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GAL3ST1  -  galactose-3-O-sulfotransferase 1

Homo sapiens

Synonyms: 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase, 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase, CST, Cerebroside sulfotransferase, GalCer sulfotransferase, ...
 
 
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Disease relevance of GAL3ST1

 

Psychiatry related information on GAL3ST1

  • The CST records were examined for: per cent late deceleration, baseline FHR, presence of FHR accelerations, duration of the latency period (time from onset of contraction to onset of deceleration), and amplitude of deceleration [6].
  • To address this issue, 112 individuals, 20-79 years old, took the California Trail Making Test (CTMT) and the California Stroop Test (CST), subtests of the Delis-Kaplan Executive Function Scale (D. C. Delis, E. Kaplan, & J. H. Kramer, in press) that include measurement of component skills embedded in the executive function tasks [7].
  • CONCLUSIONS: These findings suggest that spouse-assisted CST can enhance self-efficacy and improve the coping abilities of OA patients in the long term [8].
  • Individual differences in the long-term outcome of spouse-assisted CST were noted, with some patients (those showing increases in marital satisfaction and self-efficacy) showing much better outcomes than others [8].
  • METHODS: A followup study was conducted with 88 OA patients who had been randomly assigned to 1 of 3 treatment conditions: 1) spouse-assisted coping skills training (spouse-assisted CST), 2) a conventional CST intervention with no spouse involvement, and 3) an arthritis education-spousal support (AE-SS) control condition [8].
 

High impact information on GAL3ST1

  • In CST patients, T-cell MC was detected in 5 patients, of whom 3 were mixed only during the first month [2].
  • In conclusion, molecular remission can be induced in most patients after NST, albeit with different kinetics from CST [2].
  • Recently, we cloned a human CST cDNA from a SMKT-R3 cDNA library (K. Honke et al., J. Biol. Chem., 272: 4864-4868, 1997) [3].
  • Furthermore, we examined the effects of epidermal growth factor (EGF), tetradecanoylphorbol-13-acetate, and genistein, which are known to regulate CST activity in SMKT-R3 cells, on CST-gene expression in various RCC cells [3].
  • Sulfoglycolipid analysis revealed that expression of lactosylceramide sulfate was correlated with the CST level [3].
 

Chemical compound and disease context of GAL3ST1

 

Biological context of GAL3ST1

 

Anatomical context of GAL3ST1

 

Associations of GAL3ST1 with chemical compounds

  • Furthermore, soluble Protein A-CST expressed in the presence of tunicamycin was almost inactive, and accumulated in transfected cells [19].
  • Moreover, transfecting CST mutants lacking both N-glycosylation sites, or only Asn-312, reduced significantly the amount of sulphatide synthesized, whereas substituting Asn-66 with a glutamine residue did not [19].
  • Sulphatide is synthesized in the Golgi apparatus by galactosylceramide sulphotransferase (CST; EC 2.8.2.11) [19].
  • In contrast, a reduction of CST mRNA and activity by tetradecanoylphorbol-13-acetate and genistein was observed in all of the lines examined [3].
  • Taken together, these findings indicate that in human RCC cells, the CST gene is generally overexpressed via a signaling pathway involving protein kinase-C and tyrosine kinases [3].
 

Other interactions of GAL3ST1

 

