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Gene Review

HUNK  -  hormonally up-regulated Neu-associated kinase

Homo sapiens

Synonyms: B19, Hormonally up-regulated neu tumor-associated kinase, MAKV, Serine/threonine-protein kinase MAK-V
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Disease relevance of HUNK


Psychiatry related information on HUNK

  • New LightCycler PCR for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in relapsing infections [5].
  • OBJECTIVES: to clarify the approximation of the frequency of B19-related nonimmune hydrops fetalis (NIHF), and to know the critical period during which maternal infection led to NIHF [6].
  • Human parvovirus B19 antibodies in infantile autism [7].
  • We describe a young man who had AIDS complicated by parvovirus B19 infection and RBC aplasia and who developed a painless, progressive dyspraxia of the left arm and an expressive dysphasia 4 weeks after commencing effective HAART [8].

High impact information on HUNK


Chemical compound and disease context of HUNK


Biological context of HUNK

  • We have isolated a 5.0-kb full-length cDNA clone that contains the 714-amino-acid open reading frame encoding Hunk [15].
  • During fetal development and in the adult mouse, Hunk mRNA expression is developmentally regulated and tissue-specific [15].
  • This culture system allowed study at a molecular level of events associated with the B19 life cycle [16].
  • B19 parvovirus has been shown to persist in some immunocompromised patients, and treatment with specific antibodies can lead to decreased quantities of circulating virus and hematologic improvement [17].
  • Distinctive neuron-specific (B5 versus B19) and state-specific (growing versus non-growing) differences in calcium homeostasis were observed in cultured identified Helisoma neurons [18].

Anatomical context of HUNK


Associations of HUNK with chemical compounds

  • Analysis of this cDNA reveals that Hunk is most closely related to the SNF1 family of serine/threonine kinases and contains a newly described SNF1 homology domain [15].
  • When applied simultaneously with serotonin, ACh prevents the inhibition of Helisoma neuron B19 neurite elongation that would occur in response to application of 5-HT alone [22].
  • Acetylcholine-sensitive assay cells were micromanipulated into contact with B19 somata to assess its secretory state [23].
  • Fura-2 studies revealed that A23187 induced a transient rise in intracellular calcium in growing neurons B5 but a sustained rise in growing neurons B19 [18].
  • Photolysis of a calcium cage, DM-nitrophen, accelerated the frequency of synaptic currents in muscle-contacted, but not novel neuron-contacted, B19 somata [23].

