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CKAP2  -  cytoskeleton associated protein 2

Homo sapiens

Synonyms: CTCL tumor antigen se20-10, Cytoskeleton-associated protein 2, FLJ10749, LB1, TMAP, ...
 
 
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Disease relevance of CKAP2

  • Previously, we reported the cloning of a cytoskeleton-associated protein, TMAP/CKAP2, which was up-regulated in primary human gastric cancers [1].
  • CKAP2 protein-expressing cells were also found in gastric adenomas [2].
  • Interestingly, the capacity of RAR-alpha, -beta and -gamma to bind the LB1 RARE appears to be differentially modulated by factor(s) present in HeLa cells infected with RAR-expressing vaccinia virus vectors [3].
  • Reactivity of aLB1 with apoptotic blebs does not seem to play a direct role in mediating this protection, since LB1 is buried within apoptotic blebs and inaccessible to circulating aLB1 [4].
  • While LB1 is based solely on one NTHI adhesin, the latter immunogen, LPD-LB1(f)(2,1,3), was designed to incorporate two NTHI antigens shown to play a role in the pathogenesis of otitis media; lipoprotein D (LPD) and the P5-homologous fimbrin adhesin [5].
 

Psychiatry related information on CKAP2

  • Preliminary findings using this system with 2035 clinical visits conducted for the bipolar disorder module of TMAP Phase 3 are presented [6].
 

High impact information on CKAP2

  • Transcription of the murine laminin B1 (LB1) gene is induced by retinoic acid (RA), but responds only 24-28 h after RA treatment in F9 EC cells [3].
  • Here we have shown by gel retardation assay that all three retinoic acid receptors (RARs) alpha, beta and gamma expressed in Cos cells can bind directly to the previously characterized retinoic acid response element (RARE) of the LB1 promoter, albeit with a weaker affinity than to the RAR-beta gene RARE [3].
  • Thus, RARs can participate directly in transcriptional induction of the LB1 gene, even though this induction is cycloheximide sensitive and RARs are present in F9 cells prior to RA addition [3].
  • Liang Bua 1 (LB1) exhibits marked craniofacial and postcranial asymmetries and other indicators of abnormal growth and development [7].
  • Mandibular and dental features of LB1 and LB6/1 either show no substantial deviation from modern Homo sapiens or share features (receding chins and rotated premolars) with Rampasasa pygmies now living near Liang Bua Cave [7].
 

Chemical compound and disease context of CKAP2

 

Biological context of CKAP2

  • Furthermore, LB1 gene mapped to chromosome 13q14, a region that has been involved as a chromosomal breakpoint in DLBL [9].
  • LB1 open reading frame encodes a 683 amino-acid polypeptide that does not show significant homology upon comparison to protein databases, nor any structural domain relating LB1 to an already known protein family [9].
  • LB1 was found to be translocated into surface membrane blebs during apoptosis and to be entirely enclosed within the apoptotic bleb plasma membrane of Jurkat and endothelial cells [4].
  • The expression of A2B5 gangliosides by 5-20% of GFAP-positive IPSB-18 cells, and their co-expression with the ganglioside GD3 identified by the LB1 monoclonal antibody, shows that cells with a similar phenotype to the type 1 and type 2 astrocytes of optic nerve are present in cultured gliomas, even after long term sequential passaging [10].
 

Anatomical context of CKAP2

 

Associations of CKAP2 with chemical compounds

  • Each protomer binds l-glutamate within the crevice between the LB1 and LB2 domains [11].
  • Peptic cleavage of the short linker region that connects the last cysteine residue of LB1 and the first cysteine residue of LB2 yielded two discrete fragments, thus excluding the presence of intermodule disulfide bonds [12].
  • MICs of cefoxitin, ceftazidime, and cefotaxime against LB1 were 4, 1, and 0.06 micrograms/ml, respectively [13].
  • Similarly, the chinchilla model of middle ear and nasopharyngeal clearance has been used to show that two P5 fimbrin adhesin-derived immunogens, LB1 and lipoprotein D (LPD)-LB1(f)(2,1,3), are highly efficacious as parenteral immunogens [14].
  • LB1 and LB2 have a similar pattern of calcium ligands, but the orientations of the indole rings of the tryptophan residues W23 and W66 differ, with the latter limiting solvent access to the calcium ion [15].
 

Physical interactions of CKAP2

  • We also show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 and that the KEN box motif near the N terminus is necessary for its destruction [16].
 

