby [13].
• A significant increase in myometrial mesotocin receptor concentrations occurs only in the gravid uterus on Day 23 of the 26-day gestation [13].
• This study examined whether or not mesotocin receptors are present in the myometrium and are up-regulated at the equivalent stage of the luteal phase in unmated tammars [13].
• In contrast, the serum concentrations of mesotocin and prolactin remained unaffected by oviposition [1].

Anatomical context of mesotocin

• Mesotocin receptor gene and protein expression in the prostate gland, but not testis, of the tammar wallaby, Macropus eugenii [14].
• Mesotocin-like-immunoreactive cell bodies were located almost exclusively in the preoptic area, with only a few other cells located in the amygdala pars medialis [15].
• (3) In the intermediate lobe, thyrotropin-releasing hormone- and mesotocin (or neurophysin I)-immunoreactivities were systematically found in the same 120-nm dense core vesicles; these thyrotropin-releasing hormone-/mesotocin-immunoreactive axon terminals frequently made synaptic contacts with melanotropic cells [16].
• The supraoptico-neurohypophysial tract, formed by vasotocin- and mesotocin-containing axons, enters the internal zone of the median eminence and ends in the posterior lobe of the pituitary [17].
• Immuno-enzyme cytochemical investigations showed that the whole amphibian pars intermedia of the hypophysis is innervated by an intercellular network of peptidergic varicose nerve fibres which contain mesotocin or (and) parts of the mesotocin molecule [18].

Associations of mesotocin with other chemical compounds

• The possible modulatory effect of mesotocin on thyrotropin-releasing hormone-induced alpha-melanocyte-stimulating hormone secretion was investigated using perifused frog neurointermediate lobes [16].
• The data confirm that a local fetal influence is more important than systemic factors, such as estrogen, in the regulation of uterine mesotocin receptors in the tammar wallaby [13].
• The hypothalamo-hypophysial system of the chick embryo has been studied with a monoclonal antibody which cross-reacts with arginine vasotocin and mesotocin, using thick (100 micron) sections in conjunction with a peroxidase-conjugated rabbit anti-mouse antibody [19].
• These results suggest an osmoregulatory role for AVT and prolactin, whereas mesotocin may be involved in volume control [1].
• Central administration of mesotocin, isotocin and conopressin-S (5-500 pmol each) had no significant effect on blood pressure [20].

Gene context of mesotocin

• Colocalization of both PRLR-like immunoreactivity and arginine vasotocin-like or mesotocin-like immunoreactivity was demonstrated in the magnocellular preoptic nucleus [21].
• 1. The melanotropin-releasing activity of arginine-vasopressin (AVP), arginine-vasotocin (AVT), oxitocin (OT), mesotocin (MT) and corticotropin-releasing factor (CRF) was studied in the duck using dispersed, perfused pituitary cells and a specific alpha-MSH RIA [22].
• The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT) [23].
• MT/OT-like immunoreactive (MT/OT-lir) cell groups were found in the anterior parvocellular, posterior parvocellular, and magnocellular preoptic nuclei [24].
• Mesotocin antiserum did not alter (P greater than 0.05) PRL release induced by posterior pituitary extract [25].

Analytical, diagnostic and therapeutic context of mesotocin

• We have applied the indirect immunofluorescence technique to examine whether vasotocin (AVT) and/or mesotocin (MT) are located in frog adrenal (interrenal) tissue [26].
• Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors [23].
• A radioimmunoassay for mesotocin was validated in the tammar and this assay allowed direct measurement in 50 microliters unextracted plasma with a sensitivity of 12.5 pmol l-1 [27].
• Although the distribution of AVT, identified by immunohistochemistry of adjacent serial sections within the hypothalamus, was similar to the distribution of AVT mRNA, the possibility that some positive staining was due to mesotocin neurons was not excluded [28].
• Pituitary glands and corpora lutea collected at various stages of the reproductive cycle of the tammar wallaby (Macropus eugenii), were extracted and fractionated by high-performance liquid chromatography, and specific radioimmunoassays were used to measure mesotocin ([Ile8]-oxytocin) and oxytocin [29].

References