Analytical, diagnostic and therapeutic context of GAL3ST1

References

  1. Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene. Tsuda, M., Egashira, M., Niikawa, N., Wada, Y., Honke, K. Eur. J. Biochem. (2000) [Pubmed]
  2. Kinetics of minimal residual disease and chimerism in patients with chronic myeloid leukemia after nonmyeloablative conditioning and allogeneic stem cell transplantation. Uzunel, M., Mattsson, J., Brune, M., Johansson, J.E., Aschan, J., Ringdén, O. Blood (2003) [Pubmed]
  3. Cancer-associated expression of glycolipid sulfotransferase gene in human renal cell carcinoma cells. Honke, K., Tsuda, M., Hirahara, Y., Miyao, N., Tsukamoto, T., Satoh, M., Wada, Y. Cancer Res. (1998) [Pubmed]
  4. Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus. Smith, P.R., de Jesus, O., Turner, D., Hollyoake, M., Karstegl, C.E., Griffin, B.E., Karran, L., Wang, Y., Hayward, S.D., Farrell, P.J. J. Virol. (2000) [Pubmed]
  5. Anhidrosis and absence of sweat glands in mice hemizygous for the Tabby gene: supportive evidence for the hypothesis of homology between Tabby and human anhidrotic (hypohidrotic) ectodermal dysplasia (Christ-Siemens-Touraine syndrome). Blecher, S.R. J. Invest. Dermatol. (1986) [Pubmed]
  6. The role of a trial of labor with a positive contraction stress test. Bissonnette, J.M., Johnson, K., Toomey, C. Am. J. Obstet. Gynecol. (1979) [Pubmed]
  7. Age effects on executive ability. Wecker, N.S., Kramer, J.H., Wisniewski, A., Delis, D.C., Kaplan, E. Neuropsychology. (2000) [Pubmed]
  8. Spouse-assisted coping skills training in the management of knee pain in osteoarthritis: long-term followup results. Keefe, F.J., Caldwell, D.S., Baucom, D., Salley, A., Robinson, E., Timmons, K., Beaupre, P., Weisberg, J., Helms, M. Arthritis care and research : the official journal of the Arthritis Health Professions Association. (1999) [Pubmed]
  9. Adrenal insufficiency in patients with ruptured abdominal aortic aneurysms. Parikshak, M., Shepard, A.D., Reddy, D.J., Nypaver, T.J. J. Vasc. Surg. (2004) [Pubmed]
  10. Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease. Jiménez-Jiménez, F.J., de Bustos, F., Molina, J.A., Benito-León, J., Tallón-Barranco, A., Gasalla, T., Ortí-Pareja, M., Guillamón, F., Rubio, J.C., Arenas, J., Enríquez-de-Salamanca, R. Journal of neural transmission (Vienna, Austria : 1996) (1997) [Pubmed]
  11. Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides. Honke, K., Tsuda, M., Koyota, S., Wada, Y., Iida-Tanaka, N., Ishizuka, I., Nakayama, J., Taniguchi, N. J. Biol. Chem. (2001) [Pubmed]
  12. A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc. El-Fasakhany, F.M., Uchimura, K., Kannagi, R., Muramatsu, T. J. Biol. Chem. (2001) [Pubmed]
  13. Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. Suzuki, A., Hiraoka, N., Suzuki, M., Angata, K., Misra, A.K., McAuliffe, J., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (2001) [Pubmed]
  14. Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase. Honke, K., Tsuda, M., Hirahara, Y., Ishii, A., Makita, A., Wada, Y. J. Biol. Chem. (1997) [Pubmed]
  15. Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain. Benjamins, J.A., Hadden, T., Skoff, R.P. J. Neurochem. (1982) [Pubmed]
  16. Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures. Siegrist, H.P., Jutzi, H., Steck, A.J., Burkart, T., Wiesmann, U., Herschkowitz, N. Biochim. Biophys. Acta (1977) [Pubmed]
  17. Characterization of a sulfotransferase from human airways responsible for the 3-O-sulfation of terminal galactose in N-acetyllactosamine-containing mucin carbohydrate chains. Lo-Guidice, J.M., Périni, J.M., Lafitte, J.J., Ducourouble, M.P., Roussel, P., Lamblin, G. J. Biol. Chem. (1995) [Pubmed]
  18. Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine. Masuno, H., Blanchette-Mackie, E.J., Schultz, C.J., Spaeth, A.E., Scow, R.O., Okuda, H. J. Lipid Res. (1992) [Pubmed]
  19. N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase. Eckhardt, M., Fewou, S.N., Ackermann, I., Gieselmann, V. Biochem. J. (2002) [Pubmed]
  20. Menstrual cycle-associated regulation of anabolic and catabolic enzymes causes luteal phase-characteristic expression of sulfatide in human endometrium. Kamei, K., Kubushiro, K., Fujii, T., Tsukazaki, K., Nozawa, S., Iwamori, M. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  21. A streamlined three-dimensional volume estimation method accurately classifies prostate tumors by volume. Chen, M.E., Johnston, D., Reyes, A.O., Soto, C.P., Babaian, R.J., Troncoso, P. Am. J. Surg. Pathol. (2003) [Pubmed]
  22. Influence of IN-1 antibody and acidic FGF-fibrin glue on the response of injured corticospinal tract axons to human Schwann cell grafts. Guest, J.D., Hesse, D., Schnell, L., Schwab, M.E., Bunge, M.B., Bunge, R.P. J. Neurosci. Res. (1997) [Pubmed]
 
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