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Gene Review

Postn  -  periostin, osteoblast specific factor

Mus musculus

Synonyms: A630052E07Rik, AI747096, OSF-2, Osf2, Osteoblast-specific factor 2, ...
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Disease relevance of Postn

  • periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype [1].
  • We found here that periostin mRNA expression is markedly downregulated in a variety of human cancer cell lines and human lung cancer tissues [2].
  • Human cancer cell lines with reduced endogenous periostin gene expression that were infected with a recombinant retrovirus containing the periostin gene had reduced anchorage-independent growth [2].
  • The establishment of the baculovirus expression system with a high productivity of recombinant OSF-2 (around 40 micrograms/ml at maximum) and its heparin binding properties should allow us to obtain large amounts of rmOSF-2 [3].
  • The data suggest that in insulin-dependent diabetes mellitus the balance between beta cell destruction, associated with intra-islet infiltration, and nondestructive (potential protective) peri-islet insulitis may depend on both the antigens recognized, and the prevailing cytokine environment [4].

Psychiatry related information on Postn

  • Our findings suggest that the time between PN 3 and PN 7 represents a critical period during which elements of the OPL are assembled [5].
  • Mice that were selected for over 108 generations for body weight at the postnatal (PN) day 21 were examined in the open field (OF) test and in the Lashley maze (LM) for their exploratory behavior and spatial learning [6].

High impact information on Postn


Chemical compound and disease context of Postn

  • An alternative explanation for glutamate-mediated injury is hypoxia due to peri-infarct spreading depression-like depolarizations [9].
  • These data demonstrate an active role for periostin in EMT and metastasis that requires cross-talk between integrin and EGFR signaling pathways [10].
  • The proinflammatory and potential neurotoxic cytokine tumor necrosis factor (TNF) is produced by activated CNS resident microglia and infiltrating blood-borne macrophages in infarct and peri-infarct areas following induction of focal cerebral ischemia [11].
  • Reproductive toxicity of gamma-ethyl-gamma-phenyl-butyrolactone, a new anticonvulsant and hypnotic drug, in mice. Fertility and peri- and post-natal studies [12].
  • These preliminary results suggest that peri-operative administration of nafamostat mesilate may prevent metastasis into the liver after surgery for gastrointestinal malignancies [13].

Biological context of Postn


Anatomical context of Postn

  • In the periostin-rich areas of jaw bones, but not in the long bones, portions of AAC-like mineralized layers were often replaced with and/or covered by acellular extrinsic fiber cementum (AEFC)-like tissue [16].
  • Because TGF-beta has dramatic effects on periosteal expansion and the recruitment of osteoblast precursors, this factor was tested for its effects on periostin expression [15].
  • Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta [15].
  • Based on this observation and the fact that other proteins have been called OSF-2, the protein was renamed "periostin." Western blot analysis showed that periostin is a disulfide linked 90 kDa protein secreted by osteoblasts and osteoblast-like cell lines [15].
  • Periostin mRNA is initially present within the E9.5 first branchial arch epithelium and then shifts to underlying ectomesenchyme [17].

Associations of Postn with chemical compounds

  • Tunicamycin treatment of infected cells resulted in a mobility shift of OSF-2 (approximately 90-kDa band) on Western blots [3].
  • These studies indicate that tumorigenic activity of methylated phenanthrenes requires inhibition of dihydrodiol formation at the K-region (9,10-positions) in addition to a bay-region methyl group and a free peri position, both adjacent to an unsubstituted angular ring [18].
  • Odor deprivation and a decrease in functional activity in experimental bulbs was evident from deoxyglucose autoradiographs at PN 21 and PN 30 [19].
  • The generation of peri-infarct spreading depressions and the associated metabolic workload can be suppressed by NMDA and non-NMDA antagonists [9].
  • The expression of osteoblast-specific factor 2 and leukocyte 12/15 lipoxygenase, which are also expressed in LE under the control of P4, were not increased by LIF [20].

Regulatory relationships of Postn

  • Spatiotemporal comparison of the fasciclin-containing secreted adhesion genes, TGFbeta induced clone H3 (betaigH3) and periostin, revealed that they are co-localized within the outflow tract endocardial cushions, but that betaigH3 expression is restricted to the septal cushions within the atrioventricular canal [21].

