The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NDE1  -  nudE neurodevelopment protein 1

Homo sapiens

Synonyms: FLJ20101, HOM-TES-87, LIS4, MHAC, NDE, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NDE1


Psychiatry related information on NDE1

  • Genetically athymic and asplenic (Lasat), athymic (Nude), asplenic (Dh) or normal littermate (Hetero) mice with a BALB/c genetic background were injected either intracerebrally or intraperitoneally with a 1% or 10% homogenate of mouse brains infected with the Fukuoka 1 strain of the Creutzfeldt-Jakob disease (CJD) agent [6].

High impact information on NDE1

  • These proteins play a crucial role in centrosome positioning, with Nde1 functioning mainly during progenitor cell divisions and Ndel1 functioning in neuronal migration [7].
  • METHODS: Nude mice were given an injection of the Bcr/Abl-positive human leukemia cell lines KU812 or MC3 [8].
  • METHODS: Nude male mice bearing SK-ES-1 and MNNG/HOS tumors were treated for 4 and 3 weeks, respectively, with MZ-4-71 administered from osmotic minipumps at a dose of 40 micrograms per animal per day [9].
  • The hypothesis was tested by first inducing transformation in a rat liver epithelial cell line by chronic exposure to low levels of arsenic, as confirmed by the development of highly aggressive, malignant tumors after inoculation of cells into Nude mice [10].
  • Two additional loci displayed an evidence of linkage (LOD > 3) and included a locus on 16p13, proximal to the gene encoding NDE1, which has been shown to biologically interact with DISC1 [11].

Chemical compound and disease context of NDE1


Biological context of NDE1

  • Moreover, we found that Nde1 is subjected to phosphorylation in vivo [17].
  • DNAs from 22 acute myeloid leukaemia (AML) patients were screened for activated transforming genes using NIH3T3 transfection followed by assay for tumor formation in Nude mice [18].
  • Ablation of Nde1 by gene specific small interfering RNA causes mitotic delay and cell death, coupled with a modest decrease in the incidence of the cells that harbor excessive centrosomes [17].
  • p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability [19].
  • Genetic alterations of the FOXN1 transcription factor, selectively expressed in thymic epithelia and skin, are responsible in both mice and humans for the Nude/SCID phenotype [20].

Anatomical context of NDE1

  • EXPERIMENTAL DESIGN: Nude rats with human ovarian xenografts implanted in the abdominal wall were used in experiments to facilitate in vivo measurement of tumor pressure and the treatment of the tumor with i.p. solutions at high pressures [21].
  • While there may be other defects in Nude mice that might contribute to the effects shown here, these data suggest that the brief influx of T cells in this model of chemically-induced demyelination could play a role in macrophage/microglial activation and demyelination [22].
  • Bcl-xL gene induces metastasis in the lung, lymph nodes and bone when breast cancer cells are inoculated in Nude Balb/c mice [23].
  • We show that there is a significant reduction in macrophage/microglial activation and myelin clearance after LPC injection in Nude mice as compared with wildtype controls [22].
  • In the present study, we examined whether this brief influx of T cells contributes to the activation of macrophages/microglia and demyelination by injecting LPC into the dorsal column white matter of athymic Nude mice that lack T cells [22].

Associations of NDE1 with chemical compounds

  • EXPERIMENTAL DESIGN: Nude mice were pretreated with control (1% Tween 80), ZD1839 (50 mg/kg) alone, celecoxib (50 mg/kg) alone, or a combination of ZD1839 and celecoxib at the same dosages for 7 days before injection of a human SCCHN cell line Tu212 [24].
  • Treatment with BANB-6, but not cisplatin, was able to prolong the life span of Nude mice bearing tumors formed by Hepa 1-6/R cells orthotopically implanted in the liver [25].
  • METHODS: Nude mice bearing PC-3 tumors received JV-1-38 (20 microg), RC-160 (50 microg) or a combination of JV-1-38 and RC-160 [26].
  • METHODS: Nude mice (nu/nu) of BALB/c background were treated with iron chelators [desferrioxamine (DFO), deferiprone (L1), or starch-DFO conjugate] or were fed with an iron-poor diet 6 weeks prior to subcutaneous injection of Si-Ha cells [27].
  • METHODS: Nude rats (6-8 rats per group) with s.c. SK-RC-52 tumors were i.v. injected with 4 MBq 111InDTPA-cG250, 20 MBq 89Zr-Df-cG250 or 4 MBq [18F]FDG [28].

