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Chemical Compound Review

AG-K-62706     2-[4-[4-(3,5-diphenyl-1H- tetrazol-2-yl)-3...

Synonyms: AC1L2MBU, CTK4I6870, AR-1D0102, AC1Q3AO2
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Disease relevance of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

 

High impact information on 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

 

Chemical compound and disease context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

 

Biological context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

 

Anatomical context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

  • Infarct size (as a percent of risk region) was then determined by incubating myocardium with para-nitro blue tetrazolium [18].
  • Based on two differentiation markers, nitro blue tetrazolium reduction and the OKM-5 monocyte-specific surface antigen, 28B.4 exhibits a greater response to RA than does 5B. c-fms mRNA is not detected in uninduced HL60/MRI and HL60 but is expressed during RA-induced differentiation of HL60/MRI to monocytes/macrophages and HL60 to granulocytes [19].
  • The cells became adherent, developed pseudopodia, displayed macrophage characteristics by light microscopy, developed nonspecific acid esterase activity, phagocytized yeast, slightly reduced nitro blue tetrazolium, displayed Fc-immunoglobulin G receptors, and killed bacteria [20].
  • Perfusion of infected livers with nitro blue tetrazolium revealed that superoxide was produced in the cytoplasm of hepatocytes, especially in association with plasmacytic infiltrates near portal triads [21].
  • We have selected HL-60 cells resistant to nitroprusside-induced differentiation as assessed by acquisition of the OKM-1 antigen, reduction of nitro blue tetrazolium, and morphologic maturation [22].
 

Associations of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole with other chemical compounds

 

Gene context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

  • The same time and concentration dependence for Me2SO was shown for the decline in FPGS activity, increase in nitro blue tetrazolium-positive cells, and decline in the level of a 2.1-kilobase FPGS mRNA during exposure to this inducer [27].
  • In this report we tested this assumption, comparing the effect of TNF and LT on mediation of early (activation of the transcription factor NF-kappa B) and late (reduction of nitro blue tetrazolium, NBT) cellular responses in the human myelomonoblastic leukemic cell line ML-1a [28].
  • Phenotypic characterization of the clones revealed that BCR/ABL induces a slight decrease in the proliferation and viability, without a marked effect on cell cycle distribution, the rate of apoptosis or on cellular differentiation, as judged by several cell surface markers and capacity to reduce nitro blue tetrazolium [29].
  • Antidigoxigenin-alkaline-phosphatase conjugate and nitro blue tetrazolium, producing a blue color reaction, was used to visualize GRP mRNA, and for GRP-R mRNA, avidin-alkaline phosphatase and vector red, were used resulting in a vivid red color [30].
  • L. casei administration induced activation of phagocytes as evidenced by the strong myeloperoxidase activity and the nitro blue tetrazolium assay in lung [31].
 

Analytical, diagnostic and therapeutic context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

References

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