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Gene Review

Rps15  -  ribosomal protein S15

Mus musculus

Synonyms: 40S ribosomal protein S15, RIG protein, Rig, insulinoma, rat insulinoma gene, ...
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Disease relevance of Rps15


High impact information on Rps15

  • Membrane preparations from COS 7 cells transfected with the full-length 1,267-bp cDNA elicited a proliferative response from the reporter T cells comparable to that of the defined peptide epitope and native insulinoma antigen [6].
  • Analysis of the antigens recognized by individual T cell clones from the Th1 line included reactivity against an insulinoma membrane fraction enriched in proteins of approximately 38 kD [7].
  • CD4+ T cell lines were generated from the spleens of diabetic NOD mice against crude membrane preparations derived from a rat insulinoma [7].
  • To test the biological consequences of the 8-bp repeat sequence in the insulin promoter, a normal and variant promoter were subcloned into a luciferase plasmid, and reporter gene activity assessed by transient transfection into mouse insulinoma (beta TC1) and hamster insulinoma (HIT) cells [8].
  • Mice were examined for the presence of splenocytes specifically cytotoxic for a rat insulinoma cell line (RIN) during the induction of diabetes by streptozotocin (SZ) in multiple low doses (Multi-Strep) [9].

Chemical compound and disease context of Rps15


Biological context of Rps15


Anatomical context of Rps15

  • The observed pattern of cleavage site selectivities mimicked that of the endogenous endoproteases of the insulinoma and bovine adrenomedullary chromaffin cells, suggesting that PC2 and PC3 may represent important core endoproteases in the catalysis of prohormone processing in many neuroendocrine cell types [17].
  • We now show that the bone marrow can contribute to myofibroblast and fibroblast populations in tumor stroma in a mouse model of pancreatic insulinoma [18].
  • Because the induction of IL-6 appears to be an important host cell response to injury, we have examined whether IL-6 is produced by murine pancreatic islets or rat insulinoma (RIN-m5F) cells after their exposure to IFN-gamma and TNF-alpha [19].
  • In an attempt to identify novel pancreatic beta-cell surface antigens, mouse monoclonal antibodies (MoAbs) were raised against rat insulinoma (RIN5F) cells with standard techniques [20].
  • Although GLP-I activates adenylate cyclase, the arylpiperazine has no effect on this enzyme or on the binding of 125I-labeled GLP-I to its receptor on RINm5F rat insulinoma cell membranes [21].

