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Chemical Compound Review

Ticarpen     disodium6-[(2-carboxylato-2- thiophen-3-yl...

Synonyms: SureCN4935403, AC-4338, LS-153103, AC1L2H26, 4697-14-7, ...
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Disease relevance of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid


Psychiatry related information on 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

  • Adverse reactions were uncommon but did include one patient treated with timentin who developed unexplained hallucinations [4].

High impact information on 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid


Chemical compound and disease context of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid


Biological context of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid


Anatomical context of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid


Associations of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid with other chemical compounds


Gene context of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid


Analytical, diagnostic and therapeutic context of 6-[(2-carboxy-2-thiophen-3-yl-acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

  • Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units [26].
  • The transformation was performed through two stages of cocultivation, the first stage occurring on antibiotic-free medium for 3 days, and the subsequent stage on medium containing 100 mg/l timentin for 1 month [27].
  • One hundred and one adult patients undergoing tonsillectomy for chronic/recurrent tonsillitis completed a prospective, randomized, double-blind, placebo-controlled study in which ticarcillin disodium and clavulanate potassium (Timentin) or placebo was administered intravenously at the time of surgery and for 12 hours postoperatively [28].


  1. Timentin versus piperacillin in the therapy of serious urinary tract infections. File, T.M., Tan, J.S., Salstrom, S.J., Johnson, L. Am. J. Med. (1985) [Pubmed]
  2. Timentin therapy for bone, joint, and deep soft tissue infections in children. Jacobs, R.F., Augustine, R.A., Aronson, J., McCarthy, R.E., Steele, R.W., Yamauchi, T. Am. J. Med. (1985) [Pubmed]
  3. Ticarcillin plus clavulanic acid (Timentin) therapy for osteomyelitis. Gentry, L.O., Macko, V., Lind, R., Heilman, A. Am. J. Med. (1985) [Pubmed]
  4. Timentin versus piperacillin or moxalactam in the therapy of acute bacterial infections. File, T.M., Tan, J.S., Salstrom, S.J., Johnson, L.A., Douglas, G.F. Antimicrob. Agents Chemother. (1984) [Pubmed]
  5. Timentin in the treatment of symptomatic complicated urinary tract infections in adult patients. Gebhart, R.J., Duma, R.J., Patterson, P.M. Am. J. Med. (1985) [Pubmed]
  6. Clinical pharmacology and safety evaluation of Timentin. Jackson, D., Cockburn, A., Cooper, D.L., Langley, P.F., Tasker, T.C., White, D.J. Am. J. Med. (1985) [Pubmed]
  7. Pharmacokinetics and distribution of ticarcillin-clavulanic acid (Timentin) in experimental animals. Woodnutt, G., Kernutt, I., Mizen, L. Antimicrob. Agents Chemother. (1987) [Pubmed]
  8. Pharmacokinetics and serum bactericidal activity of ticarcillin and clavulanic acid. Höffken, G., Tetzel, H., Koeppe, P., Lode, H. J. Antimicrob. Chemother. (1985) [Pubmed]
  9. The efficacy of the combination of Timentin and tobramycin in the treatment of patients with bacteraemia. Degener, J.E., Wagenvoort, J.H., Dzoljic-Danilovic, G., Michel, M.F., Brus-Weijer, A. J. Antimicrob. Chemother. (1986) [Pubmed]
  10. Clinical experience with Timentin in severe hospital infections. Meylan, P.R., Calandra, T., Casey, P.A., Glauser, M.P. J. Antimicrob. Chemother. (1986) [Pubmed]
  11. An open study of Timentin for the initial treatment of serious infections. Davey, P.G., Main, J., Scott, A.C. J. Antimicrob. Chemother. (1986) [Pubmed]
