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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Fatal Outcome

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Disease relevance of Fatal Outcome


High impact information on Fatal Outcome


Chemical compound and disease context of Fatal Outcome


Biological context of Fatal Outcome

  • In patients who did not have a transplant, a fatal outcome was seen for 26/82 (32%), and was associated with late presentation, coma grade, prothrombin time prolongation, metabolic acidosis, and renal dysfunction [16].
  • BACKGROUND: Progress in molecular genetics has led to the identification of point mutations in the transthyretin (TTR) gene in FAP--a dominantly inherited neuropathy with a fatal outcome [17].
  • A significant association (P<.001) was found between fatal outcome and genotype at IL1B (nucleotide position -511) [18].
  • The fatal outcome of K virus infection in infant mice and cytoxan-treated adult mice is related to their inability to mount a prompt antibody response to the virus [19].
  • The following histopathologic features (in order of decreasing significance) were correlated with poor prognosis (recurrency or fatal outcome): less than 50% of the tumor cells heavily positive for S100, presence of mitoses, absence of TTR-positive cells, brain invasion by cell nests, absence of marked stromal edema, and presence of necrotic areas [20].

Anatomical context of Fatal Outcome


Associations of Fatal Outcome with chemical compounds


Gene context of Fatal Outcome

  • A few deviations from the reference sequences were identified; most interestingly being a splice site mutation that was detected in UBE4B/UFD2 in a stage 3 NBL with a fatal outcome [30].
  • We conclude that increased concentrations of cytokines and soluble cytokine receptors represent a normal host response to P. falciparum infections but that excessive secretion of cytokines like IL-6 may predispose to cerebral malaria and a fatal outcome while beta-2-glycoprotein I may protect against a fatal outcome of cerebral malaria [31].
  • CONCLUSIONS: In septic patients, high amounts of circulating IL-8 concentrations correlate with fatal outcome, whereas only low plasma concentrations of IL-8 are present in patients with nonseptic, multiple organ failure [32].
  • Molecular analysis revealed a hitherto undescribed combined pharmacogenetic syndrome, consisting of heterozygosity for the DPD IVS14+1 G > A mutation and UGT1A1 (TA)(6/7) heterozygosity, which probably contributed to the fatal outcome in this patient [33].
  • Notably, primary tumors with intense mRNA signal for TIMP-2 (No = 14) were uniformly associated with a fatal outcome [34].

