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Chemical Compound Review

NeuNGl     (2S,4S,5R,6R)-2,4-dihydroxy- 5-(2...

Synonyms: GcNeu, NGNA, SureCN22503, CHEMBL496421, CHEBI:62084, ...
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Disease relevance of N-glycolylneuraminic acid


High impact information on N-glycolylneuraminic acid


Chemical compound and disease context of N-glycolylneuraminic acid


Biological context of N-glycolylneuraminic acid


Anatomical context of N-glycolylneuraminic acid


Associations of N-glycolylneuraminic acid with other chemical compounds


Gene context of N-glycolylneuraminic acid


Analytical, diagnostic and therapeutic context of N-glycolylneuraminic acid


  1. Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer. Higashi, H., Hirabayashi, Y., Fukui, Y., Naiki, M., Matsumoto, M., Ueda, S., Kato, S. Cancer Res. (1985) [Pubmed]
  2. N-glycolylneuraminic acid-containing GM1 is a new molecule for serum antibody in Guillain-Barré syndrome. Odaka, M., Yuki, N., Yoshino, H., Kasama, T., Handa, S., Irie, F., Hirabayashi, Y., Suzuki, A., Hirata, K. Ann. Neurol. (1998) [Pubmed]
  3. Quantitative determination of N-glycolylneuraminic acid expression in human cancerous tissues and avian lymphoma cell lines as a tumor-associated sialic acid by gas chromatography-mass spectrometry. Kawai, T., Kato, A., Higashi, H., Kato, S., Naiki, M. Cancer Res. (1991) [Pubmed]
  4. The addition of exogenous gangliosides to cultured human cells results in the cell type-specific expression of novel surface antigens by a biosynthetic process. Furukawa, K., Thampoe, I.J., Yamaguchi, H., Lloyd, K.O. J. Immunol. (1989) [Pubmed]
  5. Sialic acid species as a determinant of the host range of influenza A viruses. Suzuki, Y., Ito, T., Suzuki, T., Holland, R.E., Chambers, T.M., Kiso, M., Ishida, H., Kawaoka, Y. J. Virol. (2000) [Pubmed]
  6. Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Martin, M.J., Rayner, J.C., Gagneux, P., Barnwell, J.W., Varki, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Germinal Center Marker GL7 Probes Activation-Dependent Repression of N-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation. Naito, Y., Takematsu, H., Koyama, S., Miyake, S., Yamamoto, H., Fujinawa, R., Sugai, M., Okuno, Y., Tsujimoto, G., Yamaji, T., Hashimoto, Y., Itohara, S., Kawasaki, T., Suzuki, A., Kozutsumi, Y. Mol. Cell. Biol. (2007) [Pubmed]
  8. Ganglioside biosynthetic gene expression in experimental mouse brain tumors. Ecsedy, J.A., Manfredi, M.G., Yohe, H.C., Seyfried, T.N. Cancer Res. (1997) [Pubmed]
  9. The breast tumor-associated epitope defined by monoclonal antibody 3E1.2 is an O-linked mucin carbohydrate containing N-glycolylneuraminic acid. Devine, P.L., Clark, B.A., Birrell, G.W., Layton, G.T., Ward, B.G., Alewood, P.F., McKenzie, I.F. Cancer Res. (1991) [Pubmed]
  10. Had-1, a uridine 5'-diphosphogalactose transport-defective mutant of mouse mammary tumor cell FM3A: composition of glycolipids, cell growth inhibition by lactosylceramide, and loss of tumorigenicity. Taki, T., Ogura, K., Rokukawa, C., Hara, T., Kawakita, M., Endo, T., Kobata, A., Handa, S. Cancer Res. (1991) [Pubmed]
  11. Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks. Ito, T., Suzuki, Y., Suzuki, T., Takada, A., Horimoto, T., Wells, K., Kida, H., Otsuki, K., Kiso, M., Ishida, H., Kawaoka, Y. J. Virol. (2000) [Pubmed]
  12. The hemagglutinins of the human influenza viruses A and B recognize different receptor microdomains. Suzuki, Y., Nagao, Y., Kato, H., Suzuki, T., Matsumoto, M., Murayama, J. Biochim. Biophys. Acta (1987) [Pubmed]
  13. Hydroxylation of CMP-NeuAc controls the expression of N-glycolylneuraminic acid in GM3 ganglioside of the small intestine of inbred rats. Bouhours, J.F., Bouhours, D. J. Biol. Chem. (1989) [Pubmed]
  14. An activation-associated ganglioside in rat thymocytes. Nohara, K., Sano, T., Shiraishi, F. J. Biol. Chem. (1993) [Pubmed]
  15. Purification, characterization, and sugar binding specificity of an N-Glycolylneuraminic acid-specific lectin from the mushroom Chlorophyllum molybdites. Kobayashi, Y., Kobayashi, K., Umehara, K., Dohra, H., Murata, T., Usui, T., Kawagishi, H. J. Biol. Chem. (2004) [Pubmed]
  16. Purification, cloning, and expression of a cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi. Tullius, M.V., Munson, R.S., Wang, J., Gibson, B.W. J. Biol. Chem. (1996) [Pubmed]
