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Gene Review

Car5a  -  carbonic anhydrase 5a, mitochondrial

Rattus norvegicus

Synonyms: CA-VA, Ca5, Ca5a, Carbonate dehydratase VA, Carbonic anhydrase 5A, mitochondrial, ...
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Disease relevance of Ca5a


Psychiatry related information on Ca5a


High impact information on Ca5a

  • Further characterization of the vascular response revealed that HSP70 induction occurred in both the thoracic and abdominal aortas as well as in the vena cava [7].
  • Microdialysis probes placed within the vena cava and brain cortex were used to directly compare steady-state, interstitial unbound diazepam levels in both Wistar and genetically analbuminemic rats [8].
  • Indeed after an oral or intraduodenal dose of 5 mg/kg aspirin, generation of portal vein 6-keto-PGF1 alpha was inhibited to much the same extent as platelet TxB2, while inferior vena cava 6-keto-PGF1 alpha formation was spared [9].
  • In contrast, AII infusion did not alter release of 6-keto-PGF1 alpha or PGE2 from inferior vena cava segments or from renal cortex slices [10].
  • Heparinized catheters were placed into the portal vein, inferior vena cava, aorta, and left ventricle with exit from the neck [11].

Chemical compound and disease context of Ca5a


Biological context of Ca5a

  • Transient transfection experiments identify the minimal promoter region between -270 and -143 and sequence between -270 and -248 that are required for transcription of the alpha1BAR gene in aorta and vena cava SMC during normoxia and hypoxia [1].
  • Elevation of venous pressure within the vascular bed by gradual occlusion of the inferior vena cava led to a significant vasoconstriction of the smaller vessels, suggesting that a significant myogenic component was present [17].
  • Isolated SMC from these rabbit blood vessels as well as from the aorta and vena cava of the rat, when cultured on a collagen or laminin matrix, uniformly revealed an ETB-R-mediated increase in apoptosis upon exposure to mechanical deformation plus exogenous ET-1 (10 nmol/L) [18].
  • Removal of the adrenal glands or cannulation of the vena cava prevented the accumulation of epinephrine and the rise in inhibitor-1 phosphorylation [19].
  • Reporter gene transfection assays in rat aorta and vena cava SMCs showed that this 5'-flanking region, which lacks a TATA-box, possesses strong promoter activity [20].

Anatomical context of Ca5a

  • A systematic survey of endothelial junctions in elastic (aorta) and muscular (mesenteric) arteries and in medium (renal and mesenteric) and large (cava inferior) size veins has been carried out in the rat using freeze-cleaved preparations [21].
  • Consequently, we prepared acid extracts of the pulmonary artery and vena cava of female rats [22].
  • We previously demonstrated that alpha1B-adrenergic receptor (AR) gene transcription, mRNA, and functionally coupled receptors increase during 3% O2 exposure in aorta, but not in vena cava smooth muscle cells (SMC) [1].
  • The discharge characteristics of mechanoreceptors located in the left superior vena cava were determined in an in vitro preparation developed from the rat [23].
  • In cirrhotic rats, blood pressures in the portal vein and the terminal portal venule were 173 and 100 mm H2O, respectively, while those in the terminal hepatic venule and the inferior vena cava were elevated only slightly above normal [24].

Associations of Ca5a with chemical compounds

  • After 4 days of biliary drainage, rat livers were perfused in vitro in either forward (through the portal vein) or backward direction (through the vena cava) in single-pass arrangement with taurodeoxycholate (32 nmol.min-1.g liver-1) [25].
  • Using the selective OT receptor ligand compound VI, we detected a high number of OT-binding sites in the rat vena cava and aorta [22].
  • An inverted V-shape polyethylene cannula, either heparin bonded or silicon coated, was inserted into the portal vein and inferior vena cava to maintain venous return from the splanchnic and lower caval regions of the anhepatic rat [26].
  • After 30 min of vena cava occlusion and 10 min of reperfusion a more marked increase in chemiluminescence (37 +/- 5 cps/cm2), hydrogen peroxide (0.30 +/- 0.01 mumol/L), lactate dehydrogenase (730 +/- 10 U/L) and aspartate aminotransferase (140 +/- 10 U/L) was observed [27].
  • The role of the liver in the pancreatic hormonal response to endotoxin was investigated by infusing lipopolysaccharide slowly into the portal vein or systemic inferior vena cava [28].

