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EBPL  -  emopamil binding protein-like

Homo sapiens

Synonyms: EBRP, ERP, Emopamil-binding protein-like, Emopamil-binding-related protein
 
 
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Disease relevance of EBPL

  • Multiple system atrophy and idiopathic Parkinson's disease patient groups had minimal ERP abnormalities [1].
  • New findings are: (a) a high frequency of positive ERP in invasive lobular carcinoma (12 of 13, 92.3%) compared to typical ductal tumors (64 of 117, 54.7%); and (b) low frequency of positive ERP(5 of 21, 23.8%) in tumors with a prominent local lymphocyte reaction [2].
  • Three ERP-positive noncarcinomatous specimens were fibroadenomas of high epithelial cellularity from patients under 30 years [2].
  • Neuropsychological test, behavioural performance and ERP data all indicated that verbal working memory is especially susceptible to impairment by multiple sclerosis, while visuospatial working memory is less susceptible [3].
  • A post-ERP pancreatitis was defined as a three-fold increase of amylase or lipase and at least two of the clinical symptoms: abdominal pain, nausea, vomiting, and peritonism during 24 hours after ERP [4].
 

Psychiatry related information on EBPL

  • Successively less fragmented images were presented during high-density ERP recording, which permitted the monitoring of brain activity during perceptual closure processes prior to object recognition [5].
  • The results of karyotypic, clinical, and ERP investigations of this family suggest that the recently described genes DISC1 and DISC2, which are directly disrupted by the breakpoint on chromosome 1, may have a role in the development of a disease phenotype that includes schizophrenia as well as unipolar and bipolar affective disorders [6].
  • The results of the study support the view that bradykinetic-rigid syndromes involve some attentional deficits, but also have distinct reaction time and ERP characteristics, which may be helpful in differential diagnosis [1].
  • ERP activities time-locked to stimulus presentation and task performance are often observed separately at individual scalp channels based on averaged time series across epochs and experimental subjects [7].
  • Decreased amplitude of the P300 wave of evoked related potentials (ERP) has long been shown to be associated with alcohol and drug dependence [8].
 

High impact information on EBPL

  • In addition, ERP and single-neuron recordings, as well as neuroimaging and modelling studies, have suggested that temporal cortical regions, including the hippocampus, are also involved [9].
  • Work on brain event-related potentials (ERPs) suggests that people with high IQ test scores: (1) show faster responses in some test conditions; (2) have ERP waveforms that can be distinguished from those of people with lower IQs; and (3) might have less variability in their ERPs [10].
  • ERP recordings provide critical temporal information for analyzing the functional neuroanatomy of visual attention [11].
  • Early amygdala reaction to fear spreading in occipital, temporal, and frontal cortex: a depth electrode ERP study in human [12].
  • Mean atrial ERP and FRP during driving were, respectively, 231+/-15.3 and 264+/-14.9 ms before and 266+/-18.6 and 296+/-19.7 ms after ouabain (P less than 0.01 and P less than 0.01) [13].
 

Chemical compound and disease context of EBPL

  • The use of methylene blue for occult breast tumor localization is not recommended when an ERP binding-capacity assay is anticipated [14].
  • The use of isosulfan blue for localization of occult breast tumor is suggested when an ERP binding capacity assay is anticipated [15].
  • In the awake restrained rat the intrathecal administration of substance P or the partial substance P homologue eledoisin-related peptide (ERP) reduced reaction time to a noxious radiant heat stimulus and, at high doses, produced additional behavioural responses suggesting that the animals had reacted to what they perceived as a painful stimulus [16].
  • Our study is the first to examine the long-term effectiveness of cognitive therapy (CT) and to compare long-term effectiveness of CT alone, exposure in vivo with response prevention (ERP) alone, and CBT (either CT or ERP) in combination with fluvoxamine in the treatment of OCD [17].
  • Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task [18].
 

