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Chemical Compound Review

AG-K-62706     2-[4-[4-(3,5-diphenyl-1H- tetrazol-2-yl)-3...

Synonyms: AC1L2MBU, CTK4I6870, AR-1D0102, AC1Q3AO2
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Disease relevance of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole


High impact information on 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole


Chemical compound and disease context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole


Biological context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole


Anatomical context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

  • Infarct size (as a percent of risk region) was then determined by incubating myocardium with para-nitro blue tetrazolium [18].
  • Based on two differentiation markers, nitro blue tetrazolium reduction and the OKM-5 monocyte-specific surface antigen, 28B.4 exhibits a greater response to RA than does 5B. c-fms mRNA is not detected in uninduced HL60/MRI and HL60 but is expressed during RA-induced differentiation of HL60/MRI to monocytes/macrophages and HL60 to granulocytes [19].
  • The cells became adherent, developed pseudopodia, displayed macrophage characteristics by light microscopy, developed nonspecific acid esterase activity, phagocytized yeast, slightly reduced nitro blue tetrazolium, displayed Fc-immunoglobulin G receptors, and killed bacteria [20].
  • Perfusion of infected livers with nitro blue tetrazolium revealed that superoxide was produced in the cytoplasm of hepatocytes, especially in association with plasmacytic infiltrates near portal triads [21].
  • We have selected HL-60 cells resistant to nitroprusside-induced differentiation as assessed by acquisition of the OKM-1 antigen, reduction of nitro blue tetrazolium, and morphologic maturation [22].

Associations of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole with other chemical compounds


Gene context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole

  • The same time and concentration dependence for Me2SO was shown for the decline in FPGS activity, increase in nitro blue tetrazolium-positive cells, and decline in the level of a 2.1-kilobase FPGS mRNA during exposure to this inducer [27].
  • In this report we tested this assumption, comparing the effect of TNF and LT on mediation of early (activation of the transcription factor NF-kappa B) and late (reduction of nitro blue tetrazolium, NBT) cellular responses in the human myelomonoblastic leukemic cell line ML-1a [28].
  • Phenotypic characterization of the clones revealed that BCR/ABL induces a slight decrease in the proliferation and viability, without a marked effect on cell cycle distribution, the rate of apoptosis or on cellular differentiation, as judged by several cell surface markers and capacity to reduce nitro blue tetrazolium [29].
  • Antidigoxigenin-alkaline-phosphatase conjugate and nitro blue tetrazolium, producing a blue color reaction, was used to visualize GRP mRNA, and for GRP-R mRNA, avidin-alkaline phosphatase and vector red, were used resulting in a vivid red color [30].
  • L. casei administration induced activation of phagocytes as evidenced by the strong myeloperoxidase activity and the nitro blue tetrazolium assay in lung [31].

Analytical, diagnostic and therapeutic context of 2-[4-[4-(3,5-diphenyl-1H-tetrazol-2-yl)-3-methoxy-phenyl]-2-methoxy-phenyl]-3,5-diphenyl-1H-tetrazole


