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Gene Review

POSTN  -  periostin, osteoblast specific factor

Homo sapiens

Synonyms: OSF-2, OSF2, Osteoblast-specific factor 2, PDLPOSTN, PN, ...
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Disease relevance of POSTN


Psychiatry related information on POSTN


High impact information on POSTN


Chemical compound and disease context of POSTN

  • These data demonstrate an active role for periostin in EMT and metastasis that requires cross-talk between integrin and EGFR signaling pathways [9].

Biological context of POSTN


Anatomical context of POSTN

  • We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells [11].
  • PN is expressed in several normal tissues but not in normal ovaries and has a tendency for higher expression in fetal tissues [3].
  • Furthermore, alpha(V)beta(3) integrin, but not beta(1) integrins, colocalizes to the focal adhesion plaques formed on PN [3].
  • Cells plated on PN form fewer stress fibers and are more motile compared with those plated on fibronectin [3].
  • Although the expression of periostin mRNA was detected in 100% (5/5) of normal bladder tissues, it was not detected in 3 human bladder cancer cell lines examined [4].

Associations of POSTN with chemical compounds

  • OSF-2 has a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain and a C-terminal domain [12].
  • Glutamate receptor agonists, on the other hand, induced NF-kappaB nuclear translocation in the cerebellum of 5 PN mice, which is a stage in which NF-kappaB is not yet endogenously activated [13].
  • In the MObr/y receiving intraperitoneal injections of cupric chloride (CuCl2) on postnatal (PN) days seven and ten, Purkinje cells appeared similar, if not identical, to those of controls at PN day 15 [14].
  • Pup corticosterone was decreased at 2 days postnatal (PN) life [15].
  • At 21 days PN oestradiol in RR and CR and progesterone in RR were reduced; at 70 days PN luteinizing hormone (LH) in all restricted groups was reduced in dioestrus while follicle stimulating hormone (FSH) was unchanged [15].

Other interactions of POSTN

  • The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02-3.01 and OR 1.70, 95%CI 1.04-2.78, respectively) [2].
  • Further, periostin protein was mostly located in the cytoplasma of VSMCs in culture and abundantly secreted into the culture medium (CM) after stimulation with FGF-2, which significantly promoted VSMC migration in vitro [16].
  • In vitro, periostin mRNA expression in cultured VSMCs was stimulated by growth factors (transforming growth factor-beta1 (TGF-beta1), fibroblast growth factors (FGFs), PDGF-BB, and angiotensin II) [16].
  • The resulting expression profile showed that collagen type I and type III were the most abundant genes and that osteogenesis-related proteins, such as SPARC/osteonectin and osteoblast specific factor 2, were highly expressed [17].
  • These aggressive tumors were also characterized by overexpression of the integrin ligand periostin, and in some biopsies also of osteopontin and of the upstream Rac-regulator dedicator of cytokinesis 10 (DOCK10) [18].

