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Gene Review

SLAMF7  -  SLAM family member 7

Homo sapiens

Synonyms: 19A, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, CD319, CRACC, ...
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Disease relevance of SLAMF7


High impact information on SLAMF7


Chemical compound and disease context of SLAMF7


Biological context of SLAMF7

  • In isolated lymphocytes, expression of 19A is induced by various activation stimuli, and enforced expression of the 19A gene promotes homotypic cell adhesion in a B-cell-line model [12].
  • Extensive cross-reactions were observed between capsular PSs of streptococcal strains 14636/74, 4907, 4731 and pneumococcal type 19F and 19A antisera [13].
  • Intestinal function was studied in Ussing chambers: chloride secretion was assessed from the variations in short circuit current, and epithelial barrier capacity was monitored by the electrical resistance of the HT29 cl 19A cell monolayers and by measuring intact or degraded fluxes of the macromolecular tracer horseradish peroxidase [14].
  • Further investigations are necessary to elucidate the exact role of CS-1 and ubiquinone biosynthesis protein COQ7 in the setting of hypertension-induced LVH [15].
  • At 15 microM H(2)O(2) DNA damage in HT29 and HT29 19A cells was significantly lower than that observed in normal colonocytes (P < 0.01) [16].

Anatomical context of SLAMF7


Associations of SLAMF7 with chemical compounds

  • Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs [17].
  • Signaling lymphocytic activating molecule ((SLAM) CDw150) is a glycoprotein that belongs to the CD2 subset of the immunoglobulin superfamily and is expressed on the surface of activated T- and B-cells [20].
  • The effects of such cytokines were therefore measured on chloride secretion and macromolecular transport in intestinal HT29 cl 19A cells [14].
  • Relation between chloride secretion and intracellular cyclic adenosine monophosphate in a cloned human intestinal cell line HT-29 cl 19A [21].
  • The effect of 5-aminosalicylic acid (5-ASA) on IFN gamma induced changes in transepithelial resistance and permeability was investigated in HT29 clone 19A and Caco 2 monolayers [22].
  • Neutralizing Abs against lymphotoxin A, TNF-alpha, and/or flt3 ligand abolished the ability of CS1 on the B cell proliferation [23].

Other interactions of SLAMF7

  • Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP [17].
  • CD84 is a member of the CD2 subset of the immunoglobulin superfamily of cell surface receptors [24].

Analytical, diagnostic and therapeutic context of SLAMF7

  • Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily [25].
  • Serotype 19A isolates obtained from children <5 years old between January 2003 and June 2004 were characterized by serotyping, antibiotic susceptibility testing, and pulsed-field gel electrophoresis (PFGE) [4].
  • In addition, correlations between opsonophagocytic titers and IgG antibody levels by ELISA were high for 6B and 19F serotypes but low for 6A and 19A serotypes [26].
  • We concluded that vaccination with type 19F polysaccharide antigen, included in the current pneumococcal vaccine, does not induce a satisfactory heteroimmunogenic response to type 19A [27].
  • The immunogenicity of the two major group 19 pneumococcal polysaccharides, types 19F and 19A, was studied in human volunteers [27].


