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Gene Review

Ifnb1  -  interferon beta 1, fibroblast

Rattus norvegicus

Synonyms: IFN-beta, Ifnb, Interferon beta
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Disease relevance of Ifnb1


High impact information on Ifnb1


Chemical compound and disease context of Ifnb1

  • In view of treatment of MS relapses, the synergistic effects in this study corroborate the use of a combination therapy with high-dose MP and IFN-beta [8].

Biological context of Ifnb1


Anatomical context of Ifnb1

  • From the results of reverse transcription-PCR and cytopathic activity assay, this ORF expressed IFN beta in COS-1 cells [1].
  • In subsequent experiments, the abilities of interferon beta (IFN beta), tumor necrosis factor alpha (TNF alpha), prostaglandin E2 (PGE2), and transforming growth factor beta (TFG beta), alone or in combinations of 2, to modulate tumoricidal activity triggered in BMM phagocytes by IFN gamma or CP, were compared [11].
  • In the present work, we have found that IFN-beta treatment promotes the survival of astrocytes through stimulation of the phosphatidylinositol 3-kinase (PI-3K)/Akt pathway [9].
  • IFN-beta tended to decrease T cell infiltration (46.1 +/- 12.7 cells/mm2) compared to controls (59.2 +/- 18.5 cells/mm2) [8].
  • These data indicate that IFN-beta exerts direct antiinflammatory effects on brain endothelial cells thereby contributing to reduced lesion formation as observed in MS patients [12].

Associations of Ifnb1 with chemical compounds

  • The inhibition of osteoclast formation by FR901228 was abrogated by the addition of IFN-beta-neutralizing Ab [5].
  • In showing that IFN beta and TNF alpha were mostly enhancing and TGF beta mostly suppressive, whereas PGE2 suppressed induction but enhanced expression of tumoricidal activity, our findings provide further support for the concept that these macrophage-derived molecules have a key role in autocrine regulation of macrophage functional activities [11].
  • BBB disruption was ameliorated after IFN-beta but significantly only in combination with MP [8].
  • However, the membrane response to IFN-beta in the subthreshold range was prevented by ZD7288 (a specific blocker of I(h)) but not by Ni2+, carbachol, or bicuculline, pointing to a dependence on an intact I(h) [4].
  • In contrast, COP-1, the phosphodiesterase inhibitors rolipram and pentoxifylline, the cytokines interleukin-10 (IL-10) and interferon-beta (IFN-beta) as well as the steroids beta-estradiol, testosterone, and dehydroepiandrosterone (DHEA) showed no inhibitory effect [13].

Regulatory relationships of Ifnb1

  • Our results show that both IFN-gamma and IFN-beta can induce a state of antiviral resistance in neural cells whereas TNF-alpha is effective only in astrocytes at low m.o.i.; they suggest an antiviral role of cytokines in the immune response to virus infections of the CNS [14].
  • CONCLUSION: KE-758 suppressed LPS induced iNOS gene expression by murine macrophage cells by inhibiting IFN-beta/IRF-1 expression [10].
  • IFN beta stimulates class I weakly and induced class II in one experiment but the effects seen when IFN gamma and IFN beta were used together were additive, not synergistic [15].

