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Gene Review

Nr3c2  -  nuclear receptor subfamily 3, group C,...

Mus musculus

Synonyms: MR, Mineralocorticoid receptor, Mlr, Nuclear receptor subfamily 3 group C member 2, aldosterone receptor, ...
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Disease relevance of Nr3c2


Psychiatry related information on Nr3c2

  • These MR-related alterations may participate in the pathogenesis of hippocampal changes observed in ageing, chronic stress and affective disorders [5].
  • For this purpose, the role of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in control of HPA activity was examined during the SHRP and in response to 24 h of maternal deprivation [6].
  • This is the first detailed study of the ontogeny of these two genes and, in combination with previous work on the ontogeny of 11beta-HSD2 and the mineralocorticoid receptor, suggests potential critical periods of glucocorticoid sensitivity during development for several organ systems [7].

High impact information on Nr3c2


Chemical compound and disease context of Nr3c2


Biological context of Nr3c2


Anatomical context of Nr3c2


Associations of Nr3c2 with chemical compounds


Regulatory relationships of Nr3c2


Other interactions of Nr3c2


Analytical, diagnostic and therapeutic context of Nr3c2

  • To understand the role of glucocorticoid and mineralocorticoid signalling during development and in whole animal physiology, we have disrupted the mouse glucocorticoid and mineralocorticoid receptor gene by gene targeting [28].
  • Levels of GR and MR mRNA were examined by in situ hybridization and high-resolution silver emulsion autoradiography [29].
  • Indeed, chromatin immunoprecipitation assays demonstrated that endogenous MR, Ubc9, and SRC-1 were recruited to an endogenous ENaC gene promoter in a largely aldosterone-dependent manner [19].
  • Using a specific polyclonal antiserum raised in rabbit against amino acids 1-23 of the mouse mineralocorticoid receptor (MR) we investigated the developmental profile of MR expression in the murine CNS by immunocytochemistry [30].
  • Immunoprecipitation of the native MR from either partially purified or crude preparations of rat kidney cytosol with hMRsN, followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and silver stain, demonstrated a major protein band with a mol wt of 116 kilodaltons [31].


