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Gene Review

CCRN4L  -  CCR4 carbon catabolite repression 4-like...

Homo sapiens

Synonyms: CCR4, CCR4L, Carbon catabolite repression 4-like protein, Ccr4c, Circadian deadenylase NOC, ...
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Disease relevance of CCRN4L

  • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo [1].
  • Superoxide generation links nociceptin/orphanin FQ (NOC/oFQ) release to impaired N-methyl-D-aspartate cerebrovasodilation after brain injury [2].
  • This study was designed to determine the role of altered cAMP and K(+) channel-dependent mechanisms in impaired pial artery dilation to the newly described opioid, nociceptin/orphanin FQ (NOC/oFQ) following hypoxia/ischemia in newborn pigs equipped with a closed cranial window [3].
  • Topical NOC/oFQ (10(-8), 10(-6) M) induced vasodilation was attenuated by ischemia/reperfusion (I+R) and reversed to vasoconstriction by hypoxia/ischemia/reperfusion (H+I+R) at 1 h of reperfusion (control, 9+/-1 and 16+/-1%; I+R, 3+/-1 and 6+/-1%; H+I+R, -7+/-1 and -12+/-1%) [3].
  • With the exception of elevated serum prolactin levels, there were no significant differences in biochemical tests or history of oral contraceptive use between the prolactinoma group and patients with prolonged "functional" amenorrhea (OC plus NOC groups) [4].

Psychiatry related information on CCRN4L

  • There was no significant relationship between acute sleep deprivation and total mood disturbance, whether PC or NOC [5].
  • Health Canada has issued a Notice of Compliance with conditions (NOC/c) for memantine in the treatment of moderate to severe Alzheimer's disease (AD) [6].
  • METHODS: 1000 subjects who called the Anxiety Disorders Association of America (ADAA) were surveyed and divided in three groups: (a) callers with OCD (OCD) and two overlapping control groups: (b) callers with no axis I disorder (NAC) and (c) with no-OCD (NOC) using a 97-item questionnaire [7].

High impact information on CCRN4L

  • Leukemic blast peripheral blood cells were evaluated for expression of CD34 and Thy-1 (CD90) antigens [1].
  • In contrast, treatment of chondrocytes with diazeniumdiolates (or the "NOC" compounds, NOC-5 and NOC-12) at concentrations as high as 2.0 mM did not cause cell death [8].
  • Therefore, these data suggest that cyclooxygenase-dependent O(2)(-) generation links NOC/oFQ release to impaired NMDA-induced cerebrovasodilation after brain injury [2].
  • CONCLUSIONS: These data show that NOC/oFQ, in concentrations present in cerebrospinal fluid after FPI, increased O(2)(-) production in a cyclooxygenase-dependent manner and contributes to such production after FPI [2].
  • [F/G] NOC/oFQ (1-13) NH(2) and indomethacin also blunted the NBT reduction observed after FPI (1+/-1 to 15+/-1 versus 1+/-1 to 4+/-1 versus 1+/-1 to 4+/-1 pmol/mm(2) for sham, NOC/oFQ antagonist, and indomethacin-treated animals, respectively) [2].

Chemical compound and disease context of CCRN4L


Biological context of CCRN4L

  • Women who neither exercised nor took oral contraceptives (NE/NOC) had the greatest percentage increases in cross-sectional area (4.98 +/- 2.29%), cross-sectional moment of inertia (9.45 +/- 2.37%), total bone mineral density (2.07 +/- 2.09%), fracture index (8.03 +/- 2.03%), and safety factor (20.03 +/- 5.79%) over the 24 month exercise program [9].
  • Changes in immune cell counts were consistently greater during Lut in OC vs. NOC, regardless of MP, but only neutrophil responses reached statistical significance (P = 0.01) [10].
  • The drugs of blood pressure control (acetylcholine chloride (AcChCl), NOC 7 and NG-monomethyl-L-arginine (L-NMMA)) were assessed with this endothelial cellular biosensing system [11].
  • These results suggest that SNAP, GSNO, and NOC compounds are suitable for pharmacological studies in HIF-1-mediated VEGF gene activation by NO [12].
  • RESULTS: When the authors applied a cutoff of >or= 35% for the n = 817 training set of OC, NOC-CP, and NOC-Mets predictive probabilities, the OLOGIT model predicted OC PCA with an accuracy of 91%, whereas the GENN model predicted the same with an accuracy of 95% [13].