Other interactions of Ifnb1


Analytical, diagnostic and therapeutic context of Ifnb1


  1. Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells. Yokoyama, S., Ohishi, N., Shamoto, M., Watanabe, Y., Yagi, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  2. Phagocytosis of neuronal or glial debris by microglial cells: upregulation of MHC class II expression and multinuclear giant cell formation in vitro. Beyer, M., Gimsa, U., Eyüpoglu, I.Y., Hailer, N.P., Nitsch, R. Glia (2000) [Pubmed]
  3. Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro. Malik, O., Compston, D.A., Scolding, N.J. J. Neuroimmunol. (1998) [Pubmed]
  4. Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability. Hadjilambreva, G., Mix, E., Rolfs, A., Müller, J., Strauss, U. J. Neurophysiol. (2005) [Pubmed]
  5. Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta production. Nakamura, T., Kukita, T., Shobuike, T., Nagata, K., Wu, Z., Ogawa, K., Hotokebuchi, T., Kohashi, O., Kukita, A. J. Immunol. (2005) [Pubmed]
  6. Double-stranded RNA-activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells. Lee, J.H., Park, E.J., Kim, O.S., Kim, H.Y., Joe, E.H., Jou, I. Glia (2005) [Pubmed]
  7. Interferons activate the p42/44 mitogen-activated protein kinase and JAK-STAT (Janus kinase-signal transducer and activator transcription factor) signalling pathways in hepatocytes: differential regulation by acute ethanol via a protein kinase C-dependent mechanism. Nguyen, V.A., Chen, J., Hong, F., Ishac, E.J., Gao, B. Biochem. J. (2000) [Pubmed]
  8. Interferon-beta treatment of experimental autoimmune encephalomyelitis leads to rapid nonapoptotic termination of T cell infiltration. Schmidt, J., Stürzebecher, S., Toyka, K.V., Gold, R. J. Neurosci. Res. (2001) [Pubmed]
  9. Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. Barca, O., Ferré, S., Seoane, M., Prieto, J.M., Lema, M., Señarís, R., Arce, V.M. J. Neuroimmunol. (2003) [Pubmed]
  10. KE-298 and its active metabolite KE-758 suppress nitric oxide production by murine macrophage cells and peritoneal cells from rats with adjuvant induced arthritis. Inoue, T., Hamada, Y., Takeshita, K., Fukushima, K., Higaki, M. J. Rheumatol. (2001) [Pubmed]
  11. Modulation of tumoricidal activity, induced in bone-marrow-derived mononuclear phagocytes by interferon gamma or Corynebacterium parvum, by interferon beta, tumor necrosis factor, prostaglandin E2, and transforming growth factor beta. Keller, R., Keist, R., van der Meide, P.H. Int. J. Cancer (1991) [Pubmed]
  12. Interferon-beta directly influences monocyte infiltration into the central nervous system. Floris, S., Ruuls, S.R., Wierinckx, A., van der Pol, S.M., Döpp, E., van der Meide, P.H., Dijkstra, C.D., De Vries, H.E. J. Neuroimmunol. (2002) [Pubmed]
  13. Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells. Lieb, K., Engels, S., Fiebich, B.L. Neurochem. Int. (2003) [Pubmed]
  14. Tumour necrosis factor-alpha, interferon-gamma and interferon-beta exert antiviral activity in nervous tissue cells. Schijns, V.E., Van der Neut, R., Haagmans, B.L., Bar, D.R., Schellekens, H., Horzinek, M.C. J. Gen. Virol. (1991) [Pubmed]
  15. Synergy between interferons and monokines in MHC induction on brain endothelium. Male, D., Pryce, G. Immunol. Lett. (1988) [Pubmed]
  16. Interferon-beta inhibits the expression of metalloproteinases in rat glial cell cultures: implications for multiple sclerosis pathogenesis and treatment. Liuzzi, G.M., Latronico, T., Fasano, A., Carlone, G., Riccio, P. Mult. Scler. (2004) [Pubmed]
  17. Interferon-gamma (IFN-gamma) and IL-4 expressed during mercury-induced membranous nephropathy are toxic for cultured podocytes. Coers, W., Vos, J.T., Van der Meide, P.H., Van der Horst, M.L., Huitema, S., Weening, J.J. Clin. Exp. Immunol. (1995) [Pubmed]
  18. Elevated expression of transforming growth factor betas and the tumor necrosis factor family in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Murata, N., Tsutsumi, M., Nakae, D., Konishi, Y. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2001) [Pubmed]
  19. Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes. Akazawa, Y., Kawaguchi, H., Funahashi, M., Watanabe, Y., Yamaoka, K., Hashida, M., Takakura, Y. Journal of pharmaceutical sciences. (2002) [Pubmed]
  20. Interferon-beta fails to protect in a model of transient focal stroke. Maier, C.M., Yu, F., Nishi, T., Lathrop, S.J., Chan, P.H. Stroke (2006) [Pubmed]
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