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Chemical Compound Review

ANGIOTENSINAMIDE     2-[[1-[2-[[2-[[2-[[2-[[2-[(2- amino-3...

Synonyms: Ipertensina, Hypertensine, NSC-107678, AC1L1LCU, LS-15802, ...
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Disease relevance of Angiotensin amide


High impact information on Angiotensin amide


Chemical compound and disease context of Angiotensin amide


Biological context of Angiotensin amide


Anatomical context of Angiotensin amide


Associations of Angiotensin amide with other chemical compounds

  • These data suggest that O2 induced impairment in activity of angiotensin-converting enzyme at the endothelial membrane level has functionally significant effects on cardiovascular homeostasis, probably via reduced generation of endogenous AII [24].
  • Furthermore, the effect of a non-specific COX inhibitor (sulpyrine), a COX-2-specific inhibitor (NS398), and an Ang receptor antagonist (CS866) on renal function and renal PG contents were evaluated [25].
  • Systolic BP (SBP) and mean arterial pressure (MAP) were significantly lower in spirapril-treated rats, and the dose-response curve to ANGI was shifted to the right.(ABSTRACT TRUNCATED AT 250 WORDS)[26]
  • BK perfusion prevented this deterioration in a concentration-dependent manner, whereas the Ang II receptor antagonist saralasin was only marginally effective [4].
  • 3. Atrial natriuretic peptide caused a dose-dependent increase in FBF both before and after L-NMMA and significantly reduced the plasma concentration of angiotensin (Ang) II [27].

Gene context of Angiotensin amide

  • The combined effects of the elevations in circulating ET-1 and Ang II, as well as the associated ROS production, may contribute to the development of hypertension induced by chronic ET-1 infusion [28].
  • Angiotensin II is a central neurotransmitter acting through AT1 and AT2 receptors [29].
  • The final shaping of AngII signaling depends on cross-talk between nNOS and AngII receptors at both molecular and protein levels [18].
  • Interactions between AT1 and AT2 receptors in uterine arteries from pregnant ewes [30].
  • Furthermore, intrarenal COX isoforms may play differential roles, with COX-1 participating in modulation of renal hemodynamics, and COX-2 contributing to sodium excretion and Ang II formation [25].

