Disease relevance of SLC35A1

• Functional expression of the CMP-sialic acid transporter in Escherichia coli and its identification as a simple mobile carrier [1].
• RESULTS: Inactive persons were significantly (P < 0.05) more likely to be women, older (75+), have functional limitations, be underweight (BMI < 20) or overweight (BMI > 25), have severe pain, or not have prescription drug insurance coverage [2].
• Group 1; Clearance, Group 2; Inactive healthy carrier, Group 3; Chronic hepatitis, Group 4; Liver cirrhosis [3].
• RESULTS: deltaQLF(D) values of Active white spot group (n = 7) were compared with those of Inactive white spot group (n = 27) using a two-sample t-test [4].
• RESULTS: Inactive toxoplasmosis (IgG levels) is of rather high prevalence in the human population in the Eastern Region of Saudi Arabia (25%) [5].

Psychiatry related information on SLC35A1

• Sixty male subjects were placed into four equal groups based upon age and level of physical activity: Old Active, Old Inactive, Young Active, and Young Inactive [6].
• Simple and choice knee extension response time was measured on four groups of subjects: Old Active, Old Inactive, Young Active, and Young Inactive [7].

High impact information on SLC35A1

• Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter [8].
• The Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor AG1478 Increases the Formation of Inactive Untethered EGFR Dimers: IMPLICATIONS FOR COMBINATION THERAPY WITH MONOCLONAL ANTIBODY 806 [9].
• Site-specific Phosphorylation Differentiates Active from Inactive Forms of the Human T-cell Leukemia Virus Type 1 Tax Oncoprotein [10].
• CMP-sialic acid is transported into the lumen of the Golgi complex through the CMP-sialic acid transporter, an antiporter that also functions to transport CMP into the cytosol [11].
• The CMP-sialic Acid Transporter Is Localized in the Medial-Trans Golgi and Possesses Two Specific Endoplasmic Reticulum Export Motifs in Its Carboxyl-terminal Cytoplasmic Tail [11].

Chemical compound and disease context of SLC35A1

• 3. Inactive renin was slightly increased by orthostasis, but was not significantly influenced by acute administration of frusemide or inhibition of prostaglandin synthesis by indomethacin [12].

Biological context of SLC35A1

• Human UDP-Gal transporter 1 (hUGT1) and the human CMP-Sia transporter (hCST) are similar in structure, with amino acid sequences that are 43% identical, but they have quite distinct transport substrates [13].
• Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters [13].
• Using an expression cloning strategy, we isolated a cDNA encoding the hamster CMP-Sia-Tr which complements the Lec2 phenotype [14].
• Induction of the pump mRNA was suppressed by the protein kinase C inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and by down-regulation of protein kinase C. Inactive phorbol ester 4 alpha-phorbol didecanoate also failed to mimic the PMA effect [15].
• CONCLUSIONS: Inactive ALDH2 genotype was frequently observed in DM-Mt3243 [16].

Anatomical context of SLC35A1

• Functional expression of human golgi CMP-sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant [17].
• A peptide antibody against the C-terminus of the hCST protein detected the cDNA products expressed in the microsomes of the transformants [17].
• 1. Inactive renin was isolated from human amniotic fluid by chromatography with DEAE-cellulose, pepstatin-aminobutyl-agarose, octylagarose and Cibacron Blue F3GA columns [18].
• We explored the possibility that over expressing nucleotide sugar transporters, particularly the CMP-sialic acid transporter (CMP-SAT) would improve the sialylation process in Chinese hamster ovary cells (CHO) [19].
• CONCLUSIONS: Inactive ALDH2 is a risk factor for multiple carcinoma of the esophagus in alcoholics [20].

Associations of SLC35A1 with chemical compounds

• One is the human CMP-sialic acid transporter gene, and the other is a group of homologous genes with an undefined function that are distributed in man, mouse, and rat, and show significant similarity to the yeast UDP-N-acetylglucosamine transporter [21].
• While the G189A mutant was able to complement CMP-sialic acid transport-deficient Chinese hamster ovary mutants, the exchange of glycine 189 into glutamine or isoleucine dramatically affected the transport activity of the CMP-sialic acid transporter [22].
• Mutations of CB(1) T210 Produce Active and Inactive Receptor Forms: Correlations with Ligand Affinity, Receptor Stability, and Cellular Localization [23].
• CONCLUSIONS: Inactive heterozygous ALDH2, alcohol flushing, and increased MCV were positively associated with hangover susceptibility in Japanese workers, suggesting that acetaldehyde is etiologically linked to the development of hangover [24].
• Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells [19].

Regulatory relationships of SLC35A1

• FINDINGS: Inactive SARS-CoV could induce THP-1 cells secret RANTES and this increase effect could not be suppressed by DXM [25].

Other interactions of SLC35A1

• Expression and activity of chimeric molecules between human UDP-galactose transporter and CMP-sialic acid transporter [26].
• Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell [27].
• Short-term changes in sedentary behaviour during adolescence: Project STIL (Sedentary Teenagers and Inactive Lifestyles) [28].
• 3. Inactive renin can also be activated by exposure of plasma to exogenous trypsin, and in normal plasma the quantities of inactive renin that are activated after acidification and with trypsin are identical [29].
• The Active and the Inactive Form of the hAT1 Receptor Have an Identical Ligand-Binding Environment: An MPA Study on a Constitutively Active Angiotensin II Receptor Mutant [30].

Analytical, diagnostic and therapeutic context of SLC35A1

• Molecular cloning of the hamster CMP-sialic acid transporter [14].
• The subcellular localization of the hCST protein in the Golgi membrane was demonstrated by immunofluorescence microscopy, using the hCST-specific antibody [17].
• Excipients which are included in the 1996 FDA 'Inactive Ingredient Guide,' but do not appear in the PDR or Handbook on Injectable Drugs, were included as a separate list [31].
• We characterized the CST mutations in these cells by Northern blotting and RT-PCR [32].

References