The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Galr1  -  galanin receptor 1

Rattus norvegicus

Synonyms: GAL1-R, GALR-1, Galanin receptor type 1, Galnr, Galnr1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Galr1


Psychiatry related information on Galr1

  • Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus [6].
  • The results clearly support the hypothesis that neuropeptides such as GAL are an integral component of the neural response to psychological stress, although the functional significance of the changes in GAL receptor density described in this study awaits elucidation [7].
  • Nonpeptide, bioavailable, subtype-selective galanin receptor antagonists may provide tools to test the hypothesis that antagonism of endogenous galanin, which is overexpressed in the basal forebrain in Alzheimer's patients, can contribute to the alleviation of the cognitive deficits associated with Alzheimer's disease [8].

High impact information on Galr1


Chemical compound and disease context of Galr1


Biological context of Galr1


Anatomical context of Galr1


Associations of Galr1 with chemical compounds


Regulatory relationships of Galr1


Other interactions of Galr1


Analytical, diagnostic and therapeutic context of Galr1


  1. Galanin inhibits tyrosine hydroxylase expression in midbrain dopaminergic neurons. Counts, S.E., McGuire, S.O., Sortwell, C.E., Crawley, J.N., Collier, T.J., Mufson, E.J. J. Neurochem. (2002) [Pubmed]
  2. Cloning and characterization of the rat GALR1 galanin receptor from Rin14B insulinoma cells. Parker, E.M., Izzarelli, D.G., Nowak, H.P., Mahle, C.D., Iben, L.G., Wang, J., Goldstein, M.E. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  3. Galanin modulates neuronal and synaptic properties in the rat supraoptic nucleus in a use and state dependent manner. Kozoriz, M.G., Kuzmiski, J.B., Hirasawa, M., Pittman, Q.J. J. Neurophysiol. (2006) [Pubmed]
  4. Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia. Sun, Y.G., Li, J., Yang, B.N., Yu, L.C. J. Neurosci. Res. (2004) [Pubmed]
  5. Galanin-induced membrane depolarization of neonatal rat cultured dorsal root ganglion cells. Puttick, R.M., Pinnock, R.D., Woodruff, G.N. Eur. J. Pharmacol. (1994) [Pubmed]
  6. Activity of centrally administered galanin fragments on stimulation of feeding behavior and on galanin receptor binding in the rat hypothalamus. Crawley, J.N., Austin, M.C., Fiske, S.M., Martin, B., Consolo, S., Berthold, M., Langel, U., Fisone, G., Bartfai, T. J. Neurosci. (1990) [Pubmed]
  7. Acute and chronic restraint stress: effects on [125I]-galanin binding in normotensive and hypertensive rat brain. Sweerts, B.W., Jarrott, B., Lawrence, A.J. Brain Res. (2000) [Pubmed]
  8. Galanin inhibits performance on rodent memory tasks. McDonald, M.P., Gleason, T.C., Robinson, J.K., Crawley, J.N. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  9. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Lu, X., Barr, A.M., Kinney, J.W., Sanna, P., Conti, B., Behrens, M.M., Bartfai, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Liu, H.X., Brumovsky, P., Schmidt, R., Brown, W., Payza, K., Hodzic, L., Pou, C., Godbout, C., Hökfelt, T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  11. Expression of galanin and a galanin receptor in several sensory systems and bone anlage of rat embryos. Xu, Z.Q., Shi, T.J., Hökfelt, T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  12. Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus. Kinney, G.A., Emmerson, P.J., Miller, R.J. J. Neurosci. (1998) [Pubmed]
  13. Systemic galnon, a low-molecular weight galanin receptor agonist, reduces heat hyperalgesia in rats with nerve injury. Wu, W.P., Hao, J.X., Lundström, L., Wiesenfeld-Hallin, Z., Langel, U., Bartfai, T., Xu, X.J. Eur. J. Pharmacol. (2003) [Pubmed]
  14. Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: behavioral, electrophysiological and in situ hybridization studies. Xu, X.J., Farkas-Szallasi, T., Lundberg, J.M., Hökfelt, T., Wiesenfeld-Hallin, Z., Szallasi, A. Brain Res. (1997) [Pubmed]
