Disease relevance of Drug and Narcotic Control

• METHODS: In studies, CBF (intraarterial (133)Xe technique) was measured in healthy baboons during isoflurane anesthesia at (1) baseline and during (2) induced hypertension with intravenous phenylephrine, (3) concurrent infusions of intravenous phenylephrine and intracarotid SNP, and (4) intracarotid verapamil (positive control drug) [1].
• On the other side, compounds 7-9 indicated significant antibacterial activity against the Gram-negative enterobacter Pseudomonas aeruginosa having MIC values of 50 microg/ml, providing either the same effect as tetracycline or higher activity than streptomycin, but showing less potency than the compared control drug gentamycin [2].
• Consequently alpha, alpha-trehalose-6-phosphate was synthesised and assessed for onchocerciatic activity against O. volvulus; using diethylcarbamizine citrate as the control drug [3].
• We have previously described how a series of trials sponsored by Pfizer of its antifungal drug, fluconazole, in cancer patients with neutropenia handicapped the control drug, amphotericin B, by flaws in design and analysis [4].
• Risk factors were similar in both groups, and no toxicity was seen with either the control drug, cefazolin, or the test drug, cefonicid [5].

Psychiatry related information on Drug and Narcotic Control

• To investigate the effects of venlafaxine on relapse to opiate dependence, the morphine CPP was used and a dopamine D2 antagonist sulpiride was selected as a control drug [6].
• Program efficacy was demonstrated particularly for decreasing drug control problems and consequences; increasing GPA and school bonding; and desired changes in self-esteem and deviant peer bonding [7].

High impact information on Drug and Narcotic Control

• Chlorothiazide, a diuretic that does not stimulate prostaglandin E synthesis, was used as the control drug in 33 other infants [8].
• These findings demonstrate how the molecular activities of SXR can be manipulated to control drug clearance [9].
• Drug regulation in the EEC [10].
• We compared the effects of this "depletion regimen" with the responses in two control groups: a stimulation control group, which was subjected to high-frequency right vagus stimulation only, and a drug control group, which received a hemicholinium-3 infusion only [11].
• Cells were exposed for 1 h either to no drug (control) or to varying concentrations, ranging from 1 to 250 microM, of either FUra, FUH2, or alpha-fluoro-beta-alanine [12].

Chemical compound and disease context of Drug and Narcotic Control

• Statistical analysis of data demonstrated that coenzyme A has a significant cholesterol-lowering action (with an increase in HDL-cholesterol) and a more pronounced hypotriglyceridemic effect in both types of dyslipidemia considered, results on both variables proving more satisfactory than with the control drug [13].
• Thirty-nine of 43 patients treated with a control drug (gentamicin, cefotaxime, cefamandole, or tobramycin) had a satisfactory clinical response, 25 of 34 such patients showed microbiologic cure, and 12 experienced relapse, reinfection, or superinfection [14].

Biological context of Drug and Narcotic Control

• P-Glycoprotein and homologous multidrug transporters contain a phosphorylatable linker sequence that was proposed to control drug efflux on the basis that it was indeed phosphorylated in vitro and in vivo, and that inhibitors of protein kinase C (PKC) inhibited both P-glycoprotein phosphorylation and activity [15].
• This drug regulation pattern for 5-HT1C sites of down-regulation by both 5-HT1C/2 receptor agonists and antagonists is similar to that for 5-HT2 receptors and is consistent with the classification of 5-HT1C and 5-HT2 receptors in the same superfamily [16].
• The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate [17].
• In this system gossypol is carried on a polymer of polylactic acid which controls drug release and can also be injected into the vas deferens so that the drug can act continuously and directly on spermatogenesis [18].

Anatomical context of Drug and Narcotic Control

• In contrast to drug regulation of enzyme activity, chronic imipramine treatment did not decrease levels of TH immunoreactivity in any of the dopaminergic cell body or terminal field regions studied, although levels of TH immunoreactivity were decreased in locus coeruleus (LC) as previously reported [19].
• Sixty seconds after the onset of seizure activity, the animals either received no drug (control) or propranolol (IV or IO via an 18-gauge spinal needle placed in the right proximal tibia) [20].

Associations of Drug and Narcotic Control with chemical compounds

• First, we compared the effectiveness of prednisone to placebo and active drug controls (aspirin, chloroquine, or deflazacort) using standard meta-analysis methods for continuous data [21].
• Three groups of "young," 8-week-old mice received high-dose frentizole (80-84 mg/kg/day), low-dose frentizole (8 mg/kg/day), or no drug (controls); these mice were followed until spontaneous death [22].
• Use of lithium to control drug abuse [23].
• In a few cases, Mendelian loci which control drug susceptibility (e.g., to isoniazid) have been described [24].
• Drug control of reverse cholesterol transport [25].

Gene context of Drug and Narcotic Control

• RESULTS: Endothelin-1 in plasma increased in all dogs with pacing induced HF (placebo control 1.57 +/- 0.5 vs placebo HF 2.2 +/- 0.6 pg/ml and drug control 1.5 +/- 0.16 v.s. drug HF 14.6 +/- 3.8 pg/ml [p < 0.05]) [26].
• Antipsychotic drug regulation of AMPA receptor affinity states and GluR1, GluR2 splice variant expression [27].
• Immunotoxins may provide a means to control drug refractory GVHD [28].
• The rapid turnover of 15-PGDH indicates that the enzyme activity depends on continued enzyme synthesis, and this could be susceptible to hormone and drug control mechanisms [29].
• In the current study we have investigated the mechanism by which cAMP-dependent protein kinase controls drug resistance [30].

Analytical, diagnostic and therapeutic context of Drug and Narcotic Control

• Coded formulations of the control vehicle or the following test agents were administered in prevention and intervention treatment protocols: 1% formulations of AL-3789, AL-4940, and cortisol acetate as a positive drug control [31].
• Brodimoprim uptake by PMNs was determined by a velocity-gradient centrifugation technique under various experimental conditions and was expressed as the ratio of the intracellular to the extracellular drug concentration (C/E) in comparison with the C/E of trimethoprim, which was used as a control drug [32].
• We have fabricated uniform rhodamine- and piroxicam-containing microspheres, 10 to 100 microm in diameter, to better understand how microsphere size controls drug release [33].
• During the 1990 Strictly Against Illegal Drug Campaign (Yan Da), the Chinese government implemented a compulsory detoxification plan and a Community Drug Rehabilitation Camp strategy to deal with the diverse aspects of the illegal drug control [34].

References