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Gene Review

OPN1MW  -  opsin 1 (cone pigments), medium-wave...

Homo sapiens

Synonyms: CBBM, CBD, COD5, GCP, GOP, ...
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Disease relevance of OPN1MW

  • The main indications for hepaticojejunostomy were iatrogenic strictures of CBD (60 patients), and choledocholithiasis with markedly dilated duct (41 patients) [1].
  • These overall results are a strong argument for hepaticojejunostomy which, compared with choledochoduodenostomy, avoids the hazards of the so-called sump syndrome and of the reflux of enteric contents in the CBD [1].
  • Pathologic review showed that 22 patients (32.8%) had at least one risk factor for failure after ampullectomy: lymph node metastasis (n = 6, 9.0%), perineural invasion (n = 1), or mucosal tumor infiltration along the CBD or P-duct (n = 15, 22.4%) [2].
  • These data suggest GCP has potential as an effective chemopreventive agent against prostate cancer cell growth [3].
  • We also found that an O-sialoglycoprotease (GCP) from Pasteurella haemolytica is capable of inhibiting homotypic aggregation [4].

Psychiatry related information on OPN1MW

  • Compared to placebo, alcohol and alcohol plus CBD, but not CBD alone, produced significant impairments of motor and psychomotor performances, overestimations of time production and subjective responses indicating an accurate self-perception of their intoxication and deficits [5].
  • GCPP includes standardization of both experimental factors (lumped constant, arterialization, purity of tracer, regions of interest, relative rates) and clinical factors (state of the subject, wakefulness, anxiety, gender, course of the disease) in PET performance [6].
  • Cognitive decline, prompting the diagnosis of dementia, may be the most common presentation of CBD that is misdiagnosed [7].
  • The purpose of this study was to explore a difference in sphincter of Oddi (SO) motor activity among patients with intrahepatic (I, N = 5), intra- and extrahepatic (IE, N = 15), and common bile duct (CBD, N = 6) stones [8].
  • We examined oral calculation in patients with corticobasal degeneration (CBD; N=17), frontotemporal dementia (FTD; N=17), and Alzheimer's disease (AD; N=20), as well as 17 healthy seniors matched for age and education [9].

High impact information on OPN1MW

  • (iv) CBD caused agglutination of EL-4 cells, murine B and T lymphocytes, human thymocytes, and two T-cell hybridomas [10].
  • In the present study, employing two unrelated Na+/Ca2+ exchange inhibitors, 3',4'-dichlorobenzamil (DCB) and bepridil, we investigated the role of NCX in platelet activation induced by various agonists in detail [11].
  • Biochemical and ultrastructural analyses showed that NCX inhibitors, particularly DCB, made platelets "thrombasthenic". These findings suggest that the NCX is involved in the common steps of inside-out signaling through integrin IIbbeta3 [11].
  • 3',4'-Dichlorobenzamil (DCB) and bepridil, relatively specific inhibitors of Na+/Ca2+ exchanger, also inhibited the chymotrypsin-induced alpha IIb beta 3 activation, and the IC50 values of these inhibitors for fibrinogen binding were 25 mumol/L and 52 mumol/L, respectively [12].
  • Moreover, platelet aggregation induced by various physiologic agonists was inhibited by DCB or bepridil, while platelet agglutination by ristocetin was not [12].

Chemical compound and disease context of OPN1MW

  • We examined the antidepressant efficacy and drug safety of Ze 117 and fluoxetine in a multicentric prospective randomized double-blind parallel group comparison according to generally accepted guidelines such as the Declaration of Helsinki and GCP [13].
  • OBJECTIVE: The aim of this phase II study was to evaluate the efficacy and toxicity of gemcitabine, carboplatin, and paclitaxel (GCP) combination as salvage therapy in patients with relapsed ovarian or peritoneal cancer who had previously received platinum-based chemotherapy [14].
  • Urine samples, serum samples, and liver tissue extracts (S-9) from infested and control hamsters were used with the Ames Salmonella/microsome test to follow 3,3'-dichlorobenzidine (DCB), aflatoxin B1 (AFB1), and 2-acetylaminofluorene (AAF) mutagenicity [15].
  • CBD and DMHP-CBD had no significant inhibitory effect on 14C serotonin release from normal platelets when tested either at migraine-free period plasma or plasma obtained during migraine attack [16].
  • Overexpression of a GFP fusion protein containing the putative CBD of the retroviral MA resulted in a considerable decrease in production of infectious retrovirus [17].

