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Chemical Compound Review

Doxantrol     10,10-dioxo-3-(2H-tetrazol- 5...

Synonyms: DOXANTRAZOLE, CHEMBL22336, AG-F-75514, SureCN5494067, Ambcb5582494, ...
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Disease relevance of AIDS-128973


High impact information on AIDS-128973


Chemical compound and disease context of AIDS-128973


Biological context of AIDS-128973


Anatomical context of AIDS-128973


Associations of AIDS-128973 with other chemical compounds

  • Antibiotics and doxantrazole (a mast cell membrane stabilizer) significantly inhibited the effect of ethanol [22].
  • These results are discussed in terms of the functional heterogeneity of mast cells from different sources and identify a group of compounds other than doxantrazole (reported previously), which inhibit histamine secretion by MMC [23].
  • 1 Dextran-induced release of histamine from rat mast cells was inhibited equally in complete and glucose-free Tyrode solution by doxantrazole (0.03-3 micronmol/l), theophylline (0.1-3 mmol/l) and dicumarol (0.01-10 micronmol/litre) [15].
  • The activity of a mast cell stabilizer (doxantrazole), kinin antagonists (des-Arg 10-[Leu9]-kallidin, B1, HOE 140, B2) and tachykinin antagonists (CP 99, 994, NK1, SR 142801, NK3) were tested against the distension-induced depressor responses in control and post-infected rats [24].
  • Doxantrazole and KNO3 significantly reduced iodoacetamide-induced increase in gastric MPO activity, increased MMC number, and decreased RMCP II serum level in basal conditions [13].

Gene context of AIDS-128973


Analytical, diagnostic and therapeutic context of AIDS-128973


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  5. Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation. Anton, P.M., Theodorou, V., Fioramonti, J., Bueno, L. Pain (2001) [Pubmed]
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  10. Antiallergy activity of 10-oxo-10-H-pyridazino[6,1-b]quinazoline-2-carboxylic acids. Schwender, C.F., Sunday, B.R., Kerbleski, J.J., Herzig, D.J. J. Med. Chem. (1980) [Pubmed]
  11. Antiallergy activity of substituted 11-oxo-11 H-pyrido[2,1-b]quinazoline-8-carboxylic acids. Schwender, C.F., Sunday, B.R., Herzig, D.J., Kusner, E.K., Schumann, P.R., Gawlak, D.L. J. Med. Chem. (1979) [Pubmed]
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  13. Effect of dietary nitric oxide on gastric mucosal mast cells in absence or presence of an experimental gastritis in rats. Larauche, M., Buéno, L., Fioramonti, J. Life Sci. (2003) [Pubmed]
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  23. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. Pearce, F.L., Befus, A.D., Bienenstock, J. J. Allergy Clin. Immunol. (1984) [Pubmed]
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