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Gene Review

IGFBP7  -  insulin-like growth factor binding protein 7

Homo sapiens

Synonyms: AGM, FSTL2, IBP-7, IGF-binding protein 7, IGFBP-7, ...
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Disease relevance of IGFBP7


Psychiatry related information on IGFBP7


High impact information on IGFBP7

  • Here we report gene transfer experiments showing that expression of PSF complementary DNA in the human lymphoblastoid cell line mutant 721.134 restores normal levels of surface HLA-A2 and -B5 [7].
  • Based on experiments in mice, it is proposed that some proliferative disorders of the pluripotential haemopoietic stem cell or its progeny may result from the abnormal production and secretion of PSF by these cells themselves [8].
  • We showed that steroid synthesis could also be activated in mouse steroidogenic adrenal cells by transfection with cDNA encoding either mVL30 RNA tracts that form a complex with PSF or a small interfering RNA (siRNA) that degrades PSF transcripts [9].
  • CTGF, like mac25/IGFBP-7, specifically binds IGFs, although with relatively low affinity [10].
  • We have recently demonstrated that the product of the mac25/IGFBP-7 gene, which shows significant conservation in the NH2 terminus, including an "IGFBP motif' (GCGCCXXC), exhibits low-affinity IGF binding [10].

Chemical compound and disease context of IGFBP7


Biological context of IGFBP7

  • The deduced amino acid sequence of the human mac25 propeptide shares a 20-25% identity to human insulin-like growth factor-binding proteins (IGFBPs), suggesting that mac25 could be another member of the IGFBP family [1].
  • These data indicate that SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation [15].
  • IGFBP-rP1 (also known as MAC25/angiomodulin/prostacyclin-stimulating factor and T1A12), regulates cellular proliferation, adhesion, and angiogenesis and stimulates prostacyclin synthesis [16].
  • Quantitative PCR was used to access the methylation status of the NotI site just 5' to the coding region and the expression level of the mac25/igfbp-7 gene [17].
  • An altered locus/spot (S130) was cloned and found to correspond to sequences in the 5' flanking region and 5' portion of the cDNA for the murine mac25/insulin-like growth factor binding protein-7 (Igfbp-7) gene [17].

Anatomical context of IGFBP7

  • The mac25 cDNA was originally cloned from leptomeningial cells and subsequently reisolated through differential display as a sequence preferentially expressed in senescent human mammary epithelial cells [1].
  • A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines [18].
  • An increase and sustained activation of adenosine 3',5'-cyclic monophosphate (cAMP) levels induced NE-like differentiation in NSCLC cell lines, and a concomitant increase in the expression of mac25/IGFBP-rP1 and 25.1 was observed during the cAMP-regulated differentiation of NCI-H157 cells, suggesting the involvement of these proteins [2].
  • IGFBP-rP1 was readily detectable in serum, urine, amniotic fluid, and cerebrospinal fluid by immunoblot analysis [16].
  • The monoclonal anti-IGFBP-rP1 antibodies also readily detected IGFBP-rP1 expression in human tissue sections, with preferential expression of IGFBP-rP1 in the microvascular endothelium associated with tumorigenesis [16].

Associations of IGFBP7 with chemical compounds


Physical interactions of IGFBP7

  • In conclusion, mac25 specifically binds IGFs and constitutes a new member of the IGFBP family, IGFBP-7 [1].

