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Gene Review

Car5a  -  carbonic anhydrase 5a, mitochondrial

Mus musculus

Synonyms: CA Y, CA-VA, CAV, Ca5, Ca5a, ...
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Disease relevance of Car5a

  • Some patients also have pulmonic stenosis, persistence of a left-sided superior vena cava or transposition of the great arteries [1].
  • Thrombus was formed in the inferior vena cava of wild-type mice and injected, 48-hours after induction, with either a control virus at 10(8) plaque-forming units (pfu) or ad.uPA at 10(7) or 10(8) pfu [2].
  • All 15 offspring with "abdominal heterotaxy" had anomalies of the posterior vena cava, and three of them also had tetralogy of Fallot [3].
  • Seven with the "variation type" of situs had cardiovascular anomalies, such as aortic stenosis, endocardial cushion defect, and posterior vena cava interruption (41%) [3].
  • CONCLUSION: These studies provide evidence for a role of TAFIa in venous thrombosis in mice, and describe an optimized vena cava injury model appropriate for the evaluation of antithrombotic drugs and the characterization of novel therapeutic targets [4].

High impact information on Car5a


Chemical compound and disease context of Car5a


Biological context of Car5a


Anatomical context of Car5a

  • METHODS: Compression tests were performed on individual caudal vertebrae (Ca4, Ca5, Ca6) obtained from male and female mice from two transgenic lines (TG420 and TG450) and nontransgenic control mice [13].
  • Recently, we have established a mouse model for vein graft arteriosclerosis by grafting autologous jugular veins or vena cava to carotid arteries [14].
  • At incubation of tissues with [3H]Trp-P-1 (0.75 microM) there was also a selective binding of radioactive substance in endothelial cells of the lung and liver and in the vena cava from BNF-treated mice but not from vehicle-treated control mice [15].
  • C57BL/6 mice receiving pretransplant immunization with C3H.SW spleen cells via the portal vein, but not the vena cava, show Ag-specific delayed rejection of allogeneic C3H.SW skin grafts [10].
  • The blood was collected using one of four methods: intracardiac (IC), a single attempt at collection from the caudal vena cava (VC), collection from the caudal vena cava with collection of any extravasated blood from the peritoneum (MC), or retroorbital phlebotomy (RO) [16].

Associations of Car5a with chemical compounds

  • The crystal structure of F65A/Y131C murine alpha-carbonic anhydrase V (CAV), covalently modified at cysteine residues with 4-chloromethylimidazole, is reported at 1.88 A resolution [17].
  • In this modified CAV variant, C131-MI acts as a proton shuttle, facilitating the deprotonation of a zinc-bound water molecule to regenerate the nucleophilic zinc-bound hydroxide ion [17].
  • Biomatrix was isolated from intact rat livers by reverse perfusion via the inferior vena cava with sodium deoxycholate, nucleases and lipid extracting solvents [18].
  • (+/-)-[6]-Gingerol also potentiated the PGF2 alpha-induced contraction in longitudinal segments of rat mesenteric vein and vena cava, but inhibited it in circular segments of rat aorta and longitudinal segments of mouse mesenteric arteries [19].
  • The potential antiproliferative and antiradical activities of an enzymatic extract of Ecklonia cava together with its crude polysaccharide (CpoF) and crude polyphenolic fractions (CphF) were evaluated in vitro [20].

Regulatory relationships of Car5a

  • METHODS AND RESULTS: Inferior vena cava-to-carotid artery interposition grafting between C57Bl/6 and congenic beta-galactosidase-expressing ROSA26 mice was performed [21].

Analytical, diagnostic and therapeutic context of Car5a

  • Northern blot analyses of total RNAs from mouse tissues and Western blot analyses of mouse tissue homogenates showed differences in tissue-specific expression between CA VB and CA VA [6].
  • The probes were ferritin molecules, cationized to pI's 6.8, 7.15, 7.6, 8.0 and 8.4, which were introduced by retrograde or anterograde perfusion through the aorta or vena cava after the blood was removed from the vasculature [22].
  • METHODS: Mice underwent inferior vena cava ligation to induce thrombosis [23].
  • Colchicine was administered as a bolus in the jugular vein (1.5 mg kg-1) and its hippocampal extracellular fluid (ECF) and blood kinetics were determined over a 4 h period using two microdialysis probes, one in the dorsal hippocampus, the other in the inferior vena cava [24].
  • The diameters of the aorta and the inferior vena cava were measured first with the transrectal ultrasound technique and then with direct visualization upon laparotomy for 10 mice [25].


