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Gene Review

Irf1  -  interferon regulatory factor 1

Rattus norvegicus

Synonyms: IRF-1, Interferon regulatory factor 1
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Disease relevance of Irf1


High impact information on Irf1

  • LPS, IL-6, or IFN-gamma induced a novel binding complex for GAS, which also existed in the 5'-flanking region of the IRF-1 gene [5].
  • LPS or IL-6 increased binding complexes for the IRF site, which was compatible with induction of IRF-1 [5].
  • Our studies show that the gene for IRF-1 is an immediate-early gene in Prl-stimulated T cells, which suggests that IRF-1 is a multifunctional molecule [6].
  • In addition to its role in regulating growth-inhibitory interferon genes, IRF-1 may, therefore, also play a stimulatory role in cell proliferation [6].
  • Surprisingly, DNA sequence analysis of c25 cDNA revealed that this Prl-inducible early-response gene is the rat homolog of the mouse transcription factor interferon-regulatory factor 1 (IRF-1), sharing 91% coding sequence similarity with mouse IRF-1 [6].

Chemical compound and disease context of Irf1


Biological context of Irf1


Anatomical context of Irf1

  • There was no functional difference in the signal transducers and activators of transcription (STAT) pathways between progenitors and mature oligodendrocytes as determined by induction of IRF1 mRNA in response to IFNG [10].
  • The suppression of the proinflammatory chemokine RANTES/CCL5 x 13cRA in fibroblasts could be mapped to a promoter module comprising IRF-1 and nuclear factor-kappaB binding elements, but direct binding of retinoid receptors to promoter elements could be excluded [11].
  • Sequential binding of IRF-1 to form a dimeric complex has not been described previously, and we show that formation of this dimeric complex is essential for full activation of the iNOS gene by cytokines in vascular smooth muscle cells [9].
  • The transcription factor interferon regulatory factor-1 is expressed during both early G1 and the G1/S transition in the prolactin-induced lymphocyte cell cycle [12].
  • The observed MPA suppression of NO release and iNOS and IRF-1 induction in astrocytes were efficiently prevented by exogenous guanosine, indicating that the drug acted through reduction of IMPDH-dependent synthesis of guanosine nucleotides [2].

