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Chemical Compound Review

Pentolinium     1-methyl-1-[5-(1-methyl- 2,3,4,5...

Synonyms: Pentolonum, Pentolonium, pentolineum, CHEMBL1271, SureCN210048, ...
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Disease relevance of Pentolinium


High impact information on Pentolinium


Chemical compound and disease context of Pentolinium


Biological context of Pentolinium

  • Measurements were made prior to induction of anesthesia; before and 10, 20, and 60 minutes after administration of pentolinium (0.3 mg/kg); 15 minutes after return of arterial blood pressure to control values [16].
  • Pentolinium (7.5 mg/kg i.v.) or adrenal demedullation attenuated the peak increase in MAP by attenuating increases in mesenteric and hindquarters vascular resistance, but did not affect the sustained increase in MAP [17].
  • The subsequent treatment with pentolinium did not affect milk ejection [18].
  • Two mechanisms can explain the reduction in serum K+ concentration: (1) decreased hepatic glycogenolysis and (2) attenuation of the suppressive effect of adrenaline on insulin release, both effects being secondary to the ganglion-blocking property of pentolinium [19].
  • Autonomic ganglion blockade with a mixture of hexamethonium and pentolinium was followed by comparable percent reductions in CO (-/- = 28+/-4, +/+ = 29+/-3), HR (-/- = 9+/-4, +/+ = 16+/-4) and SV(-/- = 21+/-4, +/+ = 15+/-6) in both genotypes [20].

Anatomical context of Pentolinium


Associations of Pentolinium with other chemical compounds


Gene context of Pentolinium

  • Sixty minutes after the administration of pentolinium, systolic and diastolic blood pressures were reduced in both groups of rats and the pressor responses to arginine vasopressin were similarly and significantly enhanced [31].
  • Pentolinium in the management of autonomic hyperreflexia [32].
  • Intravenous injections of the ganglionic blocker pentolinium blocked the cardiovascular and plasma catecholamine responses to i.t. injections of DiME-SP [33].
  • Since PVR decreased in the face of reductions in both pulmonary arterial and left atrial pressures despite a significant increase (at 10 minutes) or no change (at 20 and 60 minutes) in pulmonary blood flow, the results suggest an active decrease in pulmonary vascular tone, presumably due to autonomic inhibition by pentolinium [34].
  • However, there were differential changes in regional vascular sensitivity of NPY following administration of pentolinium and captopril, indicating that 'buffer' mechanisms were an important determinant of responses to NPY [35].

Analytical, diagnostic and therapeutic context of Pentolinium

  • The hyperglyaemia in response to 2-DG was attenuated by pentolinium and by left splanchnicotomy plus right adrenalectomy [36].
  • Pulmonary and systemic hemodynamic responses to administration of pentolinium (0.3 mg/kg) were studied in eight patients undergoing total hip replacement during N2O-halothane anesthesia with PaCO2 maintained at 35-40 mm Hg [34].
  • The QTL on Chr 3 persisted after treatment with the three agents while the QTL on Chr 5 and Chr 1 disappeared after pentolinium administration [37].
  • In the control group the arterial pressure was maintained within the patients' normal ranges, while in the study group pentolinium was administered i.v. (average 22 mg per patient) to achieve and maintain a mean arterial pressure of 50 mm Hg (+/-10 SEM) [19].
  • Neither bilateral vagotomy nor ganglionic blockade with pentolinium reduced the hypotension induced by both kinins [38].