  1. Interruption of sympathetic and vagal-mediated afferent responses by transmural myocardial infarction. Barber, M.J., Mueller, T.M., Davies, B.G., Gill, R.M., Zipes, D.P. Circulation (1985) [Pubmed]
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  9. Induction of plasminogen activator secretion in macrophages by electrochemical stimulation of the hexose monophosphate shunt with methylene blue. Schnyder, J., Baggiolini, M. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  10. Cancer procoagulant and tissue factor are differently modulated by all-trans-retinoic acid in acute promyelocytic leukemia cells. Falanga, A., Consonni, R., Marchetti, M., Locatelli, G., Garattini, E., Passerini, C.G., Gordon, S.G., Barbui, T. Blood (1998) [Pubmed]
  11. Differentiation of HL-60 promyelocytic leukemia cells monitored by flow cytometric measurement of nitro blue tetrazolium (NBT) reduction. Blair, O.C., Carbone, R., Sartorelli, A.C. Cytometry. (1985) [Pubmed]
  12. Evaluation of the fructosamine test in obesity: consequences for the assessment of past glycemic control in diabetes. Broussolle, C., Tricot, F., Garcia, I., Orgiazzi, J., Revol, A. Clin. Biochem. (1991) [Pubmed]
  13. Structure-activity relationships for the induction of differentiation of HL-60 human acute promyelocytic leukemia cells by anthracyclines. Schwartz, E.L., Sartorelli, A.C. Cancer Res. (1982) [Pubmed]
  14. Differentiation of WEHI-3B D+ monomyelocytic leukemia cells by retinoic acid and aclacinomycin A. Gamba-Vitalo, C., Blair, O.C., Keyes, S.R., Sartorelli, A.C. Cancer Res. (1986) [Pubmed]
  15. The monocytic differentiation of HL60 induced by rat kidney NADPH-linked high-Km aldehyde reductase protein. Takahashi, N., Breitman, T.R., Saito, T., Ichikawa, A. J. Biol. Chem. (1989) [Pubmed]
  16. In situ detection of oxidative stress in rat hepatocytes. Mochida, S., Masaki, N., Ohta, Y., Matsui, A., Ogata, I., Fujiwara, K. J. Pathol. (1992) [Pubmed]
  17. Superoxide production in experimental seizures in cats. Bauknight, G.C., Wei, E.P., Kontos, H.A. Stroke (1992) [Pubmed]
  18. Ischemic preconditioning reduces infarct size in swine myocardium. Schott, R.J., Rohmann, S., Braun, E.R., Schaper, W. Circ. Res. (1990) [Pubmed]
  19. Changes in c-myc, c-fms, and N-ras proto-oncogene expression associated with retinoic acid-induced monocytic differentiation of human leukemia HL60/MRI cells. Imaizumi, M., Breitman, T.R. Cancer Res. (1988) [Pubmed]
  20. Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation. Koeffler, H.P., Bar-Eli, M., Territo, M.C. Cancer Res. (1981) [Pubmed]
  21. Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus. Sipowicz, M.A., Chomarat, P., Diwan, B.A., Anver, M.A., Awasthi, Y.C., Ward, J.M., Rice, J.M., Kasprzak, K.S., Wild, C.P., Anderson, L.M. Am. J. Pathol. (1997) [Pubmed]
  22. Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation. Pilz, R.B., Berjis, M., Idriss, S.D., Scheele, J.S., Suhasini, M., Gao, L., Scheffler, I.E., Boss, G.R. J. Biol. Chem. (1994) [Pubmed]
  23. Actions of adenosine on nitro blue tetrazolium deposition and surface pH during intestinal reperfusion injury. Kaminski, P.M., Proctor, K.G. Circ. Res. (1990) [Pubmed]
  24. Clinical outcome in stage I to III breast carcinoma and eIF4E overexpression. Li, B.D., McDonald, J.C., Nassar, R., De Benedetti, A. Ann. Surg. (1998) [Pubmed]
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  26. Enhanced luminol-dependent chemiluminescence of stimulated rat alveolar macrophages by pretreatment with alveolar lining material. Webb, D.S., Jeska, E.L. J. Leukoc. Biol. (1986) [Pubmed]
  27. Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation. Egan, M.G., Sirlin, S., Rumberger, B.G., Garrow, T.A., Shane, B., Sirotnak, F.M. J. Biol. Chem. (1995) [Pubmed]
  28. Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response. Chaturvedi, M.M., LaPushin, R., Aggarwal, B.B. J. Biol. Chem. (1994) [Pubmed]
  29. Establishment and phenotypic characterization of human U937 cells with inducible P210 BCR/ABL expression reveals upregulation of CEACAM1 (CD66a). Håkansson, P., Lassen, C., Olofsson, T., Baldetorp, B., Karlsson, A., Gullberg, U., Fioretos, T. Leukemia (2004) [Pubmed]
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  31. Lactobacillus casei administration reduces lung injuries in a Streptococcus pneumoniae infection in mice. Racedo, S., Villena, J., Medina, M., Ag??ero, G., Rodr??guez, V., Alvarez, S. Microbes Infect. (2006) [Pubmed]
  32. K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation. Yu, G., Smithgall, T.E., Glazer, R.I. J. Biol. Chem. (1989) [Pubmed]
  33. Adhesion and activation of human neutrophils onto collagen chains separated by electrophoresis. Garnotel, R., Wegrowski, J., Bellon, G., Monboisse, J.C., Perreau, C., Borel, J.P. Exp. Cell Res. (1993) [Pubmed]
  34. Significance of an in vitro phenomenon in which murine erythrocytes are lysed by autologous spleen cells and spherules of Coccidioides immitis. Danley, D.L., Hilger, A.E., Boonlayangoor, P., Millhouse, E.W. Infect. Immun. (1979) [Pubmed]
  35. Comparison of biotinylated DNA and RNA probes for rapid detection of varicella-zoster virus genome by in situ hybridization. Forghani, B., Yu, G.J., Hurst, J.W. J. Clin. Microbiol. (1991) [Pubmed]
  36. Stability-indicating methods for quantitative determination of spironolactone using high-pressure liquid chromatography and blue tetrazolium reaction. Das Gupta, V., Ghanekar, A.G. Journal of pharmaceutical sciences. (1978) [Pubmed]
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