Biological context of EBPL

  • Amino acid sequence alignments and phylogenetic analysis revealed that EBPL is distantly related to EBP (31% identity and 52% similarity) and found in animals but not in plants [19].
  • EBPL is encoded by four exons on human chromosome 13q14.2 covering 30.7 kb, and a partially processed EBPL pseudogene was found on 16q21 [19].
  • Third, fundamental differences occur between the atrium and ventricle regarding changes in local conduction as a function of changes in ERP, suggesting that factors involved in sudden changes in refractoriness (eg, heart rate acceleration) could produce divergent effects on atrial and ventricular arrhythmogenesis [20].
  • Results of a genomewide linkage screen are presented for amplitude of the N4 and P3 components of the ERP, measured at 19 scalp locations in response to a semantic priming task for 604 individuals in 100 pedigrees ascertained as part of the Collaborative Study on the Genetics of Alcoholism [21].
  • During hypoglycaemia, ERP measures of selective attention (selection negativity), response choice (lateralized readiness potential) and reaction time were delayed compared with baseline performance [22].
 

Anatomical context of EBPL

  • BACKGROUND: Asymmetric reduction of the P3 event-related potential (ERP) has provided evidence of left temporal lobe dysfunction in schizophrenia [23].
  • Late follow-up electrophysiological study (92+/-7 days) showed that change in ventricular rate negatively correlated with change in AV node ERP (r=-.926, P=.0001) and WBCL (r=-.969, P=.0001) [24].
  • Second, latency and amplitude measurements on the 40-Hz ERP indicate it may contain useful information on the number and basilar membrane location of the auditory nerve fibers a given tone excites [25].
  • ERP in cytosols was assayed by incubation with [3H]estradiol in the presence and absence of "cold" estradiol followed by dextran-charcoal treatment [2].
  • We found robust motion-related activity in extrastriate motion processing areas in the ERP and MEG signals even when primary visual cortex was heavily suppressed by our manipulation [26].
 

Associations of EBPL with chemical compounds

  • We propose that EBPL has a yet-to-be-discovered function other than cholesterol biosynthesis [19].
  • Upon heterologous expression in yeast EBPL had no detectable 3beta-hydroxysteroid sterol delta8-delta7 isomerase and sigma-ligand-binding activity [19].
  • ERP during a target detection task, and regional cerebral glucose metabolism (CMRglc) measured simultaneously, may be influenced by the same neurophysiologic processes [27].
  • There is a medial frontal event-related potential (ERP) index of attention selection, the anterior positivity (P2a), associated with DA reward system input to the MFC for the identification of task-relevant perceptual representations [28].
  • The earliest ERP component (C1 at 50-90 ms) was unaffected by attention and was localized by dipole modeling to calcarine cortex [29].
 

Other interactions of EBPL

  • Nine out of ten amino acid residues essential for catalytic activity of EBP were conserved in EBPL [19].
 

Analytical, diagnostic and therapeutic context of EBPL

  • We compared processing of semantic meaning in language and music, investigating the semantic priming effect as indexed by behavioral measures and by the N400 component of the event-related brain potential (ERP) measured by electroencephalography (EEG) [30].
  • DESIGN AND SETTING: We collected ERP and fMRI data while subjects performed a NoGo task requiring a speedy button press to X stimuli (P=.88) but not to K stimuli (P=.12) [31].
  • Herein we report a combined positron emission tomography and event-related potential (ERP) experiment that was designed to distinguish between neural correlates of task-related and item-related processes of memory retrieval [32].
  • Functional neuroimaging studies have implicated the fusiform gyri (FG) in structural encoding of faces, while event-related potential (ERP) and magnetoencephalography studies have shown that such encoding occurs approximately 170 ms poststimulus [33].
  • Categorical perception of happiness and fear facial expressions: an ERP study [34].