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  3. Cardiovascular reflexes mediated by capsaicin sensitive cardiac afferent neurones in the dog. Staszewska-Woolley, J., Luk, D.E., Nolan, P.N. Cardiovasc. Res. (1986) [Pubmed]
  4. Pentolinium in postoperative hypertension. Walters, F. British journal of anaesthesia. (1982) [Pubmed]
  5. The role of renal sympathetic nervous system in the pathogenesis of ischemic acute renal failure. Fujii, T., Kurata, H., Takaoka, M., Muraoka, T., Fujisawa, Y., Shokoji, T., Nishiyama, A., Abe, Y., Matsumura, Y. Eur. J. Pharmacol. (2003) [Pubmed]
  6. Augmented sympathetic nerve activity and pressor responsiveness in DOCA hypertensive rats. Takeda, K., Buñag, R.D. Hypertension (1980) [Pubmed]
  7. Central cardiovascular action of urotensin II in conscious rats. Lin, Y., Tsuchihashi, T., Matsumura, K., Abe, I., Iida, M. J. Hypertens. (2003) [Pubmed]
  8. Short exposure of maturing, bone marrow-derived dendritic cells to norepinephrine: impact on kinetics of cytokine production and Th development. Maestroni, G.J. J. Neuroimmunol. (2002) [Pubmed]
  9. Blood pressure, heart rate, and behavioral responses to psychological "novelty" stress in freely moving rats. van den Buuse, M., Van Acker, S.A., Fluttert, M., De Kloet, E.R. Psychophysiology. (2001) [Pubmed]
  10. Causes of differential cardiovascular sensitivity to cocaine. I: Studies in conscious rats. Branch, C.A., Knuepfer, M.M. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  11. Role of bradykinin B2-receptor in the sympathoadrenal effects of 'new pressor protein' related to human blood coagulation factor XII fragment. Amfilochiadis, A.A., Papageorgiou, P.C., Kogan, N., Boomsma, F., Osmond, D.H. J. Hypertens. (2004) [Pubmed]
  12. Cardiovascular effects of noradrenaline microinjected into the dorsal periaqueductal gray area of unanaesthetized rats. Pelosi, G.G., Corrêa, F.M. Eur. J. Neurosci. (2005) [Pubmed]
  13. Autonomic mechanisms in the acute cardiovascular effects of cocaine in conscious rats. Poon, J., van den Buuse, M. Eur. J. Pharmacol. (1998) [Pubmed]
  14. Cardiovascular responses elicited by intrathecal kinins in the conscious rat. Lopes, P., Couture, R. Eur. J. Pharmacol. (1992) [Pubmed]
  15. Haemodynamic responses to induced arterial hypotension in children. Salem, M.R., Toyama, T., Wong, A.Y., Jacobs, H.K., Bennett, E.J. British journal of anaesthesia. (1978) [Pubmed]
  16. Hemodynamic response to ganglionic blockade with pentolinium during N2O-halothane anesthesia in man. Fahmy, N.R., Laver, M.B. Anesthesiology (1976) [Pubmed]
  17. Cardiovascular responses to cocaine are initially mediated by the central nervous system in rats. Knuepfer, M.M., Branch, C.A. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  18. Activation of the adrenal cortex or the peripheral sympatho-adrenomedullary system does not necessarily influence milk ejection in the rat. Lau, C. J. Endocrinol. (1988) [Pubmed]
  19. Effects of pentolinium on blood sugar and serum potassium concentrations during anaesthesia and surgery. Fahmy, N.R., Battit, G.E. British journal of anaesthesia. (1975) [Pubmed]
  20. Chronic hypertension in ANP knockout mice: contribution of peripheral resistance. Melo, L.G., Veress, A.T., Ackermann, U., Pang, S.C., Flynn, T.G., Sonnenberg, H. Regul. Pept. (1999) [Pubmed]
  21. Development of hypertension from unilateral renal artery stenosis in conscious dogs. Anderson, W.P., Ramsey, D.E., Takata, M. Hypertension (1990) [Pubmed]
  22. Autonomic hyperreflexia: intraoperative control with pentolinium tartrate. Basta, J.W., Niejadlik, K., Pallares, V. British journal of anaesthesia. (1977) [Pubmed]
  23. The effect of tobacco smoke upon airway secretion in the cat. Peatfield, A.C., Davies, J.R., Richardson, P.S. Clin. Sci. (1986) [Pubmed]
  24. Hypothermia augments non-cholinergic neuronal bronchoconstriction in pithed guinea-pigs. Rechtman, M.P., King, R.G., Boura, A.L. Eur. J. Pharmacol. (1991) [Pubmed]
  25. Increased systemic vascular responsiveness to catecholamines in spontaneously hypertensive rats. Walsh, G.M. Clinical and experimental hypertension. Part A, Theory and practice. (1983) [Pubmed]
  26. Neonatal treatment with capsaicin influences hormonal regulation of blood pressure in adult, water-deprived Long-Evans but not Brattleboro rats. Bennett, T., Gardiner, S.M. Neurosci. Lett. (1986) [Pubmed]
  27. Influences of beta-blocking agents on cardiovascular actions induced by endothelin-3 administered intracerebroventricularly in anesthetized rats. Ono, N., Kaneko, M. Life Sci. (1995) [Pubmed]
  28. Human coagulation factor XII-related "new pressor protein": role of PACAP in its cardiovascular and sympathoadrenal effects. Simos, D., Boomsma, F., Osmond, D.H. The Canadian journal of cardiology. (2002) [Pubmed]
  29. Unimportance of perivascular H+ AND K+ activities for the adjustment of pial arterial diameter during changes of arterial blood pressure in cats. Wahl, M., Kuschinsky, W. Pflugers Arch. (1979) [Pubmed]
  30. Abnormal blood pressure recovery during ganglion blockade in diabetic rats. Hebden, R.A., Bennett, T., Gardiner, S.M. Am. J. Physiol. (1987) [Pubmed]
  31. Pressor sensitivity to exogenous vasopressin in conscious, adult rats treated neonatally with capsaicin. Bennett, T., Gardiner, S.M. Br. J. Pharmacol. (1985) [Pubmed]
  32. Pentolinium in the management of autonomic hyperreflexia. Texter, J.H., Reece, R.W., Hranowsky, N. J. Urol. (1976) [Pubmed]
  33. Cardiovascular effects of spinal cord substance P: studies with a stable receptor agonist. Keeler, J.R., Charlton, C.G., Helke, C.J. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  34. Pulmonary vasomotor tone during general anesthesia and deliberate hypotension in man. Fahmy, N.R., Selwyn, A.S., Patel, D., Lappas, D.G. Anesthesiology (1976) [Pubmed]
  35. Regional haemodynamic effects of neuropeptide Y, vasopressin and angiotensin II in conscious, unrestrained, Long Evans and Brattleboro rats. Gardiner, S.M., Bennett, T., Compton, A.M. J. Auton. Nerv. Syst. (1988) [Pubmed]
  36. Effect of capsaicin-sensitive sensory nerves on plasma glucose and catecholamine levels during 2-deoxyglucose-induced stress in conscious rats. Zhou, X.F., Livett, B.G. Br. J. Pharmacol. (1990) [Pubmed]
  37. Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. Ueno, T., Tremblay, J., Kunes, J., Zicha, J., Dobesova, Z., Pausova, Z., Deng, A.Y., Sun, Y.L., Jacob, H.J., Hamet, P. J. Mol. Med. (2003) [Pubmed]
  38. Mechanisms of kinin B1-receptor-induced hypotension in the anesthetized dog. Lamontagne, D., Nakhostine, N., Couture, R., Nadeau, R. J. Cardiovasc. Pharmacol. (1996) [Pubmed]
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