Anatomical context of CCRN4L

  • An NO donor, diethylamine/NO complex (NOC 5), increased sTNF-RI in the supernatants of ECV304, a human umbilical vein cell line, in a dose-dependent manner [14].
  • Exercise-induced immune cell count and IL-6 changes were similar between men and NOC, except for an approximately 38% greater lymphocyte response in NOC vs. men (P = 0.07) [10].
  • NOC 7 immediately released NO regardless of eNOS activation in endothelial cells [11].
  • NOC increased shortening and [Ca(2+)]( i ) transient amplitude in STZ myocytes by 45 and 24%, respectively (compared with 4 and 6% in controls) [15].
  • OC/PA fields adjacent to the alveolar crest contained significantly more intersects with macrophage-like cells (10.7+/-1.1 versus 5.3+/-0.6%, P=0.0003), lymphocytes (4.6+/-1.1 versus 0.7+/-0.2%, P=0.0013), plasma cells (13.3+/-2.7 versus 2.1+/-0.6%, P=0.0004), and less with collagen (48.9+/-3.5 versus 75.0+/-2.0%, P=0.0001) than NOC/PQ fields [16].

Associations of CCRN4L with chemical compounds

  • These data show that NOC/oFQ contributes to impaired NMDA-induced pial artery dilation after FPI [2].
  • Indomethacin (5 mg/kg IV) blunted such NBT reduction (1+/-1 to 6+/-2 pmol/mm(2)), whereas the NOC/oFQ receptor antagonist [F/G] NOC/oFQ (1-13) NH(2) (10(-)(6) mol/L) blocked NBT reduction [2].
  • Nor was there a difference between the OC and NOC groups in response to medroxyprogesterone acetate, clomiphene citrate, or luteinizing hormone-releasing factor [4].
  • These data indicate that impaired NOC/oFQ dilation following I+R results form altered adenylate cyclase and K(ATP) channel-dependent mechanisms [3].
  • CONCLUSIONS: These data indicate that a low, clinically relevant dose of ketamine offer significant neuroprotection during prolonged exposure to NMDA but not to NOC [17].

Analytical, diagnostic and therapeutic context of CCRN4L

  • The pathologic stage of these cases, as determined by results from radical prostatectomy, lymphadenectomy, or bone scan, categorized the PCA as either OC, non-OC due to capsular penetration only (NOC-CP) or advanced disease with metastasis (NOC-Mets), i.e., seminal vesicle and/or lymph-node positive or bone-scan positive [13].
  • Multifactorial analysis of NOC lung carcinoma radiotherapy [18].
  • An intensive care unit tested the intervention that included the adoption and use of the NANDA, NOC, and NIC terminologies [19].
  • Fetal behavioral state recordings were made before delivery by Cesarean section and data were expressed as percentage of quiet sleep coincidence (C1F), of activity state coincidence (C2-4F) and of no coincidence (NOC) [20].


