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Gene Review

COMMD3  -  COMM domain containing 3

Homo sapiens

Synonyms: BUP, C10orf8, COMM domain-containing protein 3, Protein Bup, Protein PIL
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Disease relevance of COMMD3


Psychiatry related information on COMMD3

  • Atypical antipsychotic drug treatment enhanced smoking cessation responses to BUP [6].
  • METHODS: Thirty-two subjects meeting DSM-IV criteria for schizophrenia or schizoaffective disorder and nicotine dependence were randomized to bupropion SR (BUP, 300 mg/day) or placebo (PLA) [6].
  • These results demonstrate that both BUP and BUP/NX served as reinforcers under these conditions and that they may have similar abuse liability in recently detoxified individuals who abuse heroin [7].
  • Neuropathological findings in cerebral B-protein amyloidosis. Differences and similarities in those cases presenting as a cerebral hemorrhage and those presenting as a dementia of the Alzheimer type [8].

High impact information on COMMD3

  • Transient assays in maize and yeast were used to analyze the functional domains of the B protein and its interaction with C1 [9].
  • Analysis of fusion constructs encoding the DNA-binding domain of yeast GAL4 and portions of B failed to reveal a transcriptional activation domain in the B protein [9].
  • LPS induced a 4.7-fold greater increase in factor B protein than in factor B mRNA, whereas IFN-gamma stimulated comparable increases in protein and mRNA [10].
  • Both parents, two uncles, and three of four grandparents had increased LDL B protein levels and normal total and LDL cholesterol levels [11].
  • The plasma level of the major apoprotein of low density lipoprotein (LDL), the B protein, was very high (mean 173 mg/dl) in these five sibs, while the LDL cholesterol level was moderately increased (209 mg/dl) [11].

Chemical compound and disease context of COMMD3


Biological context of COMMD3

  • An increased LDL B protein level permits the identification of heterozygotes in these families, even though in the fasting state they show no phytosterolaemia [11].
  • The phenotype of hyperapoB is based on an elevated level of LDL B protein in the presence of a normal LDL cholesterol level (low LDL sterol to LDL B ratio) [17].
  • The patterns of amino acid conservation between the tyrosine-specific protein kinases and the v-erb B protein, and between the v-erb B protein and the catalytic subunit of bovine protein kinase, suggest a possible functional as well as structural relatedness [18].
  • Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein [19].
  • Together these data show that multisite phosphorylation of cdc25C by p34cdc2-cyclin B protein kinase occurs at the G2-M transition and is sufficient to induce the autoamplification of cdc2/M-phase promoting factor necessary to drive somatic mammalian cells into mitosis [20].

Anatomical context of COMMD3

  • The results therefore indicate that not only does LDL B better separate coronary and noncoronary groups than other lipid parameters studied, but also, among those with coronary artery disease, there exists a group with normal LDL cholesterol but with levels of LDL B protein similar to those observed in type II hyperlipoproteinemia [21].
  • In the cytosol, the c-Rel-p65 (RelA) complex existed in a latent, non-DNA-binding form but could be activated by detergent treatment, suggesting that it was associated with an I kappa B protein [22].
  • The relative level of factor B mRNA expression in these cells parallels their level of factor B protein synthesis (i.e., HepG2 cells greater than A-431 cells greater than human keratinocytes) [23].
  • Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor (IL-2R) alpha chain promoter on resting T cells [24].
  • Thus, this study demonstrates that granzyme A and B protein-expressing lymphocytes infiltrate the kidney allografts during an acute cellular rejection but not in several other inflammatory renal diseases.(ABSTRACT TRUNCATED AT 250 WORDS)[25]

Associations of COMMD3 with chemical compounds

  • Here, we present further analyses of the plasma levels of the plant sterol, sitosterol, of low density (beta) lipoprotein (LDL) sterol, and of LDL B protein [17].
  • A number of lines of evidence suggest that the N-terminal sub-domain of the DNA gyrase B protein contains the binding site for the coumarin antibiotics [26].
  • RESULTS: Bupropion significantly increased trial endpoint 7-day point prevalence smoking abstinence rates compared with placebo [BUP, 8/16 (50.0%), PLA, 2/16 (12.5%); chi(2) = 5.24, df = 1, p <.05], and reduced CO levels during the trial [Medication x Time interaction; Z = 3.09, p <.01] [6].
  • Vitamin C supplementation also prevented the nicotine-induced increases in surfactant apoprotein-B protein [27].
  • Oxidant-based radioiodination of "inactive" creatine kinase B protein [28].

