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Gene Review

SRGN  -  serglycin

Homo sapiens

Synonyms: Hematopoietic proteoglycan core protein, P.PG, PPG, PRG, PRG1, ...
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Disease relevance of SRGN


Psychiatry related information on SRGN


High impact information on SRGN

  • Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation [6].
  • Contrary to the view that PFN acts as a gateway for granzymes through the plasma membrane, monomeric PFN and, strikingly, PFN-SG complexes were shown to mediate cytosolic delivery of macromolecular GrB-SG without producing detectable plasma membrane pores [6].
  • These results indicate that granule-mediated apoptosis represents a phenomenon whereby the target cell perceives granule contents as a multimeric complex consisting of SG, PFN, and granzymes, which are, respectively, the scaffold, translocator, and targeting/informational components of this modular delivery system [6].
  • Recent evidence indicates that the physiological apoptosis-inducing form is a multi-component macro-complex consisting of cationic granule proteins non-covalently linked to the chondroitin-sulfate proteoglycan, serglycin [7].
  • PPG arose in an early ancestor of anthropoids (catarrhines and platyrrhines), and GGTA1 itself became an unprocessed pseudogene in the late catarrhine stem lineage [8].

Chemical compound and disease context of SRGN


Biological context of SRGN


Anatomical context of SRGN


Associations of SRGN with chemical compounds


Physical interactions of SRGN


Regulatory relationships of SRGN


Other interactions of SRGN


Analytical, diagnostic and therapeutic context of SRGN


  1. Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Hamilton, J.A., Callaghan, M.J., Sutherland, R.L., Watts, C.K. Mol. Endocrinol. (1997) [Pubmed]
  2. DNase I hypersensitivity patterns of the serglycin proteoglycan gene in resting and phorbol 12-myristate 13-acetate-stimulated human erythroleukemia (HEL), CHRF 288-11, and HL-60 cells compared with neutrophils and human umbilical vein endothelial cells. Castronuevo, P., Thornton, M.A., McCarthy, L.E., Klimas, J., Schick, B.P. J. Biol. Chem. (2003) [Pubmed]
  3. Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases. Omtvedt, L.A., Kolset, S.O., Thoen, J., Førre, Y., Gill, M.R. Scand. J. Rheumatol. (2001) [Pubmed]
  4. Processing of macromolecular heparin by heparanase. Gong, F., Jemth, P., Escobar Galvis, M.L., Vlodavsky, I., Horner, A., Lindahl, U., Li, J.P. J. Biol. Chem. (2003) [Pubmed]
  5. Leuprolide acetate suppresses pedophilic urges and arousability. Schober, J.M., Kuhn, P.J., Kovacs, P.G., Earle, J.H., Byrne, P.M., Fries, R.A. Archives of sexual behavior. (2005) [Pubmed]
  6. Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation. Metkar, S.S., Wang, B., Aguilar-Santelises, M., Raja, S.M., Uhlin-Hansen, L., Podack, E., Trapani, J.A., Froelich, C.J. Immunity (2002) [Pubmed]
  7. Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism. Raja, S.M., Metkar, S.S., Froelich, C.J. Curr. Opin. Immunol. (2003) [Pubmed]
  8. Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Koike, C., Uddin, M., Wildman, D.E., Gray, E.A., Trucco, M., Starzl, T.E., Goodman, M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  9. Expression of mRNA for serglycin core protein and other platelet alpha granule proteins is increased in human erythroleukemia cells by phorbol myristate acetate. Schick, B.P., Thornton, R.D. Leukemia (1993) [Pubmed]
  10. Relationship between P-glycoprotein positivity, doxorubicin binding ability and histologic response to chemotherapy in osteosarcomas. Kusuzaki, K., Hirata, M., Takeshita, H., Murata, H., Hashiguchi, S., Ashihara, T., Hirasawa, Y. Cancer Lett. (1999) [Pubmed]
  11. Role of cholinergic nervous system in healing neuropathic lesions: preliminary studies and prospective, double-blinded, placebo-controlled studies. Dillon, R.S. Angiology. (1991) [Pubmed]
  12. Phosphorothioate oligonucleotides cause degradation of secretory but not intracellular serglycin proteoglycan core protein in a sequence-independent manner in human megakaryocytic tumor cells. Schick, B.P., Eras, J.L., Mintz, P.S. Antisense Res. Dev. (1995) [Pubmed]
  13. The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Veugelers, K., Motyka, B., Frantz, C., Shostak, I., Sawchuk, T., Bleackley, R.C. Blood (2004) [Pubmed]
  14. The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells. Humphries, D.E., Nicodemus, C.F., Schiller, V., Stevens, R.L. J. Biol. Chem. (1992) [Pubmed]
  15. Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin. Raja, S.M., Wang, B., Dantuluri, M., Desai, U.R., Demeler, B., Spiegel, K., Metkar, S.S., Froelich, C.J. J. Biol. Chem. (2002) [Pubmed]
  16. Serglycin-binding proteins in activated macrophages and platelets. Kolset, S.O., Mann, D.M., Uhlin-Hansen, L., Winberg, J.O., Ruoslahti, E. J. Leukoc. Biol. (1996) [Pubmed]
  17. Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells. Schick, B.P., Gradowski, J.F., San Antonio, J.D. Blood (2001) [Pubmed]
  18. Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells. Toyama-Sorimachi, N., Kitamura, F., Habuchi, H., Tobita, Y., Kimata, K., Miyasaka, M. J. Biol. Chem. (1997) [Pubmed]
  19. Stimulation of serglycin and CD44 mRNA expression in endothelial cells exposed to TNF-alpha and IL-1alpha. Kulseth, M.A., Kolset, S.O., Ranheim, T. Biochim. Biophys. Acta (1999) [Pubmed]
  20. Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes. Schick, B.P., Jacoby, J.A. J. Cell. Physiol. (1995) [Pubmed]
  21. Proteoglycan metabolism in normal and inflammatory human macrophages. Uhlin-Hansen, L., Wik, T., Kjellén, L., Berg, E., Forsdahl, F., Kolset, S.O. Blood (1993) [Pubmed]
  22. Serglycin Is the Major Secreted Proteoglycan in Macrophages and Has a Role in the Regulation of Macrophage Tumor Necrosis Factor-{alpha} Secretion in Response to Lipopolysaccharide. Zernichow, L., Abrink, M., Hallgren, J., Grujic, M., Pejler, G., Kolset, S.O. J. Biol. Chem. (2006) [Pubmed]
  23. Localization of serglycin in human neutrophil granulocytes and their precursors. Niemann, C.U., Cowland, J.B., Klausen, P., Askaa, J., Calafat, J., Borregaard, N. J. Leukoc. Biol. (2004) [Pubmed]
  24. StatPal II pH and Blood Gas Analysis System evaluated. Wong, R.J., Mahoney, J.J., Harvey, J.A., Van Kessel, A.L. Clin. Chem. (1994) [Pubmed]
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