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MeSH Review

Mice, Inbred DBA

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Disease relevance of Mice, Inbred DBA


Psychiatry related information on Mice, Inbred DBA


High impact information on Mice, Inbred DBA

  • Transplantation of H57-597-treated B10.BR T cells into irradiated AKR or DBA mice resulted in protection from GVHD, which was otherwise lethal in transplanted recipients receiving untreated T cells [8].
  • By S1 nuclease mapping and comparison of the sequence of cDNA clones representing these mRNAs in DBA/LiHa and C57BL/6J mice, we determined that this size difference or polymorphism observed in the largest mRNA is the result of the insertion of a member of the B1 family of repeats into the 3' untranslated region of the RP2 gene in DBA mice [9].
  • In particular, depletions of hepatic GSH, NADH, NADPH and ATP coupled with significant increases in oxidized glutathione were observed in the DBA mouse [10].
  • Antitumor activity of DL-threo-beta-fluoroasparagine against human leukemia cells in culture and L1210 cells in DBA mice [11].
  • At 14 to 15 days of gestation, DBA mice were randomized to receive LPS (2.4 mg/kg) or vehicle intraperitoneally [12].

Chemical compound and disease context of Mice, Inbred DBA

  • The mean toxicity scores did not show a significant difference when a single exposure (1.0 and 2.0 mg/kg domoic acid) and repeated exposure of the same dose were compared in the DBA mice [13].

Biological context of Mice, Inbred DBA


Anatomical context of Mice, Inbred DBA

  • Although a similar accumulation of P53 was also observed in bone marrow cells from FLV-infected DBA mice treated with TBI, the amount appeared to be parallel to that of mice treated with TBI alone and was much lower than that of FLV- plus TBI-treated C3H mice [19].
  • Nicotine was administered by continuous i.v. infusion through cannulae implanted in the right jugular veins of DBA mice [20].
  • There was a decrease in intracellular chloride and sodium content, and an increase in intracellular potassium content in cerebral cortex, cerebellum, and brainstem from DBA mice at both 21 and 110 days [21].
  • Similarly, nicotine inhibited alpha-[125I]bungarotoxin binding with equal potency in all brain regions of each of the four strains; however, the binding of this ligand was significantly lower in the midbrain and hippocampus of DBA mice than it was in these regions in the other three strains [22].
  • In nominal HCO3(-)-free HEPES-buffered Hanks' balanced salt solution (HEPES HBSS), when the pH of medium (pHo) was maintained at 7.4, the steady-state pHi of cultured astrocytes from DBA mice was 6.98 +/- 0.03, and that from C57 mice was 7.01 +/- 0.03 [23].

Associations of Mice, Inbred DBA with chemical compounds

  • When, however, fasted DBA mice received HCB, they excreted it at rates similar to those of C57 mice fed ad libitum [14].
  • The angiotensinogen concentration in pooled plasma from eight DBA mice was 104.5 ng angiotensin I/mL and was clearly lower than that in Sprague-Dawley rats (772.4 +/- 37.3 ng angiotensin I/mL, n = 4) [24].
  • There are few significant differences in the GABA steady-state levels between 21-day-old seizure-prone DBA mice when compared with seizure-resistant C57 mice [25].
  • In the female DBA mouse cholesterol ester depletion in response to ACTH is maximal [26].
  • TCPOBOP alone induced 100% tumor incidence in DBA mice within 60 weeks [27].

Gene context of Mice, Inbred DBA

  • However, amount of ras p21 in the membrane fraction showed significant differences, with C57BL/6 and BALB/c having 3-5-fold more than NIH Swiss, AKR and DBA mice [28].
  • We have used CD40 knockout (KO) mice and complement C5 deficient mice DBA/2 as islet allograft recipients as well as cobra venom factor (CVF), a complement blocker, treatment [29].
  • In C57 mice the maximum amount of CA II per cell at each dose occurred 24 h after acetazolamide treatment, whereas the amount in DBA mice continued to increase with time and dose up to 5 days [30].
  • Comparative sequence analysis was performed, and protein levels were compared between C57 and DBA mice for Creb1 [31].
  • DBA mice exhibited greater levels of MT-mRNA, mainly for the MT-I isoform, MT-protein content, and number of MT positive cells relative to C57 mice [32].