  1. Induction of the epithelial Na+ channel via glucocorticoids in mineralocorticoid receptor knockout mice. Schulz-Baldes, A., Berger, S., Grahammer, F., Warth, R., Goldschmidt, I., Peters, J., Schütz, G., Greger, R., Bleich, M. Pflugers Arch. (2001) [Pubmed]
  2. The establishment of the long terminal repeat of the mouse mammary tumor virus into CV-1 cells allows a functional analysis of steroid receptors. Couette, B., Le Ricousse, S., Fortin, D., Rafestin-Oblin, M.E., Richard-Foy, H. Biochim. Biophys. Acta (1994) [Pubmed]
  3. Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice. Hubert, C., Gasc, J.M., Berger, S., Schütz, G., Corvol, P. Mol. Endocrinol. (1999) [Pubmed]
  4. Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. Trune, D.R., Kempton, J.B., Gross, N.D. Hear. Res. (2006) [Pubmed]
  5. Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. Gass, P., Kretz, O., Wolfer, D.P., Berger, S., Tronche, F., Reichardt, H.M., Kellendonk, C., Lipp, H.P., Schmid, W., Schütz, G. EMBO Rep. (2000) [Pubmed]
  6. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Schmidt, M.V., Schmidt, M., Levine, S., Oitzl, M.S., van der Mark, M., Müller, M.B., Holsboer, F., de Kloet, E.R. Endocrinology (2005) [Pubmed]
  7. Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. Speirs, H.J., Seckl, J.R., Brown, R.W. J. Endocrinol. (2004) [Pubmed]
  8. Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes. Morris, D.L., Rothstein, T.L. J. Exp. Med. (1993) [Pubmed]
  9. Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action. Zennaro, M.C., Le Menuet, D., Viengchareun, S., Walker, F., Ricquier, D., Lombès, M. J. Clin. Invest. (1998) [Pubmed]
  10. Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Berger, S., Wolfer, D.P., Selbach, O., Alter, H., Erdmann, G., Reichardt, H.M., Chepkova, A.N., Welzl, H., Haas, H.L., Lipp, H.P., Schütz, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Karst, H., Berger, S., Turiault, M., Tronche, F., Schütz, G., Joëls, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients. Keidar, S., Gamliel-Lazarovich, A., Kaplan, M., Pavlotzky, E., Hamoud, S., Hayek, T., Karry, R., Abassi, Z. Circ. Res. (2005) [Pubmed]
  13. Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway. Michel, F., Ambroisine, M.L., Duriez, M., Delcayre, C., Levy, B.I., Silvestre, J.S. Circulation (2004) [Pubmed]
  14. The type I and type II 11beta-hydroxysteroid dehydrogenase enzymes. Krozowski, Z., Li, K.X., Koyama, K., Smith, R.E., Obeyesekere, V.R., Stein-Oakley, A., Sasano, H., Coulter, C., Cole, T., Sheppard, K.E. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  15. Regulation of rat mineralocorticoid receptor expression in neurons by progesterone. Castrén, M., Patchev, V.K., Almeida, O.F., Holsboer, F., Trapp, T., Castrén, E. Endocrinology (1995) [Pubmed]
  16. Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice. Gross, N.D., Kempton, J.B., Trune, D.R. Laryngoscope (2002) [Pubmed]
  17. Impairment of mineralocorticoid receptor (MR)-dependent biological response by oxidative stress and aging: correlation with post-translational modification of MR and decreased ADP-ribosylatable level of elongating factor 2 in kidney cells. Piwien-Pilipuk, G., Ayala, A., Machado, A., Galigniana, M.D. J. Biol. Chem. (2002) [Pubmed]
  18. The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Kingsley-Kallesen, M., Mukhopadhyay, S.S., Wyszomierski, S.L., Schanler, S., Schütz, G., Rosen, J.M. Mol. Endocrinol. (2002) [Pubmed]
  19. Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9. Yokota, K., Shibata, H., Kurihara, I., Kobayashi, S., Suda, N., Murai-Takeda, A., Saito, I., Kitagawa, H., Kato, S., Saruta, T., Itoh, H. J. Biol. Chem. (2007) [Pubmed]
  20. Corticosteroids enhance convulsion susceptibility via central mineralocorticoid receptors. Roberts, A.J., Keith, L.D. Psychoneuroendocrinology (1995) [Pubmed]
  21. Structural determinants of aldosterone binding selectivity in the mineralocorticoid receptor. Rogerson, F.M., Dimopoulos, N., Sluka, P., Chu, S., Curtis, A.J., Fuller, P.J. J. Biol. Chem. (1999) [Pubmed]
  22. Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line. Gaeggeler, H.P., Gonzalez-Rodriguez, E., Jaeger, N.F., Loffing-Cueni, D., Norregaard, R., Loffing, J., Horisberger, J.D., Rossier, B.C. J. Am. Soc. Nephrol. (2005) [Pubmed]
  23. Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus. Wiegert, O., Joëls, M., Krugers, H. Learn. Mem. (2006) [Pubmed]
  24. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. Johar, S., Cave, A.C., Narayanapanicker, A., Grieve, D.J., Shah, A.M. FASEB J. (2006) [Pubmed]
  25. Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84. Braun, S., Lösel, R., Wehling, M., Boldyreff, B. FEBS Lett. (2004) [Pubmed]
  26. Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Matsui, Y., Jia, N., Okamoto, H., Kon, S., Onozuka, H., Akino, M., Liu, L., Morimoto, J., Rittling, S.R., Denhardt, D., Kitabatake, A., Uede, T. Hypertension (2004) [Pubmed]
  27. Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II/NG-nitro-L-arginine methyl ester-induced myocardial injury. Oestreicher, E.M., Martinez-Vasquez, D., Stone, J.R., Jonasson, L., Roubsanthisuk, W., Mukasa, K., Adler, G.K. Circulation (2003) [Pubmed]
  28. Molecular genetic analysis of glucocorticoid and mineralocorticoid signaling in development and physiological processes. Berger, S.A., Cole, T.J., Schmid, W., Schütz, G. Steroids (1996) [Pubmed]
  29. Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro. Erdeljan, P., MacDonald, J.F., Matthews, S.G. Brain Res. (2001) [Pubmed]
  30. The mineralocorticoid receptor expression in the mouse CNS is conserved during development. Kretz, O., Schmid, W., Berger, S., Gass, P. Neuroreport (2001) [Pubmed]
  31. Demonstration of nuclear translocation of the mineralocorticoid receptor (MR) using an anti-MR antibody and confocal laser scanning microscopy. Robertson, N.M., Schulman, G., Karnik, S., Alnemri, E., Litwack, G. Mol. Endocrinol. (1993) [Pubmed]
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