Physical interactions of COMMD3


Regulatory relationships of COMMD3

  • We propose that the XbaI polymorphism is associated with amino acid changes in the apo B protein which influences LDL binding to the LDL-receptor [29].

Other interactions of COMMD3

  • Expression of PDGF-B protein and mRNA was restricted to the breast epithelium and tumor cells except for scattered tissue macrophages [30].
  • DMBT1 (deleted in malignant brain tumor 1), which encodes a large scavenger receptor cysteine rich (SRCR) B protein, has been proposed to be a tumor suppressor gene, due to the high frequency of its homozygous deletion and the lack of expression in a variety of cancers [31].
  • Endogenous MIM-B protein is widely expressed and its expression is maintained in various metastatic cell lines [32].
  • They also showed that the GR-B protein had a stronger transactivating effect in transient transfection experiments [33].
  • This was indicative that failure to detect PR-B protein in endometriotic tissues is due to the absence of PR-B transcripts [34].

Analytical, diagnostic and therapeutic context of COMMD3


  1. Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Ross, R., Masuda, J., Raines, E.W., Gown, A.M., Katsuda, S., Sasahara, M., Malden, L.T., Masuko, H., Sato, H. Science (1990) [Pubmed]
  2. Association of hyperapobetalipoproteinemia with endogenous hypertriglyceridemia and atherosclerosis. Sniderman, A.D., Wolfson, C., Teng, B., Franklin, F.A., Bachorik, P.S., Kwiterovich, P.O. Ann. Intern. Med. (1982) [Pubmed]
  3. Complete nucleotide sequence of the neuraminidase gene of influenza B virus. Shaw, M.W., Lamb, R.A., Erickson, B.W., Briedis, D.J., Choppin, P.W. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  4. Biosynthesis of factor XIII B subunit by human hepatoma cell lines. Nagy, J.A., Henriksson, P., McDonagh, J. Blood (1986) [Pubmed]
  5. Molecular basis defining human Chlamydia trachomatis tissue tropism. A possible role for tryptophan synthase. Fehlner-Gardiner, C., Roshick, C., Carlson, J.H., Hughes, S., Belland, R.J., Caldwell, H.D., McClarty, G. J. Biol. Chem. (2002) [Pubmed]
  6. A placebo controlled trial of bupropion for smoking cessation in schizophrenia. George, T.P., Vessicchio, J.C., Termine, A., Bregartner, T.A., Feingold, A., Rounsaville, B.J., Kosten, T.R. Biol. Psychiatry (2002) [Pubmed]
  7. Self-administration of intravenous buprenorphine and the buprenorphine/naloxone combination by recently detoxified heroin abusers. Comer, S.D., Collins, E.D. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  8. Neuropathological findings in cerebral B-protein amyloidosis. Differences and similarities in those cases presenting as a cerebral hemorrhage and those presenting as a dementia of the Alzheimer type. Bots, G.T. Clinical neurology and neurosurgery. (1992) [Pubmed]
  9. Functional analysis of the transcriptional activator encoded by the maize B gene: evidence for a direct functional interaction between two classes of regulatory proteins. Goff, S.A., Cone, K.C., Chandler, V.L. Genes Dev. (1992) [Pubmed]
  10. Synergism between gamma interferon and lipopolysaccharide for synthesis of factor B, but not C2, in human fibroblasts. Katz, Y., Cole, F.S., Strunk, R.C. J. Exp. Med. (1988) [Pubmed]
  11. Hyperapobetalipoproteinaemia in two families with xanthomas and phytosterolaemia. Kwiterovich, P.O., Bachorik, P.S., Smith, H.H., McKusick, V.A., Connor, W.E., Teng, B., Sniderman, A.D. Lancet (1981) [Pubmed]
  12. Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D. Singh, C.R., Moulton, R.A., Armitige, L.Y., Bidani, A., Snuggs, M., Dhandayuthapani, S., Hunter, R.L., Jagannath, C. J. Immunol. (2006) [Pubmed]
  13. Detection of coronary disease patients at high risk for recurrent myocardial infarction by elevated plasma inactive creatine kinase B protein levels. Burnam, M.H., Crouch, M.A., Chew, C.Y., Carnegie, W., Hecht, H., Singh, B.N. Am. Heart J. (1981) [Pubmed]
