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Gene Review

Gal3st1  -  galactose-3-O-sulfotransferase 1

Mus musculus

Synonyms: 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase, 3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase, 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase, Cerebroside sulfotransferase, Cst, ...
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Disease relevance of Gal3st1


High impact information on Gal3st1

  • To investigate the physiological role of sulfoglycolipids and to determine whether sulfatide and seminolipid are biosynthesized in vivo by a single sulfotransferase, Cst-null mice were generated by gene targeting [5].
  • Although compact myelin was preserved, Cst(-/-) mice displayed abnormalities in paranodal junctions [5].
  • Cst(-/-) mice lacked sulfatide in brain and seminolipid in testis, proving that a single gene copy is responsible for their biosynthesis [5].
  • On the other hand, Cst(-/-) males were sterile because of a block in spermatogenesis before the first meiotic division, whereas females were able to breed [5].
  • Cst(-/-) mice were born healthy, but began to display hindlimb weakness by 6 weeks of age and subsequently showed a pronounced tremor and progressive ataxia [5].

Chemical compound and disease context of Gal3st1


Biological context of Gal3st1

  • These observations suggest that the tissue-specific expression of the CST gene is explained by alternative usage of multiple 5'-UTR exons flanked with tissue-specific promoters [8].
  • In addition, we isolated CST genomic DNA clones from a mouse genomic library [8].
  • Although the rates of cell proliferation in vitro for mock and CST transfectants were similar, tumorigenicity of J5/CST-1 and -2 cells inoculated into syngeneic C57/BL6 mice was greatly decreased or even absent [1].
  • RESULTS: At baseline, diestrus females had a higher CST compared with males and estrus females [4].
  • Ovariectomy brought the baseline CST to the male level and resulted in significant expression of both phases of morphine effect but did not abolish the sex difference in responsiveness to morphine [4].

Anatomical context of Gal3st1


Associations of Gal3st1 with chemical compounds

  • We established the stable CST transfectants, J5/CST-1 and J5/CST-2 clones, highly expressing sulfated lactosylceramide (SM3) [1].
  • These results demonstrate that endogenous SM3 negatively regulates beta(1) integrin expression at the transcriptional level, and the decrease of alpha integrin proteins in the CST transfectants was due to the post-transcriptional modification [1].
  • Deglycosylation by endoglycosidase H treatment clearly demonstrated that the precursor form of beta(1) integrin, possessing high mannose oligosaccharide chains, was preferentially decreased in the CST transfectants [1].
  • Galactosylceramide sulfotransferase (EC catalyzes the biosynthesis of sulfatide from galactocerebroside and adenosine 3'-phosphate 5'-phosphosulfate (PAPS) [11].
  • Cerebroside-sulfotransferase (CST), creatine-phosphokinase (CPK), and 3-hydroxy-3-methylglutaroyl CoA (HMG CoA) reductase activity, protein, and DNA content were measured in an easy-to-perform organotypic culture system of newborn normal and jimpy brains [12].

Other interactions of Gal3st1


Analytical, diagnostic and therapeutic context of Gal3st1


  1. Suppression of integrin expression and tumorigenicity by sulfation of lactosylceramide in 3LL Lewis lung carcinoma cells. Kabayama, K., Ito, N., Honke, K., Igarashi, Y., Inokuchi , J. J. Biol. Chem. (2001) [Pubmed]
  2. Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. Ogawa, D., Shikata, K., Honke, K., Sato, S., Matsuda, M., Nagase, R., Tone, A., Okada, S., Usui, H., Wada, J., Miyasaka, M., Kawashima, H., Suzuki, Y., Suzuki, T., Taniguchi, N., Hirahara, Y., Tadano-Aritomi, K., Ishizuka, I., Tedder, T.F., Makino, H. J. Biol. Chem. (2004) [Pubmed]
  3. Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis. Zhang, Y., Hayashi, Y., Cheng, X., Watanabe, T., Wang, X., Taniguchi, N., Honke, K. Glycobiology (2005) [Pubmed]
  4. Sex and estrus cycle differences in the modulatory effects of morphine on seizure susceptibility in mice. Riazi, K., Honar, H., Homayoun, H., Rashidi, N., Dehghani, M., Sadeghipour, H., Gaskari, S.A., Dehpour, A.R. Epilepsia (2004) [Pubmed]
  5. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Honke, K., Hirahara, Y., Dupree, J., Suzuki, K., Popko, B., Fukushima, K., Fukushima, J., Nagasawa, T., Yoshida, N., Wada, Y., Taniguchi, N. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Sialylation and sulfation of lactosylceramide distinctly regulate anchorage-independent growth, apoptosis, and gene expression in 3LL Lewis lung carcinoma cells. Uemura, S., Kabayama, K., Noguchi, M., Igarashi, Y., Inokuchi, J. Glycobiology (2003) [Pubmed]
  7. Biological roles of sulfoglycolipids and pathophysiology of their deficiency. Honke, K., Zhang, Y., Cheng, X., Kotani, N., Taniguchi, N. Glycoconj. J. (2004) [Pubmed]
  8. cDNA cloning, genomic cloning, and tissue-specific regulation of mouse cerebroside sulfotransferase. Hirahara, Y., Tsuda, M., Wada, Y., Honke, K. Eur. J. Biochem. (2000) [Pubmed]
  9. Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null mice. Hirahara, Y., Bansal, R., Honke, K., Ikenaka, K., Wada, Y. Glia (2004) [Pubmed]
  10. Growth properties and biochemical characterization of mouse Schwann cells cultured in vitro. White, F.V., Ceccarini, C., Georgieff, I., Matthieu, J.M., Costantino-Ceccarini, E. Exp. Cell Res. (1983) [Pubmed]
  11. Purification and activation of brain sulfotransferase. Sundaram, K.S., Lev, M. J. Biol. Chem. (1992) [Pubmed]
  12. Abnormal metabolism of 35SO4-sulfatide in jimpy brains expressed in brain organotypic cultures. Wiesmann, U.N., Burkart, T., Hofmann, K., Siegrist, H.P., Herschkowitz, N. J. Neuropathol. Exp. Neurol. (1980) [Pubmed]
  13. Biochemical expression of mosaicism in female mice heterozygous for the jimpy gene. Benjamins, J.A., Skoff, R.P., Beyer, K. J. Neurochem. (1984) [Pubmed]
  14. Synthesis of lipids in mouse brain cell cultures during development. Siegrist, H.P., Bologa-Sandru, L., Burkart, T., Wiesmann, U., Hofmann, K., Herschkowitz, N. J. Neurosci. Res. (1981) [Pubmed]
  15. Abnormal sulfate metabolism in a hereditary demyelinating neuropathy. Matthieu, J.M., Reigner, J., Costantino-Ceccarini, E., Bourre, J.M., Rutti, M. Brain Res. (1980) [Pubmed]
  16. Developmental dissociation of myelin synthesis and "myelin-associated" enzyme activities in the shiverer mouse. Bird, T.D., Farrell, D.F., Stranahan, S., Austin, E. Neurochem. Res. (1980) [Pubmed]
  17. Theophylline reduces the activity of cerebroside-sulfotransferase, a key enzyme in myelination, in cell cultures from newborn mouse brain. Siegrist, H.P., Burkart, T., Hoffmann, K., Wiesmann, U., Herschkowitz, N. Pediatr. Res. (1980) [Pubmed]
  18. Dispersive analysis of turnover rates of a CST reactor by flow-through microfluorometry under conditions of growth. Sernetz, M., Willems, H., Keiner, K. Ann. N. Y. Acad. Sci. (1990) [Pubmed]
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