  17. Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis. Integration into a discrete locus generates mutants expressing high levels of N-glycolylneuraminic acid. Hubbard, S.C., Walls, L., Ruley, H.E., Muchmore, E.A. J. Biol. Chem. (1994) [Pubmed]
  18. Surface alterations in calf lymphocytes oxidized by sodium periodate. Presant, C.A., Parker, S. J. Biol. Chem. (1976) [Pubmed]
  19. Developmental changes of hematoside of rat small intestine. Postnatal hydroxylation of fatty acids and sialic acid. Bouhours, D., Bouhours, J.F. J. Biol. Chem. (1983) [Pubmed]
  20. Tissue-specific expression of GM3(NeuGc) and GD3(NeuGc) in epithelial cells of the small intestine of strains of inbred rats. Absence of NeuGc in intestine and presence in kidney gangliosides of brown Norway and spontaneously hypertensive rats. Bouhours, D., Bouhours, J.F. J. Biol. Chem. (1988) [Pubmed]
  21. Detection of CMP-N-acetylneuraminic acid hydroxylase activity in fractionated mouse liver. Shaw, L., Schauer, R. Biochem. J. (1989) [Pubmed]
  22. Subcellular fractionation of rat sciatic nerve and specific localization of ganglioside LM1 in rat nerve myelin. Chou, K.H., Nolan, C.E., Jungalwala, F.B. J. Neurochem. (1985) [Pubmed]
  23. The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-capped alpha2-->5-Oglycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase. Kitazume, S., Kitajima, K., Inoue, S., Haslam, S.M., Morris, H.R., Dell, A., Lennarz, W.J., Inoue, Y. J. Biol. Chem. (1996) [Pubmed]
  24. Identification of novel gangliosides containing lactosaminyl-GM1 structure from rat spleen. Nohara, K., Suzuki, M., Inagaki, F., Ito, H., Kaya, K. J. Biol. Chem. (1990) [Pubmed]
  25. A second uniquely human mutation affecting sialic acid biology. Angata, T., Varki, N.M., Varki, A. J. Biol. Chem. (2001) [Pubmed]
  26. Relationship between mitogenic activity of influenza viruses and the receptor-binding specificity of their hemagglutinin molecules. Anders, E.M., Scalzo, A.A., Rogers, G.N., White, D.O. J. Virol. (1986) [Pubmed]
  27. Determination of sialic acids in the serum of cancer patients by capillary electrophoresis. Dong, X., Xu, X., Han, F., Ping, X., Yuang, X., Lin, B. Electrophoresis (2001) [Pubmed]
  28. Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues. Kelm, S., Brossmer, R., Isecke, R., Gross, H.J., Strenge, K., Schauer, R. Eur. J. Biochem. (1998) [Pubmed]
  29. Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid. Kawano, T., Koyama, S., Takematsu, H., Kozutsumi, Y., Kawasaki, H., Kawashima, S., Kawasaki, T., Suzuki, A. J. Biol. Chem. (1995) [Pubmed]
  30. Cell surface characteristics of an allotransplantable TA3 ascites subline resulting from a process of immunoselection. Codington, J.F., Das, H.R., Dalianis, T., Klein, G., Miller, S.C., Silber, C., Lampert, L.A., Darby, D.M., Jeanloz, R.W. Cancer Res. (1983) [Pubmed]
  31. O-glycosylation in hinge region of mouse immunoglobulin G2b. Kim, H., Yamaguchi, Y., Masuda, K., Matsunaga, C., Yamamoto, K., Irimura, T., Takahashi, N., Kato, K., Arata, Y. J. Biol. Chem. (1994) [Pubmed]
  32. Two human monoclonal antibodies reacting with the major gangliosides of human melanomas and comparison with corresponding mouse monoclonal antibodies. Furukawa, K., Yamaguchi, H., Oettgen, H.F., Old, L.J., Lloyd, K.O. Cancer Res. (1989) [Pubmed]
  33. Expression of mouse sialic acid on gangliosides of a human glioma grown as a xenograft in SCID mice. Ecsedy, J.A., Holthaus, K.A., Yohe, H.C., Seyfried, T.N. J. Neurochem. (1999) [Pubmed]
  34. Fish egg polysialoglycoproteins: circular dichroism and proton nuclear magnetic resonance studies of novel oligosaccharide units containing one sialidase-resistant N-glycolylneuraminic acid residue in each molecule. Kitajima, K., Nomoto, H., Inoue, Y., Iwasaki, M., Inoue, S. Biochemistry (1984) [Pubmed]
  35. Determination of N-acetylneuraminic acid and N-glycolylneuraminic acid in glycoproteins by high-performance liquid chromatography without derivatization. Ogawa, H.K., Takeuchi, Y., Uchibori, H., Matsumoto, I., Seno, N. J. Chromatogr. (1993) [Pubmed]
  36. Purification and partial characterization of a N-glycolylneuraminic acid specific lectin from the clam Anadara granosa (L). Dam, T.K., Sarkar, M., Ghosal, J., Choudhury, A. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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