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Chemical Compound Review

Araminol     3-[(1S,2S)-2-amino-1-hydroxy- propyl]phenol

Synonyms: Pressonex, Pressorol, Metaradrin, Metaradrine, metaraminol, ...
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Disease relevance of m-Hydroxynorephedrine


High impact information on m-Hydroxynorephedrine


Chemical compound and disease context of m-Hydroxynorephedrine


Biological context of m-Hydroxynorephedrine


Anatomical context of m-Hydroxynorephedrine

  • 3. Increases in arterial pressure sufficient to activate peripheral baroreceptors were achieved by intravenous bolus infusions of metaraminol (10 micrograms/10 microliters) [18].
  • Conversely, metaraminol permeated the membrane of the chromaffin granule through the apolar lipid phase and distributed according to the delta pH alone [19].
  • In the gerbil, 4 hours after placing a clip on one carotid artery, metaraminol-induced increases in blood pressure had no such protective effect on the metabolic changes or on oedema [20].
  • To examine whether the uterine perfusion-sparing property of ephedrine is due to local actions, we examined the effects in vitro of ephedrine and the alpha-adrenergic agonist metaraminol (10(-10)-10(-3) M) in uterine and femoral vessels, with and without functional endothelium, from nonpregnant and pregnant ewes [21].
  • The disappearance of LAQ094, metaraminol, and (-)-isoproterenol following 1-h incubation with human liver microsomes was 73, 85, and 66%, respectively, in the presence of 1% methanol, but was only 3, 15, and 24%, respectively, in the absence of organic solvent [22].

Associations of m-Hydroxynorephedrine with other chemical compounds


Gene context of m-Hydroxynorephedrine

  • Meningismus after metaraminol administration in a patient with Familial Mediterranean fever [27].
  • 5. The presynaptic alpha 2-adrenoreceptor antagonists idazoxan and yohimbine, and the neuronal uptake blockers desipramine and metaraminol, prolonged the PTP and enhanced but shortened the secondary rise in tetanic tension [28].
  • In 15 other cases with a SBP 134.9 +/- 18.3 mmHg and no PVC's at rest a metaraminol infusion was started [29].