  15. Molecular cloning and characterization of a new receptor for galanin. Howard, A.D., Tan, C., Shiao, L.L., Palyha, O.C., McKee, K.K., Weinberg, D.H., Feighner, S.D., Cascieri, M.A., Smith, R.G., Van Der Ploeg, L.H., Sullivan, K.A. FEBS Lett. (1997) [Pubmed]
  16. Galanin receptors in the hippocampus and entorhinal cortex of aged Fischer 344 male rats. Planas, B., Kolb, P.E., Raskind, M.A., Miller, M.A. Neurobiol. Aging (1998) [Pubmed]
  17. Chimeric galanin analogs that function as antagonists in the CNS are full agonists in gastrointestinal smooth muscle. Gu, Z.F., Rossowski, W.J., Coy, D.H., Pradhan, T.K., Jensen, R.T. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  18. Galanin and spatial learning in the rat. Evidence for a differential role for galanin in subregions of the hippocampal formation. Schött, P.A., Hökfelt, T., Ogren, S.O. Neuropharmacology (2000) [Pubmed]
  19. Expression of galanin and galanin receptor-1 in normal bone and during fracture repair in the rat. McDonald, A.C., Schuijers, J.A., Shen, P.J., Gundlach, A.L., Grills, B.L. Bone (2003) [Pubmed]
  20. Mechanisms of galanin-induced contraction in the rat myometrium. Niiro, N., Nishimura, J., Hirano, K., Nakano, H., Kanaide, H. Br. J. Pharmacol. (1998) [Pubmed]
  21. Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover. Smith, K.E., Forray, C., Walker, M.W., Jones, K.A., Tamm, J.A., Bard, J., Branchek, T.A., Linemeyer, D.L., Gerald, C. J. Biol. Chem. (1997) [Pubmed]
  22. Expression of GalR1 and GalR2 galanin receptor messenger ribonucleic acid in proopiomelanocortin neurons of the rat arcuate nucleus: effect of testosterone. Bouret, S., Prevot, V., Croix, D., Howard, A., Habert-Ortoli, E., Jegou, S., Vaudry, H., Beauvillain, J.C., Mitchell, V. Endocrinology (2000) [Pubmed]
  23. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Horvath, T.L., Naftolin, F., Leranth, C., Sahu, A., Kalra, S.P. Endocrinology (1996) [Pubmed]
  24. Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Quynh, N.T., Islam, S.M., Florén, A., Bartfai, T., Langel, U., Ostenson, C.G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  25. GALR1 galanin receptor mRNA is co-expressed by galanin neurons but not cholinergic neurons in the rat basal forebrain. Miller, M.A., Kolb, P.E., Raskind, M.A. Brain Res. Mol. Brain Res. (1997) [Pubmed]
  26. The role of galanin and its receptor in the feedback regulation of growth hormone secretion. Chan, Y.Y., Grafstein-Dunn, E., Delemarre-van de Waal, H.A., Burton, K.A., Clifton, D.K., Steiner, R.A. Endocrinology (1996) [Pubmed]
  27. Galanin receptor antagonists decrease fat preference in Brattleboro rat. Odorizzi, M., Fernette, B., Angel, E., Burlet, C., Tankosic, P., Burlet, A. Neuropharmacology (2002) [Pubmed]
  28. Role of galanin receptor 1 in gastric motility in rat. Guerrini, S., Raybould, H.E., Anselmi, L., Agazzi, A., Cervio, E., Reeve, J.R., Tonini, M., Sternini, C. Neurogastroenterol. Motil. (2004) [Pubmed]
  29. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Bellido, I., Hansson, A.C., Gómez-Luque, A.J., Andbjer, B., Agnati, L.F., Fuxe, K. Neuroreport (2004) [Pubmed]
  30. Regional stimulatory and inhibitory effects of guanine nucleotides on [125I]galanin binding in rat brain: relationship with the rate of occupancy of galanin receptors by endogenous galanin. Lagny-Pourmir, I., Epelbaum, J. Neuroscience (1992) [Pubmed]
  31. Retrovirus-mediated expression of the GalR1 galanin receptor: implication for efficient stable expression of functional G protein-coupled receptors. Wang, S., Clemmons, A., Bayne, M., Graziano, M.P. J. Recept. Signal Transduct. Res. (1998) [Pubmed]
  32. Expression of galanin receptor-1 (GALR1) in the rat trigeminal ganglia and molar teeth. Suzuki, H., Iwanaga, T., Yoshie, H., Li, J., Yamabe, K., Yanaihara, N., Langel, U., Maeda, T. Neurosci. Res. (2002) [Pubmed]
  33. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. O'Donnell, D., Ahmad, S., Wahlestedt, C., Walker, P. J. Comp. Neurol. (1999) [Pubmed]
WikiGenes - Universities