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Gene Review

RENBP  -  renin binding protein

Homo sapiens

Synonyms: AGE, GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase, N-acylglucosamine 2-epimerase, RBP, ...
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Disease relevance of RENBP

  • In the present study, we have expressed human RnBP in Escherichia coli JM 109 cells under the transcriptional control of taq promoter and purified it by conventional column chromatographies [1].
  • The data do not exclude a role of RnBP in essential hypertension [2].
  • A fragment of the human RnBP gene (nucleotides -739 to +244) linked to the chloramphenicol acetyltransferase gene was transfected into human Wilms' tumor G401 and mouse L929 cells [3].
  • Its closest homologue, CUG-binding protein (CUG-bp), is a human RBP that has been implicated in the disease myotonic dystrophy and binds CUG repeats in the 3' untranslated region (UTR) of the mRNA for myotonic dystrophy protein kinase (DMPK) [7] [8] [4].
  • None of the patients with tumour demonstrated any indication of hepatic metastases pre-operatively or at the time of laparotomy but, as a group, had lower pre-operative concentrations of RBP (p < 0.001) and pre-albumin (p < 0.01) than patients with no tumour load [5].

High impact information on RENBP

  • A technique to detect RNA-binding proteins (RBP) involving hybridization of RNA probe to proteins transferred to a membrane was used to study RBP in different mammalian cells and in cells after genotoxic stress [6].
  • The expression of these RBP varied substantially in nine different human and hamster cell lines, with no detectable RBP in two human myeloid lines [6].
  • We have examined the affinity of two recently synthesized flavin analogs for the isoalloxazine binding site of riboflavin-binding protein (RBP) [7].
  • Herein, a molecular genetic approach was employed to investigate if RnBP might affect renin, prorenin and/or blood pressure levels [2].
  • The complete genomic structure of the RnBP gene, including the identified repetitive sequence elements, provides an essential tool for further studies of the RnBP gene in hypertensive patients with a different genetic background [2].

Chemical compound and disease context of RENBP

  • To identify the active site residue(s), we have constructed ten cysteine residue mutants (C41S, C66S, C104S, C125S, C210S, C239S, C302S, C380S, C386S, and C390S) for human GlcNAc 2-epimerase and expressed them in Escherichia coli cells [8].
  • To further investigate the relationship between structure and function of recombinant human (rh) RnBP as a GlcNAc 2-epimerase, we have constructed several C-terminal deletion and multi-cysteine/serine mutants of rhGlcNAc 2-epimerase and expressed them in Escherichia coli cells [9].
  • The serum and cutaneous concentrations of beta-carotene and vitamin A and the serum concentrations of retinal-binding protein (RBP) and prealbumin were investigated in ten patients with chronic renal failure [10].
  • Recently, the N-acylglucosamine 2-epimerase (AGE) gene from porcine kidney was cloned in E. coli, and a strain with a high AGE expression level was constructed for practical applications, which enabled the complete enzymatic synthesis of NeuAc with a high conversion rate from the substrates, namely, N-acetylglucosamine and pyruvate [11].
  • By using the affinity purified antibody against RBP obtained from the urine of the patients with cadmium poisoning (Itai-Itai disease), the immunoreactive substances were located by light microscopy in the proximal tubules of the human kidney [12].