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  2. Adenoviral urokinase-type plasminogen activator (uPA) gene transfer enhances venous thrombus resolution. Gossage, J.A., Humphries, J., Modarai, B., Burnand, K.G., Smith, A. J. Vasc. Surg. (2006) [Pubmed]
  3. Situs variation and cardiovascular anomalies in the transgenic mouse insertional mutation, inv. Morishima, M., Yasui, H., Nakazawa, M., Ando, M., Ishibashi, M., Takao, A. Teratology (1998) [Pubmed]
  4. Murine model of ferric chloride-induced vena cava thrombosis: evidence for effect of potato carboxypeptidase inhibitor. Wang, X., Smith, P.L., Hsu, M.Y., Ogletree, M.L., Schumacher, W.A. J. Thromb. Haemost. (2006) [Pubmed]
  5. Factors influencing the expression of stress fibers in vascular endothelial cells in situ. White, G.E., Gimbrone, M.A., Fujiwara, K. J. Cell Biol. (1983) [Pubmed]
  6. Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. Shah, G.N., Hewett-Emmett, D., Grubb, J.H., Migas, M.C., Fleming, R.E., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Steudel, W., Ichinose, F., Huang, P.L., Hurford, W.E., Jones, R.C., Bevan, J.A., Fishman, M.C., Zapol, W.M. Circ. Res. (1997) [Pubmed]
  8. Mitochondrial carbonic anhydrase (isozyme V) in mouse and rat: cDNA cloning, expression, subcellular localization, processing, and tissue distribution. Nagao, Y., Srinivasan, M., Platero, J.S., Svendrowski, M., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice. Ali, Z.A., Bursill, C.A., Hu, Y., Choudhury, R.P., Xu, Q., Greaves, D.R., Channon, K.M. Circulation (2005) [Pubmed]
  10. Gamma delta TCR+ hybridomas derived from mice preimmunized via the portal vein adoptively transfer increased skin allograft survival in vivo. Gorczynski, R.M., Cohen, Z., Leung, Y., Chen, Z. J. Immunol. (1996) [Pubmed]
  11. Transfer of full-length Dmd to the diaphragm muscle of Dmd(mdx/mdx) mice through systemic administration of plasmid DNA. Liu, F., Nishikawa, M., Clemens, P.R., Huang, L. Mol. Ther. (2001) [Pubmed]
  12. Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis. Oh, S.P., Li, E. Dev. Dyn. (2002) [Pubmed]
  13. Human growth hormone transgene expression increases the biomechanical structural properties of mouse vertebrae. Steinke, B., Patwardhan, A.G., Havey, R.M., King, D. Spine. (1999) [Pubmed]
  14. Loss of p53 accelerates neointimal lesions of vein bypass grafts in mice. Mayr, U., Mayr, M., Li, C., Wernig, F., Dietrich, H., Hu, Y., Xu, Q. Circ. Res. (2002) [Pubmed]
  15. Metabolic activation of the food mutagen 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) in endothelial cells of cytochrome P-450-induced mice. Brittebo, E.B., Brandt, I. Cancer Res. (1994) [Pubmed]
  16. Effect of blood collection technique in mice on clinical pathology parameters. Schnell, M.A., Hardy, C., Hawley, M., Propert, K.J., Wilson, J.M. Hum. Gene Ther. (2002) [Pubmed]
  17. Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Jude, K.M., Wright, S.K., Tu, C., Silverman, D.N., Viola, R.E., Christianson, D.W. Biochemistry (2002) [Pubmed]
  18. Cell surface expression by adult rat hepatocytes of a non-collagen glycoprotein present in rat liver biomatrix. Hixson, D.C., DeLourdes Ponce, M., Allison, J.P., Walborg, E.F. Exp. Cell Res. (1984) [Pubmed]
  19. Modulation of eicosanoid-induced contraction of mouse and rat blood vessels by gingerols. Kimura, I., Kimura, M., Pancho, L.R. Jpn. J. Pharmacol. (1989) [Pubmed]
  20. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Athukorala, Y., Kim, K.N., Jeon, Y.J. Food Chem. Toxicol. (2006) [Pubmed]
  21. Graft-extrinsic cells predominate in vein graft arterialization. Zhang, L., Freedman, N.J., Brian, L., Peppel, K. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  22. Differentiated microdomains of the luminal plasmalemma of murine muscle capillaries: segmental variations in young and old animals. Simionescu, M., Simionescu, N., Santoro, F., Palade, G.E. J. Cell Biol. (1985) [Pubmed]
  23. Decreased venous thrombosis with an oral inhibitor of P selectin. Myers, D.D., Rectenwald, J.E., Bedard, P.W., Kaila, N., Shaw, G.D., Schaub, R.G., Farris, D.M., Hawley, A.E., Wrobleski, S.K., Henke, P.K., Wakefield, T.W. J. Vasc. Surg. (2005) [Pubmed]
  24. Simultaneous microdialysis in brain and blood of the mouse: extracellular and intracellular brain colchicine disposition. Evrard, P.A., Ragusi, C., Boschi, G., Verbeeck, R.K., Scherrmann, J.M. Brain Res. (1998) [Pubmed]
  25. Transrectal ultrasound assessment of murine aorta and iliac arteries. Chiou, A.C., Chiu, B., Oppat, W.F., Matsumura, J.S., Chisholm, R.L., Pearce, W.H. J. Surg. Res. (2000) [Pubmed]
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