References

  1. Attention and cognition in bradykinetic-rigid syndromes: an event-related potential study. Pirtosek, Z., Jahanshahi, M., Barrett, G., Lees, A.J. Ann. Neurol. (2001) [Pubmed]
  2. Pathological review of breast lesions analyzed for estrogen receptor protein. Rosen, P.P., Menendez-Botet, C.J., Nisselbaum, J.S., Urban, J.A., Miké, V., Fracchia, A., Schwartz, M.K. Cancer Res. (1975) [Pubmed]
  3. Event-related brain potential evidence for a verbal working memory deficit in multiple sclerosis. Ruchkin, D.S., Grafman, J., Krauss, G.L., Johnson, R., Canoune, H., Ritter, W. Brain (1994) [Pubmed]
  4. Post-ERP pancreatitis as a model for cytokine induced acute phase response in acute pancreatitis. Messmann, H., Vogt, W., Holstege, A., Lock, G., Heinisch, A., von Fürstenberg, A., Leser, H.G., Zirngibl, H., Schölmerich, J. Gut (1997) [Pubmed]
  5. Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Doniger, G.M., Foxe, J.J., Murray, M.M., Higgins, B.A., Javitt, D.C. Arch. Gen. Psychiatry (2002) [Pubmed]
  6. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Blackwood, D.H., Fordyce, A., Walker, M.T., St Clair, D.M., Porteous, D.J., Muir, W.J. Am. J. Hum. Genet. (2001) [Pubmed]
  7. Mapping single-trial EEG records on the cortical surface through a spatiotemporal modality. Tsai, A.C., Liou, M., Jung, T.P., Onton, J.A., Cheng, P.E., Huang, C.C., Duann, J.R., Makeig, S. Neuroimage (2006) [Pubmed]
  8. Association between the cannabinoid receptor gene (CNR1) and the P300 event-related potential. Johnson, J.P., Muhleman, D., MacMurray, J., Gade, R., Verde, R., Ask, M., Kelley, J., Comings, D.E. Mol. Psychiatry (1997) [Pubmed]
  9. Contribution of human hippocampal region to novelty detection. Knight, R. Nature (1996) [Pubmed]
  10. Neuroscience and human intelligence differences. Deary, I.J., Caryl, P.G. Trends Neurosci. (1997) [Pubmed]
  11. Involvement of striate and extrastriate visual cortical areas in spatial attention. Martínez, A., Anllo-Vento, L., Sereno, M.I., Frank, L.R., Buxton, R.B., Dubowitz, D.J., Wong, E.C., Hinrichs, H., Heinze, H.J., Hillyard, S.A. Nat. Neurosci. (1999) [Pubmed]
  12. Early amygdala reaction to fear spreading in occipital, temporal, and frontal cortex: a depth electrode ERP study in human. Krolak-Salmon, P., Hénaff, M.A., Vighetto, A., Bertrand, O., Mauguière, F. Neuron (2004) [Pubmed]
  13. The electrophysiological effects of ouabain on sinus node and atrium in man. Dhingra, R.C., Amat-Y-Leon, F., Wyndham, C., Wu, D., Denes, P., Rosen, K.M. J. Clin. Invest. (1975) [Pubmed]
  14. Effect of methylene blue on estrogen-receptor activity. Hirsch, J.I., Banks, W.L., Sullivan, J.S., Horsley, J.S. Radiology. (1989) [Pubmed]
  15. Noninterference of isosulfan blue on estrogen-receptor activity. Hirsch, J.I., Banks, W.L., Sullivan, J.S., Horsley, J.S. Radiology. (1989) [Pubmed]
  16. Substance P reduces tail-flick latency: implications for chronic pain syndromes. Yasphal, K., Wright, D.M., Henry, J.L. Pain (1982) [Pubmed]
  17. Cognitive therapy and exposure in vivo alone and in combination with fluvoxamine in obsessive-compulsive disorder: a 5-year follow-up. van Oppen, P., van Balkom, A.J., de Haan, E., van Dyck, R. The Journal of clinical psychiatry. (2005) [Pubmed]
  18. Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task. Lawrence, C.A., Barry, R.J., Clarke, A.R., Johnstone, S.J., McCarthy, R., Selikowitz, M., Broyd, S.J. Psychopharmacology (Berl.) (2005) [Pubmed]