Other interactions of Postn


Analytical, diagnostic and therapeutic context of Postn


  1. periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype. Rios, H., Koushik, S.V., Wang, H., Wang, J., Zhou, H.M., Lindsley, A., Rogers, R., Chen, Z., Maeda, M., Kruzynska-Frejtag, A., Feng, J.Q., Conway, S.J. Mol. Cell. Biol. (2005) [Pubmed]
  2. Suppression of anchorage-independent growth of human cancer cell lines by the TRIF52/periostin/OSF-2 gene. Yoshioka, N., Fuji, S., Shimakage, M., Kodama, K., Hakura, A., Yutsudo, M., Inoue, H., Nojima, H. Exp. Cell Res. (2002) [Pubmed]
  3. Expression and characterization of murine osteoblast-specific factor 2 (OSF-2) in a baculovirus expression system. Sugiura, T., Takamatsu, H., Kudo, A., Amann, E. Protein Expr. Purif. (1995) [Pubmed]
  4. In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. Healey, D., Ozegbe, P., Arden, S., Chandler, P., Hutton, J., Cooke, A. J. Clin. Invest. (1995) [Pubmed]
  5. Development of the outer retina in the mouse. Sharma, R.K., O'Leary, T.E., Fields, C.M., Johnson, D.A. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  6. Selection for body weight induces differences in exploratory behavior and learning in mice. Wirth-Dzieciołowska, E., Lipska, A., Wesierska, M. Acta neurobiologiae experimentalis. (2005) [Pubmed]
  7. Local regulation of fat metabolism in peripheral nerves. Verheijen, M.H., Chrast, R., Burrola, P., Lemke, G. Genes Dev. (2003) [Pubmed]
  8. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Zhao, Q., Kho, A., Kenney, A.M., Yuk Di, D.I., Kohane, I., Rowitch, D.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Hossmann, K.A. Brain Pathol. (1994) [Pubmed]
  10. Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. Yan, W., Shao, R. J. Biol. Chem. (2006) [Pubmed]
  11. Microglia and macrophages express tumor necrosis factor receptor p75 following middle cerebral artery occlusion in mice. Lambertsen, K.L., Clausen, B.H., Fenger, C., Wulf, H., Owens, T., Dagnaes-Hansen, F., Meldgaard, M., Finsen, B. Neuroscience (2007) [Pubmed]
  12. Reproductive toxicity of gamma-ethyl-gamma-phenyl-butyrolactone, a new anticonvulsant and hypnotic drug, in mice. Fertility and peri- and post-natal studies. Chamorro, G., Vega, F., Madrigal, E., Salazar, M. Arzneimittel-Forschung. (2002) [Pubmed]
  13. Inhibitory effect of nafamostat mesilate on metastasis into the livers of mice and on invasion of the extracellular matrix by cancer cells. Kimura, T., Fuchimoto, S., Iwagaki, H., Hizuta, A., Orita, K. J. Int. Med. Res. (1992) [Pubmed]
  14. Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration. Goetsch, S.C., Hawke, T.J., Gallardo, T.D., Richardson, J.A., Garry, D.J. Physiol. Genomics (2003) [Pubmed]
  15. Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. Horiuchi, K., Amizuka, N., Takeshita, S., Takamatsu, H., Katsuura, M., Ozawa, H., Toyama, Y., Bonewald, L.F., Kudo, A. J. Bone Miner. Res. (1999) [Pubmed]
  16. Formation of acellular cementum-like layers, with and without extrinsic fiber insertion, along inert bone surfaces of aging c-Src gene knockout mice. Baba, O., Miyata, A., Abe, T., Shibata, S., Nakano, Y., Terashima, T., Oda, T., Kudo, A., Takano, Y. Eur. J. Oral Sci. (2006) [Pubmed]
  17. Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction. Kruzynska-Frejtag, A., Wang, J., Maeda, M., Rogers, R., Krug, E., Hoffman, S., Markwald, R.R., Conway, S.J. Dev. Dyn. (2004) [Pubmed]
  18. Tumor-initiating activity and metabolism of polymethylated phenanthrenes. LaVoie, E.J., Bedenko, V., Tulley-Freiler, L., Hoffmann, D. Cancer Res. (1982) [Pubmed]
  19. Effects of sensory deprivation on the developing mouse olfactory system: a light and electron microscopic, morphometric analysis. Benson, T.E., Ryugo, D.K., Hinds, J.W. J. Neurosci. (1984) [Pubmed]
  20. Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation. Sherwin, J.R., Freeman, T.C., Stephens, R.J., Kimber, S., Smith, A.G., Chambers, I., Smith, S.K., Sharkey, A.M. Mol. Endocrinol. (2004) [Pubmed]
  21. Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis. Lindsley, A., Li, W., Wang, J., Maeda, N., Rogers, R., Conway, S.J. Gene Expr. Patterns (2005) [Pubmed]
  22. Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation. Kruzynska-Frejtag, A., Machnicki, M., Rogers, R., Markwald, R.R., Conway, S.J. Mech. Dev. (2001) [Pubmed]
  23. Cbfa1/osf2 transduced bone marrow stromal cells facilitate bone formation in vitro and in vivo. Zheng, H., Guo, Z., Ma, Q., Jia, H., Dang, G. Calcif. Tissue Int. (2004) [Pubmed]
  24. Vascular injury induces expression of periostin: implications for vascular cell differentiation and migration. Lindner, V., Wang, Q., Conley, B.A., Friesel, R.E., Vary, C.P. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
  25. Periostin is an extracellular matrix protein required for eruption of incisors in mice. Kii, I., Amizuka, N., Minqi, L., Kitajima, S., Saga, Y., Kudo, A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  26. Antibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy. Basadonna, G.P., Auersvald, L., Khuong, C.Q., Zheng, X.X., Kashio, N., Zekzer, D., Minozzo, M., Qian, H., Visser, L., Diepstra, A., Lazarovits, A.I., Poppema, S., Strom, T.B., Rothstein, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. In vivo and in vitro production of IFN-beta and IFN-gamma during graft vs host disease. Cleveland, M.G., Annable, C.R., Klimpel, G.R. J. Immunol. (1988) [Pubmed]
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