Analytical, diagnostic and therapeutic context of Angiotensin amide


  1. Role of AT1 and AT2 receptor subtypes in salt-sensitive hypertension induced by sensory nerve degeneration. Huang, Y., Wang, D.H. J. Hypertens. (2001) [Pubmed]
  2. Chronic AT1 receptor blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effects on cardiac hypertrophy and survival. Bastien, N.R., Juneau, A.V., Ouellette, J., Lambert, C. Cardiovasc. Res. (1999) [Pubmed]
  3. Angiotensinamide in the treatment of probable anaphylaxis to succinylated gelatin (Gelofusine). McKinnon, R.P., Sinclair, C.J. Anaesthesia. (1994) [Pubmed]
  4. Local inhibition of bradykinin degradation in ischemic hearts. Linz, W., Martorana, P.A., Schölkens, B.A. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  5. Valsartan and coronary haemodynamics in early post-myocardial infarction in rats. Gervais, M., Richer, C., Fornes, P., De Gasparo, M., Giudicelli, J.F. Fundamental & clinical pharmacology. (1999) [Pubmed]
  6. AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. AbdAlla, S., Lother, H., Quitterer, U. Nature (2000) [Pubmed]
  7. Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. Hunyady, L., Baukal, A.J., Gaborik, Z., Olivares-Reyes, J.A., Bor, M., Szaszak, M., Lodge, R., Catt, K.J., Balla, T. J. Cell Biol. (2002) [Pubmed]
  8. AT1 and AT2 angiotensin receptor gene expression in human heart failure. Haywood, G.A., Gullestad, L., Katsuya, T., Hutchinson, H.G., Pratt, R.E., Horiuchi, M., Fowler, M.B. Circulation (1997) [Pubmed]
  9. Agonist-induced phosphorylation of the endogenous AT1 angiotensin receptor in bovine adrenal glomerulosa cells. Smith, R.D., Baukal, A.J., Zolyomi, A., Gaborik, Z., Hunyady, L., Sun, L., Zhang, M., Chen, H.C., Catt, K.J. Mol. Endocrinol. (1998) [Pubmed]
  10. Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting. Audoly, L.P., Oliverio, M.I., Coffman, T.M. Trends Endocrinol. Metab. (2000) [Pubmed]
  11. Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes. Cerbai, E., Crucitti, A., Sartiani, L., De Paoli, P., Pino, R., Rodriguez, M.L., Gensini, G., Mugelli, A. Cardiovasc. Res. (2000) [Pubmed]
  12. Time course of inhibition of hypertension by antisense oligonucleotides targeted to AT1 angiotensin receptor mRNA in spontaneously hypertensive rats. Gyurko, R., Tran, D., Phillips, M.I. Am. J. Hypertens. (1997) [Pubmed]
  13. Characteristics of 15,314 hypertensive patients at high coronary risk. The VALUE trial. The Valsartan Antihypertensive Long-term Use Evaluation. Kjeldsen, S.E., Julius, S., Brunner, H., Hansson, L., Henis, M., Ekman, S., Laragh, J., McInnes, G., Smith, B., Weber, M., Zanchetti, A. Blood Press. (2001) [Pubmed]
  14. Effect of acute and chronic captopril infusion on blood pressure in the two-kidney, one clip hypertensive rat. Wallace, E.C., Balmforth, A.J., Morton, J.J. J. Hypertens. (1985) [Pubmed]
  15. Simple and accurate assessment of forward cardiac output by use of 1-(11)C-acetate PET verified in a pig model. Sörensen, J., Ståhle, E., Långström, B., Frostfeldt, G., Wikström, G., Hedenstierna, G. J. Nucl. Med. (2003) [Pubmed]
  16. Bradykinin-induced water intake and brain fos-like immunoreactivity in rats. Rowland, N.E., Fregly, M.J., Cimmerer, A.L. Brain Res. (1995) [Pubmed]
  17. Two distinct pathways in the down-regulation of type-1 angiotension II receptor gene in rat glomerular mesangial cells. Makita, N., Iwai, N., Inagami, T., Badr, K.F. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  18. Heat acclimation affects the neuromodulatory role of AngII and nitric oxide during combined heat and hypohydration stress. Schwimmer, H., Gerstberger, R., Horowitz, M. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  19. Water drinking in rats resulting from intravenous relaxin and its modification by other dipsogenic factors. Sinnayah, P., Burns, P., Wade, J.D., Weisinger, R.S., McKinley, M.J. Endocrinology (1999) [Pubmed]
  20. Sudden pressure elevation can trigger acute muscle cell death of the heart and aorta. Nakamura, M., Tanaka, M., Abe, S., Fujiwara, H. Atherosclerosis (1999) [Pubmed]
  21. Characterization of a membrane glycoprotein having pharmacological and biochemical properties of an AT2 angiotensin II receptor from human myometrium. Lazard, D., Villageois, P., Briend-Sutren, M.M., Cavaillé, F., Bottari, S., Strosberg, A.D., Nahmias, C. Eur. J. Biochem. (1994) [Pubmed]
  22. Effect of losartan on haematology and haemorheology in elderly patients with essential hypertension: a pilot study. Shand, B.I., Gilchrist, N.L., Nicholls, M.G., Bailey, R.R. Journal of human hypertension. (1995) [Pubmed]
  23. Relaxin and drinking in pregnant rats. Hornsby, D.J., Wilson, B.C., Summerlee, A.J. Prog. Brain Res. (2001) [Pubmed]
  24. Hyperoxia-induced converting enzyme insufficiency in conscious rat: cardiovascular effects. Oparil, S., Daise, M., Abrahams, C., Winternitz, S.R., Szidon, J.P. Exp. Lung Res. (1987) [Pubmed]
  25. Distinct role of intrarenal cyclooxygenase-1/2 in chronic unilateral renal ischemia. Tokuyama, H., Hayashi, K., Matsuda, H., Kubota, E., Honda, M., Okubo, K., Ozawa, Y., Saruta, T. Nephron (2002) [Pubmed]
  26. Effect of spirapril on left ventricular hypertrophy due to volume overload in rats. Umemura, K., Zierhut, W., Rudin, M., Novosel, D., Robertson, E., Pedersen, B., Hof, R.P. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
  27. Nitric oxide-mediated vasodilatory effect of atrial natriuretic peptide in forearm vessels of healthy humans. Sugamori, T., Ishibashi, Y., Shimada, T., Sakane, T., Takahashi, N., Ohata, S., Kodani, N., Kunizawa, Y., Inoue, S., Ohta, Y., Nakamura, K., Shimizu, H., Katoh, H., Murakami, Y. Clin. Exp. Pharmacol. Physiol. (2002) [Pubmed]
  28. Olmesartan improves endothelin-induced hypertension and oxidative stress in rats. Yao, L., Kobori, H., Rahman, M., Seth, D.M., Shokoji, T., Fan, Y., Zhang, G.X., Kimura, S., Abe, Y., Nishiyama, A. Hypertens. Res. (2004) [Pubmed]
  29. Effects of losartan on neuroleptic-induced catalepsy in mice. Pires, J.G., Silva, S.R., Futuro-Neto, H.A. Braz. J. Med. Biol. Res. (1996) [Pubmed]
  30. Interactions between AT1 and AT2 receptors in uterine arteries from pregnant ewes. McMullen, J.R., Gibson, K.J., Lumbers, E.R., Burrell, J.H., Wu, J. Eur. J. Pharmacol. (1999) [Pubmed]
  31. Effects of captopril on responses to bradykinin in the hindquarters vascular bed of the rat. Nossaman, B.D., Kaye, A.D., Kang, B., Feng, C.J., Kadowitz, P.J. Peptides (1997) [Pubmed]
  32. Molecular cloning of AT1 angiotensin receptors. Murphy, T.J., Takeuchi, K., Alexander, R.W. Am. J. Hypertens. (1992) [Pubmed]
  33. Effect of the renin response during renin inhibition: oral Ro 42-5892 in normal humans. Camenzind, E., Nussberger, J., Juillerat, L., Munafo, A., Fischli, W., Coassolo, P., van Brummelen, P., Kleinbloesem, C.H., Waeber, B., Brunner, H.R. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  34. Mechanism of captopril-induced drinking. Schiffrin, E.L., Genest, J. Am. J. Physiol. (1982) [Pubmed]
  35. Effect of losartan microinjections into the NTS on the cardiovascular components of chemically evoked reflexes in a rabbit model of acute heart ischemia. Rosário, L.B., Rocha, I., Silva-Carvalho, L. Adv. Exp. Med. Biol. (2003) [Pubmed]
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