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Gene Review

P2rx7  -  purinergic receptor P2X, ligand-gated ion...

Mus musculus

Synonyms: AI467586, ATP receptor, P2X purinoceptor 7, P2X(7), P2X7, ...
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Disease relevance of P2rx7


High impact information on P2rx7

  • We show here that treatment of infected macrophages with ATP leads to killing of chlamydiae through ligation of the purinergic receptor, P2X(7)R [7].
  • NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor [8].
  • ART2-catalyzed ADP-ribosylation activates the cytolytic P2X7 purinoceptor, causing calcium flux, pore formation, phosphatidylserine exposure, shedding of CD62L, cell shrinkage, and propidium iodide uptake [8].
  • This effect was specifically mediated by the P2Z receptor, because selective receptor antagonists prevented NF-kappaB activation [9].
  • Cells of the macrophage lineage express a peculiar surface receptor for extracellular ATP, designated P2Z/P2X7 purinergic receptor, that induces pore formation and collapse of the plasma membrane potential [9].

Biological context of P2rx7


Anatomical context of P2rx7


Associations of P2rx7 with chemical compounds


Physical interactions of P2rx7


Enzymatic interactions of P2rx7


Regulatory relationships of P2rx7


Other interactions of P2rx7


Analytical, diagnostic and therapeutic context of P2rx7


  1. Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages. Hu, Y., Fisette, P.L., Denlinger, L.C., Guadarrama, A.G., Sommer, J.A., Proctor, R.A., Bertics, P.J. J. Biol. Chem. (1998) [Pubmed]
  2. P2X7 nucleotide receptor activation enhances IFN gamma-induced type II nitric oxide synthase activity in BV-2 microglial cells. Gendron, F.P., Chalimoniuk, M., Strosznajder, J., Shen, S., González, F.A., Weisman, G.A., Sun, G.Y. J. Neurochem. (2003) [Pubmed]
  3. Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor. Humphreys, B.D., Rice, J., Kertesy, S.B., Dubyak, G.R. J. Biol. Chem. (2000) [Pubmed]
  4. The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Elliott, J.I., McVey, J.H., Higgins, C.F. Arthritis Res. Ther. (2005) [Pubmed]
  5. P2X7 receptors regulate NKT cells in autoimmune hepatitis. Kawamura, H., Aswad, F., Minagawa, M., Govindarajan, S., Dennert, G. J. Immunol. (2006) [Pubmed]
  6. Effect of the purinergic receptor P2X7 on Chlamydia infection in cervical epithelial cells and vaginally infected mice. Darville, T., Welter-Stahl, L., Cruz, C., Sater, A.A., Andrews, C.W., Ojcius, D.M. J. Immunol. (2007) [Pubmed]
  7. Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Coutinho-Silva, R., Stahl, L., Raymond, M.N., Jungas, T., Verbeke, P., Burnstock, G., Darville, T., Ojcius, D.M. Immunity (2003) [Pubmed]
  8. NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Seman, M., Adriouch, S., Scheuplein, F., Krebs, C., Freese, D., Glowacki, G., Deterre, P., Haag, F., Koch-Nolte, F. Immunity (2003) [Pubmed]
  9. Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. Ferrari, D., Wesselborg, S., Bauer, M.K., Schulze-Osthoff, K. J. Cell Biol. (1997) [Pubmed]
  10. P2Z/P2X7 receptor-dependent apoptosis of dendritic cells. Coutinho-Silva, R., Persechini, P.M., Bisaggio, R.D., Perfettini, J.L., Neto, A.C., Kanellopoulos, J.M., Motta-Ly, I., Dautry-Varsat, A., Ojcius, D.M. Am. J. Physiol. (1999) [Pubmed]
  11. Maturation and release of interleukin-1beta by lipopolysaccharide-primed mouse Schwann cells require the stimulation of P2X7 receptors. Colomar, A., Marty, V., Médina, C., Combe, C., Parnet, P., Amédée, T. J. Biol. Chem. (2003) [Pubmed]
  12. P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide. Kawamura, H., Aswad, F., Minagawa, M., Malone, K., Kaslow, H., Koch-Nolte, F., Schott, W.H., Leiter, E.H., Dennert, G. J. Immunol. (2005) [Pubmed]
  13. Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts. Korcok, J., Raimundo, L.N., Ke, H.Z., Sims, S.M., Dixon, S.J. J. Bone Miner. Res. (2004) [Pubmed]
  14. Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Gudipaty, L., Munetz, J., Verhoef, P.A., Dubyak, G.R. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  15. Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. Verhoef, P.A., Kertesy, S.B., Lundberg, K., Kahlenberg, J.M., Dubyak, G.R. J. Immunol. (2005) [Pubmed]
  16. Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland. Nakamoto, T., Brown, D.A., Catalán, M.A., Gonzalez-Begne, M., Romanenko, V.G., Melvin, J.E. J. Biol. Chem. (2009) [Pubmed]
  17. Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen. Kuehnel, M.P., Rybin, V., Anand, P.K., Anes, E., Griffiths, G. J. Cell. Sci. (2009) [Pubmed]
  18. ATP released by LPS increases nitric oxide production in raw 264.7 macrophage cell line via P2Z/P2X7 receptors. Sperlágh, B., Haskó, G., Németh, Z., Vizi, E.S. Neurochem. Int. (1998) [Pubmed]
  19. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. Le Feuvre, R.A., Brough, D., Iwakura, Y., Takeda, K., Rothwell, N.J. J. Biol. Chem. (2002) [Pubmed]
  20. Dissociation of the pore-forming and phospholipase D activities stimulated via P2z purinergic receptors in BAC1.2F5 macrophages. Product inhibition of phospholipase D enzyme activity. el-Moatassim, C., Dubyak, G.R. J. Biol. Chem. (1993) [Pubmed]
  21. Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. Taylor, S.R., Gonzalez-Begne, M., Dewhurst, S., Chimini, G., Higgins, C.F., Melvin, J.E., Elliott, J.I. J. Immunol. (2008) [Pubmed]
  22. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. Le Stunff, H., Auger, R., Kanellopoulos, J., Raymond, M.N. J. Biol. Chem. (2004) [Pubmed]
  23. Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation. Wilson, H.L., Francis, S.E., Dower, S.K., Crossman, D.C. J. Immunol. (2004) [Pubmed]
  24. Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Kahlenberg, J.M., Dubyak, G.R. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  25. Are second messengers crucial for opening the pore associated with P2X7 receptor? Faria, R.X., Defarias, F.P., Alves, L.A. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  26. ATP-induced apoptotic cell death in porcine ovarian theca cells through P2X7 receptor activation. Vázquez-Cuevas, F.G., Juárez, B., Garay, E., Arellano, R.O. Mol. Reprod. Dev. (2006) [Pubmed]
  27. Tissue distribution of the P2X7 receptor. Collo, G., Neidhart, S., Kawashima, E., Kosco-Vilbois, M., North, R.A., Buell, G. Neuropharmacology (1997) [Pubmed]
  28. Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization. Adriouch, S., Dubberke, G., Diessenbacher, P., Rassendren, F., Seman, M., Haag, F., Koch-Nolte, F. Cell. Immunol. (2005) [Pubmed]
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