Biological context of OPN1MW

  • BglII RFLP in DXS 498 between the pigment gene repeat unit, RCP and GCP [18].
  • Determination of the partial amino acid sequence of the beta subunit of cryptomonad strain CBD phycoerythrin 566 established the nature, locations, and modes of attachment of the three bilin prosthetic groups and revealed a site of posttranslational methylation [19].
  • However, DCB 3503 showed no direct effects on T cell proliferation and B cell antibody response [20].
  • Polyclonal antibodies raised against the peptides inhibit cell adhesion to the peptides, the recombinant CBD, and to intact TS [21].
  • The diagnosis of osteoporosis was based upon the bone density (BD) of the lumbar spine measured by quantitative computed tomography (CBD: BD > 108 mg/cm3; OPBD: BD < 70 mg/cm3) [22].

Anatomical context of OPN1MW

  • One of the glycoprotein complexes present in all GCP and synaptosome fractions analyzed is gp93 [23].
  • Consistent with its effects in vivo, DCB 3503 significantly suppressed the synthesis of proinflammatory cytokines in inflamed joints as well as cytokine synthesis by macrophages examined ex vivo [20].
  • The effect of DCB 3503 on LPS-induced proinflammatory cytokines from bone marrow-derived dendritic cells was determined by flow cytometry [20].
  • Length of biliary (CBD) and/or pancreatic (PD) sphincter of Oddi (SO) was measured during perendoscopic or intraoperative manometry in 21 control subjects and in 46 patients with biliary disease [24].
  • CONCLUSIONS: GCP has potent growth-inhibitory effects against prostate cancer cell lines in vitro and in vivo [3].

Associations of OPN1MW with chemical compounds

  • Moreover, DCB 3503 completely blocked the LPS-triggered acceleration of joint inflammation and destruction [20].
  • A concentrated aglycone isoflavone preparation (GCP) that demonstrates potent anti-prostate cancer activity in vitro and in vivo [3].
  • EXPERIMENTAL DESIGN: Androgen-sensitive LNCaP and androgen-independent PC-3 cells were grown with various concentrations of GCP [3].
  • There were no significant changes in the luminal diameters of the CHD or the CBD after tegaserod compared to placebo in any cohort [25].
  • Changes in luminal diameter of the CHD and the CBD were used as a surrogate marker for sphincter of Oddi function [25].

Other interactions of OPN1MW

  • The red (RCP) and green (GCP) color pigment genes are located in Xq28, a chromosomal region implicated in many genetic disorders [18].

