The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Allopregnanolone     1- [(3R,5S,8S,9S,10S,13S,14S,17S) -3-hydroxy...

Synonyms: Allopregnalone, CHEMBL207538, SureCN588060, CHEBI:50169, P8887_SIGMA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C13712


Psychiatry related information on C13712


High impact information on C13712


Chemical compound and disease context of C13712


Biological context of C13712


Anatomical context of C13712


Associations of C13712 with other chemical compounds


Gene context of C13712


Analytical, diagnostic and therapeutic context of C13712


  1. 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Frye, C.A., Rhodes, M.E., Petralia, S.M., Walf, A.A., Sumida, K., Edinger, K.L. Neuroscience (2006) [Pubmed]
  2. Adenosinergic modulation of 3alpha-hydroxy-5alpha-pregnan-20-one induced catalepsy in mice. Mandhane, S.N., Khisti, R.T., Chopde, C.T. Psychopharmacology (Berl.) (1999) [Pubmed]
  3. Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. Reddy, D.S., Rogawski, M.A. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  4. Ethanol-induced elevation of 3 alpha-hydroxy-5 alpha-pregnan-20-one does not modulate motor incoordination in rats. Khisti, R.T., VanDoren, M.J., Matthews, D.B., Morrow, A.L. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
  5. 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia. Smith, C.D., Wekstein, D.R., Markesbery, W.R., Frye, C.A. Psychopharmacology (Berl.) (2006) [Pubmed]
  6. Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats. Walf, A.A., Sumida, K., Frye, C.A. Psychopharmacology (Berl.) (2006) [Pubmed]
  7. Observational study on the stability of the psychological status during normal pregnancy and increased blood levels of neuroactive steroids with GABA-A receptor agonist activity. Paoletti, A.M., Romagnino, S., Contu, R., Orrù, M.M., Marotto, M.F., Zedda, P., Lello, S., Biggio, G., Concas, A., Melis, G.B. Psychoneuroendocrinology (2006) [Pubmed]
  8. Neuroactive ring A-reduced metabolites of progesterone in human plasma during pregnancy: elevated levels of 5 alpha-dihydroprogesterone in depressed patients during the latter half of pregnancy. Pearson Murphy, B.E., Steinberg, S.I., Hu, F.Y., Allison, C.M. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  9. Olanzapine increases allopregnanolone in the rat cerebral cortex. Marx, C.E., Duncan, G.E., Gilmore, J.H., Lieberman, J.A., Morrow, A.L. Biol. Psychiatry (2000) [Pubmed]
  10. Human saturated steroid 6alpha-hydroxylase. Dombroski, R., Casey, M.L., Macdonald, P.C. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  11. GABA physiology: modulation by benzodiazepines and hormones. Wilson, M.A. Critical reviews in neurobiology. (1996) [Pubmed]
  12. Role of brain cytochrome P450 in regulation of the level of anesthetic steroids in the brain. Strömstedt, M., Warner, M., Banner, C.D., MacDonald, P.C., Gustafsson, J.A. Mol. Pharmacol. (1993) [Pubmed]
  13. Rats bred for high versus low anxiety responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP levels as adults. Frye, C.A., Sumida, K., Zimmerberg, B., Brunelli, S.A. Behav. Neurosci. (2006) [Pubmed]
  14. Mating stimuli influence endogenous variations in the neurosteroids 3alpha,5alpha-THP and 3alpha-Diol. Frye, C.A., Bayon, L.E. J. Neuroendocrinol. (1999) [Pubmed]
  15. Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors. Han, M., Zorumski, C.F., Covey, D.F. J. Med. Chem. (1996) [Pubmed]
  16. Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864. Belelli, D., McCauley, L., Gee, K.W. J. Neurochem. (1990) [Pubmed]
  17. The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. Finn, D.A., Gee, K.W. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  18. Discriminative stimulus effects of ethanol and 3 alpha-hydroxy-5 alpha-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis). Grant, K.A., Azarov, A., Shively, C.A., Purdy, R.H. Psychopharmacology (Berl.) (1997) [Pubmed]
  19. Effects of steroids on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina. Woodward, R.M., Polenzani, L., Miledi, R. Mol. Pharmacol. (1992) [Pubmed]
  20. Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Jin, Y., Stayrook, S.E., Albert, R.H., Palackal, N.T., Penning, T.M., Lewis, M. Biochemistry (2001) [Pubmed]
  21. The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors. Belelli, D., Casula, A., Ling, A., Lambert, J.J. Neuropharmacology (2002) [Pubmed]
  22. Neurosteroid modulation of GABA binding sites in developing avian central nervous system. Viapiano, M.S., de Novara, A.M., de Plazas, S.F. Neurochem. Int. (1998) [Pubmed]
  23. Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function. Serra, M., Mostallino, M.C., Talani, G., Pisu, M.G., Carta, M., Mura, M.L., Floris, I., Maciocco, E., Sanna, E., Biggio, G. J. Neurochem. (2006) [Pubmed]
  24. Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder. Hardoy, M.C., Serra, M., Carta, M.G., Contu, P., Pisu, M.G., Biggio, G. Journal of clinical psychopharmacology. (2006) [Pubmed]
  25. Temporal changes in activities of enzymes reducing ring-A of progesterone in the fetus and placenta of the rat. Sanyal, M.K., Villee, C.A. Endocrinology (1976) [Pubmed]
  26. Social isolation increases the response of peripheral benzodiazepine receptors in the rat. Serra, M., Pisu, M.G., Floris, I., Floris, S., Cannas, E., Mossa, A., Trapani, G., Latrofa, A., Purdy, R.H., Biggio, G. Neurochem. Int. (2004) [Pubmed]
  27. In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters. Petralia, S.M., Frye, C.A. Psychopharmacology (Berl.) (2005) [Pubmed]
  28. Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine. Grobin, A.C., VanDoren, M.J., Porrino, L.J., Morrow, A.L. Psychopharmacology (Berl.) (2005) [Pubmed]
  29. Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures. Zorumski, C.F., Mennerick, S.J., Covey, D.F. Synapse (1998) [Pubmed]
  30. Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice. Khisti, R.T., Chopde, C.T. Brain Res. (2000) [Pubmed]
  31. Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition? Puia, G., Ducić, I., Vicini, S., Costa, E. Recept. Channels (1993) [Pubmed]
  32. Comparison of 5 alpha-pregnan-3 alpha-ol-20-one and phenobarbital on cortical synaptic activation and inhibition studied in vitro. Taubøll, E., Gjerstad, L. Epilepsia (1993) [Pubmed]
  33. Radioimmunoassay of 3 alpha-hydroxy-5 alpha-pregnan-20-one in rat and human plasma. Purdy, R.H., Moore, P.H., Rao, P.N., Hagino, N., Yamaguchi, T., Schmidt, P., Rubinow, D.R., Morrow, A.L., Paul, S.M. Steroids (1990) [Pubmed]
  34. The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. Brot, M.D., Akwa, Y., Purdy, R.H., Koob, G.F., Britton, K.T. Eur. J. Pharmacol. (1997) [Pubmed]
  35. 3alpha,5alpha-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Rhodes, M.E., McCormick, C.M., Frye, C.A. Pharmacol. Biochem. Behav. (2004) [Pubmed]
WikiGenes - Universities