Enzymatic interactions of IGFBP7


Regulatory relationships of IGFBP7


Other interactions of IGFBP7


Analytical, diagnostic and therapeutic context of IGFBP7


  1. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II. Oh, Y., Nagalla, S.R., Yamanaka, Y., Kim, H.S., Wilson, E., Rosenfeld, R.G. J. Biol. Chem. (1996) [Pubmed]
  2. Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1. Walker, G.E., Antoniono, R.J., Ross, H.J., Paisley, T.E., Oh, Y. Oncogene (2006) [Pubmed]
  3. Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. Kawahara, C., Forster, T., Chapman, K., Carr, A., Loughlin, J. Ann. Rheum. Dis. (2005) [Pubmed]
  4. Bisulfite-modified target DNA array for aberrant methylation analysis. Zhou, D., Qiao, W., Yang, L., Lu, Z. Anal. Biochem. (2006) [Pubmed]
  5. Methylation patterns of IGFBP7 in colon cancer cell lines are associated with levels of gene expression. Lin, J., Lai, M., Huang, Q., Ma, Y., Cui, J., Ruan, W. J. Pathol. (2007) [Pubmed]
  6. Linking perceptions of the community to behavior: are protective social factors associated with physical activity? Brennan, L.K., Baker, E.A., Haire-Joshu, D., Brownson, R.C. Health education & behavior : the official publication of the Society for Public Health Education. (2003) [Pubmed]
  7. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Spies, T., DeMars, R. Nature (1991) [Pubmed]
  8. Role of a single haemopoietic growth factor in multiple proliferative disorders of haemopoietic and related cells. Schrader, J.W. Lancet (1984) [Pubmed]
  9. Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. Song, X., Sui, A., Garen, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Kim, H.S., Nagalla, S.R., Oh, Y., Wilson, E., Roberts, C.T., Rosenfeld, R.G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  11. Restoration of insulin-like growth factor binding protein-related protein 1 has a tumor-suppressive activity through induction of apoptosis in human prostate cancer. Mutaguchi, K., Yasumoto, H., Mita, K., Matsubara, A., Shiina, H., Igawa, M., Dahiya, R., Usui, T. Cancer Res. (2003) [Pubmed]
  12. Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients. Shao, L., Huang, Q., Luo, M., Lai, M. Endocr. Relat. Cancer (2004) [Pubmed]
  13. Effect of high-calcium diet on urinary oxalate excretion in urinary stone formers. Nakada, T., Sasagawa, I., Furuta, H., Katayama, T., Shimazaki, J. Eur. Urol. (1988) [Pubmed]
  14. Cytotoxicity and DNA cross-linking induced by peptide conjugated m-L-sarcolysin in human melanoma cells. Hansson, J., Lewensohn, R., Ringborg, U. Anticancer Res. (1991) [Pubmed]
  15. Suppression of growth and tumorigenicity in the prostate tumor cell line M12 by overexpression of the transcription factor SOX9. Drivdahl, R., Haugk, K.H., Sprenger, C.C., Nelson, P.S., Tennant, M.K., Plymate, S.R. Oncogene (2004) [Pubmed]
  16. Generation of anti-insulin-like growth factor-binding protein-related protein 1 (IGFBP-rP1/MAC25) monoclonal antibodies and immunoassay: quantification of IGFBP-rP1 in human serum and distribution in human fluids and tissues. López-Bermejo, A., Khosravi, J., Corless, C.L., Krishna, R.G., Diamandi, A., Bodani, U., Kofoed, E.M., Graham, D.L., Hwa, V., Rosenfeld, R.G. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  17. Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic mice, screened by restriction landmark genomic scanning for methylation (RLGS-M). Komatsu, S., Okazaki, Y., Tateno, M., Kawai, J., Konno, H., Kusakabe, M., Yoshiki, A., Muramatsu, M., Held, W.A., Hayashizaki, Y. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  18. A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines. Nagakubo, D., Murai, T., Tanaka, T., Usui, T., Matsumoto, M., Sekiguchi, K., Miyasaka, M. J. Immunol. (2003) [Pubmed]
  19. Proteolytic processing of IGFBP-related protein-1 (TAF/angiomodulin/mac25) modulates its biological activity. Ahmed, S., Yamamoto, K., Sato, Y., Ogawa, T., Herrmann, A., Higashi, S., Miyazaki, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  20. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1. Ruan, W.J., Lin, J., Xu, E.P., Xu, F.Y., Ma, Y., Deng, H., Huang, Q., Lv, B.J., Hu, H., Cui, J., Di, M.J., Dong, J.K., Lai, M.D. Journal of Zhejiang University. Science. B. (2006) [Pubmed]
  21. Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid. Swisshelm, K., Ryan, K., Tsuchiya, K., Sager, R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  22. Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25). Ahmed, S., Jin, X., Yagi, M., Yasuda, C., Sato, Y., Higashi, S., Lin, C.Y., Dickson, R.B., Miyazaki, K. FEBS J. (2006) [Pubmed]
  23. Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis. Sprenger, C.C., Vail, M.E., Evans, K., Simurdak, J., Plymate, S.R. Oncogene (2002) [Pubmed]
  24. Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) has potential tumour-suppressive activity in human lung cancer. Chen, Y., Pacyna-Gengelbach, M., Ye, F., Knösel, T., Lund, P., Deutschmann, N., Schlüns, K., Kotb, W.F., Sers, C., Yasumoto, H., Usui, T., Petersen, I. J. Pathol. (2007) [Pubmed]
  25. Gene expression profiling of ductal carcinomas in situ and invasive breast tumors. Seth, A., Kitching, R., Landberg, G., Xu, J., Zubovits, J., Burger, A.M. Anticancer Res. (2003) [Pubmed]
  26. Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization. Girard, J.P., Baekkevold, E.S., Yamanaka, T., Haraldsen, G., Brandtzaeg, P., Amalric, F. Am. J. Pathol. (1999) [Pubmed]
  27. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Dal-Pra, S., F??rthauer, M., Van-Celst, J., Thisse, B., Thisse, C. Dev. Biol. (2006) [Pubmed]
  28. Genomic-scale analysis of psoriatic skin reveals differentially expressed insulin-like growth factor-binding protein-7 after phototherapy. Hochberg, M., Zeligson, S., Amariglio, N., Rechavi, G., Ingber, A., Enk, C.D. Br. J. Dermatol. (2007) [Pubmed]
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