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Chemical Compound Review

mesotocin     (2S)-1-[[(4S,7S,10S,16S,19S)- 19-amino-10...

Synonyms: AC1L3XBD, 8-Ile-oxytocin, 362-39-0, Oxytocin, ile(8)-, Oxytocin, isoleucine(8)-, ...
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Disease relevance of mesotocin


Psychiatry related information on mesotocin


High impact information on mesotocin


Chemical compound and disease context of mesotocin


Biological context of mesotocin


Anatomical context of mesotocin

  • Mesotocin receptor gene and protein expression in the prostate gland, but not testis, of the tammar wallaby, Macropus eugenii [14].
  • Mesotocin-like-immunoreactive cell bodies were located almost exclusively in the preoptic area, with only a few other cells located in the amygdala pars medialis [15].
  • (3) In the intermediate lobe, thyrotropin-releasing hormone- and mesotocin (or neurophysin I)-immunoreactivities were systematically found in the same 120-nm dense core vesicles; these thyrotropin-releasing hormone-/mesotocin-immunoreactive axon terminals frequently made synaptic contacts with melanotropic cells [16].
  • The supraoptico-neurohypophysial tract, formed by vasotocin- and mesotocin-containing axons, enters the internal zone of the median eminence and ends in the posterior lobe of the pituitary [17].
  • Immuno-enzyme cytochemical investigations showed that the whole amphibian pars intermedia of the hypophysis is innervated by an intercellular network of peptidergic varicose nerve fibres which contain mesotocin or (and) parts of the mesotocin molecule [18].

Associations of mesotocin with other chemical compounds

  • The possible modulatory effect of mesotocin on thyrotropin-releasing hormone-induced alpha-melanocyte-stimulating hormone secretion was investigated using perifused frog neurointermediate lobes [16].
  • The data confirm that a local fetal influence is more important than systemic factors, such as estrogen, in the regulation of uterine mesotocin receptors in the tammar wallaby [13].
  • The hypothalamo-hypophysial system of the chick embryo has been studied with a monoclonal antibody which cross-reacts with arginine vasotocin and mesotocin, using thick (100 micron) sections in conjunction with a peroxidase-conjugated rabbit anti-mouse antibody [19].
  • These results suggest an osmoregulatory role for AVT and prolactin, whereas mesotocin may be involved in volume control [1].
  • Central administration of mesotocin, isotocin and conopressin-S (5-500 pmol each) had no significant effect on blood pressure [20].

Gene context of mesotocin

  • Colocalization of both PRLR-like immunoreactivity and arginine vasotocin-like or mesotocin-like immunoreactivity was demonstrated in the magnocellular preoptic nucleus [21].
  • 1. The melanotropin-releasing activity of arginine-vasopressin (AVP), arginine-vasotocin (AVT), oxitocin (OT), mesotocin (MT) and corticotropin-releasing factor (CRF) was studied in the duck using dispersed, perfused pituitary cells and a specific alpha-MSH RIA [22].
  • The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT) [23].
  • MT/OT-like immunoreactive (MT/OT-lir) cell groups were found in the anterior parvocellular, posterior parvocellular, and magnocellular preoptic nuclei [24].
  • Mesotocin antiserum did not alter (P greater than 0.05) PRL release induced by posterior pituitary extract [25].