Analytical, diagnostic and therapeutic context of Mice, Inbred DBA

  • Female DBA mice were implanted with jugular cannulas and infused with saline or various doses of nicotine (0.25, 0.5, 1.0 or 2.0 mg/kg/hr) for 10 days [33].
  • RESULTS: (a) Either cocaine or morphine promoted significant CPP at lower doses in C57 than in DBA mice; (b) only drug-trained C57 mice showed a significant CPP compared with the control group; and (c) only C57 mice showed dose-dependent effects of cocaine on CPP [34].
  • Using thin-layer and gas-liquid chromatography, we analyzed the lipid components of the kidneys from 120-day-old DBA/2FG-pcy (pcy) having PKD as compared to normal DBA/2J (DBA) mice [35].


  1. Correlation between toxicity and effects on intermediary metabolism in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated male C57BL/6J and DBA/2J mice. Weber, L.W., Lebofsky, M., Stahl, B.U., Smith, S., Rozman, K.K. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  2. Chronomodulatory effect of cyclosporine upon survival of DBA mice with L1210 leukemia. Sánchez de la Peña, S., Halberg, E., Halberg, F., Sánchez, E., Cornélissen, G. Chronobiologia. (1986) [Pubmed]
  3. Chronic toxic and carcinogenic effects of cadmium chloride in male DBA/2NCr and NFS/NCr mice: strain-dependent association with tumors of the hematopoietic system, injection site, liver, and lung. Waalkes, M.P., Rehm, S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1994) [Pubmed]
  4. Changes in hepatic enzyme activities related to ethanol metabolism in mice following chronic ethanol administration. Kishimoto, R., Fujiwara, I., Kitayama, S., Goda, K., Nakata, Y. J. Nutr. Sci. Vitaminol. (1995) [Pubmed]
  5. Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes. Ben-David, Y., Lavigueur, A., Cheong, G.Y., Bernstein, A. New Biol. (1990) [Pubmed]
  6. Seizure susceptibility in DBA and C57 mice: the effects of various convulsants. Engstrom, F.L., Woodbury, D.M. Epilepsia (1988) [Pubmed]
  7. Effects of kappa-opioid receptor agonists on locomotor activity and memory processes in mice. Castellano, C., Ammassari-Teule, M., Libri, V., Pavone, F. Polish journal of pharmacology and pharmacy. (1988) [Pubmed]
  8. Treatment of donor mice with an alpha beta T-cell receptor monoclonal antibody induces prolonged T-cell nonresponsiveness and effectively prevents lethal graft-versus-host disease in murine recipients of major histocompatibility complex (MHC)-matched and MHC-mismatched donor marrow grafts. Drobyski, W.R., Majewski, D. Blood (1996) [Pubmed]
  9. Polymorphism in an androgen-regulated mouse gene is the result of the insertion of a B1 repetitive element into the transcription unit. King, D., Snider, L.D., Lingrel, J.B. Mol. Cell. Biol. (1986) [Pubmed]
  10. Hepatic biochemical changes as a result of acute cocaine administration in the mouse. Boyer, C.S., Petersen, D.R. Hepatology (1991) [Pubmed]
  11. Antitumor activity of DL-threo-beta-fluoroasparagine against human leukemia cells in culture and L1210 cells in DBA mice. Stern, A.M., Abeles, R.H., Tashjian, A.H. Cancer Res. (1984) [Pubmed]
  12. Mechanism of acute fetal cardiovascular depression after maternal inflammatory challenge in mouse. Rounioja, S., Räsänen, J., Ojaniemi, M., Glumoff, V., Autio-Harmainen, H., Hallman, M. Am. J. Pathol. (2005) [Pubmed]
  13. Repeated independent exposures to domoic acid do not enhance symptomatic toxicity in outbred or seizure-sensitive inbred mice. Peng, Y.G., Clayton, E.C., Means, L.W., Ramsdell, J.S. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
  14. Adipose tissue content as a modifier of the tissue distribution, biological effects, and excretion of a hexachlorobiphenyl in C57BL/6J and DBA/JBOMf mice. Ahotupa, M., Mäntylä, E. Mol. Pharmacol. (1983) [Pubmed]
