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Chemical Compound Review

Butylhydroxybutylnitrosamine     N-butyl-N-(4- hydroxybutyl)nitrous amide

Synonyms: CCRIS 836, CHEMBL164923, LS-7237, DSSTox_CID_210, AC1L2ELE, ...
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Disease relevance of Butylhydroxybutylnitrosamine


High impact information on Butylhydroxybutylnitrosamine


Chemical compound and disease context of Butylhydroxybutylnitrosamine


Biological context of Butylhydroxybutylnitrosamine


Anatomical context of Butylhydroxybutylnitrosamine


Associations of Butylhydroxybutylnitrosamine with other chemical compounds


Gene context of Butylhydroxybutylnitrosamine


Analytical, diagnostic and therapeutic context of Butylhydroxybutylnitrosamine


  1. 13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. Grubbs, C.J., Moon, R.C., Squire, R.A., Farrow, G.M., Stinson, S.F., Goodman, D.G., Brown, C.C., Sporn, M.B. Science (1977) [Pubmed]
  2. Comparative carcinogenicity of N-butyl-N-(3-carboxypropyl)-nitrosamine and N-butyl-N-(4-hydroxybutyl)nitrosamine for the urinary bladder of (C57BL/6 X DBA/2)F1 mice. Irving, C.C., Murphy, W.M., Daniel, D.S. J. Natl. Cancer Inst. (1984) [Pubmed]
  3. N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder cancer in C57BL/6 X DBA/2 F1 mice as a useful model for study of chemoprevention of cancer with retinoids. Becci, P.J., Thompson, H.J., Strum, J.M., Brown, C.C., Sporn, M.B., Moon, R.C. Cancer Res. (1981) [Pubmed]
  4. L-ascorbic acid amplification of bladder carcinogenesis promotion by K2CO3. Fukushima, S., Kurata, Y., Hasegawa, R., Asamoto, M., Shibata, M.A., Tamano, S. Cancer Res. (1991) [Pubmed]
  5. Inhibition of urinary bladder cancer by N-(ethyl)-all-trans-retinamide and N-(2-hydroxyethyl)-all-trans-retinamide in rats and mice. Thompson, H.J., Becci, P.J., Grubbs, C.J., Shealy, Y.F., Stanek, E.J., Brown, C.C., Sporn, M.B., Moon, R.C. Cancer Res. (1981) [Pubmed]
  6. L-isoleucine and L-leucine: tumor promoters of bladder cancer in rats. Nishio, Y., Kakizoe, T., Ohtani, M., Sato, S., Sugimura, T., Fukushima, S. Science (1986) [Pubmed]
  7. Chromosomal characteristics and malignancy of urothelial cells from carcinogen-treated rats. Debiec-Rychter, M., Zukowski, K., Wang, C.Y. J. Natl. Cancer Inst. (1989) [Pubmed]
  8. Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Fujita, J., Ohuchi, N., Ito, N., Reynolds, S.H., Yoshida, O., Nakayama, H., Kitamura, Y. J. Natl. Cancer Inst. (1988) [Pubmed]
  9. Aging and urinary bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine. Fukushima, S., Shibata, M., Tamano, S., Ito, N., Suzuki, E., Okada, M. J. Natl. Cancer Inst. (1987) [Pubmed]
  10. Marked reduction in percentage of rosette-forming thymocytes of rats during induction of bladder tumors and restorative effect of thymosin in vitro. Kimura, S., Ozaki, Y., Toyokawa, T., Nishio, S., Maekawa, M., Goldstein, A.L., Kinoshita, Y. J. Natl. Cancer Inst. (1986) [Pubmed]
  11. L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3. Fukushima, S., Imaida, K., Shibata, M.A., Tamano, S., Kurata, Y., Shirai, T. Cancer Res. (1988) [Pubmed]
  12. Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Okajima, E., Denda, A., Ozono, S., Takahama, M., Akai, H., Sasaki, Y., Kitayama, W., Wakabayashi, K., Konishi, Y. Cancer Res. (1998) [Pubmed]
  13. Absence of ras oncogene activation in rat urinary bladder carcinomas induced by N-methyl-N-nitrosourea or N-butyl-N-(4-hydroxybutyl)nitrosamine. Masui, T., Mann, A.M., Macatee, T.L., Okamura, T., Garland, E.M., Smith, R.A., Cohen, S.M. Carcinogenesis (1992) [Pubmed]
  14. Spermidine/spermine N1-acetyltransferase, a new biochemical marker for epithelial proliferation in rat bladder. Matsui-Yuasa, I., Otani, S., Yano, Y., Takada, N., Shibata, M.A., Fukushima, S. Jpn. J. Cancer Res. (1992) [Pubmed]
  15. Immunohistochemically demonstrated variation in expression of cathepsin E between uracil-induced papillomatosis and N-butyl-N-(4-hydroxybutyl)nitrosamine-induced preneoplastic and neoplastic changes in rat urinary bladder. Yamamoto, S., Yonezawa, S., Ichinose, M., Miki, K., Masui, T., Fukushima, S., Inoue, H., Tatematsu, M. Virchows Arch. (1996) [Pubmed]
  16. High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Ozaki, K., Sukata, T., Yamamoto, S., Uwagawa, S., Seki, T., Kawasaki, H., Yoshitake, A., Wanibuchi, H., Koide, A., Mori, Y., Fukushima, S. Cancer Res. (1998) [Pubmed]