Analytical, diagnostic and therapeutic context of POSTN


  1. Leptin concentrations in women in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy. Haffner, S.M., Mykkänen, L., Stern, M.P. Am. J. Epidemiol. (1997) [Pubmed]
  2. Polymorphisms in the KDR and POSTN Genes: Association with Breast Cancer Susceptibility and Prognosis. F??rsti, A., Jin, Q., Altieri, A., Johansson, R., Wagner, K., Enquist, K., Grzybowska, E., Pamula, J., Pekala, W., Hallmans, G., Lenner, P., Hemminki, K. Breast Cancer Res. Treat. (2007) [Pubmed]
  3. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. Gillan, L., Matei, D., Fishman, D.A., Gerbin, C.S., Karlan, B.Y., Chang, D.D. Cancer Res. (2002) [Pubmed]
  4. Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells. Kim, C.J., Yoshioka, N., Tambe, Y., Kushima, R., Okada, Y., Inoue, H. Int. J. Cancer (2005) [Pubmed]
  5. Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Row, B.W., Kheirandish, L., Neville, J.J., Gozal, D. Pediatr. Res. (2002) [Pubmed]
  6. The role of psychological variables in post-chemotherapy nausea: anxiety and expectation. Andrykowski, M.A., Gregg, M.E. Psychosomatic medicine. (1992) [Pubmed]
  7. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Shao, R., Bao, S., Bai, X., Blanchette, C., Anderson, R.M., Dang, T., Gishizky, M.L., Marks, J.R., Wang, X.F. Mol. Cell. Biol. (2004) [Pubmed]
  8. Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Kudo, Y., Ogawa, I., Kitajima, S., Kitagawa, M., Kawai, H., Gaffney, P.M., Miyauchi, M., Takata, T. Cancer Res. (2006) [Pubmed]
  9. Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. Yan, W., Shao, R. J. Biol. Chem. (2006) [Pubmed]
  10. A novel in vivo model to study endochondral bone formation; HIF-1alpha activation and BMP expression. Emans, P.J., Spaapen, F., Surtel, D.A., Reilly, K.M., Cremers, A., van Rhijn, L.W., Bulstra, S.K., Voncken, J.W., Kuijer, R. Bone (2007) [Pubmed]
  11. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. Takayama, G., Arima, K., Kanaji, T., Toda, S., Tanaka, H., Shoji, S., McKenzie, A.N., Nagai, H., Hotokebuchi, T., Izuhara, K. J. Allergy Clin. Immunol. (2006) [Pubmed]
  12. Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Takeshita, S., Kikuno, R., Tezuka, K., Amann, E. Biochem. J. (1993) [Pubmed]
  13. Glutamate-dependent activation of NF-kappaB during mouse cerebellum development. Guerrini, L., Molteni, A., Wirth, T., Kistler, B., Blasi, F. J. Neurosci. (1997) [Pubmed]
  14. Abnormalities of Purkinje cell arborization in brindled mouse cerebellum. A Golgi study. Yamano, T., Suzuki, K. J. Neuropathol. Exp. Neurol. (1985) [Pubmed]
  15. Protein restriction during fetal and neonatal development in the rat alters reproductive function and accelerates reproductive ageing in female progeny. Guzmán, C., Cabrera, R., Cárdenas, M., Larrea, F., Nathanielsz, P.W., Zambrano, E. J. Physiol. (Lond.) (2006) [Pubmed]
  16. Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro. Li, G., Oparil, S., Sanders, J.M., Zhang, L., Dai, M., Chen, L.B., Conway, S.J., McNamara, C.A., Sarembock, I.J. Atherosclerosis (2006) [Pubmed]
  17. Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene. Yamada, S., Murakami, S., Matoba, R., Ozawa, Y., Yokokoji, T., Nakahira, Y., Ikezawa, K., Takayama, S., Matsubara, K., Okada, H. Gene (2001) [Pubmed]
  18. Gene expression in poorly differentiated papillary thyroid carcinomas. Fluge, Ø., Bruland, O., Akslen, L.A., Lillehaug, J.R., Varhaug, J.E. Thyroid (2006) [Pubmed]
  19. Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta(4) integrin and the PI3k pathway. Baril, P., Gangeswaran, R., Mahon, P.C., Caulee, K., Kocher, H.M., Harada, T., Zhu, M., Kalthoff, H., Crnogorac-Jurcevic, T., Lemoine, N.R. Oncogene (2007) [Pubmed]
  20. The paralysé mouse mutant: a new animal model of anterior horn motor neuron degeneration. Houenou, L.J., Blondet, B., Li, L., Murawsky, M., Oppenheim, R.W., Rieger, F. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
  21. Prenatal exposure to betamethasone decreases anxiety in developing rats: hippocampal neuropeptide y as a target molecule. Velísek, L. Neuropsychopharmacology (2006) [Pubmed]
  22. Localization of cholecystokinin binding sites in the adult and developing Brazilian opossum brain. Kuehl-Kovarik, M.C., Ross, L.R., Elmquist, J.K., Jacobson, C.D. J. Comp. Neurol. (1993) [Pubmed]
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