  15. Sulfhydryl modification of two nicotinic binding sites in mouse brain. Stitzel, J.A., Campbell, S.M., Collins, A.C., Marks, M.J. J. Neurochem. (1988) [Pubmed]
  16. Pharmacogenetics of cocaine: II. Mesocorticolimbic and striatal dopamine and cocaine receptors in C57BL and DBA mice. Erwin, V.G., Womer, D.E., Campbell, A.D., Jones, B.C. Pharmacogenetics (1993) [Pubmed]
  17. Dissociation of the effect of aminoglutethimide on corticosterone biosynthesis from ataxic and hypothermic effects in DBA and C57 mice. Roberts, A.J., Gallaher, E.J., Keith, L.D. Neuroendocrinology (1993) [Pubmed]
  18. Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains. Ng, G.Y., O'Dowd, B.F., George, S.R. Eur. J. Pharmacol. (1994) [Pubmed]
  19. Friend leukemia virus infection enhances DNA damage-induced apoptosis of hematopoietic cells, causing lethal anemia in C3H hosts. Kitagawa, M., Yamaguchi, S., Hasegawa, M., Tanaka, K., Sado, T., Hirokawa, K., Aizawa, S. J. Virol. (2002) [Pubmed]
  20. Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. Marks, M.J., Stitzel, J.A., Collins, A.C. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  21. Extracellular (36Cl) space, electrolyte, protein, and DNA content in brain of DBA and C57 mice: effects of age. Engstrom, F.L., Kemp, J.W., Chow, S.Y., Woodbury, D.M. Epilepsia (1986) [Pubmed]
  22. Genetics of nicotine response in four inbred strains of mice. Marks, M.J., Burch, J.B., Collins, A.C. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  23. Studies on pH regulatory mechanisms in cultured astrocytes of DBA and C57 mice. Chow, S.Y., Yen-Chow, Y.C., Woodbury, D.M. Epilepsia (1992) [Pubmed]
  24. Hypertension in the transgenic rat TGR(mRen-2)27 may be due to enhanced kinetics of the reaction between mouse renin and rat angiotensinogen. Tokita, Y., Franco-Saenz, R., Reimann, E.M., Mulrow, P.J. Hypertension (1994) [Pubmed]
  25. Age-dependent changes in brain GABA turnover rates in two inbred strains of mice. Ciesielski, L., Simler, S., Clement, J., Mandel, P. J. Neurochem. (1985) [Pubmed]
  26. Strain-dependent gonadal effects upon the response of adrenal cholesterol esters to ACTH in C57BL/10J and DBA/2J mice. Stylianopoulou, F., Clayton, R.B. Endocrinology (1976) [Pubmed]
  27. Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine. Diwan, B.A., Lubet, R.A., Ward, J.M., Hrabie, J.A., Rice, J.M. Carcinogenesis (1992) [Pubmed]
  28. Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254. Ramakrishna, G., Anderson, L.M. Carcinogenesis (1998) [Pubmed]
  29. The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Sánchez-Fueyo, A., Domenig, C., Strom, T.B., Zheng, X.X. Transplantation (2002) [Pubmed]
  30. Induction of new carbonic anhydrase II following treatment with acetazolamide in DBA and C57 mice. Banks, D.A., Anderson, R.E., Woodbury, D.M. Epilepsia (1986) [Pubmed]
  31. Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. Kirstein, S.L., Davidson, K.L., Ehringer, M.A., Sikela, J.M., Erwin, V.G., Tabakoff, B. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  32. Expression of metallothionein protein in the lungs of Wistar rats and C57 and DBA mice exposed to cadmium oxide fumes. McKenna, I.M., Gordon, T., Chen, L.C., Anver, M.R., Waalkes, M.P. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  33. An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment. Pauly, J.R., Marks, M.J., Gross, S.D., Collins, A.C. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  34. Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains. Orsini, C., Bonito-Oliva, A., Conversi, D., Cabib, S. Psychopharmacology (Berl.) (2005) [Pubmed]
  35. Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney disease. Aukema, H.M., Yamaguchi, T., Takahashi, H., Celi, B., Holub, B.J. Lipids (1992) [Pubmed]
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