Biological context of RENBP


Anatomical context of RENBP


Associations of RENBP with chemical compounds


Regulatory relationships of RENBP


Other interactions of RENBP


Analytical, diagnostic and therapeutic context of RENBP


  1. Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase. Takahashi, S., Takahashi, K., Kaneko, T., Ogasawara, H., Shindo, S., Kobayashi, M. J. Biochem. (1999) [Pubmed]
  2. Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males. Knöll, A., Schunkert, H., Reichwald, K., Danser, A.H., Bauer, D., Platzer, M., Stein, G., Rosenthal, A. Hum. Mol. Genet. (1997) [Pubmed]
  3. The human gene for renin-binding protein. Takahashi, S., Inoue, H., Miyake, Y. J. Biol. Chem. (1992) [Pubmed]
  4. ETR-1, a homologue of a protein linked to myotonic dystrophy, is essential for muscle development in Caenorhabditis elegans. Milne, C.A., Hodgkin, J. Curr. Biol. (1999) [Pubmed]
  5. Plasma-specific proteins: their response to surgical trauma and tumour load, and modification of this response by post-operative metabolic support. Broom, J., Casson, E., Morison, I., Simpson, W.G. Clinical nutrition (Edinburgh, Scotland) (1991) [Pubmed]
  6. Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents. Carrier, F., Gatignol, A., Hollander, M.C., Jeang, K.T., Fornace, A.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Use of riboflavin-binding protein to investigate steric and electronic relationships in flavin analogs and models. Wessiak, A., Schopfer, L.M., Yuan, L.C., Bruice, T.C., Massey, V. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  8. Identification of cysteine-380 as the essential residue for the human N-acetyl-D-glucosamine 2-epimerase (renin binding protein). Takahashi, S., Takahashi, K., Kaneko, T., Ogasawara, H., Shindo, S., Saito, K., Kobayashi, M. J. Biochem. (1999) [Pubmed]
  9. Identification of functionally important cysteine residues of the human renin-binding protein as the enzyme N-acetyl-D-glucosamine 2-epimerase. Takahashi, S., Takahashi, K., Kaneko, T., Ogasawara, H., Shindo, S., Saito, K., Kawamura, Y. J. Biochem. (2001) [Pubmed]
  10. Skin content and plasma transport of vitamin A and beta-carotene in chronic renal failure. Vahlquist, A., Berne, B., Berne, C. Eur. J. Clin. Invest. (1982) [Pubmed]
  11. Why is sialic acid attracting interest now? Complete enzymatic synthesis of sialic acid with N-acylglucosamine 2-epimerase. Maru, I., Ohnishi, J., Ohta, Y., Tsukada, Y. J. Biosci. Bioeng. (2002) [Pubmed]
  12. Immunocytochemical demonstration of retinol-binding protein in the lysosomes of the proximal tubules of the human kidney. Usuda, N., Kameko, M., Kanai, M., Nagata, T. Histochemistry (1983) [Pubmed]
  13. Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray. Lapteva, N., Nieda, M., Ando, Y., Ide, K., Hatta-Ohashi, Y., Dymshits, G., Ishikawa, Y., Juji, T., Tokunaga, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  14. Properties of renin-binding protein. Murakami, K., Hirose, S., Chino, S., Ueno, N., Miyazaki, H. Clinical and experimental hypertension. Part A, Theory and practice. (1982) [Pubmed]
  15. A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase. Stäsche, R., Hinderlich, S., Weise, C., Effertz, K., Lucka, L., Moormann, P., Reutter, W. J. Biol. Chem. (1997) [Pubmed]
  16. Leucine zipper motif in porcine renin-binding protein (RnBP) and its relationship to the formation of an RnBP-renin heterodimer and an RnBP homodimer. Inoue, H., Takahashi, S., Fukui, K., Miyake, Y. J. Biol. Chem. (1991) [Pubmed]
  17. Biosynthesis of a renin binding protein. Fukoshi, K., Inoue, H., Takahashi, S., Miyake, Y. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  18. Evidence for a local renin angiotensin system in primary cultured human preadipocytes. Schling, P., Mallow, H., Trindl, A., Löffler, G. Int. J. Obes. Relat. Metab. Disord. (1999) [Pubmed]
  19. Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein). Takahashi, S., Kumagai, M., Shindo, S., Saito, K., Kawamura, Y. J. Biochem. (2000) [Pubmed]
  20. Effects of Nucleotides on the Interaction of Renin with GlcNAc 2-Epimerase (Renin Binding Protein, RnBP). Takahashi, S., Hori, K., Ogasawara, H., Hiwatashi, K., Sugiyama, T. J. Biochem. (2006) [Pubmed]
  21. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA. Chang, D.Y., Nelson, B., Bilyeu, T., Hsu, K., Darlington, G.J., Maraia, R.J. Mol. Cell. Biol. (1994) [Pubmed]
  22. Comparison of the periplasmic receptors for L-arabinose, D-glucose/D-galactose, and D-ribose. Structural and Functional Similarity. Vyas, N.K., Vyas, M.N., Quiocho, F.A. J. Biol. Chem. (1991) [Pubmed]
  23. Binding study of riboflavin-binding protein with riboflavin and its analogues by differential scanning calorimetry. Wasylewski, M. J. Protein Chem. (2000) [Pubmed]
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