Analytical, diagnostic and therapeutic context of Ca5a

  • In contrast, if the liver was bypassed by performing a portacaval shunt or by injecting into the inferior vena cava, radioactivity was maximal in the lung (2,454.3% +/- 302.3 10 min after IVC injection) with activity in the liver of only 89.3% +/- 10 [29].
  • Reverse-phase HPLC of aorta and vena cava extracts revealed a single peak corresponding to the amidated OT nonapeptide [22].
  • In group 1, completion of portal vein (PV), suprahepatic vena cava (SVC), and descending vena cava anastomoses resulted in decreased NADH levels toward those after preparation of the vessels before ligation [30].
  • Rapid (1 min) antegrade (by way of portal vein) or retrograde (through hepatic veins by way of vena cava) perfusions were performed in a nonrecirculating (once-through) mode in Ca+(+)-free medium [31].
  • Blood samples for the measurement of tumor necrosis factor and endotoxin were collected by way of an indwelling catheter placed in the suprahepatic vena cava [32].


  1. Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Eckhart, A.D., Yang, N., Xin, X., Faber, J.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Importance of platelets in experimental venous thrombosis in the rat. Herbert, J.M., Bernat, A., Maffrand, J.P. Blood (1992) [Pubmed]
  3. Na,K-ATPase in isolated nephron segments in rats with experimental heart failure. Wald, H., Scherzer, P., Popovtzer, M.M. Circ. Res. (1991) [Pubmed]
  4. Abnormal ion and water composition of veins and normotensive arteries in coarctation hypertension in rats. Pamnani, M.B., Overbeck, H.W. Circ. Res. (1976) [Pubmed]
  5. Endothelin-1 is involved in the pathogenesis of ischemia/reperfusion liver injury by hepatic microcirculatory disturbances. Goto, M., Takei, Y., Kawano, S., Nagano, K., Tsuji, S., Masuda, E., Nishimura, Y., Okumura, S., Kashiwagi, T., Fusamoto, H. Hepatology (1994) [Pubmed]
  6. Reduced feeding during water deprivation depends on hydration of the gut. Schoorlemmer, G.H., Evered, M.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  7. Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response. Udelsman, R., Blake, M.J., Stagg, C.A., Li, D.G., Putney, D.J., Holbrook, N.J. J. Clin. Invest. (1993) [Pubmed]
  8. Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation. Dubey, R.K., McAllister, C.B., Inoue, M., Wilkinson, G.R. J. Clin. Invest. (1989) [Pubmed]
  9. Biochemical selectivity of oral versus intravenous aspirin in rats. Inhibition by oral aspirin of cyclooxygenase activity in platelets and presystemic but not systemic vessels. Cerletti, C., Gambino, M.C., Garattini, S., de Gaetano, G. J. Clin. Invest. (1986) [Pubmed]
  10. Angiotensin II-induced hypertension in the rat. Effects on the plasma concentration, renal excretion, and tissue release of prostaglandins. Diz, D.I., Baer, P.G., Nasjletti, A. J. Clin. Invest. (1983) [Pubmed]
  11. Ritanserin decreases portal pressure in conscious and unrestrained cirrhotic rats. Mastai, R., Giroux, L., Semret, M., Huet, P.M. Gastroenterology (1990) [Pubmed]
  12. Host and tumor responses to varying rates of nitrogen infusion in the tumor-bearing rat. Popp, M.B., Wagner, S.C., Enrione, E.B., Brito, O.J. Ann. Surg. (1988) [Pubmed]
  13. Hepatic osteodystrophy in rats results mainly from portasystemic shunting. van der Merwe, S.W., van den Bogaerde, J.B., Goosen, C., Maree, F.F., Milner, R.J., Schnitzler, C.M., Biscardi, A., Mesquita, J.M., Engelbrecht, G., Kahn, D., Fevery, J. Gut (2003) [Pubmed]
  14. Prostacyclin (PGI2) synthesis in the vascular wall of rats with bilateral renal artery stenosis. Morera, S., Santoro, F.M., Rosón, M.I., de la Riva, I.J. Hypertension (1983) [Pubmed]