Analytical, diagnostic and therapeutic context of Fatal Outcome


  1. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Kwiatkowski, D., Hill, A.V., Sambou, I., Twumasi, P., Castracane, J., Manogue, K.R., Cerami, A., Brewster, D.R., Greenwood, B.M. Lancet (1990) [Pubmed]
  2. Arterial and venous thromboembolism with fatal outcome and resistance to activated protein C. Lindblad, B., Svensson, P.J., Dahlbäck, B. Lancet (1994) [Pubmed]
  3. Anti-inflammatory cytokine profile and mortality in febrile patients. van Dissel, J.T., van Langevelde, P., Westendorp, R.G., Kwappenberg, K., Frölich, M. Lancet (1998) [Pubmed]
  4. Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia. Manabe, A., Coustan-Smith, E., Kumagai, M., Behm, F.G., Raimondi, S.C., Pui, C.H., Campana, D. Blood (1994) [Pubmed]
  5. The mutational spectrum of human malignant autosomal recessive osteopetrosis. Sobacchi, C., Frattini, A., Orchard, P., Porras, O., Tezcan, I., Andolina, M., Babul-Hirji, R., Baric, I., Canham, N., Chitayat, D., Dupuis-Girod, S., Ellis, I., Etzioni, A., Fasth, A., Fisher, A., Gerritsen, B., Gulino, V., Horwitz, E., Klamroth, V., Lanino, E., Mirolo, M., Musio, A., Matthijs, G., Nonomaya, S., Notarangelo, L.D., Ochs, H.D., Superti Furga, A., Valiaho, J., van Hove, J.L., Vihinen, M., Vujic, D., Vezzoni, P., Villa, A. Hum. Mol. Genet. (2001) [Pubmed]
  6. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. Sampson, H.A., Mendelson, L., Rosen, J.P. N. Engl. J. Med. (1992) [Pubmed]
  7. Treatment of severe chloroquine poisoning. Riou, B., Barriot, P., Rimailho, A., Baud, F.J. N. Engl. J. Med. (1988) [Pubmed]
  8. Prevention of hepatocellular carcinoma in patients with chronic active hepatitis C and cirrhosis. Nishiguchi, S., Shiomi, S., Nakatani, S., Takeda, T., Fukuda, K., Tamori, A., Habu, D., Tanaka, T. Lancet (2001) [Pubmed]
  9. Genetic influence on cytokine production and fatal meningococcal disease. Westendorp, R.G., Langermans, J.A., Huizinga, T.W., Elouali, A.H., Verweij, C.L., Boomsma, D.I., Vandenbroucke, J.P., Vandenbrouke, J.P. Lancet (1997) [Pubmed]
  10. Fatal outcome of pyruvate loading test in child with restrictive cardiomyopathy. Matthys, D., Van Coster, R., Verhaaren, H. Lancet (1991) [Pubmed]
  11. Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis. Hack, C.E., Nuijens, J.H., Felt-Bersma, R.J., Schreuder, W.O., Eerenberg-Belmer, A.J., Paardekooper, J., Bronsveld, W., Thijs, L.G. Am. J. Med. (1989) [Pubmed]
  12. Fulminant hepatitis and fatal toxic epidermal necrolysis (Lyell disease) coincident with clarithromycin administration in an alcoholic patient receiving disulfiram therapy. Masiá, M., Gutiérrez, F., Jimeno, A., Navarro, A., Borrás, J., Matarredona, J., Martín-Hidalgo, A. Arch. Intern. Med. (2002) [Pubmed]
  13. The clinical spectrum of renal cholesterol embolization. Smith, M.C., Ghose, M.K., Henry, A.R. Am. J. Med. (1981) [Pubmed]
  14. Endotoxaemia and complement activation in acute pancreatitis in man. Foulis, A.K., Murray, W.R., Galloway, D., McCartney, A.C., Lang, E., Veitch, J., Whaley, K. Gut (1982) [Pubmed]
  15. Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B. INTERPRED Trial Group. Krogsgaard, K., Marcellin, P., Trepo, C., Berthelot, P., Sanchez-Tapias, J.M., Bassendine, M., Tran, A., Ouzan, D., Ring-Larsen, H., Lindberg, J., Enriquez, J., Benhamou, J.P., Bindslev, N. J. Hepatol. (1996) [Pubmed]
  16. Serious paracetamol poisoning and the results of liver transplantation. Mutimer, D.J., Ayres, R.C., Neuberger, J.M., Davies, M.H., Holguin, J., Buckels, J.A., Mayer, A.D., McMaster, P., Elias, E. Gut (1994) [Pubmed]
  17. Genotypic-phenotypic variations in a series of 65 patients with familial amyloid polyneuropathy. Planté-Bordeneuve, V., Lalu, T., Misrahi, M., Reilly, M.M., Adams, D., Lacroix, C., Said, G. Neurology (1998) [Pubmed]
  18. An interleukin-1 genotype is associated with fatal outcome of meningococcal disease. Read, R.C., Camp, N.J., di Giovine, F.S., Borrow, R., Kaczmarski, E.B., Chaudhary, A.G., Fox, A.J., Duff, G.W. J. Infect. Dis. (2000) [Pubmed]
  19. Pathogenesis of K papovavirus infection in athymic nude mice. Mokhtarian, F., Shah, K.V. Infect. Immun. (1983) [Pubmed]
  20. Clinicopathologic correlations in epithelial choroid plexus neoplasms: a study of 52 cases. Paulus, W., Jänisch, W. Acta Neuropathol. (1990) [Pubmed]