Analytical, diagnostic and therapeutic context of m-Hydroxynorephedrine


  1. Metaraminol for priapism. Stanners, A., Colin-Jones, D. Lancet (1984) [Pubmed]
  2. Evaluation of the ratio of cerebral blood flow to cerebral blood volume as an index of local cerebral perfusion pressure. Schumann, P., Touzani, O., Young, A.R., Morello, R., Baron, J.C., MacKenzie, E.T. Brain (1998) [Pubmed]
  3. Effect of metaraminol during acute inferior wall myocardial infarction accompanied by hypotension: preliminary study. Sagie, A., Sclarovsky, S., Klainman, E., Strasberg, B., Rechavia, E., Mager, A., Kusniec, J., Agmon, J. J. Am. Coll. Cardiol. (1987) [Pubmed]
  4. Mollaret's meningitis. A variant of recurrent hereditary polyserositis, both provoked by metaraminol. Barakat, M.H., Mustafa, H.T., Shakir, R.A. Arch. Neurol. (1988) [Pubmed]
  5. Metaraminol for haemodialysis-associated priapism. Branger, B., Ramperez, P., Oules, R., Balducchi, J.P., Fourcade, J., Shaldon, S., Costa, P., Louis, J.F., Navratil, H. Lancet (1985) [Pubmed]
  6. Metaraminol provocation test for familial Mediterranean fever. Cattan, D., Dervichian, M., Courillon, A., Nurit, Y. Lancet (1984) [Pubmed]
  7. Regional changes in cerebral blood flow and blood-brain barrier permeability during epileptiform seizures and in acute hypertension in rabbits. Suzuki, R., Nitsch, C., Fujiwara, K., Klatzo, I. J. Cereb. Blood Flow Metab. (1984) [Pubmed]
  8. The role of the peripheral sympathetic nervous system in cerebral blood flow autoregulation. Hernández-Pérez, M.J., Raichle, M.E., Stone, H.L. Stroke (1975) [Pubmed]
  9. Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Tatsuta, M., Iishi, H., Baba, M., Yano, H., Sakai, N., Uehara, H., Hirasawa, R., Nakaizumi, A. Int. J. Cancer (1998) [Pubmed]
  10. Comparison of metaraminol and ephedrine infusions for maintaining arterial pressure during spinal anesthesia for elective cesarean section. Ngan Kee, W.D., Lau, T.K., Khaw, K.S., Lee, B.B. Anesthesiology (2001) [Pubmed]
  11. Norepinephrine and metaraminol in septic shock: a comparison of the hemodynamic effects. Natalini, G., Schivalocchi, V., Rosano, A., Taranto, M., Pletti, C., Bernardini, A. Intensive care medicine. (2005) [Pubmed]
  12. Use of alpha-agonists for management of anaphylaxis occurring under anaesthesia: case studies and review. Heytman, M., Rainbird, A. Anaesthesia. (2004) [Pubmed]
  13. Isobaric bupivacaine for spinal anaesthesia in acute war injuries. Bion, J.F. Anaesthesia. (1984) [Pubmed]
  14. Response of tertiary centres to pressure changes. Is there a mechano-electrical association? Sideris, D.A., Toumanidis, S.T., Kostis, E.B., Stagiannis, K., Spyropoulos, G., Moulopoulos, S.D. Cardiovasc. Res. (1990) [Pubmed]
  15. Induction of tumour blood flow stasis and necrosis: a new function for epinephrine similar to that of combretastatin A-4 derivative AVE8062 (AC7700). Hori, K., Saito, S. Br. J. Cancer (2004) [Pubmed]
  16. Dialyzer-augmented whole blood and plasma exchange for patients with hepatic or hepatorenal failure. Buselmeier, T.J., Merino, G.E., Rodrigo, F., Meyer, R.M., Bosl, B.H., Kjellstrand, C.M., Simmons, R.L., Najarian, J.S. Crit. Care Med. (1975) [Pubmed]
  17. Failure of K+ to affect the potency of inhibitors of the neuronal noradrenaline carrier in the rat vas deferens. Ungell, A.L., Graefe, K.H. Naunyn Schmiedebergs Arch. Pharmacol. (1987) [Pubmed]
  18. Lateral hypothalamic lesions alter baroreceptor-evoked inhibition of rat supraoptic vasopressin neurones. Nissen, R., Cunningham, J.T., Renaud, L.P. J. Physiol. (Lond.) (1993) [Pubmed]
  19. Mechanisms of accumulation of tyramine, metaraminol, and isoproterenol in isolated chromaffin granules and ghosts. Johnson, R.G., Carty, S.E., Hayflick, S., Scarpa, A. Biochem. Pharmacol. (1982) [Pubmed]
  20. The effect of increased blood pressure on hemispheric lactate and water content during acute cerebral ischaemia in the rat and gerbil. Aspey, B.S., Ehteshami, S., Hurst, C.M., McCoy, A.L., Harrison, M.J. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  21. The vascular mechanism of ephedrine's beneficial effect on uterine perfusion during pregnancy. Tong, C., Eisenach, J.C. Anesthesiology (1992) [Pubmed]
  22. Methanol solvent may cause increased apparent metabolic instability in in vitro assays. Yin, H., Tran, P., Greenberg, G.E., Fischer, V. Drug Metab. Dispos. (2001) [Pubmed]
  23. Disordered cholinergic neurotransmission and dysautoregulation after acute cerebral infarction. Ott, E.O., Abraham, J., Meyer, J.S., Achari, A.N., Chee, A.N., Mathew, N.T. Stroke (1975) [Pubmed]
  24. Metaraminol-induced reversal of acute myocardial ischaemia associated with hypotension and refractory to intravenous nitroglycerin. Figueras, J., Lidon, R.M., Cortadellas, J. Eur. Heart J. (1991) [Pubmed]
  25. Sympathetic noradrenergic innervation of guinea-pig liver: histofluorescence and pharmacological studies. Fuller, R.W., Felten, S.Y., Perry, K.W., Snoddy, H.D., Felten, D.L. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  26. Extracellular GABA concentrations in rat supraoptic nucleus during lactation and following haemodynamic changes: an in vivo microdialysis study. Voisin, D.L., Chapman, C., Poulain, D.A., Herbison, A.E. Neuroscience (1994) [Pubmed]
  27. Meningismus after metaraminol administration in a patient with Familial Mediterranean fever. Kapur, S., Mutagi, H., Raphael, J. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2006) [Pubmed]
  28. Adrenergic modulation of 'non-adrenergic' twitches in the rat vas deferens. Amobi, N.I., Smith, I.C. Journal of autonomic pharmacology. (1988) [Pubmed]
  29. Antihypertensive treatment for the management of premature ventricular complexes. Pilot study. Sideris, D.A., Kontoyannis, D.A., Diakos, A., Kontoyannis, S.A., Moulopoulos, S.D. Acta cardiologica. (1988) [Pubmed]
  30. Metaraminol provocative test: a specific diagnostic test for familial Mediterranean fever. Barakat, M.H., El-Khawad, A.O., Gumaa, K.A., El-Sobki, N.I., Fenech, F.F. Lancet (1984) [Pubmed]
  31. Cerebral blood flow autoregulation in the rat. Hernández, M.J., Brennan, R.W., Bowman, G.S. Stroke (1978) [Pubmed]
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