Gene Review:
Pmch - pro-melanin-concentrating hormone
Mus musculus
Synonyms:
A230109K23Rik, MCH, Mch, Pro-MCH, melanin-concentrating hormone
Basso,
Bratcher,
Gallagher,
Cowart,
Zhao,
Sun,
Esbenshade,
Brune,
Fox,
Schmidt,
Collins,
Souers,
Iyengar,
Vasudevan,
Kym,
Hancock,
Rueter,
Bjursell,
Gerdin,
Ploj,
Svensson,
Svensson,
Oscarsson,
Snaith,
Törnell,
Bohlooly-Y,
Bradley,
Mansfield,
Maratos-Flier,
Souers,
Gao,
Brune,
Bush,
Wodka,
Vasudevan,
Judd,
Mulhern,
Brodjian,
Dayton,
Shapiro,
Hernandez,
Marsh,
Sham,
Collins,
Kym,
McBriar,
Guzik,
Xu,
Paruchova,
Li,
Palani,
Clader,
Greenlee,
Hawes,
Kowalski,
O'Neill,
Spar,
Weig,
Broberger,
De Lecea,
Sutcliffe,
Hökfelt,
Tritos,
Mastaitis,
Kokkotou,
Maratos-Flier,
Marsh,
Weingarth,
Novi,
Chen,
Trumbauer,
Chen,
Guan,
Jiang,
Feng,
Camacho,
Shen,
Frazier,
Yu,
Metzger,
Kuca,
Shearman,
Gopal-Truter,
MacNeil,
Strack,
MacIntyre,
Van der Ploeg,
Qian,
Rokosz,
Hobbs,
- Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Marsh, D.J., Weingarth, D.T., Novi, D.E., Chen, H.Y., Trumbauer, M.E., Chen, A.S., Guan, X.M., Jiang, M.M., Feng, Y., Camacho, R.E., Shen, Z., Frazier, E.G., Yu, H., Metzger, J.M., Kuca, S.J., Shearman, L.P., Gopal-Truter, S., MacNeil, D.J., Strack, A.M., MacIntyre, D.E., Van der Ploeg, L.H., Qian, S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Segal-Lieberman, G., Bradley, R.L., Kokkotou, E., Carlson, M., Trombly, D.J., Wang, X., Bates, S., Myers, M.G., Flier, J.S., Maratos-Flier, E. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. Elias, C.F., Saper, C.B., Maratos-Flier, E., Tritos, N.A., Lee, C., Kelly, J., Tatro, J.B., Hoffman, G.E., Ollmann, M.M., Barsh, G.S., Sakurai, T., Yanagisawa, M., Elmquist, J.K. J. Comp. Neurol. (1998)
- Estradiol-induced anorexia is independent of leptin and melanin-concentrating hormone. Tritos, N.A., Segal-Lieberman, G., Vezeridis, P.S., Maratos-Flier, E. Obes. Res. (2004)
- Biological examination of melanin concentrating hormone receptor 1: multi-tasking from the hypothalamus. Rokosz, L.L., Hobbs, D.W. Drug News Perspect. (2006)
- The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. Georgescu, D., Sears, R.M., Hommel, J.D., Barrot, M., Bolaños, C.A., Marsh, D.J., Bednarek, M.A., Bibb, J.A., Maratos-Flier, E., Nestler, E.J., DiLeone, R.J. J. Neurosci. (2005)
- Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice. Zhou, D., Shen, Z., Strack, A.M., Marsh, D.J., Shearman, L.P. Regul. Pept. (2005)
- Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety. Basso, A.M., Bratcher, N.A., Gallagher, K.B., Cowart, M.D., Zhao, C., Sun, M., Esbenshade, T.A., Brune, M.E., Fox, G.B., Schmidt, M., Collins, C.A., Souers, A.J., Iyengar, R., Vasudevan, A., Kym, P.R., Hancock, A.A., Rueter, L.E. Eur. J. Pharmacol. (2006)
- Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Yamada, M., Miyakawa, T., Duttaroy, A., Yamanaka, A., Moriguchi, T., Makita, R., Ogawa, M., Chou, C.J., Xia, B., Crawley, J.N., Felder, C.C., Deng, C.X., Wess, J. Nature (2001)
- Mice lacking melanin-concentrating hormone are hypophagic and lean. Shimada, M., Tritos, N.A., Lowell, B.B., Flier, J.S., Maratos-Flier, E. Nature (1998)
- A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Qu, D., Ludwig, D.S., Gammeltoft, S., Piper, M., Pelleymounter, M.A., Cullen, M.J., Mathes, W.F., Przypek, R., Kanarek, R., Maratos-Flier, E. Nature (1996)
- Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity. Souers, A.J., Gao, J., Brune, M., Bush, E., Wodka, D., Vasudevan, A., Judd, A.S., Mulhern, M., Brodjian, S., Dayton, B., Shapiro, R., Hernandez, L.E., Marsh, K.C., Sham, H.L., Collins, C.A., Kym, P.R. J. Med. Chem. (2005)
- The role of recombinant human erythropoietin in the treatment of thalassemia. Rachmilewitz, E.A., Aker, M. Ann. N. Y. Acad. Sci. (1998)
- Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight. Bjursell, M., Gerdin, A.K., Ploj, K., Svensson, D., Svensson, L., Oscarsson, J., Snaith, M., Törnell, J., Bohlooly-Y, M. Diabetes (2006)
- Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3. Maekawa, F., Quah, H.M., Tanaka, K., Ohki-Hamazaki, H. Diabetes (2004)
- Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. Mashiko, S., Ishihara, A., Gomori, A., Moriya, R., Ito, M., Iwaasa, H., Matsuda, M., Feng, Y., Shen, Z., Marsh, D.J., Bednarek, M.A., MacNeil, D.J., Kanatani, A. Endocrinology (2005)
- Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Tritos, N.A., Elmquist, J.K., Mastaitis, J.W., Flier, J.S., Maratos-Flier, E. Endocrinology (1998)
- Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes. Bradley, R.L., Mansfield, J.P., Maratos-Flier, E., Cheatham, B. Am. J. Physiol. Endocrinol. Metab. (2002)
- Different structural requirements for melanin-concentrating hormone (MCH) interacting with rat MCH-R1 (SLC-1) and mouse B16 cell MCH-R. Schlumberger, S.E., Saito, Y., Giller, T., Hintermann, E., Tanner, H., Jäggin, V., Zumsteg, U., Civelli, O., Eberle, A.N. J. Recept. Signal Transduct. Res. (2003)
- Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. McBriar, M.D., Guzik, H., Xu, R., Paruchova, J., Li, S., Palani, A., Clader, J.W., Greenlee, W.J., Hawes, B.E., Kowalski, T.J., O'Neill, K., Spar, B., Weig, B. J. Med. Chem. (2005)
- MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance. Jeon, J.Y., Bradley, R.L., Kokkotou, E.G., Marino, F.E., Wang, X., Pissios, P., Maratos-Flier, E. Diabetes (2006)
- Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice. Smith, D.G., Davis, R.J., Rorick-Kehn, L., Morin, M., Witkin, J.M., McKinzie, D.L., Nomikos, G.G., Gehlert, D.R. Neuropsychopharmacology (2006)
- Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Li, J.Y., Finniss, S., Yang, Y.K., Zeng, Q., Qu, S.Y., Barsh, G., Dickinson, C., Gantz, I. Endocrinology (2000)
- Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Tritos, N.A., Mastaitis, J.W., Kokkotou, E., Maratos-Flier, E. Brain Res. (2001)
- Characterization of MCH-mediated obesity in mice. Ito, M., Gomori, A., Ishihara, A., Oda, Z., Mashiko, S., Matsushita, H., Yumoto, M., Ito, M., Sano, H., Tokita, S., Moriya, M., Iwaasa, H., Kanatani, A. Am. J. Physiol. Endocrinol. Metab. (2003)
- Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes. Bradley, R.L., Mansfield, J.P., Maratos-Flier, E. Obes. Res. (2005)
- Melanin concentrating hormone is a novel regulator of islet function and growth. Pissios, P., Ozcan, U., Kokkotou, E., Okada, T., Liew, C.W., Liu, S., Peters, J.N., Dahlgren, G., Karamchandani, J., Kudva, Y.C., Kurpad, A.J., Kennedy, R.T., Maratos-Flier, E., Kulkarni, R.N. Diabetes (2007)
- Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. Broberger, C., De Lecea, L., Sutcliffe, J.G., Hökfelt, T. J. Comp. Neurol. (1998)
- Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice. Huang, Q., Viale, A., Picard, F., Nahon, J., Richard, D. Neuroendocrinology (1999)