  17. Significant overexpression of metallothionein and cyclin D1 and apoptosis in the early process of rat urinary bladder carcinogenesis induced by treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium L-ascorbate. Takaba, K., Saeki, K., Suzuki, K., Wanibuchi, H., Fukushima, S. Carcinogenesis (2000) [Pubmed]
  18. The dynamics of the imprinted H19 gene expression in the mouse model of bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Elkin, M., Ayesh, S., Schneider, T., de Groot, N., Hochberg, A., Ariel, I. Carcinogenesis (1998) [Pubmed]
  19. Oncogene expression of FANFT- or BBN-induced rat urothelial cells. Debiec-Rychter, M., Jones, R.F., Zukowski, K., Wang, C.Y. Int. J. Cancer (1990) [Pubmed]
  20. The kinetics of cellular proliferation in rat urinary bladder treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Tsujihashi, H., Matsuda, H., Uejima, S., Akiyama, T., Kurita, T. J. Urol. (1990) [Pubmed]
  21. Thymus lymphocytes in rats during induction of bladder tumors and effects of thymosin fraction 5 in vitro. Wada, S., Ozaki, Y., Nishio, S., Maekawa, M., Kimura, S., Kinoshita, Y. J. Natl. Cancer Inst. (1985) [Pubmed]
  22. Lack of enhancing effect of mucosal regeneration following ulceration of the urinary bladder on N-butyl-N-(4-hydroxybutyl)nitrosamine carcinogenesis in rats. Shirai, T. Cancer Res. (1980) [Pubmed]
  23. Promoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. Hagiwara, A., Tamano, S., Ogiso, T., Asakawa, E., Fukushima, S. Jpn. J. Cancer Res. (1990) [Pubmed]
  24. Thymosin fraction 5 does not influence urinary tract carcinogenesis by phenacetin and N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice. Murai, T., Iwata, H., Mori, S., Hato, F., Kimura, S., Kinoshita, Y., Wada, S., Kishimoto, T., Makino, S., Oohara, T. Oncol. Res. (1995) [Pubmed]
  25. Basement membrane and tumor invasion: ultrastructural observations in the basement membrane of rat bladder with invasive transitional cell carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Zhang, X.H., Takenaka, I. Urol. Res. (1994) [Pubmed]
  26. Trisodium nitriloacetate monohydrate: promoting effect in urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Hiasa, Y., Kitahori, Y., Konishi, N., Shimoyama, T., Miyashiro, A. J. Natl. Cancer Inst. (1985) [Pubmed]
  27. Effect of leupeptin, a protease inhibitor, on induction of bladder tumors in rats by n-butyl-n-(4-hydroxybutyl)nitrosamine. Kakizoe, T., Takayasu, H., Kawachi, T., Sugimura, T., Takeuchi, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  28. Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentration and pH. Fukushima, S., Shibata, M., Shirai, T., Kurata, Y., Tamano, S., Imaida, K. Cancer Res. (1987) [Pubmed]
  29. Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats. Fukushima, S., Shibata, M.A., Shirai, T., Tamano, S., Ito, N. Cancer Res. (1986) [Pubmed]
  30. p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma. Gen, H., Yamamoto, S., Morimura, K., Min, W., Mitsuhashi, M., Murai, T., Mori, S., Hosono, M., Oohara, T., Makino, S., Wanibuchi, H., Fukushima, S. Jpn. J. Cancer Res. (2001) [Pubmed]
  31. Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine in mice. Kondo, Y., Himeno, S., Endo, W., Mita, M., Suzuki, Y., Nemoto, K., Akimoto, M., Lazo, J.S., Imura, N. Carcinogenesis (1999) [Pubmed]
  32. Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Yamamoto, S., Masui, T., Murai, T., Mori, S., Oohara, T., Makino, S., Fukushima, S., Tatematsu, M. Carcinogenesis (1995) [Pubmed]
  33. Agglutination of bladder cells by concanavalin A during the early phase of treatment of rats with N-butyl-N-(4-hydroxybutyl)nitrosamine. Kakizoe, T., Kawachi, T., Sugimura, T. Cancer Res. (1979) [Pubmed]
  34. Reduced expression of the CDK inhibitor p27(KIP1) in rat two-stage bladder carcinogenesis and its association with expression profiles of p21(WAF1/Cip1) and p53. Lee, C.C., Ichihara, T., Yamamoto, S., Wanibuchi, H., Sugimura, K., Wada, S., Kishimoto, T., Fukushima, S. Carcinogenesis (1999) [Pubmed]
  35. Massive apoptotic cell death in chemically induced rat urinary bladder carcinomas following in situ HSVtk electrogene transfer. Shibata, M.A., Horiguchi, T., Morimoto, J., Otsuki, Y. The journal of gene medicine. (2003) [Pubmed]
  36. Effects of intravesical instillation of antitumor chemotherapeutic and immunotherapeutic agents on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Okamura, T., Ohtani, M., Inoue, K., Fukushima, S., Ohtaguro, K., Kakizoe, T. J. Urol. (1987) [Pubmed]
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