Analytical, diagnostic and therapeutic context of HUNK


  1. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). Brown, K.E., Hibbs, J.R., Gallinella, G., Anderson, S.M., Lehman, E.D., McCarthy, P., Young, N.S. N. Engl. J. Med. (1994) [Pubmed]
  2. Treatment of parvovirus B19-associated polyarteritis nodosa with intravenous immune globulin. Viguier, M., Guillevin, L., Laroche, L. N. Engl. J. Med. (2001) [Pubmed]
  3. Parvovirus B19 as the cause of a syndrome resembling Lyme arthritis in adults. Mayo, D.R., Vance, D.W. N. Engl. J. Med. (1991) [Pubmed]
  4. Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface. Rosenfeld, S.J., Yoshimoto, K., Kajigaya, S., Anderson, S., Young, N.S., Field, A., Warrener, P., Bansal, G., Collett, M.S. J. Clin. Invest. (1992) [Pubmed]
  5. New LightCycler PCR for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in relapsing infections. Harder, T.C., Hufnagel, M., Zahn, K., Beutel, K., Schmitt, H.J., Ullmann, U., Rautenberg, P. J. Clin. Microbiol. (2001) [Pubmed]
  6. The incidence of, and factors leading to, parvovirus B19-related hydrops fetalis following maternal infection; report of 10 cases and meta-analysis. Yaegashi, N., Niinuma, T., Chisaka, H., Watanabe, T., Uehara, S., Okamura, K., Moffatt, S., Sugamura, K., Yajima, A. J. Infect. (1998) [Pubmed]
  7. Human parvovirus B19 antibodies in infantile autism. Anlar, B., Oktem, F., Török, T. J. Child Neurol. (1994) [Pubmed]
  8. Parvovirus B19 encephalitis presenting as immune restoration disease after highly active antiretroviral therapy for human immunodeficiency virus infection. Nolan, R.C., Chidlow, G., French, M.A. Clin. Infect. Dis. (2003) [Pubmed]
  9. Expression of P antigen in parvovirus B19-infected bone marrow. Kerr, J.R., McQuaid, S., Coyle, P.V. N. Engl. J. Med. (1995) [Pubmed]
  10. Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Sokal, E.M., Melchior, M., Cornu, C., Vandenbroucke, A.T., Buts, J.P., Cohen, B.J., Burtonboy, G. Lancet (1998) [Pubmed]
  11. Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry. Weigel-Kelley, K.A., Yoder, M.C., Srivastava, A. Blood (2003) [Pubmed]
  12. A novel calmodulin antagonist, CGS 9343B, modulates calcium-dependent changes in neurite outgrowth and growth cone movements. Polak, K.A., Edelman, A.M., Wasley, J.W., Cohan, C.S. J. Neurosci. (1991) [Pubmed]
  13. Acute parvovirus B19-induced pancytopenia in the setting of methotrexate therapy for rheumatoid arthritis. Naides, S.J. Arthritis Rheum. (1995) [Pubmed]
  14. Immunohistological detection of human parvovirus B19 in formalin-fixed, paraffin-embedded tissues. Morey, A.L., O'Neill, H.J., Coyle, P.V., Fleming, K.A. J. Pathol. (1992) [Pubmed]
  15. Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. Gardner, H.P., Wertheim, G.B., Ha, S.I., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Marquis, S.T., Chodosh, L.A. Genomics (2000) [Pubmed]
  16. Replication of the B19 parvovirus in human bone marrow cell cultures. Ozawa, K., Kurtzman, G., Young, N. Science (1986) [Pubmed]
  17. Immune response to B19 parvovirus and an antibody defect in persistent viral infection. Kurtzman, G.J., Cohen, B.J., Field, A.M., Oseas, R., Blaese, R.M., Young, N.S. J. Clin. Invest. (1989) [Pubmed]
  18. Neuron-specific and state-specific differences in calcium homeostasis regulate the generation and degeneration of neuronal architecture. Mills, L.R., Kater, S.B. Neuron (1990) [Pubmed]
  19. Formation and modulation of chemical connections: evoked acetylcholine release from growth cones and neurites of specific identified neurons. Haydon, P.G., Zoran, M.J. Neuron (1989) [Pubmed]
  20. Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy. Söderlund, M., von Essen, R., Haapasaari, J., Kiistala, U., Kiviluoto, O., Hedman, K. Lancet (1997) [Pubmed]
  21. Parvovirus B19-infected erythroblasts in fetal cord blood. Nerlich, A., Schwarz, T.F., Roggendorf, M., Roggendorf, H., Ostermeyer, E., Schramm, T., Gloning, K.P. Lancet (1991) [Pubmed]
  22. Interactive effects of serotonin and acetylcholine on neurite elongation. McCobb, D.P., Cohan, C.S., Connor, J.A., Kater, S.B. Neuron (1988) [Pubmed]
  23. Target contact regulates the calcium responsiveness of the secretory machinery during synaptogenesis. Zoran, M.J., Doyle, R.T., Haydon, P.G. Neuron (1991) [Pubmed]
  24. Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum. Gillespie, S.M., Cartter, M.L., Asch, S., Rokos, J.B., Gary, G.W., Tsou, C.J., Hall, D.B., Anderson, L.J., Hurwitz, E.S. JAMA (1990) [Pubmed]
  25. Identification of a novel simian parvovirus in cynomolgus monkeys with severe anemia. A paradigm of human B19 parvovirus infection. O'Sullivan, M.G., Anderson, D.C., Fikes, J.D., Bain, F.T., Carlson, C.S., Green, S.W., Young, N.S., Brown, K.E. J. Clin. Invest. (1994) [Pubmed]
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