Associations of Irf1 with chemical compounds


Regulatory relationships of Irf1


Other interactions of Irf1


Analytical, diagnostic and therapeutic context of Irf1


  1. The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury. Tsung, A., Stang, M.T., Ikeda, A., Critchlow, N.D., Izuishi, K., Nakao, A., Chan, M.H., Jeyabalan, G., Yim, J.H., Geller, D.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  2. Mycophenolic acid downregulates inducible nitric oxide synthase induction in astrocytes. Miljkovic, D., Samardzic, T., Cvetkovic, I., Mostarica Stojkovic, M., Trajkovic, V. Glia (2002) [Pubmed]
  3. Retinoic acid and polyriboinosinic acid act synergistically to enhance the antibody response to tetanus toxoid during vitamin A deficiency: possible involvement of interleukin-2 receptor-beta, signal transducer and activator of transcription-1, and interferon regulatory factor-1. DeCicco, K.L., Zolfaghari, R., Li, N., Ross, A.C. J. Infect. Dis. (2000) [Pubmed]
  4. Cytokine induction of interferon regulatory factor-1 in hepatocytes. Geller, D.A., Nguyen, D., Shapiro, R.A., Nussler, A., Di Silvio, M., Freeswick, P., Wang, S.C., Tweardy, D.J., Simmons, R.L., Billiar, T.R. Surgery (1993) [Pubmed]
  5. Transcriptional regulation of inducible nitric oxide synthase in cultured neonatal rat cardiac myocytes. Kinugawa, K., Shimizu, T., Yao, A., Kohmoto, O., Serizawa, T., Takahashi, T. Circ. Res. (1997) [Pubmed]
  6. Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells. Yu-Lee, L.Y., Hrachovy, J.A., Stevens, A.M., Schwarz, L.A. Mol. Cell. Biol. (1990) [Pubmed]
  7. Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Choi, W.H., Ji, K.A., Jeon, S.B., Yang, M.S., Kim, H., Min, K.J., Shong, M., Jou, I., Joe, E.H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. Peptide YY Reverses TNF-alpha Induced Transcription Factor Binding of Interferon Regulatory Factor-1 and p53 in Pancreatic Acinar Cells. Rizvi, I.A., Robinson, K., McFadden, D.W., Riggs, D.R., Jackson, B.J., Vona-Davis, L. J. Surg. Res. (2006) [Pubmed]
  9. Binding of the transcription factor interferon regulatory factor-1 to the inducible nitric-oxide synthase promoter. Spink, J., Evans, T. J. Biol. Chem. (1997) [Pubmed]
  10. MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells. Horiuchi, M., Itoh, A., Pleasure, D., Itoh, T. J. Biol. Chem. (2006) [Pubmed]
  11. 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Adams, J., Kiss, E., Arroyo, A.B., Bonrouhi, M., Sun, Q., Li, Z., Gretz, N., Schnitger, A., Zouboulis, C.C., Wiesel, M., Wagner, J., Nelson, P.J., Gröne, H.J. Am. J. Pathol. (2005) [Pubmed]
  12. The transcription factor interferon regulatory factor-1 is expressed during both early G1 and the G1/S transition in the prolactin-induced lymphocyte cell cycle. Stevens, A.M., Yu-Lee, L.Y. Mol. Endocrinol. (1992) [Pubmed]
  13. Growth hormone stimulates interferon regulatory factor-1 gene expression in the liver. Le Stunff, C., Rotwein, P. Endocrinology (1998) [Pubmed]
  14. Ascorbate inhibits iNOS expression in endotoxin- and IFN gamma-stimulated rat skeletal muscle endothelial cells. Wu, F., Tyml, K., Wilson, J.X. FEBS Lett. (2002) [Pubmed]
  15. Nicotinamide inhibits inducible nitric oxide synthase mRNA in primary rat glial cells. Fujimura, M., Tominaga, T., Yoshimoto, T. Neurosci. Lett. (1997) [Pubmed]
  16. Nitric oxide attenuates but superoxide enhances iNOS expression in endotoxin- and IFNgamma-stimulated skeletal muscle endothelial cells. Wu, F., Cepinskas, G., Wilson, J.X., Tyml, K. Microcirculation (New York, N.Y. : 1994) (2001) [Pubmed]
  17. Prolactin activates interferon regulatory factor-1 expression in normal lympho-hemopoietic cells. Dogusan, Z., Book, M.L., Verdood, P., Yu-Lee, L.Y., Hooghe-Peters, E.L. Eur. Cytokine Netw. (2000) [Pubmed]
  18. Strain-dependent difference in inducible nitric oxide synthesis (iNOS) expression in rat pancreatic islets correlates with interferon regulating factor 1 (IRF-1) and heat shock protein 70 (HSP70) expression. Johannesen, J., Pociot, F., Karlsen, A.E., Mandrup-Poulsen, T., Nerup, J. Eur. Cytokine Netw. (2001) [Pubmed]
  19. Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1. Tanaka, N., Ishihara, M., Taniguchi, T. Cancer Lett. (1994) [Pubmed]
  20. Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytes. Agresti, C., Bernardo, A., Del Russo, N., Marziali, G., Battistini, A., Aloisi, F., Levi, G., Coccia, E.M. Eur. J. Neurosci. (1998) [Pubmed]
  21. Ethanol inhibits prolactin-induced activation of the JAK/STAT pathway in cultured astrocytes. DeVito, W.J., Stone, S. J. Cell. Biochem. (1999) [Pubmed]
  22. Taxol activates inducible nitric oxide synthase in rat astrocytes: the role of MAP kinases and NF-kappaB. Cvetkovic, I., Miljkovic, D., Vuckovic, O., Harhaji, L., Nikolic, Z., Trajkovic, V., Mostarica Stojkovic, M. Cell. Mol. Life Sci. (2004) [Pubmed]
  23. Molecular mechanisms of iNOS induction by IL-1 beta and IFN-gamma in rat aortic smooth muscle cells. Teng, X., Zhang, H., Snead, C., Catravas, J.D. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  24. Apoptosis during bone-like tissue development in vitro. Lynch, M.P., Capparelli, C., Stein, J.L., Stein, G.S., Lian, J.B. J. Cell. Biochem. (1998) [Pubmed]
  25. Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction. Silverstein, D.M., Travis, B.R., Thornhill, B.A., Schurr, J.S., Kolls, J.K., Leung, J.C., Chevalier, R.L. Kidney Int. (2003) [Pubmed]
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