Other interactions of CKAP2

 

Analytical, diagnostic and therapeutic context of CKAP2

References

  1. A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts. Jeon, S.M., Choi, B., Hong, K.U., Kim, E., Seong, Y.S., Bae, C.D., Park, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas. Bae, C.D., Sung, Y.S., Jeon, S.M., Suh, Y., Yang, H.K., Kim, Y.I., Park, K.H., Choi, J., Ahn, G., Park, J. J. Cancer Res. Clin. Oncol. (2003) [Pubmed]
  3. The late retinoic acid induction of laminin B1 gene transcription involves RAR binding to the responsive element. Vasios, G., Mader, S., Gold, J.D., Leid, M., Lutz, Y., Gaub, M.P., Chambon, P., Gudas, L. EMBO J. (1991) [Pubmed]
  4. Association of autoantibodies to nuclear lamin B1 with thromboprotection in systemic lupus erythematosus: lack of evidence for a direct role of lamin B1 in apoptotic blebs. Dieudé, M., Senécal, J.L., Rauch, J., Hanly, J.G., Fortin, P., Brassard, N., Raymond, Y. Arthritis Rheum. (2002) [Pubmed]
  5. Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge. Kennedy, B.J., Novotny, L.A., Jurcisek, J.A., Lobet, Y., Bakaletz, L.O. Infect. Immun. (2000) [Pubmed]
  6. Development of a computerized assessment of clinician adherence to a treatment guideline for patients with bipolar disorder. Dennehy, E.B., Suppes, T., John Rush, A., Lynn Crismon, M., Witte, B., Webster, J. Journal of psychiatric research. (2004) [Pubmed]
  7. Pygmoid Australomelanesian Homo sapiens skeletal remains from Liang Bua, Flores: Population affinities and pathological abnormalities. Jacob, T., Indriati, E., Soejono, R.P., Hsü, K., Frayer, D.W., Eckhardt, R.B., Kuperavage, A.J., Thorne, A., Henneberg, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Impaired colonization of gnotobiotic and conventional rats by streptomycin-resistant strains of Streptococcus mutans. Bammann, L.L., Clark, W.B., Gibbons, R.J. Infect. Immun. (1978) [Pubmed]
  9. Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas. Maouche-Chrétien, L., Deleu, N., Badoual, C., Fraissignes, P., Berger, R., Gaulard, P., Roméo, P.H., Leroy-Viard, K. Oncogene (1998) [Pubmed]
  10. A human glioma cell line retaining expression of GFAP and gangliosides, recognized by A2B5 and LB1 antibodies, after prolonged passage. Knott, J.C., Edwards, A.J., Gullan, R.W., Clarke, T.M., Pilkington, G.J. Neuropathol. Appl. Neurobiol. (1990) [Pubmed]
  11. Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state. Sato, T., Shimada, Y., Nagasawa, N., Nakanishi, S., Jingami, H. J. Biol. Chem. (2003) [Pubmed]
  12. Folding, calcium binding, and structural characterization of a concatemer of the first and second ligand-binding modules of the low-density lipoprotein receptor. Bieri, S., Atkins, A.R., Lee, H.T., Winzor, D.J., Smith, R., Kroon, P.A. Biochemistry (1998) [Pubmed]
  13. In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins. Martínez-Martínez, L., Hernández-Allés, S., Albertí, S., Tomás, J.M., Benedi, V.J., Jacoby, G.A. Antimicrob. Agents Chemother. (1996) [Pubmed]
  14. Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx. Kyd, J.M., Cripps, A.W., Novotny, L.A., Bakaletz, L.O. Infect. Immun. (2003) [Pubmed]
  15. NMR structure of a concatemer of the first and second ligand-binding modules of the human low-density lipoprotein receptor. Kurniawan, N.D., Atkins, A.R., Bieri, S., Brown, C.J., Brereton, I.M., Kroon, P.A., Smith, R. Protein Sci. (2000) [Pubmed]
  16. Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis. Hong, K.U., Park, Y.S., Seong, Y.S., Kang, D., Bae, C.D., Park, J. Mol. Cell. Biol. (2007) [Pubmed]
  17. Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis. Hong, K.U., Kim, H.J., Kim, H.S., Seong, Y.S., Hong, K.M., Bae, C.D., Park, J. J. Biol. Chem. (2009) [Pubmed]
  18. Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties. Jin, Y., Murakumo, Y., Ueno, K., Hashimoto, M., Watanabe, T., Shimoyama, Y., Ichihara, M., Takahashi, M. Cancer Sci. (2004) [Pubmed]
  19. Human embryonic gastric xenografts in nude mice: a new model of Helicobacter pylori infection. Lozniewski, A., Muhale, F., Hatier, R., Marais, A., Conroy, M.C., Edert, D., le Faou, A., Weber, M., Duprez, A. Infect. Immun. (1999) [Pubmed]
 
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