Gene Review:
Slc9a1 - solute carrier family 9, subfamily A (NHE1...
Rattus norvegicus
Synonyms:
NHE-1, Na(+)/H(+) exchanger 1, Nhe1, Sodium/hydrogen exchanger 1, Solute carrier family 9 member 1
- Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway. Haworth, R.S., McCann, C., Snabaitis, A.K., Roberts, N.A., Avkiran, M. J. Biol. Chem. (2003)
- Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Young, M., Funder, J. Endocrinology (2003)
- Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. Hileeto, D., Cukiernik, M., Mukherjee, S., Evans, T., Barbin, Y., Downey, D., Karmazyn, M., Chakrabarti, S. Diabetes Metab. Res. Rev. (2002)
- Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes. Karmazyn, M., Liu, Q., Gan, X.T., Brix, B.J., Fliegel, L. Hypertension (2003)
- Activity and expression of Na(+)-H+ exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats. Kelly, M.P., Quinn, P.A., Davies, J.E., Ng, L.L. Circ. Res. (1997)
- Activity of the Na(+)/H(+) exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart. Xiao, X.H., Allen, D.G. Cardiovasc. Res. (2000)
- Functional observational battery and motor activity in rats after single administration of two NHE 1 inhibitors. Hübler, N., Gottschling, B., Jacobs, M., von Landenberg, F., Hewicker-Trautwein, M. Toxicol. Appl. Pharmacol. (2005)
- Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA. Laghmani, K., Borensztein, P., Ambühl, P., Froissart, M., Bichara, M., Moe, O.W., Alpern, R.J., Paillard, M. J. Clin. Invest. (1997)
- Glucose-induced changes in Na+/H+ antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C. Williams, B., Howard, R.L. J. Clin. Invest. (1994)
- Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum. Akiba, Y., Ghayouri, S., Takeuchi, T., Mizumori, M., Guth, P.H., Engel, E., Swenson, E.R., Kaunitz, J.D. Gastroenterology (2006)
- Colitis-induced changes in the expression of the Na+/H+ exchanger isoform NHE-1. Khan, I., al-Awadi, F.M., Abul, H. J. Pharmacol. Exp. Ther. (1998)
- Mechanism of garlic (Allium sativum) induced reduction of hypertension in 2K-1C rats: a possible mediation of Na/H exchanger isoform-1. Al-Qattan, K.K., Khan, I., Alnaqeeb, M.A., Ali, M. Prostaglandins Leukot. Essent. Fatty Acids (2003)
- Increased expression of Na+/H+ exchanger in the injured renal tissues of focal glomerulosclerosis in rats. Okuda, S., Tamaki, K., Ando, T., Nagashima, A., Nakayama, M., Fukuda, K., Higashi, H., Fujishima, M. Kidney Int. (1994)
- Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. Orlowski, J., Kandasamy, R.A., Shull, G.E. J. Biol. Chem. (1992)
- Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. Khan, I., Al-Qattan, K.K., Alnaqeeb, M.A., Ali, M. Nephron (2002)
- Muscarinic agonists induce phosphorylation-independent activation of the NHE-1 isoform of the Na+/H+ antiporter in salivary acinar cells. Robertson, M.A., Woodside, M., Foskett, J.K., Orlowski, J., Grinstein, S. J. Biol. Chem. (1997)
- Apical location and inhibition by arginine vasopressin of K+/H+ antiport of the medullary thick ascending limb of rat kidney. Attmane-Elakeb, A., Boulanger, H., Vernimmen, C., Bichara, M. J. Biol. Chem. (1997)
- Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways. Kandasamy, R.A., Yu, F.H., Harris, R., Boucher, A., Hanrahan, J.W., Orlowski, J. J. Biol. Chem. (1995)
- ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells. Mukhin, Y.V., Garnovskaya, M.N., Ullian, M.E., Raymond, J.R. J. Biol. Chem. (2004)
- The basolateral NHE1 Na+/H+ exchanger regulates transepithelial HCO3- absorption through actin cytoskeleton remodeling in renal thick ascending limb. Watts, B.A., George, T., Good, D.W. J. Biol. Chem. (2005)
- The role of the sodium hydrogen exchanger-1 in mediating diabetes-induced changes in the retina. Cukiernik, M., Hileeto, D., Downey, D., Evans, T., Khan, Z.A., Karmazyn, M., Chakrabarti, S. Diabetes Metab. Res. Rev. (2004)
- Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1). Li, X., Misik, A.J., Rieder, C.V., Solaro, R.J., Lowen, A., Fliegel, L. J. Biol. Chem. (2002)
- Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli. Lyall, V., Alam, R.I., Malik, S.A., Phan, T.H., Vinnikova, A.K., Heck, G.L., DeSimone, J.A. J. Physiol. (Lond.) (2004)
- Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interaction. Wakabayashi, S., Ikeda, T., Iwamoto, T., Pouysségur, J., Shigekawa, M. Biochemistry (1997)
- Stimulation of 11-beta-hydroxysteroid dehydrogenase type 2 in rat colon but not in kidney by low dietary NaCl intake. Nørregaard, R., Uhrenholt, T.R., Bistrup, C., Skøtt, O., Jensen, B.L. Am. J. Physiol. Renal Physiol. (2003)
- Differential effects of angiotensin AT1 and AT2 receptors on the expression, translation and function of the Na+-H+ exchanger and Na+-HCO3- symporter in the rat heart after myocardial infarction. Sandmann, S., Yu, M., Kaschina, E., Blume, A., Bouzinova, E., Aalkjaer, C., Unger, T. J. Am. Coll. Cardiol. (2001)
- Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. Zaun, H.C., Shrier, A., Orlowski, J. J. Biol. Chem. (2008)
- Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. Lin, C.Y., Varma, M.G., Joubel, A., Madabushi, S., Lichtarge, O., Barber, D.L. J. Biol. Chem. (2003)
- Na(+)-H+ exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats. Lucchesi, P.A., DeRoux, N., Berk, B.C. Hypertension (1994)