Analytical, diagnostic and therapeutic context of NDE1


  1. A new NDE1/PDGFRB fusion transcript underlying chronic myelomonocytic leukaemia in Noonan Syndrome. La Starza, R., Rosati, R., Roti, G., Gorello, P., Bardi, A., Crescenzi, B., Pierini, V., Calabrese, O., Baens, M., Folens, C., Cools, J., Marynen, P., Martelli, M.F., Mecucci, C., Cuneo, A. Leukemia (2007) [Pubmed]
  2. Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. Pignata, C., Gaetaniello, L., Masci, A.M., Frank, J., Christiano, A., Matrecano, E., Racioppi, L. Blood (2001) [Pubmed]
  3. An orthotopic nude mouse model of oral tongue squamous cell carcinoma. Myers, J.N., Holsinger, F.C., Jasser, S.A., Bekele, B.N., Fidler, I.J. Clin. Cancer Res. (2002) [Pubmed]
  4. Schedule-dependent activity of topotecan in OVCAR-3 ovarian carcinoma xenograft: pharmacokinetic and pharmacodynamic evaluation. Guichard, S., Montazeri, A., Chatelut, E., Hennebelle, I., Bugat, R., Canal, P. Clin. Cancer Res. (2001) [Pubmed]
  5. Locoregional alpha-radioimmunotherapy of intraperitoneal tumor cell dissemination using a tumor-specific monoclonal antibody. Huber, R., Seidl, C., Schmid, E., Seidenschwang, S., Becker, K.F., Schuhmacher, C., Apostolidis, C., Nikula, T., Kremmer, E., Schwaiger, M., Senekowitsch-Schmidtke, R. Clin. Cancer Res. (2003) [Pubmed]
  6. Lack of effect of thymus and spleen on the incubation period of Creutzfeldt-Jakob disease in mice. Mohri, S., Handa, S., Tateishi, J. J. Gen. Virol. (1987) [Pubmed]
  7. Cortical development deNUDEd. Schaar, B.T. Neuron (2004) [Pubmed]
  8. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. le Coutre, P., Mologni, L., Cleris, L., Marchesi, E., Buchdunger, E., Giardini, R., Formelli, F., Gambacorti-Passerini, C. J. Natl. Cancer Inst. (1999) [Pubmed]
  9. Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. Pinski, J., Schally, A.V., Groot, K., Halmos, G., Szepeshazi, K., Zarandi, M., Armatis, P. J. Natl. Cancer Inst. (1995) [Pubmed]
  10. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Zhao, C.Q., Young, M.R., Diwan, B.A., Coogan, T.P., Waalkes, M.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  11. Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hennah, W., Tomppo, L., Hiekkalinna, T., Palo, O.M., Kilpinen, H., Ekelund, J., Tuulio-Henriksson, A., Silander, K., Partonen, T., Paunio, T., Terwilliger, J.D., Lönnqvist, J., Peltonen, L. Hum. Mol. Genet. (2007) [Pubmed]
  12. Xenotransplantation of human lymphoid malignancies is optimized in mice with multiple immunologic defects. Hudson, W.A., Li, Q., Le, C., Kersey, J.H. Leukemia (1998) [Pubmed]
  13. Nuclear Trafficking of a Gadolinium Conjugate in Nude Mice Xenografted with Human LN-229 Glioma. Heckl, S., Vogel, U. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  14. Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C Human Prostate Cancer Cells in Nude Mice. Limpens, J., Schröder, F.H., de Ridder, C.M., Bolder, C.A., Wildhagen, M.F., Obermüller-Jevic, U.C., Krämer, K., van Weerden, W.M. J. Nutr. (2006) [Pubmed]
  15. Expression of GADD153 in tumor cells and stromal cells from xenografted tumors in nude mice treated with cisplatin: correlations with cisplatin-DNA adducts. Johnsson, A., Strand, C., Los, G. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  16. Intralesional radiolabeled human monoclonal IgM in human tumor xenografts. Borchardt, P.E., Quadri, S.M., Freedman, R.S., Vriesendorp, H.M. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1997) [Pubmed]
  17. Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation. Hirohashi, Y., Wang, Q., Liu, Q., Li, B., Du, X., Zhang, H., Furuuchi, K., Masuda, K., Sato, N., Greene, M.I. Oncogene (2006) [Pubmed]
