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Chemical Compound Review

Involucrin     [(4Z)-7-acetyloxy-1,5- dimethyl-8-propan-2...

Synonyms: AC1O5MYN, 60108-77-2
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Disease relevance of Involucrin

  • Keratinocyte proteins that are expressed in abnormal sites of the epidermis during psoriasis, i.e., keratin 16, filaggrin, and involucrin, were, after PUVA treatment, localized to their normal sites [1].
  • Hyperplasia was a result of a disturbed program of epidermal differentiation rather than an increased proliferation rate, as reflected by the strong suppression of keratin 10, involucrin, and loricrin expression in suprabasal cells [2].
  • To test the hypothesis that factor VIII expressed in the epidermis can correct hemophilia A, we generated transgenic mice in a factor VIII-deficient background that express human factor VIII under control of the involucrin promoter [3].
  • Involucrin accumulation and ionophore-assisted envelope formation, markers of keratinocyte differentiation, were found to be highly dependent on culture conditions in the malignant epidermal keratinocyte line, SCC-13, derived from a human squamous cell carcinoma [4].
  • Involucrin, which is incorporated into the cross-linked envelope by the enzyme transglutaminase, was expressed at highest levels in squamous tumors, but several of the non-squamous non-small cell lung carcinoma lines also expressed comparable amounts [5].