  1. Emergence of multiply resistant pneumococci. Jacobs, M.R., Koornhof, H.J., Robins-Browne, R.M., Stevenson, C.M., Vermaak, Z.A., Freiman, I., Miller, G.B., Witcomb, M.A., Isaäcson, M., Ward, J.I., Austrian, R. N. Engl. J. Med. (1978) [Pubmed]
  2. The anti-HIV pentameric pseudopeptide HB-19 binds the C-terminal end of nucleolin and prevents anchorage of virus particles in the plasma membrane of target cells. Nisole, S., Said, E.A., Mische, C., Prevost, M.C., Krust, B., Bouvet, P., Bianco, A., Briand, J.P., Hovanessian, A.G. J. Biol. Chem. (2002) [Pubmed]
  3. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. Komoriya, A., Green, L.J., Mervic, M., Yamada, S.S., Yamada, K.M., Humphries, M.J. J. Biol. Chem. (1991) [Pubmed]
  4. Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States. Pai, R., Moore, M.R., Pilishvili, T., Gertz, R.E., Whitney, C.G., Beall, B. J. Infect. Dis. (2005) [Pubmed]
  5. Precise breakpoint characterization of the colon adenocarcinoma cell line HT-29 clone 19A by means of 24-color fluorescence in situ hybridization and multicolor banding. Kuechler, A., Weise, A., Michel, S., Schaeferhenrich, A., Pool-Zobel, B.L., Claussen, U., Liehr, T. Genes Chromosomes Cancer (2003) [Pubmed]
  6. Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia. Denning, G.M., Ostedgaard, L.S., Cheng, S.H., Smith, A.E., Welsh, M.J. J. Clin. Invest. (1992) [Pubmed]
  7. 2B4/CD48-mediated regulation of lymphocyte activation and function. Assarsson, E., Kambayashi, T., Persson, C.M., Chambers, B.J., Ljunggren, H.G. J. Immunol. (2005) [Pubmed]
  8. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. Bouchon, A., Cella, M., Grierson, H.L., Cohen, J.I., Colonna, M. J. Immunol. (2001) [Pubmed]
  9. The structure of UDP-N-acetylglucosamine 2-epimerase reveals homology to phosphoglycosyl transferases. Campbell, R.E., Mosimann, S.C., Tanner, M.E., Strynadka, N.C. Biochemistry (2000) [Pubmed]
  10. Failure of a 5-day course of intramuscular ceftriaxone to eradicate Streptococcus pneumoniae from the middle ear. Anon, J.B., Ripple, W.L., Jacobs, M.R. Pediatr. Infect. Dis. J. (2006) [Pubmed]
  11. Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis. Fabiani, R., De Bartolomeo, A., Rosignoli, P., Servili, M., Montedoro, G.F., Morozzi, G. Eur. J. Cancer Prev. (2002) [Pubmed]
  12. A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion. Murphy, J.J., Hobby, P., Vilarino-Varela, J., Bishop, B., Iordanidou, P., Sutton, B.J., Norton, J.D. Biochem. J. (2002) [Pubmed]
  13. Capsular polysaccharides of nongroupable streptococci that cross-react with pneumococcal group 19. Lee, C.J., Koizumi, K., Henrichsen, J., Perch, B., Lin, C.S., Egan, W. J. Immunol. (1984) [Pubmed]
  14. Effect of cytokines on the epithelial function of the human colon carcinoma cell line HT29 cl 19A. Hiribarren, A., Heyman, M., L'Helgouac'h, A., Desjeux, J.F. Gut (1993) [Pubmed]
  15. Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies. Gallego-Delgado, J., Lazaro, A., Osende, J.I., Esteban, V., Barderas, M.G., Gomez-Guerrero, C., Vega, R., Vivanco, F., Egido, J. J. Am. Soc. Nephrol. (2006) [Pubmed]
  16. Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells. Rosignoli, P., Fabiani, R., De Bartolomeo, A., Spinozzi, F., Agea, E., Pelli, M.A., Morozzi, G. Carcinogenesis (2001) [Pubmed]
  17. Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Lee, J.K., Boles, K.S., Mathew, P.A. Eur. J. Immunol. (2004) [Pubmed]
  18. Human intestinal epithelial cells express a novel receptor for IgA. Kitamura, T., Garofalo, R.P., Kamijo, A., Hammond, D.K., Oka, J.A., Caflisch, C.R., Shenoy, M., Casola, A., Weigel, P.H., Goldblum, R.M. J. Immunol. (2000) [Pubmed]
  19. 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. Chuang, S.S., Kumaresan, P.R., Mathew, P.A. J. Immunol. (2001) [Pubmed]
  20. Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity. Mavaddat, N., Mason, D.W., Atkinson, P.D., Evans, E.J., Gilbert, R.J., Stuart, D.I., Fennelly, J.A., Barclay, A.N., Davis, S.J., Brown, M.H. J. Biol. Chem. (2000) [Pubmed]
  21. Relation between chloride secretion and intracellular cyclic adenosine monophosphate in a cloned human intestinal cell line HT-29 cl 19A. Nath, S.K., Huang, X., L'helgoualc'h, A., Rautureau, M., Bisalli, A., Heyman, M., Desjeux, J.F. Gut (1994) [Pubmed]
  22. 5-Aminosalicylic acid inhibits the impaired epithelial barrier function induced by gamma interferon. Di Paolo, M.C., Merrett, M.N., Crotty, B., Jewell, D.P. Gut (1996) [Pubmed]
  23. CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. Lee, J.K., Mathew, S.O., Vaidya, S.V., Kumaresan, P.R., Mathew, P.A. J. Immunol. (2007) [Pubmed]
  24. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. Tangye, S.G., van de Weerdt, B.C., Avery, D.T., Hodgkin, P.D. Eur. J. Immunol. (2002) [Pubmed]
  25. Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily. Boles, K.S., Mathew, P.A. Immunogenetics (2001) [Pubmed]
  26. Immunity to cross-reactive serotypes induced by pneumococcal conjugate vaccines in infants. Yu, X., Gray, B., Chang, S., Ward, J.I., Edwards, K.M., Nahm, M.H. J. Infect. Dis. (1999) [Pubmed]
  27. Antibody responses in adult volunteers to pneumococcal polysaccharide types 19F and 19A administered singly and in combination. Penn, R.L., Lewin, E.B., Douglas, R.G., Schiffman, G., Lee, C.J., Robbins, J.B. Infect. Immun. (1982) [Pubmed]
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