Disease relevance of POSTN

• Subjects were well matched on obesity as assessed by body mass index (kg/m2): PRE = 31.0, POSTY = 29.8, and POSTN = 31 [1].
• Polymorphisms in the KDR and POSTN Genes: Association with Breast Cancer Susceptibility and Prognosis [2].
• We further examined the role of PN in ovarian cancer [3].
• Ovarian cancer cells secrete PN, which can accumulate in malignant ascites of ovarian cancer patients [3].
• Mutational analysis revealed that the C-terminal region of periostin was sufficient to suppress cell invasiveness and metastasis of the cancer cells [4].

Psychiatry related information on POSTN

• Locomotor activity was assessed on PN d 29 and 30 [5].
• Such variability might reflect the influence of psychological factors, such as anxiety and expectations for nausea, on the experience of PN [6].

High impact information on POSTN

• Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression [7].
• Tumor cell lines engineered to overexpress periostin showed a phenotype of accelerated growth and angiogenesis as xenografts in immunocompromised animals [7].
• Here, we identified periostin as an invasion-promoting factor in HNSCC by comparing the gene expression profiles between parent HNSCC cells and a highly invasive clone [8].
• Moreover, periostin-overexpressing cells spontaneously metastasized to cervical lymph nodes and to the lung through their aggressive invasiveness in an orthotopic mouse model of HNSCC [8].
• Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer [8].

Chemical compound and disease context of POSTN

• These data demonstrate an active role for periostin in EMT and metastasis that requires cross-talk between integrin and EGFR signaling pathways [9].

Biological context of POSTN

• Immunohistochemical detection of corresponding gene products, however, revealed the presence of the proteins of TGF-beta(1), BMP-2, -4, and -7, HIF-1alpha, and POSTN within the chondrocytes during chondrogenesis [10].
• Up-regulation of KDR by periostin (POSTN) induces angiogenesis [2].
• We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each gene for further analyses [2].
• A haplotype in the POSTN gene was associated with an increased risk even after correction for multiple comparisons [2].
• Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility [3].

Anatomical context of POSTN

• We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells [11].
• PN is expressed in several normal tissues but not in normal ovaries and has a tendency for higher expression in fetal tissues [3].
• Furthermore, alpha(V)beta(3) integrin, but not beta(1) integrins, colocalizes to the focal adhesion plaques formed on PN [3].
• Cells plated on PN form fewer stress fibers and are more motile compared with those plated on fibronectin [3].
• Although the expression of periostin mRNA was detected in 100% (5/5) of normal bladder tissues, it was not detected in 3 human bladder cancer cell lines examined [4].

Associations of POSTN with chemical compounds

• OSF-2 has a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain and a C-terminal domain [12].
• Glutamate receptor agonists, on the other hand, induced NF-kappaB nuclear translocation in the cerebellum of 5 PN mice, which is a stage in which NF-kappaB is not yet endogenously activated [13].
• In the MObr/y receiving intraperitoneal injections of cupric chloride (CuCl2) on postnatal (PN) days seven and ten, Purkinje cells appeared similar, if not identical, to those of controls at PN day 15 [14].
• Pup corticosterone was decreased at 2 days postnatal (PN) life [15].
• At 21 days PN oestradiol in RR and CR and progesterone in RR were reduced; at 70 days PN luteinizing hormone (LH) in all restricted groups was reduced in dioestrus while follicle stimulating hormone (FSH) was unchanged [15].

Other interactions of POSTN

• The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02-3.01 and OR 1.70, 95%CI 1.04-2.78, respectively) [2].
• Further, periostin protein was mostly located in the cytoplasma of VSMCs in culture and abundantly secreted into the culture medium (CM) after stimulation with FGF-2, which significantly promoted VSMC migration in vitro [16].
• In vitro, periostin mRNA expression in cultured VSMCs was stimulated by growth factors (transforming growth factor-beta1 (TGF-beta1), fibroblast growth factors (FGFs), PDGF-BB, and angiotensin II) [16].
• The resulting expression profile showed that collagen type I and type III were the most abundant genes and that osteogenesis-related proteins, such as SPARC/osteonectin and osteoblast specific factor 2, were highly expressed [17].
• These aggressive tumors were also characterized by overexpression of the integrin ligand periostin, and in some biopsies also of osteopontin and of the upstream Rac-regulator dedicator of cytokinesis 10 (DOCK10) [18].

Analytical, diagnostic and therapeutic context of POSTN

• In our study, to clarify the role of the periostin in human bladder carcinogenesis, we examined the expression of periostin mRNA in normal bladder tissues, bladder cancer tissues and bladder cancer cell lines by Northern blot analysis and RT-PCR analysis [4].
• Using an enzyme-linked immunosorbent assay (ELISA) assay, we show significantly increased levels of periostin in the sera of pancreatic cancer patients compared to non-cancer controls [19].
• Affected (par/par) mice can be first recognized at approximately postnatal day (PN) 7 to 8 and are characterized by their smaller-than-normal body size, a progressive generalized muscle weakness, and lack of coordination [20].
• Using immunohistochemistry, the expression of a powerful anxiolytic molecule neuropeptide Y (NPY) was determined on postnatal day (PN) 20 in the hippocampus and basolateral amygdala (structures related to anxiety and fear) of the offspring [21].
• Receptor autoradiography was performed on coronally sectioned brains of 1 to 60 day postnatal (PN) animals and adults with 125I-Bolton Hunter-CCK-8 as the radioligand [22].

References