  14. A 4.2 kDa synthetic peptide as a potential probe to evaluate the antibacterial activity of coumarin drugs. Scatigno, A.C., Garrido, S.S., Marchetto, R. J. Pept. Sci. (2004) [Pubmed]
  15. Structural analyses of progesterone receptors. Horwitz, K.B., Wei, L.L., Francis, M.D. J. Steroid Biochem. (1986) [Pubmed]
  16. Laser Raman studies of lipid disordering by the B-protein of fd phage. Dunker, A.K., Williams, R.W., Gaber, B.P., Peticolas, W.L. Biochim. Biophys. Acta (1979) [Pubmed]
  17. Genetic analysis of plasma sitosterol, apoprotein B, and lipoproteins in a large Amish pedigree with sitosterolemia. Beaty, T.H., Kwiterovich, P.O., Khoury, M.J., White, S., Bachorik, P.S., Smith, H.H., Teng, B., Sniderman, A. Am. J. Hum. Genet. (1986) [Pubmed]
  18. The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases. Privalsky, M.L., Ralston, R., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  19. Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein. Winkler, G.S., Vermeulen, W., Coin, F., Egly, J.M., Hoeijmakers, J.H., Weeda, G. J. Biol. Chem. (1998) [Pubmed]
  20. Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. Strausfeld, U., Fernandez, A., Capony, J.P., Girard, F., Lautredou, N., Derancourt, J., Labbe, J.C., Lamb, N.J. J. Biol. Chem. (1994) [Pubmed]
  21. Association of coronary atherosclerosis with hyperapobetalipoproteinemia [increased protein but normal cholesterol levels in human plasma low density (beta) lipoproteins]. Sniderman, A., Shapiro, S., Marpole, D., Skinner, B., Teng, B., Kwiterovich, P.O. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  22. Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. Hansen, S.K., Baeuerle, P.A., Blasi, F. Mol. Cell. Biol. (1994) [Pubmed]
  23. Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway. Yancey, K.B., Overholser, O., Domloge-Hultsch, N., Li, L.J., Caughman, S.W., Bisalbutra, P. J. Invest. Dermatol. (1992) [Pubmed]
  24. Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex: role of tumor necrosis factor alpha. Pimentel-Muiños, F.X., Mazana, J., Fresno, M. Eur. J. Immunol. (1995) [Pubmed]
  25. Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection. Kummer, J.A., Wever, P.C., Kamp, A.M., ten Berge, I.J., Hack, C.E., Weening, J.J. Kidney Int. (1995) [Pubmed]
  26. The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs. Gilbert, E.J., Maxwell, A. Mol. Microbiol. (1994) [Pubmed]
  27. Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys. Proskocil, B.J., Sekhon, H.S., Clark, J.A., Lupo, S.L., Jia, Y., Hull, W.M., Whitsett, J.A., Starcher, B.C., Spindel, E.R. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  28. Oxidant-based radioiodination of "inactive" creatine kinase B protein. Burnam, M.H., Shell, W.E. Clin. Chem. (1981) [Pubmed]
  29. The fractional catabolic rate of low density lipoprotein in normal individuals is influenced by variation in the apolipoprotein B gene: a preliminary study. Houlston, R.S., Turner, P.R., Revill, J., Lewis, B., Humphries, S.E. Atherosclerosis (1988) [Pubmed]
  30. Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma. Coltrera, M.D., Wang, J., Porter, P.L., Gown, A.M. Cancer Res. (1995) [Pubmed]
  31. DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration? Kang, W., Reid, K.B. FEBS Lett. (2003) [Pubmed]
  32. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. Bompard, G., Sharp, S.J., Freiss, G., Machesky, L.M. J. Cell. Sci. (2005) [Pubmed]
  33. Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism. Russcher, H., van Rossum, E.F., de Jong, F.H., Brinkmann, A.O., Lamberts, S.W., Koper, J.W. Mol. Endocrinol. (2005) [Pubmed]
  34. Progesterone receptor isoform A but not B is expressed in endometriosis. Attia, G.R., Zeitoun, K., Edwards, D., Johns, A., Carr, B.R., Bulun, S.E. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  35. Localization of a bacterial protein in starch granules of transgenic maize kernels. Chikwamba, R.K., Scott, M.P., Mejía, L.B., Mason, H.S., Wang, K. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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