Chemical Compound Review:
AXD455 N,N'-bis[3,5-bis[N- (diaminomethylideneamin...
Synonyms:
Löwenberg,
Verhaar,
van den Blink,
ten Kate,
van Deventer,
Peppelenbosch,
Hommes,
Mendez,
Jaffray,
Wong,
Salhab,
Kramer,
Carey,
Norman,
Milligan,
Mehmert,
Hinde,
Harvey,
Martin,
Tracey,
Maier,
Watkins,
Hommes,
van den Blink,
Plasse,
Bartelsman,
Xu,
Macpherson,
Tytgat,
Peppelenbosch,
Van Deventer,
Borovikova,
Ivanova,
Nardi,
Zhang,
Yang,
Ombrellino,
Tracey,
Granert,
Abdalla,
Lindquist,
Diab,
Bahkiet,
Tracey,
Andersson,
Zamora,
Grishin,
Wong,
Boyle,
Wang,
Hackam,
Upperman,
Tracey,
Ford,
Sitaraman,
Hoteit,
Gewirtz,
Palmblad,
Erlandsson-Harris,
Tracey,
Andersson,
- Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. Bianchi, M., Bloom, O., Raabe, T., Cohen, P.S., Chesney, J., Sherry, B., Schmidtmayerova, H., Calandra, T., Zhang, X., Bukrinsky, M., Ulrich, P., Cerami, A., Tracey, K.J. J. Exp. Med. (1996)
- Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Hommes, D., van den Blink, B., Plasse, T., Bartelsman, J., Xu, C., Macpherson, B., Tytgat, G., Peppelenbosch, M., Van Deventer, S. Gastroenterology (2002)
- The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy. Kemeny, M.M., Botchkina, G.I., Ochani, M., Bianchi, M., Urmacher, C., Tracey, K.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor alpha and interleukin-1beta. Yang, J., Denham, W., Carter, G., Tracey, K.J., Norman, J. Hepatology (1998)
- Pharmacological stimulation of the cholinergic antiinflammatory pathway. Bernik, T.R., Friedman, S.G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C.J., Ivanova, S.M., Tracey, K.J. J. Exp. Med. (2002)
- Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy. Hauber, I., Bevec, D., Heukeshoven, J., Krätzer, F., Horn, F., Choidas, A., Harrer, T., Hauber, J. J. Clin. Invest. (2005)
- Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Milligan, E.D., Mehmert, K.K., Hinde, J.L., Harvey, L.O., Martin, D., Tracey, K.J., Maier, S.F., Watkins, L.R. Brain Res. (2000)
- Semapimod. Cytokine. Sitaraman, S.V., Hoteit, M., Gewirtz, A.T. Current opinion in investigational drugs (London, England : 2000) (2003)
- Strategies for targeting tumour necrosis factor in IBD. Sandborn, W.J. Best practice & research. Clinical gastroenterology. (2003)
- CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency. Cohen, P.S., Nakshatri, H., Dennis, J., Caragine, T., Bianchi, M., Cerami, A., Tracey, K.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma. Atkins, M.B., Redman, B., Mier, J., Gollob, J., Weber, J., Sosman, J., MacPherson, B.L., Plasse, T. Clin. Cancer Res. (2001)
- Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kramer, A.A., Postler, G., Salhab, K.F., Mendez, C., Carey, L.C., Rabb, H. Kidney Int. (1999)
- High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. Zamora, R., Grishin, A., Wong, C., Boyle, P., Wang, J., Hackam, D., Upperman, J.S., Tracey, K.J., Ford, H.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Suppression of macrophage activation with CNI-1493 increases survival in infant rats with systemic Haemophilus influenzae infection. Granert, C., Abdalla, H., Lindquist, L., Diab, A., Bahkiet, M., Tracey, K.J., Andersson, J. Infect. Immun. (2000)
- Targeted suppression of cytokine production in monocytes but not in T lymphocytes by a tetravalent guanylhydrazone (CNI-1493). Björk, L., Tracey, K.J., Ulrich, P., Bianchi, M., Cohen, P.S., Akerlund, K., Fehniger, T.E., Andersson, U., Andersson, J. J. Infect. Dis. (1997)
- Prevention of lethality and suppression of proinflammatory cytokines in experimental septic shock by microencapsulated CNI-1493. D'Souza, M.J., Oettinger, C.W., Milton, G.V., Tracey, K.J. J. Interferon Cytokine Res. (1999)
- Involvement of p38 mitogen-activated protein kinase in the induction of tolerance to hemorrhagic and endotoxic shock. Mendez, C., Jaffray, C., Wong, V., Salhab, K.F., Kramer, A.A., Carey, L.C., Norman, J.G. J. Surg. Res. (2000)
- Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Borovikova, L.V., Ivanova, S., Nardi, D., Zhang, M., Yang, H., Ombrellino, M., Tracey, K.J. Autonomic neuroscience : basic & clinical. (2000)
- Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease. Löwenberg, M., Verhaar, A., van den Blink, B., ten Kate, F., van Deventer, S., Peppelenbosch, M., Hommes, D. J. Immunol. (2005)
- Inhibition of tumor necrosis factor-alpha improves physiological angiogenesis and reduces pathological neovascularization in ischemic retinopathy. Gardiner, T.A., Gibson, D.S., de Gooyer, T.E., de la Cruz, V.F., McDonald, D.M., Stitt, A.W. Am. J. Pathol. (2005)
- Dynamics of early synovial cytokine expression in rodent collagen-induced arthritis : a therapeutic study using a macrophage-deactivating compound. Palmblad, K., Erlandsson-Harris, H., Tracey, K.J., Andersson, U. Am. J. Pathol. (2001)
- An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality. Bianchi, M., Ulrich, P., Bloom, O., Meistrell, M., Zimmerman, G.A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B. Mol. Med. (1995)