High impact information on Involucrin


Chemical compound and disease context of Involucrin


Biological context of Involucrin


Anatomical context of Involucrin


Associations of Involucrin with other chemical compounds


Gene context of Involucrin


Analytical, diagnostic and therapeutic context of Involucrin


  1. PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy. Vallat, V.P., Gilleaudeau, P., Battat, L., Wolfe, J., Nabeya, R., Heftler, N., Hodak, E., Gottlieb, A.B., Krueger, J.G. J. Exp. Med. (1994) [Pubmed]
  2. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Neufang, G., Furstenberger, G., Heidt, M., Marks, F., Müller-Decker, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin. Fakharzadeh, S.S., Zhang, Y., Sarkar, R., Kazazian, H.H. Blood (2000) [Pubmed]
  4. Modulation of involucrin and envelope competence in human keratinocytes by hydrocortisone, retinyl acetate, and growth arrest. Cline, P.R., Rice, R.H. Cancer Res. (1983) [Pubmed]
  5. Cross-linked envelope-related markers for squamous differentiation in human lung cancer cell lines. Levitt, M.L., Gazdar, A.F., Oie, H.K., Schuller, H., Thacher, S.M. Cancer Res. (1990) [Pubmed]
  6. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Carroll, J.M., Romero, M.R., Watt, F.M. Cell (1995) [Pubmed]
  7. Remodeling of the involucrin gene during primate evolution. Tseng, H., Green, H. Cell (1988) [Pubmed]
  8. Structure and evolution of the human involucrin gene. Eckert, R.L., Green, H. Cell (1986) [Pubmed]
  9. Enzymatic cross-linking of involucrin and other proteins by keratinocyte particulates in vitro. Simon, M., Green, H. Cell (1985) [Pubmed]
  10. Participation of membrane-associated proteins in the formation of the cross-linked envelope of the keratinocyte. Simon, M., Green, H. Cell (1984) [Pubmed]
  11. Decreased expression of retinoic acid receptors, transforming growth factor beta, involucrin, and cornifin in cervical intraepithelial neoplasia. Xu, X.C., Mitchell, M.F., Silva, E., Jetten, A., Lotan, R. Clin. Cancer Res. (1999) [Pubmed]
  12. Restoration of the epidermal phenotype by follicular outer root sheath cells in recombinant culture with dermal fibroblasts. Limat, A., Breitkreutz, D., Hunziker, T., Boillat, C., Wiesmann, U., Klein, E., Noser, F., Fusenig, N.E. Exp. Cell Res. (1991) [Pubmed]
  13. Differential effects of detergents on keratinocyte gene expression. van Ruissen, F., Le, M., Carroll, J.M., van der Valk, P.G., Schalkwijk, J. J. Invest. Dermatol. (1998) [Pubmed]
  14. Intermediate basal cells of the prostate: in vitro and in vivo characterization. Garraway, L.A., Lin, D., Signoretti, S., Waltregny, D., Dilks, J., Bhattacharya, N., Loda, M. Prostate (2003) [Pubmed]
  15. Alteration of epidermal differentiation in middle ear cholesteatoma. Stammberger, M., Bujía, J., Kastenbauer, E. The American journal of otology. (1995) [Pubmed]
  16. Fibronectin inhibits the terminal differentiation of human keratinocytes. Adams, J.C., Watt, F.M. Nature (1989) [Pubmed]
  17. A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. Haase, I., Hobbs, R.M., Romero, M.R., Broad, S., Watt, F.M. J. Clin. Invest. (2001) [Pubmed]
  18. Involucrin synthesis is correlated with cell size in human epidermal cultures. Watt, F.M., Green, H. J. Cell Biol. (1981) [Pubmed]
  19. Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia. Banks-Schlegel, S., Green, H. J. Cell Biol. (1981) [Pubmed]
  20. Tandem-repeat internal mapping (TRIM) of the involucrin gene: repeat number and repeat-pattern polymorphism within a coding region in human populations. Urquhart, A., Gill, P. Am. J. Hum. Genet. (1993) [Pubmed]
  21. Induction of squamous differentiation by interferon beta in a human non-small-cell lung cancer cell line. Nair, S., Mayotte, J., Lokshin, A., Levitt, M. J. Natl. Cancer Inst. (1994) [Pubmed]
  22. Targeted ablation of the murine involucrin gene. Djian, P., Easley, K., Green, H. J. Cell Biol. (2000) [Pubmed]
  23. Primate involucrins: antigenic relatedness and detection of multiple forms. Parenteau, N.L., Eckert, R.L., Rice, R.H. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. Immortalization of human keratinocytes by simian virus 40 large T-antigen alters keratin gene response to retinoids. Agarwal, C., Eckert, R.L. Cancer Res. (1990) [Pubmed]
  25. Involucrin cross-linking by transglutaminase 1. Binding to membranes directs residue specificity. Nemes, Z., Marekov, L.N., Steinert, P.M. J. Biol. Chem. (1999) [Pubmed]
  26. Apigenin Inhibition of Involucrin Gene Expression Is Associated with a Specific Reduction in Phosphorylation of Protein Kinase C{delta} Tyr311. Balasubramanian, S., Zhu, L., Eckert, R.L. J. Biol. Chem. (2006) [Pubmed]
  27. A novel mechanism of matrix metalloproteinase-9 gene expression implies a role for keratinization. Kobayashi, T., Kishimoto, J., Ge, Y., Jin, W., Hudson, D.L., Ouahes, N., Ehama, R., Shinkai, H., Burgeson, R.E. EMBO Rep. (2001) [Pubmed]
  28. Desmoglein isoform distribution affects stratum corneum structure and function. Elias, P.M., Matsuyoshi, N., Wu, H., Lin, C., Wang, Z.H., Brown, B.E., Stanley, J.R. J. Cell Biol. (2001) [Pubmed]
  29. Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. Katagiri, C., Nakanishi, J., Kadoya, K., Hibino, T. J. Cell Biol. (2006) [Pubmed]
  30. Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo. Arabzadeh, A., Troy, T.C., Turksen, K. Mol. Cell. Biol. (2006) [Pubmed]
  31. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. Cabral, A., Voskamp, P., Cleton-Jansen, A.M., South, A., Nizetic, D., Backendorf, C. J. Biol. Chem. (2001) [Pubmed]
  32. Modulation of the terminal differentiation of human squamous carcinoma cells in vitro by all-trans-retinoic acid. Reiss, M., Pitman, S.W., Sartorelli, A.C. J. Natl. Cancer Inst. (1985) [Pubmed]
  33. Ability of normal human keratinocytes that grow in culture in serum-free medium to be derived from suprabasal cells. Wilke, M.S., Edens, M., Scott, R.E. J. Natl. Cancer Inst. (1988) [Pubmed]
  34. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Prince, M.E., Sivanandan, R., Kaczorowski, A., Wolf, G.T., Kaplan, M.J., Dalerba, P., Weissman, I.L., Clarke, M.F., Ailles, L.E. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  35. Keratolinin: the soluble substrate of epidermal transglutaminase from human and bovine tissue. Zettergren, J.G., Peterson, L.L., Wuepper, K.D. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
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