Gene Review:
Mchr1 - melanin-concentrating hormone receptor 1
Mus musculus
Synonyms:
AW049955, G-protein coupled receptor 24, Gpr24, Gpr24-9, MCH receptor 1, ...
Souers,
Gao,
Wodka,
Judd,
Mulhern,
Napier,
Brune,
Bush,
Brodjian,
Dayton,
Shapiro,
Hernandez,
Marsh,
Sham,
Collins,
Kym,
Roy,
David,
Danao,
Baribault,
Tian,
Giorgetti,
Marsh,
Weingarth,
Novi,
Chen,
Trumbauer,
Chen,
Guan,
Jiang,
Feng,
Camacho,
Shen,
Frazier,
Yu,
Metzger,
Kuca,
Shearman,
Gopal-Truter,
MacNeil,
Strack,
MacIntyre,
Van der Ploeg,
Qian,
Bjursell,
Gerdin,
Ploj,
Svensson,
Svensson,
Oscarsson,
Snaith,
Törnell,
Bohlooly-Y,
Souers,
Gao,
Brune,
Bush,
Wodka,
Vasudevan,
Judd,
Mulhern,
Brodjian,
Dayton,
Shapiro,
Hernandez,
Marsh,
Sham,
Collins,
Kym,
Bjursell,
Egecioglu,
Gerdin,
Svensson,
Oscarsson,
Morgan,
Snaith,
Törnell,
Bohlooly-Y,
McBriar,
Guzik,
Xu,
Paruchova,
Li,
Palani,
Clader,
Greenlee,
Hawes,
Kowalski,
O'Neill,
Spar,
Weig,
Vasudevan,
Wodka,
Verzal,
Souers,
Gao,
Brodjian,
Fry,
Dayton,
Marsh,
Hernandez,
Ogiela,
Collins,
Kym,
Shearman,
Camacho,
Sloan Stribling,
Zhou,
Bednarek,
Hreniuk,
Feighner,
Tan,
Howard,
Van der Ploeg,
MacIntyre,
Hickey,
Strack,
- Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Marsh, D.J., Weingarth, D.T., Novi, D.E., Chen, H.Y., Trumbauer, M.E., Chen, A.S., Guan, X.M., Jiang, M.M., Feng, Y., Camacho, R.E., Shen, Z., Frazier, E.G., Yu, H., Metzger, J.M., Kuca, S.J., Shearman, L.P., Gopal-Truter, S., MacNeil, D.J., Strack, A.M., MacIntyre, D.E., Van der Ploeg, L.H., Qian, S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. Roy, M., David, N.K., Danao, J.V., Baribault, H., Tian, H., Giorgetti, M. Neuropsychopharmacology (2006)
- Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Astrand, A., Bohlooly-Y, M., Larsdotter, S., Mahlapuu, M., Andersén, H., Tornell, J., Ohlsson, C., Snaith, M., Morgan, D.G. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. Georgescu, D., Sears, R.M., Hommel, J.D., Barrot, M., Bolaños, C.A., Marsh, D.J., Bednarek, M.A., Bibb, J.A., Maratos-Flier, E., Nestler, E.J., DiLeone, R.J. J. Neurosci. (2005)
- A study of the involvement of melanin-concentrating hormone receptor 1 (MCHR1) in murine models of depression. Roy, M., David, N., Cueva, M., Giorgetti, M. Biol. Psychiatry (2007)
- The melanocortins and melanin-concentrating hormone in the central regulation of feeding behavior and energy homeostasis. Nahon, J.L. C. R. Biol. (2006)
- Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Segal-Lieberman, G., Bradley, R.L., Kokkotou, E., Carlson, M., Trombly, D.J., Wang, X., Bates, S., Myers, M.G., Flier, J.S., Maratos-Flier, E. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight. Bjursell, M., Gerdin, A.K., Ploj, K., Svensson, D., Svensson, L., Oscarsson, J., Snaith, M., Törnell, J., Bohlooly-Y, M. Diabetes (2006)
- Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3. Maekawa, F., Quah, H.M., Tanaka, K., Ohki-Hamazaki, H. Diabetes (2004)
- Loss of heterozygosity on murine chromosome 6 in two-stage carcinogenesis: evidence for a conserved tumor suppressor gene. Zenklusen, J.C., Hodges, L.C., Conti, C.J. Oncogene (1997)
- Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity. Souers, A.J., Gao, J., Brune, M., Bush, E., Wodka, D., Vasudevan, A., Judd, A.S., Mulhern, M., Brodjian, S., Dayton, B., Shapiro, R., Hernandez, L.E., Marsh, K.C., Sham, H.L., Collins, C.A., Kym, P.R. J. Med. Chem. (2005)
- Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Souers, A.J., Gao, J., Wodka, D., Judd, A.S., Mulhern, M.M., Napier, J.J., Brune, M.E., Bush, E.N., Brodjian, S.J., Dayton, B.D., Shapiro, R., Hernandez, L.E., Marsh, K.C., Sham, H.L., Collins, C.A., Kym, P.R. Bioorg. Med. Chem. Lett. (2005)
- Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes. Bradley, R.L., Mansfield, J.P., Maratos-Flier, E., Cheatham, B. Am. J. Physiol. Endocrinol. Metab. (2002)
- Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. McBriar, M.D., Guzik, H., Xu, R., Paruchova, J., Li, S., Palani, A., Clader, J.W., Greenlee, W.J., Hawes, B.E., Kowalski, T.J., O'Neill, K., Spar, B., Weig, B. J. Med. Chem. (2005)
- Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Chen, Y., Hu, C., Hsu, C.K., Zhang, Q., Bi, C., Asnicar, M., Hsiung, H.M., Fox, N., Slieker, L.J., Yang, D.D., Heiman, M.L., Shi, Y. Endocrinology (2002)
- Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. Shearman, L.P., Camacho, R.E., Sloan Stribling, D., Zhou, D., Bednarek, M.A., Hreniuk, D.L., Feighner, S.D., Tan, C.P., Howard, A.D., Van der Ploeg, L.H., MacIntyre, D.E., Hickey, G.J., Strack, A.M. Eur. J. Pharmacol. (2003)
- Mice lacking the melanin-concentrating hormone receptor-1 exhibit an atypical psychomotor susceptibility to cocaine and no conditioned cocaine response. Tyhon, A., Adamantidis, A., Foidart, A., Grisar, T., Lakaye, B., Tirelli, E. Behav. Brain Res. (2006)
- Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. Vasudevan, A., Wodka, D., Verzal, M.K., Souers, A.J., Gao, J., Brodjian, S., Fry, D., Dayton, B., Marsh, K.C., Hernandez, L.E., Ogiela, C.A., Collins, C.A., Kym, P.R. Bioorg. Med. Chem. Lett. (2004)
- Importance of melanin-concentrating hormone receptor for the acute effects of ghrelin. Bjursell, M., Egecioglu, E., Gerdin, A.K., Svensson, L., Oscarsson, J., Morgan, D., Snaith, M., Törnell, J., Bohlooly-Y, M. Biochem. Biophys. Res. Commun. (2005)
- Disrupting the melanin-concentrating hormone receptor 1 in mice leads to cognitive deficits and alterations of NMDA receptor function. Adamantidis, A., Thomas, E., Foidart, A., Tyhon, A., Coumans, B., Minet, A., Tirelli, E., Seutin, V., Grisar, T., Lakaye, B. Eur. J. Neurosci. (2005)
- Relationship between the expression of differentiation-specific keratins 1 and 10 and cell proliferation in epidermal tumors. Kartasova, T., Roop, D.R., Yuspa, S.H. Mol. Carcinog. (1992)
- Development of a vacuum filtration system for the conventional microplate washer. Lee, S. Journal of pharmacological and toxicological methods. (2006)
- Melanin concentrating hormone is a novel regulator of islet function and growth. Pissios, P., Ozcan, U., Kokkotou, E., Okada, T., Liew, C.W., Liu, S., Peters, J.N., Dahlgren, G., Karamchandani, J., Kudva, Y.C., Kurpad, A.J., Kennedy, R.T., Maratos-Flier, E., Kulkarni, R.N. Diabetes (2007)