Associations of Rps15 with chemical compounds


Regulatory relationships of Rps15


Other interactions of Rps15


Analytical, diagnostic and therapeutic context of Rps15


  1. Glucose transporter isotypes switch in T-antigen-transformed pancreatic beta cells growing in culture and in mice. Tal, M., Thorens, B., Surana, M., Fleischer, N., Lodish, H.F., Hanahan, D., Efrat, S. Mol. Cell. Biol. (1992) [Pubmed]
  2. A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Neophytou, P.I., Muir, E.M., Hutton, J.C. Diabetes (1996) [Pubmed]
  3. Endocrine pancreatic tumors in MSV-SV40 large T transgenic mice. Götz, W., Schucht, C., Roth, J., Theuring, F., Herken, R. Am. J. Pathol. (1993) [Pubmed]
  4. In vitro relationship of CD4 cells from type I diabetic patients and xenogeneic beta-cell membranes. Segain, J.P., Valentin, A., Bardet, S., Feve, B., Sevestre, H., Houssaint, E., Charbonnel, B., Sai, P. Diabetes (1989) [Pubmed]
  5. A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. Goto, Y., De Silva, M.G., Toscani, A., Prabhakar, B.S., Notkins, A.L., Lan, M.S. J. Biol. Chem. (1992) [Pubmed]
  6. Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. Arden, S.D., Roep, B.O., Neophytou, P.I., Usac, E.F., Duinkerken, G., de Vries, R.R., Hutton, J.C. J. Clin. Invest. (1996) [Pubmed]
  7. In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. Healey, D., Ozegbe, P., Arden, S., Chandler, P., Hutton, J., Cooke, A. J. Clin. Invest. (1995) [Pubmed]
  8. A variant insulin promoter in non-insulin-dependent diabetes mellitus. Olansky, L., Welling, C., Giddings, S., Adler, S., Bourey, R., Dowse, G., Serjeantson, S., Zimmet, P., Permutt, M.A. J. Clin. Invest. (1992) [Pubmed]
  9. Multiple low-dose streptozotocin-induced diabetes in the mouse. Evidence for stimulation of a cytotoxic cellular immune response against an insulin-producing beta cell line. McEvoy, R.C., Andersson, J., Sandler, S., Hellerström, C. J. Clin. Invest. (1984) [Pubmed]
  10. Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumors. Galbiati, F., Polastri, L., Gregori, S., Freschi, M., Casorati, M., Cavallaro, U., Fiorina, P., Bertuzzi, F., Zerbi, A., Pozza, G., Adorini, L., Folli, F., Christofori, G., Davalli, A.M. Endocrinology (2002) [Pubmed]
  11. Secretion of CTLA4Ig by an SV40 T antigen-transformed islet cell line inhibits graft rejection against the neoantigen. Lew, A.M., Brady, J.L., Silva, A., Coligan, J.E., Georgiou, H.M. Transplantation (1996) [Pubmed]
  12. Nucleotide sequence determination of mouse, chicken and Xenopus laevis rig cDNAs: the rig-encoded protein is extremely conserved during vertebrate evolution. Sugawara, A., Nata, K., Inoue, C., Takasawa, S., Yamamoto, H., Okamoto, H. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  13. Timely immunization subverts the development of peripheral nonresponsiveness and suppresses tumor development in simian virus 40 tumor antigen-transgenic mice. Ye, X., McCarrick, J., Jewett, L., Knowles, B.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Bertolino, P., Tong, W.M., Herrera, P.L., Casse, H., Zhang, C.X., Wang, Z.Q. Cancer Res. (2003) [Pubmed]
  15. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Schuppin, G.T., Pons, S., Hügl, S., Aiello, L.P., King, G.L., White, M., Rhodes, C.J. Diabetes (1998) [Pubmed]
  16. TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Qian, F., Huang, P., Ma, L., Kuznetsov, A., Tamarina, N., Philipson, L.H. Diabetes (2002) [Pubmed]
  17. Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. Thomas, L., Leduc, R., Thorne, B.A., Smeekens, S.P., Steiner, D.F., Thomas, G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  18. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Direkze, N.C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M.R., Wright, N.A. Cancer Res. (2004) [Pubmed]
  19. Evidence for IL-6 production by and effects on the pancreatic beta-cell. Campbell, I.L., Cutri, A., Wilson, A., Harrison, L.C. J. Immunol. (1989) [Pubmed]
  20. Strong association between diabetes and displacement of mouse anti-rat insulinoma cell monoclonal antibody by human serum in vitro. Thomas, N.M., Ginsberg-Fellner, F., McEvoy, R.C. Diabetes (1990) [Pubmed]
  21. A novel insulin secretagogue is a phosphodiesterase inhibitor. Leibowitz, M.D., Biswas, C., Brady, E.J., Conti, M., Cullinan, C.A., Hayes, N.S., Manganiello, V.C., Saperstein, R., Wang, L.H., Zafian, P.T. Diabetes (1995) [Pubmed]
  22. SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R.X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T.F., Yanagisawa, M., Yamamoto, T.T., Kodama, T., Sakai, J. J. Biol. Chem. (2005) [Pubmed]
  23. Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. Hosaka, M., Suda, M., Sakai, Y., Izumi, T., Watanabe, T., Takeuchi, T. J. Biol. Chem. (2004) [Pubmed]
  24. Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha. Chang, I., Cho, N., Kim, S., Kim, J.Y., Kim, E., Woo, J.E., Nam, J.H., Kim, S.J., Lee, M.S. J. Immunol. (2004) [Pubmed]
  25. Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells. Galbiati, F., Polastri, L., Thorens, B., Dupraz, P., Fiorina, P., Cavallaro, U., Christofori, G., Davalli, A.M. Endocrinology (2003) [Pubmed]
  26. Production and characterization of monoclonal antibodies to insulin secretory granule membranes. Grimaldi, K.A., Hutton, J.C., Siddle, K. Biochem. J. (1987) [Pubmed]
  27. IFN gamma/TNF alpha synergism in MHC class II induction: effect of nicotinamide on MHC class II expression but not on islet-cell apoptosis. Kim, K.A., Kim, S., Chang, I., Kim, G.S., Min, Y.K., Lee, M.K., Kim, K.W., Lee, M.S. Diabetologia (2002) [Pubmed]
  28. The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value. Iino, S., Abeyama, K., Kawahara, K., Yamakuchi, M., Hashiguchi, T., Matsukita, S., Yonezawa, S., Taniguchi, S., Nakata, M., Takao, S., Aikou, T., Maruyama, I. Clin. Cancer Res. (2004) [Pubmed]
  29. Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin. Yoshitomi, H., Fujii, Y., Miyazaki, M., Nakajima, N., Inagaki, N., Seino, S. Am. J. Physiol. (1997) [Pubmed]
  30. Antitumorigenic effect of proteasome inhibitors on insulinoma cells. Størling, J., Allaman-Pillet, N., Karlsen, A.E., Billestrup, N., Bonny, C., Mandrup-Poulsen, T. Endocrinology (2005) [Pubmed]
  31. Fas ligand down-regulates cytokine-induced Fas receptor expression on insulinoma (NIT-1), but not islet cells, from autoimmune nonobese diabetic mice. Augstein, P., Heinke, P., Salzsieder, E., Berg, S., Rettig, R., Salzsieder, C., Harrison, L.C. Endocrinology (2004) [Pubmed]
  32. Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells. Fehmann, H.C., Strowski, M., Göke, B. Metab. Clin. Exp. (1994) [Pubmed]
  33. Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion. Ohsugi, M., Cras-Méneur, C., Zhou, Y., Bernal-Mizrachi, E., Johnson, J.D., Luciani, D.S., Polonsky, K.S., Permutt, M.A. J. Biol. Chem. (2005) [Pubmed]
  34. Metallothionein induction in islets of Langerhans and insulinoma cells. Laychock, S.G., Duzen, J., Simpkins, C.O. Mol. Cell. Endocrinol. (2000) [Pubmed]
  35. The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Passini, N., Larigan, J.D., Genovese, S., Appella, E., Sinigaglia, F., Rogge, L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  36. Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein. Tillotson, L.G., Wang, T.C., Brand, S.J. J. Biol. Chem. (1994) [Pubmed]
  37. Insulinoma-induced hypoglycemic death in mice is prevented with beta cell-specific gene therapy. Tirone, T.A., Fagan, S.P., Templeton, N.S., Wang, X., Brunicardi, F.C. Ann. Surg. (2001) [Pubmed]
  38. Transplantation of insulinoma into the diabetic Syrian hamster. Reintgen, D., Feldman, J., Vervaert, C., Seigler, H.F. Ann. Surg. (1980) [Pubmed]
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