  18. ras gene activation in a minor proportion of the blast population in acute myeloid leukemia. Toksoz, D., Farr, C.J., Marshall, C.J. Oncogene (1987) [Pubmed]
  19. p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability. Hirohashi, Y., Wang, Q., Liu, Q., Du, X., Zhang, H., Sato, N., Greene, M.I. Oncogene (2006) [Pubmed]
  20. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. Adriani, M., Martinez-Mir, A., Fusco, F., Busiello, R., Frank, J., Telese, S., Matrecano, E., Ursini, M.V., Christiano, A.M., Pignata, C. Ann. Hum. Genet. (2004) [Pubmed]
  21. Resistance of tumor interstitial pressure to the penetration of intraperitoneally delivered antibodies into metastatic ovarian tumors. Flessner, M.F., Choi, J., Credit, K., Deverkadra, R., Henderson, K. Clin. Cancer Res. (2005) [Pubmed]
  22. T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS. Ghasemlou, N., Jeong, S.Y., Lacroix, S., David, S. Glia (2007) [Pubmed]
  23. Underexpression of transcriptional regulators is common in metastatic breast cancer cells overexpressing Bcl-xL. Méndez, O., Martín, B., Sanz, R., Aragüés, R., Moreno, V., Oliva, B., Stresing, V., Sierra, A. Carcinogenesis (2006) [Pubmed]
  24. Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. Zhang, X., Chen, Z.G., Choe, M.S., Lin, Y., Sun, S.Y., Wieand, H.S., Shin, H.J., Chen, A., Khuri, F.R., Shin, D.M. Clin. Cancer Res. (2005) [Pubmed]
  25. Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases. Vallejo, M., Castro, M.A., Medarde, M., Macias, R.I., Romero, M.R., El-Mir, M.Y., Monte, M.J., Briz, O., Serrano, M.A., Marin, J.J. Biochem. Pharmacol. (2007) [Pubmed]
  26. Inhibition of proliferation of PC-3 human prostate cancer by antagonists of growth hormone-releasing hormone: lack of correlation with the levels of serum IGF-I and expression of tumoral IGF-II and vascular endothelial growth factor. Plonowski, A., Schally, A.V., Letsch, M., Krupa, M., Hebert, F., Busto, R., Groot, K., Varga, J.L. Prostate (2002) [Pubmed]
  27. Iron withdrawal strategies fail to prevent the growth of SiHa-induced tumors in mice. Simonart, T., Boelaert, J.R., Andrei, G., Clercq, E.D., Snoeck, R. Gynecol. Oncol. (2003) [Pubmed]
  28. PET radioimmunoscintigraphy of renal cell cancer using 89Zr-labeled cG250 monoclonal antibody in nude rats. Brouwers, A., Verel, I., Van Eerd, J., Visser, G., Steffens, M., Oosterwijk, E., Corstens, F., Oyen, W., Van Dongen, G., Boerman, O. Cancer Biother. Radiopharm. (2004) [Pubmed]
  29. Effective inhibition of experimental human ovarian cancers with a targeted cytotoxic bombesin analogue AN-215. Engel, J.B., Keller, G., Schally, A.V., Halmos, G., Hammann, B., Nagy, A. Clin. Cancer Res. (2005) [Pubmed]
  30. Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis. Weppler, S.A., Krause, M., Zyromska, A., Lambin, P., Baumann, M., Wouters, B.G. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2007) [Pubmed]
  31. Endogenous anti-tumor antibody responses in nude mice. Stigbrand, T., Ullén, A., Sandström, P., Rathsman, S., Rossi Norrlund, R., Arlestig, L., Riklund Ahlström, K., Hietala, S.O. Cancer (1997) [Pubmed]
  32. Advantage of yttrium-90-labeled over iodine-131-labeled monoclonal antibodies in the treatment of a human lung carcinoma xenograft. Stein, R., Chen, S., Haim, S., Goldenberg, D.M. Cancer (1997) [Pubmed]
  33. Effect of Ascorbic Acid, Lysine, Proline, and Green Tea Extract on Human Osteosarcoma Cell Line MNNG-HOS Xenografts in Nude Mice: Evaluation of Tumor Growth and Immunohistochemistry. Roomi, M.W., Ivanov, V., Kalinovsky, T., Niedzwiecki, A., Rath, M. Med. Oncol. (2006) [Pubmed]
WikiGenes - Universities