  12. Agrobacterium rhizogenes-mediated transformation of opium poppy, Papaver somniferum l., and California poppy, Eschscholzia californica cham., root cultures. Park, S.U., Facchini, P.J. J. Exp. Bot. (2000) [Pubmed]
  13. Prophylactic Timentin in patients undergoing thoracic or vascular surgery. Kitzis, M., Andreassian, B., Branger, C. J. Antimicrob. Chemother. (1986) [Pubmed]
  14. Safety of ticarcillin disodium/potassium clavulanate. Tasker, T.C., Cockburn, A., Jackson, D., Mellows, G., White, D. J. Antimicrob. Chemother. (1986) [Pubmed]
  15. A comparison between single and double dose intravenous Timentin for the prophylaxis of wound infection in elective colorectal surgery. Cuthbertson, A.M., McLeish, A.R., Penfold, J.C., Ross, H. Dis. Colon Rectum (1991) [Pubmed]
  16. Timentin--clinical and pharmacokinetic evaluation in otorhinolaryngology. Federspil, P., Koch, A., Schätzle, W., Tiesler, E. J. Antimicrob. Chemother. (1986) [Pubmed]
  17. Positive direct antiglobulin tests and haemolytic anaemia following therapy with beta-lactamase inhibitor containing drugs may be associated with nonimmunologic adsorption of protein onto red blood cells. Garratty, G., Arndt, P.A. Br. J. Haematol. (1998) [Pubmed]
  18. Ototoxicity of topical ticarcillin and clavulanic acid in the chinchilla. Jakob, T., Wright, C.G., Robinson, K., Meyerhoff, W.L. Arch. Otolaryngol. Head Neck Surg. (1995) [Pubmed]
  19. Pharmacokinetics and tissue penetration of Timentin: a simultaneous study of serum, urine, lymph, suction blister and subcutaneous thread fluid. Walstad, R.A., Hellum, K.B., Thurmann-Nielsen, E., Dale, L.G. J. Antimicrob. Chemother. (1986) [Pubmed]
  20. The pharmacokinetics of ticarcillin, clavulanic acid and their combination. Höffken, G., Tetzel, H., Koeppe, P., Lode, H. J. Antimicrob. Chemother. (1986) [Pubmed]
  21. Alcaligenes xylosoxidans keratitis post penetrating keratoplasty in a rigid gas permeable lens wearer. Lin, A., Driebe, W.T., Polack, P. The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc. (1998) [Pubmed]
  22. In vitro susceptibility-resistance patterns of bacterial isolates from burn patients to augmentin and timentin. Holder, I.A., Vanderpool, L., Wesselman, J. The Journal of burn care & rehabilitation. (1985) [Pubmed]
  23. Single-versus multiple-dose antibiotics prophylaxis for cardiac surgery. Bucknell, S.J., Mohajeri, M., Low, J., McDonald, M., Hill, D.G. The Australian and New Zealand journal of surgery. (2000) [Pubmed]
  24. High level expression of full-length estrogen receptor in Escherichia coli is facilitated by the uncoupler of oxidative phosphorylation, CCCP. Zhang, C.C., Glenn, K.A., Kuntz, M.A., Shapiro, D.J. J. Steroid Biochem. Mol. Biol. (2000) [Pubmed]
  25. Stenotrophomonas (Xanthomonas) maltophilia: in vitro susceptibility to selected antimicrobial drugs, single and combined, with and without defibrinated human blood. Traub, W.H., Leonhard, B., Bauer, D. Chemotherapy. (1998) [Pubmed]
  26. Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units. Schwigon, C.D., Hulla, F.W., Schulze, B., Maslak, A. J. Antimicrob. Chemother. (1986) [Pubmed]
  27. Agrobacterium tumefaciens-mediated transformation of an Oncidium orchid. Liau, C.H., You, S.J., Prasad, V., Hsiao, H.H., Lu, J.C., Yang, N.S., Chan, M.T. Plant Cell Rep. (2003) [Pubmed]
  28. The efficacy of perioperative antibiotic therapy on recovery following tonsillectomy in adults: randomized double-blind placebo-controlled trial. Grandis, J.R., Johnson, J.T., Vickers, R.M., Yu, V.L., Wagener, M.M., Wagner, R.L., Kachman, K.A. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1992) [Pubmed]
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