  1. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blair, A., Hogge, D.E., Ailles, L.E., Lansdorp, P.M., Sutherland, H.J. Blood (1997) [Pubmed]
  2. Superoxide generation links nociceptin/orphanin FQ (NOC/oFQ) release to impaired N-methyl-D-aspartate cerebrovasodilation after brain injury. Kulkarni, M., Armstead, W.M. Stroke (2000) [Pubmed]
  3. Role of cAMP and K(+) channel-dependent mechanisms in piglet hypoxic/ischemic impaired nociceptin/orphanin FQ-induced cerebrovasodilation. Ben-Haim, G., Armstead, W.M. Brain Res. (2000) [Pubmed]
  4. Prolonged amenorrhea and oral contraceptives. Tolis, G., Ruggere, D., Popkin, D.R., Chow, J., Boyd, M.E., De Leon, A., Lalonde, A.B., Asswad, A., Hendelman, M., Scali, V., Koby, R., Arronet, G., Yufe, B., Tweedie, F.J., Fournier, P.R., Naftolin, F. Fertil. Steril. (1979) [Pubmed]
  5. 24 hours on-call and acute fatigue no longer worsen resident mood under the 80-hour work week regulations. Kiernan, M., Civetta, J., Bartus, C., Walsh, S. Current surgery. (2006) [Pubmed]
  6. Memantine for treatment of moderate to severe Alzheimer's disease. Perras, C. Issues in emerging health technologies. (2005) [Pubmed]
  7. Obsessive-compulsive disorder in callers to the Anxiety Disorders Association of America. Hidalgo, R.B., Ross, J., Davidson, J.R. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. (2006) [Pubmed]
  8. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Del Carlo, M., Loeser, R.F. Arthritis Rheum. (2002) [Pubmed]
  9. Exercise and oral contraceptive use suppress the normal age-related increase in bone mass and strength of the femoral neck in women 18-31 years of age. Burr, D.B., Yoshikawa, T., Teegarden, D., Lyle, R., McCabe, G., McCabe, L.D., Weaver, C.M. Bone (2000) [Pubmed]
  10. Influence of gender, menstrual phase, and oral contraceptive use on immunological changes in response to prolonged cycling. Timmons, B.W., Hamadeh, M.J., Devries, M.C., Tarnopolsky, M.A. J. Appl. Physiol. (2005) [Pubmed]
  11. The construction of endothelial cellular biosensing system for the control of blood pressure drugs. Kamei, K., Haruyama, T., Mie, M., Yanagida, Y., Aizawa, M., Kobatake, E. Biosensors & bioelectronics. (2004) [Pubmed]
  12. Effects of nitric oxide donors on vascular endothelial growth factor gene induction. Kimura, H., Ogura, T., Kurashima, Y., Weisz, A., Esumi, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Prediction of prostate carcinoma stage by quantitative biopsy pathology. Veltri, R.W., Miller, M.C., Partin, A.W., Poole, E.C., O'Dowd, G.J. Cancer (2001) [Pubmed]
  14. Nitric oxide enhances expression and shedding of tumor necrosis factor receptor I (p55) in endothelial cells. Okuyama, M., Yamaguchi, S., Yamaoka, M., Nitobe, J., Fujii, S., Yoshimura, T., Tomoike, H. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  15. Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat. Shiels, H., O'connell, A., Qureshi, M.A., Howarth, F.C., White, E., Calaghan, S. Mol. Cell. Biochem. (2007) [Pubmed]
  16. Histology near periodontitis osteoclasts. Uden, C.E., Ganatra, S., Reinhardt, R.A., Patil, K.D. J. Periodontol. (1998) [Pubmed]
  17. Ketamine and thiopental sodium: individual and combined neuroprotective effects on cortical cultures exposed to NMDA or nitric oxide. Shibuta, S., Varathan, S., Mashimo, T. British journal of anaesthesia. (2006) [Pubmed]
  18. Multifactorial analysis of NOC lung carcinoma radiotherapy. Buffoli, A., Feroldi, P., Mabellini, M., Morabito, A., Tordiglione, M. Tumori. (1985) [Pubmed]
  19. Promoting safe nursing care by bringing visibility to the disciplinary aspects of interdisciplinary care. Keenan, G., Yakel, E. AMIA ... Annual Symposium proceedings [electronic resource] / AMIA Symposium. AMIA Symposium. (2005) [Pubmed]
  20. S100B protein cord blood levels and development of fetal behavioral states: a study in normal and small-for-dates fetuses. Gazzolo, D., Visser, G.H., Lituania, M., Sarli, R., Bruschettini, M., Michetti, F., Bruschettini, P.L. J. Matern. Fetal. Neonatal. Med. (2002) [Pubmed]
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