Analytical, diagnostic and therapeutic context of mesotocin


  1. Effect of dehydration, haemorrhage and oviposition on serum concentrations of vasotocin, mesotocin and prolactin in the chicken. Nouwen, E.J., Decuypere, E., Kühn, E.R., Michels, H., Hall, T.R., Chadwick, A. J. Endocrinol. (1984) [Pubmed]
  2. Relationships between renal hemodynamics and plasma levels of arginine vasotocin and mesotocin during hemorrhage in the domestic fowl (Gallus domesticus). Bottje, W.G., Holmes, K.R., Neldon, H.L., Koike, T.K. Comparative biochemistry and physiology. A, Comparative physiology. (1989) [Pubmed]
  3. Effect of heat stress on plasma levels of arginine vasotocin and mesotocin in domestic fowl (Gallus domesticus). Wang, S., Bottje, W.G., Kinzler, S., Neldon, H.L., Koike, T.I. Comparative biochemistry and physiology. A, Comparative physiology. (1989) [Pubmed]
  4. Water balance in the California newt, Taricha torosa. Brown, S.C., Brown, P.S. Am. J. Physiol. (1980) [Pubmed]
  5. Effects of central vasotocin and mesotocin manipulations on social behavior in male and female zebra finches. Goodson, J.L., Lindberg, L., Johnson, P. Hormones and behavior. (2004) [Pubmed]
  6. A sexual dimorphism in hypothalamic arginine vasotocin (AVT) gene expression and AVT plasma levels in the Japanese quail (Coturnix coturnix japonica) in response to water deprivation. Chaturvedi, C.M., Chowdhary, A., Wall, P.T., Koike, T.I., Cornett, L.E. Gen. Comp. Endocrinol. (2000) [Pubmed]
  7. Cloning and sequence analysis of cDNAs for neurohypophysial hormones vasotocin and mesotocin for the hypothalamus of toad, Bufo japonicus. Nojiri, H., Ishida, I., Miyashita, E., Sato, M., Urano, A., Deguchi, T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. Direct regulation of rat testicular steroidogenesis by neurohypophysial hormones. Divergent effects on androgen and progestin biosynthesis. Adashi, E.Y., Tucker, E.M., Hsueh, A.J. J. Biol. Chem. (1984) [Pubmed]
  9. Differential regulation of contractility and nitric oxide sensitivity in gravid and nongravid myometrium during late pregnancy in a marsupial. Ingram, J.N., Renfree, M.B., Shaw, G. Endocrinology (2001) [Pubmed]
  10. Seasonal changes in mesotocin and localization of its receptor in the prostate of the brushtail possum (Trichosurus vulpecula). Fink, J.W., McLeod, B.J., Assinder, S.J., Parry, L.J., Nicholson, H.D. Biol. Reprod. (2005) [Pubmed]
  11. Water deprivation and circadian changes in plasma arginine vasotocin and mesotocin in the domestic hen (Gallus domesticus). Chaturvedi, C.M., Chowdhury, A., Cornet, L.E. Chronobiol. Int. (2001) [Pubmed]
  12. Regulation of neurohypophysial hormone secretion in an Australian marsupial. Bathgate, R.A., Sernia, C. Am. J. Physiol. (1995) [Pubmed]
  13. Up-regulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen. Siebel, A.L., Gehring, H.M., Nave, C.D., Bathgate, R.A., Borchers, C.E., Parry, L.J. Biol. Reprod. (2002) [Pubmed]
  14. Mesotocin receptor gene and protein expression in the prostate gland, but not testis, of the tammar wallaby, Macropus eugenii. Parry, L.J., Bathgate, R.A. Biol. Reprod. (1998) [Pubmed]
  15. Identification and localization of neurohypophysial peptides in the brain of a caecilian amphibian, Typhlonectes natans (Amphibia: Gymnophiona). Hilscher-Conklin, C., Conlon, J.M., Boyd, S.K. J. Comp. Neurol. (1998) [Pubmed]
  16. Three distinct thyrotropin-releasing hormone-immunoreactive axonal systems project in the median eminence-pituitary complex of the frog Rana ridibunda. Immunocytochemical evidence for co-localization of thyrotropin-releasing hormone and mesotocin in fibers innervating pars intermedia cells. Lamacz, M., Hindelang, C., Tonon, M.C., Vaudry, H., Stoeckel, M.E. Neuroscience (1989) [Pubmed]
  17. The topography of mesotocin and vasotocin systems in the brain of the domestic mallard and Japanese quail: immunocytochemical identification. Bons, N. Cell Tissue Res. (1980) [Pubmed]
  18. Immuno-enzyme cytochemical demonstration of mesotocinergic nerve fibres in the pars intermedia of the amphibian hypophysis. Dierickx, K., Vandesande, F. Cell Tissue Res. (1976) [Pubmed]
  19. Immunocytochemical study of the development of vasotocin/mesotocin in the hypothalamo-hypophysial system of the chick embryo. Tennyson, V.M., Nilaver, G., Hou-Yu, A., Valiquette, G., Zimmerman, E.A. Cell Tissue Res. (1986) [Pubmed]
  20. Effects of central and peripheral administration of arginine vasotocin and related neuropeptides on blood pressure and heart rate in the conscious trout. Le Mevel, J.C., Pamantung, T.F., Mabin, D., Vaudry, H. Brain Res. (1993) [Pubmed]
  21. Localization of prolactin receptor in the newt brain. Hasunuma, I., Toyoda, F., Yamamoto, K., Yamashita, M., Kikuyama, S. Cell Tissue Res. (2005) [Pubmed]
  22. The regulation of the corticomelanotropic cell activity in aves. III--Effect of various peptides on the release of MSH from dispersed, perfused duck pituitary cells. Cosecretion of ACTH with MSH. Castro, M.G., Estivariz, F.E., Iturriza, F.C. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1988) [Pubmed]
  23. Molecular cloning, pharmacological characterization, and histochemical distribution of frog vasotocin and mesotocin receptors. Acharjee, S., Do-Rego, J.L., Oh, D.Y., Moon, J.S., Ahn, R.S., Lee, K., Bai, D.G., Vaudry, H., Kwon, H.B., Seong, J.Y. J. Mol. Endocrinol. (2004) [Pubmed]
  24. Putative isotocin distributions in sonic fish: relation to vasotocin and vocal-acoustic circuitry. Goodson, J.L., Evans, A.K., Bass, A.H. J. Comp. Neurol. (2003) [Pubmed]
  25. Evidence of a role for the turkey posterior pituitary in prolactin release. el Halawani, M.E., Silsby, J.L., Koike, T.I., Robinzon, B. Gen. Comp. Endocrinol. (1992) [Pubmed]
  26. Identification of vasotocin-like immunoreactivity in chromaffin cells of the frog adrenal gland: effect of vasotocin on corticosteroid secretion. Larcher, A., Delarue, C., Idres, S., Lefebvre, H., Feuilloley, M., Vandesande, F., Pelletier, G., Vaudry, H. Endocrinology (1989) [Pubmed]
  27. Release of an oxytocic peptide at parturition in the marsupial, Macropus eugenii. Parry, L.J., Guymer, F.J., Fletcher, T.P., Renfree, M.B. J. Reprod. Fertil. (1996) [Pubmed]
  28. An in situ hybridization and immunohistochemical study of vasotocin neurons in the hypothalamus of water-deprived chickens. Chaturvedi, C.M., Newton, B.W., Cornett, L.E., Koike, T.I. Peptides (1994) [Pubmed]
  29. Mesotocin and luteal function in macropodid marsupials. Curlewis, J.D., Renfree, M.B., Sheldrick, E.L., Flint, A.P. J. Endocrinol. (1988) [Pubmed]
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