  21. High-dose dexamethasone in quinine-treated patients with cerebral malaria: a double-blind, placebo-controlled trial. Hoffman, S.L., Rustama, D., Punjabi, N.H., Surampaet, B., Sanjaya, B., Dimpudus, A.J., McKee, K.T., Paleologo, F.P., Campbell, J.R., Marwoto, H. J. Infect. Dis. (1988) [Pubmed]
  22. Acute bone marrow aplasia associated with intravenous administration of deferoxamine (desferrioxamine). Sofroniadou, K., Drossou, M., Foundoulaki, L., Konstantopoulos, K., Kyriakoy, D., Zervas, J. Drug safety : an international journal of medical toxicology and drug experience. (1990) [Pubmed]
  23. A case of primary amebic meningoencephalitis in a Nigerian farmer. Lawande, R.V., Macfarlane, J.T., Weir, W.R., Awunor-Renner, C. Am. J. Trop. Med. Hyg. (1980) [Pubmed]
  24. HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, trk, and morphological differentiation with fatal outcome in PC12 cells. Kumano, T., Mutoh, T., Nakagawa, H., Kuriyama, M. Brain Res. (2000) [Pubmed]
  25. Prognostic significance of the evaluation of bronchoalveolar lavage cell populations in patients with HIV-1 infection and pulmonary involvement. Agostini, C., Zambello, R., Trentin, L., Poletti, V., Spiga, L., Gritti, F., Cipriani, A., Salmaso, L., Cadrobbi, P., Semenzato, G. Chest (1991) [Pubmed]
  26. Azathioprine and hepatic venocclusive disease in renal transplant patients. Katzka, D.A., Saul, S.H., Jorkasky, D., Sigal, H., Reynolds, J.C., Soloway, R.D. Gastroenterology (1986) [Pubmed]
  27. The use of tolazoline hydrochloride as a pulmonary vasodilator in potentially fatal episodes of pulmonary vasoconstriction after cardiac surgery in children. Jones, O.D., Shore, D.F., Rigby, M.L., Leijala, M., Scallan, J., Shinebourne, E.A., Lincoln, J.C. Circulation (1981) [Pubmed]
  28. Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy. Yamamoto, A., Takagi, H., Kitamura, D., Tatsuoka, H., Nakano, H., Kawano, H., Kuroyanagi, H., Yahagi, Y., Kobayashi, S., Koizumi, K., Sakai, T., Saito, K., Chiba, T., Kawamura, K., Suzuki, K., Watanabe, T., Mori, H., Shirasawa, T. J. Neurosci. (1998) [Pubmed]
  29. Course and prognosis of 86 episodes of diabetic coma. A five year experience with a uniform schedule of treatment. Keller, U., Berger, W., Ritz, R., Truog, P. Diabetologia (1975) [Pubmed]
  30. Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2. Krona, C., Ejeskär, K., Abel, F., Kogner, P., Bjelke, J., Björk, E., Sjöberg, R.M., Martinsson, T. Oncogene (2003) [Pubmed]
  31. Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria. Jakobsen, P.H., McKay, V., Morris-Jones, S.D., McGuire, W., van Hensbroek, M.B., Meisner, S., Bendtzen, K., Schousboe, I., Bygbjerg, I.C., Greenwood, B.M. Infect. Immun. (1994) [Pubmed]
  32. Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin. Marty, C., Misset, B., Tamion, F., Fitting, C., Carlet, J., Cavaillon, J.M. Crit. Care Med. (1994) [Pubmed]
  33. 5-Fluorouracil/irinotecan induced lethal toxicity as a result of a combined pharmacogenetic syndrome: report of a case. Steiner, M., Seule, M., Steiner, B., Bauer, I., Freund, M., Köhne, C.H., Schuff-Werner, P. J. Clin. Pathol. (2005) [Pubmed]
  34. High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma. Davidson, B., Goldberg, I., Gotlieb, W.H., Kopolovic, J., Ben-Baruch, G., Nesland, J.M., Berner, A., Bryne, M., Reich, R. Clin. Exp. Metastasis (1999) [Pubmed]
  35. Hemophagocytosis: a potential complication in small bowel transplantation. Muiesan, P., Dhawan, A., Wendon, J., Mufti, G.J., O'Grady, J., Rela, M., Heaton, N.D. Transplantation (1998) [Pubmed]
  36. Convulsions due to increased permeability of the blood-brain barrier in experimental cerebral malaria can be prevented by splenectomy or anti-T cell treatment. Hermsen, C.C., Mommers, E., van de Wiel, T., Sauerwein, R.W., Eling, W.M. J. Infect. Dis. (1998) [Pubmed]
  37. Cerebral mucormycosis in two cases of acquired immunodeficiency syndrome. Cuadrado, L.M., Guerrero, A., Garcia Asenjo, J.A., Martin, F., Palau, E., Garcia Urra, D. Arch. Neurol. (1988) [Pubmed]
  38. Absence of caspase 3 activation in neoplastic cells of nasopharyngeal carcinoma biopsies predicts rapid fatal outcome. Oudejans, J.J., Harijadi, A., Cillessen, S.A., Busson, P., Tan, I.B., Dukers, D.F., Vos, W., Hariwiyanto, B., Middeldorp, J., Meijer, C.J. Mod. Pathol. (2005) [Pubmed]
  39. Factors associated with mortality of myxedema coma: report of eight cases and literature survey. Yamamoto, T., Fukuyama, J., Fujiyoshi, A. Thyroid (1999) [Pubmed]
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