Analytical, diagnostic and therapeutic context of OPN1MW


  1. Roux-en-Y hepaticojejunostomy: a reappraisal of its indications and results. Stefanini, P., Carboni, M., Patrassi, N., Basoli, A., de Bernardinis, G., Negro, P. Ann. Surg. (1975) [Pubmed]
  2. Clinicopathologic analysis of early ampullary cancers with a focus on the feasibility of ampullectomy. Yoon, Y.S., Kim, S.W., Park, S.J., Lee, H.S., Jang, J.Y., Choi, M.G., Kim, W.H., Lee, K.U., Park, Y.H. Ann. Surg. (2005) [Pubmed]
  3. A concentrated aglycone isoflavone preparation (GCP) that demonstrates potent anti-prostate cancer activity in vitro and in vivo. Bemis, D.L., Capodice, J.L., Desai, M., Buttyan, R., Katz, A.E. Clin. Cancer Res. (2004) [Pubmed]
  4. Evidence for a third component in neutrophil aggregation: potential roles of O-linked glycoproteins as L-selectin counter-structures. Bennett, T.A., Schammel, C.M., Lynam, E.B., Guyer, D.A., Mellors, A., Edwards, B., Rogelj, S., Sklar, L.A. J. Leukoc. Biol. (1995) [Pubmed]
  5. Interaction of cannabidiol and alcohol in humans. Consroe, P., Carlini, E.A., Zwicker, A.P., Lacerda, L.A. Psychopharmacology (Berl.) (1979) [Pubmed]
  6. Glucose metabolism in psychiatric disorders: how can we facilitate comparisons among studies? Wiesel, F.A. J. Neural Transm. Suppl. (1992) [Pubmed]
  7. Corticobasal degeneration. Stover, N.P., Watts, R.L. Seminars in neurology. (2001) [Pubmed]
  8. Sphincter of Oddi motility in patients with hepatolithiasis and common bile duct stones. Kuo, K.K., Utsunomiya, N., Nabae, T., Takahata, S., Yokohata, K., Chijiiwa, K., Sheen, P.C., Tanaka, M. Dig. Dis. Sci. (2000) [Pubmed]
  9. Calculation impairment in neurodegenerative diseases. Halpern, C., McMillan, C., Moore, P., Dennis, K., Grossman, M. J. Neurol. Sci. (2003) [Pubmed]
  10. Evidence for a functional receptor for cyclosporin A on the surface of lymphocytes. Cacalano, N.A., Chen, B.X., Cleveland, W.L., Erlanger, B.F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Involvement of Na+/Ca2+ exchanger in inside-out signaling through the platelet integrin IIbbeta3. Shiraga, M., Tomiyama, Y., Honda, S., Suzuki, H., Kosugi, S., Tadokoro, S., Kanakura, Y., Tanoue, K., Kurata, Y., Matsuzawa, Y. Blood (1998) [Pubmed]
  12. Affinity modulation of the platelet integrin alpha IIb beta 3 by alpha-chymotrypsin: a possible role for Na+/Ca2+ exchanger. Shiraga, M., Tomiyama, Y., Honda, S., Kashiwagi, H., Kosugi, S., Handa, M., Ikeda, Y., Kanakura, Y., Kurata, Y., Matsuzawa, Y. Blood (1996) [Pubmed]
  13. Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0; F 32.1) with St. John's wort. Friede, M., Henneicke von Zepelin, H.H., Freudenstein, J. Pharmacopsychiatry (2001) [Pubmed]
  14. Triplet combination of gemcitabine, carboplatin, and paclitaxel in previously treated, relapsed ovarian and peritoneal carcinoma: an experience in Taiwan. Liu, F.S., Ho, E.S., Hung, M.J., Hwang, S.F., Lu, C.H., Ke, Y.M. Gynecol. Oncol. (2004) [Pubmed]
  15. Modified mutagen metabolism in Schistosoma hematobium-infested organisms. Gentile, J.M., Brown, S., Aardema, M., Clark, D., Blankespoor, H. Arch. Environ. Health (1985) [Pubmed]
  16. Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients. Volfe, Z., Dvilansky, A., Nathan, I. International journal of clinical pharmacology research. (1985) [Pubmed]
  17. Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production. Yu, Z., Beer, C., Koester, M., Wirth, M. Virol. J. (2006) [Pubmed]
  18. BglII RFLP in DXS 498 between the pigment gene repeat unit, RCP and GCP. Vits, L., Willems, P.J. Hum. Genet. (1992) [Pubmed]
  19. Posttranslational modifications of the beta subunit of a cryptomonad phycoerythrin. Sites of bilin attachment and asparagine methylation. Wilbanks, S.M., Wedemayer, G.J., Glazer, A.N. J. Biol. Chem. (1989) [Pubmed]
  20. Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response. You, X., Pan, M., Gao, W., Shiah, H.S., Tao, J., Zhang, D., Koumpouras, F., Wang, S., Zhao, H., Madri, J.A., Baker, D., Cheng, Y.C., Yin, Z. Arthritis Rheum. (2006) [Pubmed]
  21. Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1. Kosfeld, M.D., Frazier, W.A. J. Biol. Chem. (1992) [Pubmed]
  22. Clinical performances of galactosyl hydroxylysine, pyridinoline, and deoxypyridinoline in postmenopausal osteoporosis. Bettica, P., Taylor, A.K., Talbot, J., Moro, L., Talamini, R., Baylink, D.J. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  23. Variable membrane glycoproteins in different growth cone populations. Li, H.N., Quiroga, S., Pfenninger, K.H. J. Neurosci. (1992) [Pubmed]
  24. Manometric measurement of human sphincter of Oddi length. Habib, F.I., Corazziari, E., Biliotti, D., Primerano, L., Viscardi, A., Speranza, V., De Masi, E., Fegiz, G., Torsoli, A. Gut (1988) [Pubmed]
  25. Tegaserod does not alter fasting or meal-induced biliary tract motility. Fisher, R.S., Thistle, J., Lembo, A., Novick, J., O'Kane, P., Chey, W.D., Beglinger, C., Rueegg, P., Shi, V., Dogra, A., Luo, D., Earnest, D.L. Am. J. Gastroenterol. (2004) [Pubmed]
  26. Design of a pH-dependent cellulose-binding domain. Linder, M., Nevanen, T., Teeri, T.T. FEBS Lett. (1999) [Pubmed]
  27. Acute biliary pancreatitis. The roles of laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography. DeIorio, A.V., Vitale, G.C., Reynolds, M., Larson, G.M. Surgical endoscopy. (1995) [Pubmed]
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