  19. Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity. Moebius, F.F., Fitzky, B.U., Wietzorrek, G., Haidekker, A., Eder, A., Glossmann, H. Biochem. J. (2003) [Pubmed]
  20. Differential effects of changes in local myocardial refractoriness on atrial and ventricular latency. Fananapazir, L., Packer, D., Prystowsky, E.N. Circulation (1996) [Pubmed]
  21. Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. Almasy, L., Porjesz, B., Blangero, J., Goate, A., Edenberg, H.J., Chorlian, D.B., Kuperman, S., O'Connor, S.J., Rohrbaugh, J., Bauer, L.O., Foroud, T., Rice, J.P., Reich, T., Begleiter, H. Am. J. Hum. Genet. (2001) [Pubmed]
  22. Differentiation of hypoglycaemia induced cognitive impairments. An electrophysiological approach. Smid, H.G., Trümper, B.G., Pottag, G., Wagner, K., Lobmann, R., Scheich, H., Lehnert, H., Heinze, H.J. Brain (1997) [Pubmed]
  23. Left temporal lobe dysfunction in schizophrenia: event-related potential and behavioral evidence from phonetic and tonal dichotic listening tasks. Bruder, G., Kayser, J., Tenke, C., Amador, X., Friedman, M., Sharif, Z., Gorman, J. Arch. Gen. Psychiatry (1999) [Pubmed]
  24. Electrophysiological mechanisms in successful radiofrequency catheter modification of atrioventricular junction for patients with medically refractory paroxysmal atrial fibrillation. Chen, S.A., Lee, S.H., Chiang, C.E., Tai, C.T., Wu, T.J., Cheng, C.C., Wen, Z.C., Chiou, C.W., Ueng, K.C., Chang, M.S. Circulation (1996) [Pubmed]
  25. A 40-Hz auditory potential recorded from the human scalp. Galambos, R., Makeig, S., Talmachoff, P.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  26. Unmasking motion-processing activity in human brain area V5/MT+ mediated by pathways that bypass primary visual cortex. Schoenfeld, M.A., Heinze, H.J., Woldorff, M.G. Neuroimage (2002) [Pubmed]
  27. Event-related potentials correlate with task-dependent glucose metabolism. Absher, J.R., Hart, L.A., Flowers, D.L., Dagenbach, D., Wood, F.B. Neuroimage (2000) [Pubmed]
  28. When things are better or worse than expected: the medial frontal cortex and the allocation of processing resources. Potts, G.F., Martin, L.E., Burton, P., Montague, P.R. Journal of cognitive neuroscience. (2006) [Pubmed]
  29. Source analysis of event-related cortical activity during visuo-spatial attention. Di Russo, F., Martínez, A., Hillyard, S.A. Cereb. Cortex (2003) [Pubmed]
  30. Music, language and meaning: brain signatures of semantic processing. Koelsch, S., Kasper, E., Sammler, D., Schulze, K., Gunter, T., Friederici, A.D. Nat. Neurosci. (2004) [Pubmed]
  31. Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging. Ford, J.M., Gray, M., Whitfield, S.L., Turken, A.U., Glover, G., Faustman, W.O., Mathalon, D.H. Arch. Gen. Psychiatry (2004) [Pubmed]
  32. Task-related and item-related brain processes of memory retrieval. Düzel, E., Cabeza, R., Picton, T.W., Yonelinas, A.P., Scheich, H., Heinze, H.J., Tulving, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  33. Affective judgments of faces modulate early activity (approximately 160 ms) within the fusiform gyri. Pizzagalli, D.A., Lehmann, D., Hendrick, A.M., Regard, M., Pascual-Marqui, R.D., Davidson, R.J. Neuroimage (2002) [Pubmed]
  34. Categorical perception of happiness and fear facial expressions: an ERP study. Campanella, S., Quinet, P., Bruyer, R., Crommelinck, M., Guerit, J.M. Journal of cognitive neuroscience. (2002) [Pubmed]
 
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