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Gene Review

FABP4  -  fatty acid binding protein 4, adipocyte

Homo sapiens

Synonyms: A-FABP, AFABP, ALBP, Adipocyte lipid-binding protein, Adipocyte-type fatty acid-binding protein, ...
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Disease relevance of FABP4


Psychiatry related information on FABP4


High impact information on FABP4


Biological context of FABP4


Anatomical context of FABP4

  • We show that FABP4 protein is expressed within the skeletal muscle fibers and that FABP4 mRNA and protein are more abundant in the endurance trained subjects [12].
  • In this analysis, the accumulation of FABP4 during NIH 3T3-L1 differentiation into adipocytes was detected by generated antibodies, which correlates well with previously published data [10].
  • We have isolated two hybridoma clones that produced antibodies specific for recombinant and native FABP4, as shown by Western blotting and immunoprecipitation [10].
  • Finally, our data indicated that oxLDL regulates expression of ALBP related to two peroxisome proliferator-responsive elements (PPREs) which are located in ALBP promoter region [11].
  • RESULTS: Mean (SE) adiponectin concentrations in breast milk were 13.7 (0.8), range 3.9-30.4 microg/L; AFABP concentrations 26.7 (4.4), range 1.2-137.0 microg/L; EFABP concentrations 18.1 (1.4), range 0.8-47.0 microg/L; and leptin concentrations 0.50 (0.05), range 0-1.37 microg/L [13].

Associations of FABP4 with chemical compounds


Physical interactions of FABP4


Regulatory relationships of FABP4


Other interactions of FABP4


Analytical, diagnostic and therapeutic context of FABP4


  1. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Fu, Y., Luo, N., Lopes-Virella, M.F., Garvey, W.T. Atherosclerosis (2002) [Pubmed]
  2. Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas. Ohlsson, G., Moreira, J.M., Gromov, P., Sauter, G., Celis, J.E. Mol. Cell Proteomics (2005) [Pubmed]
  3. Expression of sarcoidosis related genes in lung lavage cells. Thonhofer, R., Maercker, C., Popper, H.H. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (2002) [Pubmed]
  4. Identification of differentially expressed proteins between human hepatoma and normal liver cell lines by two-dimensional electrophoresis and liquid chromatography-ion trap mass spectrometry. Yu, L.R., Zeng, R., Shao, X.X., Wang, N., Xu, Y.H., Xia, Q.C. Electrophoresis (2000) [Pubmed]
  5. Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration. Lescuyer, P., Allard, L., Zimmermann-Ivol, C.G., Burgess, J.A., Hughes-Frutiger, S., Burkhard, P.R., Sanchez, J.C., Hochstrasser, D.F. Proteomics (2004) [Pubmed]
  6. Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis. Smith, A.J., Sanders, M.A., Thompson, B.R., Londos, C., Kraemer, F.B., Bernlohr, D.A. J. Biol. Chem. (2004) [Pubmed]
  7. Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase. Shen, W.J., Liang, Y., Hong, R., Patel, S., Natu, V., Sridhar, K., Jenkins, A., Bernlohr, D.A., Kraemer, F.B. J. Biol. Chem. (2001) [Pubmed]
  8. Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ. Sha, R.S., Kane, C.D., Xu, Z., Banaszak, L.J., Bernlohr, D.A. J. Biol. Chem. (1993) [Pubmed]
  9. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. Damcott, C.M., Moffett, S.P., Feingold, E., Barmada, M.M., Marshall, J.A., Hamman, R.F., Ferrell, R.E. Metab. Clin. Exp. (2004) [Pubmed]
  10. Generation and characterization of monoclonal antibodies against FABP4. Gorbenko, O., Filonenko, V., Gout, I. Hybridoma (2005) (2006) [Pubmed]
  11. Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages. Fu, Y., Luo, L., Luo, N., Garvey, W.T. Atherosclerosis (2006) [Pubmed]
  12. Fatty acid binding protein 4 in human skeletal muscle. Fischer, H., Gustafsson, T., Sundberg, C.J., Norrbom, J., Ekman, M., Johansson, O., Jansson, E. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Bronsky, J., Karpísek, M., Bronská, E., Pechová, M., Jancíková, B., Kotolová, H., Stejskal, D., Prusa, R., Nevoral, J. Clin. Chem. (2006) [Pubmed]
  14. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. Baxa, C.A., Sha, R.S., Buelt, M.K., Smith, A.J., Matarese, V., Chinander, L.L., Boundy, K.L., Bernlohr, D.A. Biochemistry (1989) [Pubmed]
  15. In vitro phosphorylation of the adipocyte lipid-binding protein (p15) by the insulin receptor. Effects of fatty acid on receptor kinase and substrate phosphorylation. Buelt, M.K., Shekels, L.L., Jarvis, B.W., Bernlohr, D.A. J. Biol. Chem. (1991) [Pubmed]
  16. Troglitazone effects on gene expression in human skeletal muscle of type II diabetes involve up-regulation of peroxisome proliferator-activated receptor-gamma. Park, K.S., Ciaraldi, T.P., Lindgren, K., Abrams-Carter, L., Mudaliar, S., Nikoulina, S.E., Tufari, S.R., Veerkamp, J.H., Vidal-Puig, A., Henry, R.R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  17. Adipocyte fatty acid-binding protein: interaction with phospholipid membranes and thermal stability studied by FTIR spectroscopy. Gericke, A., Smith, E.R., Moore, D.J., Mendelsohn, R., Storch, J. Biochemistry (1997) [Pubmed]
  18. Gene expression profiling of progressive papillary noninvasive carcinomas of the urinary bladder. Wild, P.J., Herr, A., Wissmann, C., Stoehr, R., Rosenthal, A., Zaak, D., Simon, R., Knuechel, R., Pilarsky, C., Hartmann, A. Clin. Cancer Res. (2005) [Pubmed]
  19. Fatty acid binding proteins: same structure but different binding mechanisms? Molecular dynamics simulations of intestinal fatty acid binding protein. Friedman, R., Nachliel, E., Gutman, M. Biophys. J. (2006) [Pubmed]
  20. Molecular impacts of antisense complementary to the liver fatty acid binding protein (FABP) mRNA in DU 145 prostate cancer cells in vitro. Hammamieh, R., Chakraborty, N., Das, R., Jett, M. J. Exp. Ther. Oncol. (2004) [Pubmed]
  21. Assignment of the human adipocyte fatty acid-binding protein gene (FABP4) to chromosome 8q21 using somatic cell hybrid and fluorescence in situ hybridization techniques. Prinsen, C.F., de Bruijn, D.R., Merkx, G.F., Veerkamp, J.H. Genomics (1997) [Pubmed]
  22. Selective expression of an aP2/Fatty Acid Binding Protein4-Cre transgene in non-adipogenic tissues during embryonic development. Urs, S., Harrington, A., Liaw, L., Small, D. Transgenic Res. (2006) [Pubmed]
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