  15. Comparison of parenteral nutrition and enteral feeding with pectin in experimental colitis in the rat. Rolandelli, R.H., Saul, S.H., Settle, R.G., Jacobs, D.O., Trerotola, S.O., Rombeau, J.L. Am. J. Clin. Nutr. (1988) [Pubmed]
  16. Inversion of D-tryptophan to L-tryptophan and excretory patterns in the rat and chick. Ohara, I., Otsuka, S.I., Yugari, Y., Ariyoshi, S. J. Nutr. (1980) [Pubmed]
  17. Autoregulation of blood flow within individual arterioles in the rat cremaster muscle. Morff, R.J., Granger, H.J. Circ. Res. (1982) [Pubmed]
  18. Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent. Cattaruzza, M., Berger, M.M., Ochs, M., Fayyazi, A., Füzesi, L., Richter, J., Hecker, M. Cell Death Differ. (2002) [Pubmed]
  19. Antagonistic effects of insulin and beta-adrenergic agonists on the activity of protein phosphatase inhibitor-1 in skeletal muscle of the perfused rat hemicorpus. Foulkes, J.G., Cohen, P., Strada, S.J., Everson, W.V., Jefferson, L.S. J. Biol. Chem. (1982) [Pubmed]
  20. Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic receptor gene expression in vascular smooth muscle cells by inducing AP-2-like protein binding to alpha1D proximal promoter region. Xin, X., Yang, N., Faber, J.E. Mol. Pharmacol. (1999) [Pubmed]
  21. Segmental differentiations of cell junctions in the vascular endothelium. Arteries and veins. Simionescu, M., Simionescu, N., Palade, G.E. J. Cell Biol. (1976) [Pubmed]
  22. Oxytocin and its receptors are synthesized in the rat vasculature. Jankowski, M., Wang, D., Hajjar, F., Mukaddam-Daher, S., McCann, S.M., Gutkowska, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  23. Rapid resetting of low pressure vagal receptors in the superior vena cava of the rat. Mifflin, S.W., Kunze, D.L. Circ. Res. (1982) [Pubmed]
  24. Localization of increased hepatic vascular resistance in liver cirrhosis. Shibayama, Y., Nakata, K. Hepatology (1985) [Pubmed]
  25. Loss of zonal heterogeneity and cell polarity in rat liver with respect to bile acid secretion after bile drainage. Baumgartner, U., Schölmerich, J., Karsch, J., Gerok, W., Farthmann, E.H. Gastroenterology (1991) [Pubmed]
  26. A simplified single stage total hepatectomy in the rat with maintenance of gastrointestinal absorptive function. Yamaguchi, Y., Bollinger, R.R., DeFaria, E., Landis, B., Quarfordt, S. Hepatology (1989) [Pubmed]
  27. Oxidative stress produced by suprahepatic occlusion and reperfusion. Gonzalez-Flecha, B., Reides, C., Cutrin, J.C., Llesuy, S.F., Boveris, A. Hepatology (1993) [Pubmed]
  28. Role of the liver in endotoxin-induced hyperinsulinemia and hyperglucagonemia in rats. Cornell, R.P. Hepatology (1983) [Pubmed]
  29. Hepatic and pulmonary clearance of exogenous vasoactive intestinal peptide in the rat. Humphrey, C.S., Murray, P., Ebeid, A.M., Fischer, J.E. Gastroenterology (1979) [Pubmed]
  30. Monitoring of surface mitochondrial NADH levels as an indication of ischemia during liver isograft transplantation. Thorniley, M.S., Simpkin, S., Fuller, B., Jenabzadeh, M.Z., Green, C.J. Hepatology (1995) [Pubmed]
  31. Antibodies against the hepatic asialoglycoprotein receptor perfused in situ preferentially attach to periportal liver cells in the rat. McFarlane, B.M., Sipos, J., Gove, C.D., McFarlane, I.G., Williams, R. Hepatology (1990) [Pubmed]
  32. Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injuries after orthotopic liver transplantation in the rat. Goto, M., Takei, Y., Kawano, S., Tsuji, S., Fukui, H., Fushimi, H., Nishimura, Y., Kashiwagi, T., Fusamoto, H., Kamada, T. Hepatology (1992) [Pubmed]
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